Details of the Target

General Information of Target

Target ID LDTP04430
Target Name Breast cancer type 2 susceptibility protein (BRCA2)
Gene Name BRCA2
Gene ID 675
Synonyms
FACD; FANCD1; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination.
TTD ID
T15823
Uniprot ID
P51587
DrugMap ID
TTUARD6
Ensemble ID
ENST00000380152.8
HGNC ID
HGNC:1101

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C2636(3.50)  LDD2128  [1]
IA-alkyne
 Probe Info  		C3287(17.84); C1975(13.81)  LDD1706  [2]
DBIA
 Probe Info  		C1948(0.93); C1958(0.93)  LDD0078  [3]
NAIA_4
 Probe Info  		C1399(0.00); C3198(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		C2422(0.00); C1159(0.00)  LDD0147  [5]
TFBX
 Probe Info  		C2646(0.00); C2422(0.00); C1159(0.00); C1621(0.00)  LDD0148  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
YN-1
 Probe Info  		N.A.  LDD0447  [7]
Phosphinate-6
 Probe Info  		C1399(0.00); C279(0.00)  LDD0018  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1159(0.94); C1948(0.91); C1958(0.91)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C1159(1.07); C1809(0.87); C1820(1.19); C1948(1.27)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C1948(0.81); C1958(0.81)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1948(0.86); C1958(0.86)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1948(0.84); C1958(0.84)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1948(1.12); C1958(1.12)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1948(0.89); C1958(0.89)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1948(1.04); C1958(1.04)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1948(1.23); C1958(1.23)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1948(1.09); C1958(1.21)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1948(0.91); C1958(0.71)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1948(0.78); C1958(0.72)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C1159(1.25); C1809(0.97); C1820(1.24); C1948(1.36)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C1948(0.71); C1958(0.75)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1948(0.99); C1958(0.87)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1948(0.91); C1958(0.94)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1159(0.46)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1159(0.71)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1159(0.77)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1159(0.53)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1159(0.80)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1159(0.67)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1159(0.78)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C1159(0.73); C1809(0.77); C1820(1.28); C1948(1.25)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C1159(0.66)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1159(0.87)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1159(0.60)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1159(0.65)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1159(0.48)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1159(0.71)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1159(0.51)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1159(0.74)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1948(1.10); C1958(1.10)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1948(0.74); C1958(0.74)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1948(1.17); C1958(1.17)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1948(1.16); C1958(1.16)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1948(0.77); C1958(0.77)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1948(1.00); C1958(1.00)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1948(1.09); C1958(1.09)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1948(1.13); C1958(1.13)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1948(0.83); C1958(0.83)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1948(0.84); C1958(0.84)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1948(0.88); C1958(0.88)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1948(0.83); C1958(0.83)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C1159(1.26); C1809(0.81); C1820(1.06); C1948(1.26)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C1948(1.14); C1958(1.14)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1948(0.96); C1958(0.96)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1948(0.87); C1958(0.87)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1948(0.99); C1958(0.99)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1948(1.40); C1958(1.40)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1948(0.91); C1958(0.91)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1948(1.40); C1958(1.40)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1948(1.47); C1958(1.47)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1948(1.74); C1958(1.74)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1948(1.53); C1958(1.53)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C1159(1.11); C1809(0.89); C1820(1.47); C1948(1.26)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C1948(1.11); C1958(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1948(1.03); C1958(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1948(1.46); C1958(1.46)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1948(1.96); C1958(1.96)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1948(1.21); C1958(1.21)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1948(1.34); C1958(1.34)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1948(1.21); C1958(1.21)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1948(1.22); C1958(1.22)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C1958(1.43); C822(1.44)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C1958(1.22); C822(1.14)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C1958(1.02); C822(1.21)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C1159(0.91); C1948(1.00); C1958(1.00)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C1958(1.22); C822(1.04)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C1958(1.38); C822(0.86)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C1958(1.10); C822(1.19)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C1958(1.36); C822(1.23)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C1958(1.04); C822(1.32)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C1809(0.97); C1820(1.15); C1958(0.93)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C1809(0.89); C1820(1.19); C1958(1.06)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C1809(0.89); C1820(1.12); C1958(1.39)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C1809(0.73); C1820(1.44); C1958(1.10)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C1809(0.81); C1820(1.16); C1958(0.99)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C1948(0.91); C1958(0.91); C1159(0.94)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C1809(0.90); C1820(1.16); C1958(1.14)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C1809(0.94); C1820(1.14); C1958(0.97)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C1809(0.95); C1820(1.12); C1958(0.95)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C1809(0.92); C1820(1.14); C1958(1.09)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C1809(0.92); C1820(1.18); C1958(0.91)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C1809(0.89); C1948(1.05); C1958(1.05)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C1809(0.93); C1948(0.86); C1958(0.86)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C1809(0.84); C1948(0.82); C1958(0.82)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C1809(0.85); C1948(1.20); C1958(1.20)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C1809(0.74); C1948(1.16); C1958(1.16)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C1159(0.96); C1948(0.98); C1958(0.98)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C1809(0.78); C1948(0.91); C1958(0.91)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C1809(0.79); C1948(0.91); C1958(0.91)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C1809(0.76); C1948(0.89); C1958(0.89)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C1809(0.80); C1948(1.13); C1958(1.13)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C1809(0.78); C1948(1.01); C1958(1.01)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C1809(1.23); C1948(0.99); C1958(0.99)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C1159(1.18)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1159(0.85)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1159(1.09)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1159(1.66)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1159(0.85); C1948(0.93); C1958(0.93)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1159(1.02)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1159(1.22)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1159(0.93)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1159(0.98)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1159(0.72)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1159(1.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1159(0.94)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C1159(1.05); C1809(0.97); C1820(1.03); C1948(0.76)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C1159(1.21); C1809(0.99); C1820(0.95); C1948(0.89)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C1159(1.04); C1809(1.12); C1820(1.11); C1948(0.89)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C1159(0.98); C1809(0.90); C1820(1.55); C1948(1.11)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C1159(1.06); C1809(2.77); C1820(0.86); C1948(0.62)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C1159(1.25); C1809(0.91); C1820(1.01); C1948(0.66)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C1159(1.13); C1809(0.95); C1820(0.97); C1948(0.68)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C1159(1.84); C1809(0.85); C1820(1.01); C1948(0.74)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C1159(1.24); C1809(0.88); C1820(0.90); C1948(0.83)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C1159(1.28); C1809(0.81); C1820(1.01); C1948(0.99)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C1159(1.16); C1809(0.89); C1820(0.90); C1948(0.92)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C1159(1.32); C1809(0.87); C1820(1.04); C1948(0.85)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C1159(1.13)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1159(1.35)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C1159(0.92); C1809(0.84); C1820(1.46); C1948(0.98)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C1159(0.94)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1159(1.24)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1159(1.34)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1159(1.64)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1159(1.22)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1159(1.20)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1159(0.86)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1159(1.31)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1159(1.19)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1159(1.22)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C1159(1.54); C1809(0.81); C1820(1.46); C1948(1.05)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C1159(1.36)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1159(0.73)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1159(1.23)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C1159(1.54); C1675(1.25); C1809(1.00); C1958(1.24)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C1159(1.37); C1675(1.07); C1809(0.91); C1958(1.50)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C1159(1.59); C1675(0.79); C1809(0.92); C1958(1.03)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C1159(1.17); C1675(0.96); C1809(0.83); C1958(0.97)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C1159(1.23); C1675(0.93); C1809(0.93); C1958(1.13)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C1159(1.31); C1675(0.80); C1809(0.88); C1958(1.48)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C1159(1.12); C1675(0.89); C1809(1.13); C1958(1.40)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C1159(1.32); C1675(1.04); C1809(0.89); C1958(0.97)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C1159(1.47); C1675(0.93); C1809(1.00); C1958(1.27)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C1159(1.17); C1675(0.80); C1809(0.93); C1958(1.29)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C1159(1.71); C1675(0.86); C1809(0.91); C1958(0.96)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C1159(1.08); C1675(0.98); C1809(0.87); C1958(1.26)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C1159(1.07); C1675(1.34); C1809(0.84); C1958(1.45)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C1159(1.49); C1675(1.18); C1809(0.90); C1958(1.53)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C1159(1.00); C1675(0.71); C1809(1.16); C1958(1.87)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C1948(1.18); C1958(1.18)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1948(0.75); C1958(0.75)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C1159(1.10); C1809(0.80); C1820(1.31); C1948(1.29)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C1159(0.98); C1809(0.87); C1820(1.51); C1948(1.23)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C1159(1.04); C1809(0.81); C1820(1.63); C1948(1.54)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C1948(0.93); C1958(0.93)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C279(20.00)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C341(0.84); C2605(0.99)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C341(0.91); C2605(0.89)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C1159(0.92); C1948(0.92); C1958(0.92)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C1159(1.12); C1809(0.75); C1820(1.43); C1948(1.13)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C1159(0.90); C1809(0.77); C1820(1.16); C1948(1.49)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C1159(0.81); C1809(0.87); C1820(1.60); C1948(0.93)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C1159(1.32); C1809(0.83); C1820(1.48); C1948(0.93)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C1958(0.88); C822(0.88)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C1958(0.96); C822(0.98)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C1958(1.16); C822(1.24)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C1958(1.18); C822(1.25)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C1958(1.03); C822(0.90)  LDD0976  [3]
 LDCM0380  CL110 HEK-293T C1958(1.18); C822(0.99)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C1958(0.96); C822(0.94)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C1809(0.91); C1820(1.12); C1958(1.04)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C1809(0.99); C1820(1.22); C1958(1.11)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C1809(0.89); C1820(1.22); C1958(1.12)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C1809(0.84); C1820(1.22); C1958(0.93)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C1809(0.91); C1820(1.32); C1958(1.08)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C1809(0.88); C1948(1.29); C1958(1.29)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C1809(1.06); C1948(0.80); C1958(0.80)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C1809(0.82); C1948(0.85); C1958(0.85)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C1399(0.93)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C1809(0.85); C1948(1.01); C1958(1.01)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C1159(1.27)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1159(0.91)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1159(0.99)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1159(0.85)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C1159(1.45); C1809(0.93); C1820(1.01); C1948(0.95)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C1159(1.42); C1809(0.97); C1820(0.96); C1948(0.81)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C1159(1.22); C1809(1.06); C1820(0.98); C1948(0.83)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C1159(1.15); C1809(1.06); C1820(1.08); C1948(1.01)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C341(0.96); C2605(0.78)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C2605(1.28)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C341(0.92)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C1159(0.75)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1159(0.71)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1159(1.12)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1159(0.70)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C2605(1.06)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C1159(0.87)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1159(1.04)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1159(1.20)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1159(1.02)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1159(0.97)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1159(1.07)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1159(1.26)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1159(0.88)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1159(1.07)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1159(0.93)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C341(1.02)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C1159(1.15)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C1809(1.06); C1958(0.72); C822(0.68)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C1159(0.75)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1159(0.37)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1159(0.63)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1159(0.59)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1159(0.47)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1159(0.71)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1159(0.83)  LDD0745  [3]
 LDCM0430  CL40 HCT 116 C1159(0.36)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1159(0.54)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1159(0.30)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1159(0.67)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1159(0.60)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1159(0.62)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C1809(1.11); C1948(0.85); C1958(0.85); C822(1.00)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C1809(1.10); C1948(1.02); C1958(1.02); C822(0.97)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C1809(1.02); C1948(0.90); C1958(0.90); C822(0.82)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C1809(1.01); C1948(0.86); C1958(0.86); C822(0.98)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C341(1.33); C1399(0.81)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C1809(1.20); C1948(0.81); C1958(0.81); C822(0.93)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C1809(0.95); C1948(1.14); C1958(1.14); C822(0.80)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C1809(1.34); C1948(0.86); C1958(0.86); C822(0.81)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C1809(1.19); C1948(0.93); C1958(0.93); C822(0.78)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C1809(0.93); C1948(0.94); C1958(0.94); C822(1.01)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C1809(1.06); C1948(0.77); C1958(0.77); C822(0.85)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C1809(1.13); C1948(0.70); C1958(0.70); C822(0.86)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C1809(1.11); C1948(1.04); C1958(1.04); C822(0.86)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C1809(1.05); C1948(0.98); C1958(0.98); C822(0.99)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C1809(1.08); C1948(0.95); C1958(0.95); C822(1.04)  LDD1048  [3]
 LDCM0452  CL60 HEK-293T C1809(1.11); C1948(0.92); C1958(0.92); C822(0.93)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C1675(1.19); C1809(0.90); C1958(1.05)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C1675(1.14); C1809(0.93); C1958(1.33)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C1675(0.98); C1809(0.93); C1958(0.88)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C1675(0.81); C1809(0.89); C1958(0.86)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C1675(1.05); C1809(0.93); C1958(0.97)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C1675(1.00); C1809(0.89); C1958(1.16)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C1675(0.99); C1809(0.94); C1958(1.15)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C1675(1.01); C1809(0.78); C1958(1.16)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C1675(0.95); C1809(0.81); C1958(1.12)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C1853(1.06); C1399(1.30)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C1675(0.97); C1809(0.90); C1958(1.17)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C1675(1.07); C1809(0.90); C1958(1.24)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C1675(1.07); C1809(0.79); C1958(1.02)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C1675(1.05); C1809(0.75); C1958(1.28)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C1675(0.96); C1809(0.99); C1958(1.38)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C1809(0.70); C1958(0.86); C822(1.16)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C1809(0.66); C1958(0.83); C822(1.22)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C1809(0.54); C1958(1.21); C822(1.56)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C1809(0.62); C1958(1.07); C822(1.21)  LDD1070  [3]
 LDCM0474  CL80 HEK-293T C1809(0.68); C1958(1.06); C822(1.41)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C1809(0.65); C1958(1.14); C822(1.31)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C1809(0.89); C1958(0.82); C822(1.12)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C1809(0.92); C1958(0.94); C822(1.02)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C1809(0.58); C1958(0.94); C822(1.47)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C1809(0.63); C1958(0.91); C822(1.54)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C1809(0.55); C1958(1.35); C822(2.09)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C1809(0.66); C1958(0.90); C822(1.31)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C1809(0.68); C1958(0.99); C822(1.34)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C1809(0.73); C1958(0.96); C822(1.44)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C1399(0.93)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C1809(0.67); C1958(0.93); C822(1.00)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C1159(0.86); C1948(0.77); C1958(0.77)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1159(0.98); C1948(0.78); C1958(0.78)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1159(0.80); C1948(0.79); C1958(0.79)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1159(0.80); C1948(0.92); C1958(0.92)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1159(0.82); C1948(0.89); C1958(0.89)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1159(0.97); C1948(0.78); C1958(0.78)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1159(0.88); C1948(0.84); C1958(0.84)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1159(1.41); C1948(0.80); C1958(0.80)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1159(0.89); C1948(0.82); C1958(0.82)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C341(1.02)  LDD1698  [10]
 LDCM0575  Fragment13 Ramos C2535(0.36)  LDD2192  [11]
 LDCM0579  Fragment20 Ramos C2535(0.83)  LDD2194  [11]
 LDCM0582  Fragment23 Ramos C2535(1.58)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C2535(4.15)  LDD2197  [11]
 LDCM0589  Fragment31 Ramos C2535(4.59)  LDD2200  [11]
 LDCM0468  Fragment33 HEK-293T C1675(0.88); C1809(0.90); C1958(1.34)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C2535(11.65)  LDD2203  [11]
 LDCM0427  Fragment51 HCT 116 C1159(0.43)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C2535(0.30)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C2535(0.39)  LDD2205  [11]
 LDCM0022  KB02 HEK-293T C341(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C341(0.95)  LDD1497  [10]
 LDCM0024  KB05 OCUG-1 C2605(3.37)  LDD3373  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C2636(3.50)  LDD2128  [1]
 LDCM0021  THZ1 HCT 116 C1654(1.53); C1675(1.53); C1948(1.12); C1958(1.12)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase eta (POLH) DNA polymerase type-Y family Q9Y253
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome complex subunit SEM1 (SEM1) DSS1/SEM1 family P60896
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) PDS5 family Q9NTI5
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609
Breast cancer type 2 susceptibility protein (BRCA2) . P51587
Fanconi anemia group D2 protein (FANCD2) . Q9BXW9
Partner and localizer of BRCA2 (PALB2) . Q86YC2

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840