Details of the Target

General Information of Target

Target ID LDTP03314
Target Name Proteinase-activated receptor 1 (F2R)
Gene Name F2R
Gene ID 2149
Synonyms
CF2R; PAR1; TR; Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
Target Type
Successful
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
TTD ID
T36483
Uniprot ID
P25116
DrugMap ID
TTL935N
Ensemble ID
ENST00000319211.5
HGNC ID
HGNC:3537
ChEMBL ID
CHEMBL3974

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C411(1.20)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C411(1.20)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C411(1.11)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C411(1.06)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C411(0.97)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C411(0.92)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C411(0.90)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C411(1.02)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C411(0.96)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C411(1.04)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C411(1.32)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C411(1.07)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C411(0.88)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C411(0.80)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C411(0.94)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C411(0.83)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C411(0.83)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C411(0.84)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C411(0.86)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C411(1.01)  LDD0562  [1]
 LDCM0246  AC128 PaTu 8988t C411(1.27)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C411(1.22)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C411(1.10)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C411(1.08)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C411(1.17)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C411(1.18)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C411(1.17)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C411(1.16)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C411(1.57)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C411(1.24)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C411(1.29)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C411(1.14)  LDD1137  [1]
 LDCM0259  AC14 HCT 116 C411(1.11)  LDD0576  [1]
 LDCM0260  AC140 PaTu 8988t C411(1.30)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C411(1.25)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C411(1.12)  LDD1141  [1]
 LDCM0270  AC15 HCT 116 C411(1.14)  LDD0587  [1]
 LDCM0276  AC17 PaTu 8988t C411(1.11)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C411(1.31)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C411(1.12)  LDD1157  [1]
 LDCM0279  AC2 HCT 116 C411(1.16)  LDD0596  [1]
 LDCM0280  AC20 PaTu 8988t C411(1.04)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C411(1.17)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C411(1.15)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C411(1.43)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C411(1.33)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C411(0.85)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C411(1.11)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C411(1.02)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C411(1.19)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C411(1.12)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C411(1.05)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C411(1.09)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C411(0.90)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C411(1.03)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C411(0.99)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C411(1.13)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C411(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C411(1.02)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C411(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C411(1.01)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C411(1.22)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C411(1.27)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C411(1.44)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C411(1.02)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C411(1.09)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C411(1.16)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C411(1.27)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C411(1.37)  LDD0624  [1]
 LDCM0308  AC46 PaTu 8988t C411(1.09)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C411(1.10)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C411(1.04)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C411(1.03)  LDD1190  [1]
 LDCM0312  AC5 HCT 116 C411(1.32)  LDD0629  [1]
 LDCM0313  AC50 PaTu 8988t C411(1.25)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C411(1.09)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C411(1.33)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C411(1.39)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C411(1.42)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C411(1.22)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C411(1.26)  LDD1198  [1]
 LDCM0320  AC57 HEK-293T C296(1.00)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C296(0.86)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C296(1.22)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C411(1.05)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C296(0.95)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C296(1.01)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C296(1.03)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C296(1.25)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C296(0.85)  LDD1567  [4]
 LDCM0332  AC68 PaTu 8988t C411(0.77)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C411(1.09)  LDD1212  [1]
 LDCM0334  AC7 HCT 116 C411(1.08)  LDD0651  [1]
 LDCM0335  AC70 PaTu 8988t C411(1.01)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C411(0.82)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C411(0.81)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C411(0.90)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C411(0.86)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C411(0.90)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C411(0.80)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C411(0.87)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C411(0.93)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C411(0.85)  LDD1223  [1]
 LDCM0345  AC8 HCT 116 C411(1.13)  LDD0662  [1]
 LDCM0346  AC80 PaTu 8988t C411(0.87)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C411(0.93)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C411(0.88)  LDD1227  [1]
 LDCM0248  AKOS034007472 HCT 116 C411(1.04)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C411(1.17)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C411(1.32)  LDD0592  [1]
 LDCM0368  CL10 HEK-293T C296(2.45)  LDD1572  [4]
 LDCM0369  CL100 HCT 116 C411(1.19)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C411(1.22)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C411(1.05)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C411(1.06)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C411(1.10)  LDD0690  [1]
 LDCM0374  CL105 PaTu 8988t C411(1.11)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C411(1.26)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C411(1.04)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C411(1.24)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C411(1.32)  LDD1257  [1]
 LDCM0379  CL11 HEK-293T C296(1.59)  LDD1583  [4]
 LDCM0380  CL110 PaTu 8988t C411(1.38)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C411(1.55)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C411(1.01)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C411(1.05)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C411(1.15)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C411(1.02)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C411(1.00)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C411(1.54)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C411(1.09)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C411(1.21)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C296(1.62)  LDD1594  [4]
 LDCM0391  CL120 HCT 116 C411(1.17)  LDD0708  [1]
 LDCM0392  CL121 PaTu 8988t C411(1.09)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C411(1.13)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C411(1.31)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C411(1.20)  LDD1274  [1]
 LDCM0397  CL126 HEK-293T C296(1.05)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C296(1.03)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C296(0.93)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C296(1.09)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C296(1.64)  LDD1606  [4]
 LDCM0403  CL16 HCT 116 C411(1.13)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C411(0.99)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C411(1.15)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C411(1.10)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C296(1.16)  LDD1611  [4]
 LDCM0408  CL20 HCT 116 C411(1.13)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C411(1.56)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C411(1.92)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C411(1.13)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C411(1.53)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C411(1.33)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C411(1.12)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C411(1.15)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C411(1.22)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C411(1.18)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C296(1.11)  LDD1622  [4]
 LDCM0419  CL30 HCT 116 C411(1.07)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C411(1.12)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C411(1.02)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C411(1.04)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C411(0.99)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C411(1.11)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C411(1.24)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C411(1.16)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C411(1.01)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C296(0.93)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C411(1.41)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C411(0.96)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C411(1.05)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C411(1.08)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C411(1.08)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C411(1.05)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C296(1.44)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C296(1.72)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C296(1.64)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C296(0.88)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C296(1.01)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C296(0.80)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C296(1.01)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C296(1.45)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C296(1.08)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C296(1.23)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C296(1.81)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C296(1.47)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C296(1.41)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C296(1.15)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C296(1.57)  LDD1655  [4]
 LDCM0453  CL61 PaTu 8988t C411(1.14)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C411(1.04)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C411(0.94)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C411(1.09)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C411(1.12)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C411(1.08)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C411(1.36)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C411(1.77)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C411(1.57)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C296(1.37)  LDD1665  [4]
 LDCM0463  CL70 PaTu 8988t C411(1.43)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C411(0.96)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C411(0.94)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C411(1.39)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C411(1.19)  LDD1346  [1]
 LDCM0469  CL76 HCT 116 C411(1.14)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C411(0.89)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C411(0.97)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C411(1.29)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C296(4.53)  LDD1676  [4]
 LDCM0474  CL80 HCT 116 C411(0.97)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C411(1.23)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C411(1.36)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C411(1.49)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C411(1.87)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C411(1.19)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C411(1.04)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C411(1.24)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C411(1.37)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C411(1.80)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C296(1.66)  LDD1687  [4]
 LDCM0485  CL90 HCT 116 C411(0.94)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C411(1.21)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C411(1.20)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C411(1.14)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C411(1.49)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C411(1.51)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C411(1.19)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C411(1.05)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C411(1.08)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C411(1.14)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C296(0.93)  LDD1698  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C296(10.23)  LDD1702  [5]
 LDCM0468  Fragment33 PaTu 8988t C411(1.16)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C411(1.73)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C296(0.69)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C296(0.93)  LDD1497  [4]
 LDCM0024  KB05 MIA PaCa-2 C296(4.93); C411(6.25)  LDD3330  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial protein C receptor (PROCR) . Q9UNN8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Streptokinase Protein/peptide DB00086
Vorapaxar Small molecular drug D0VA0I
Thrombin . DB11300
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
E5555 Small molecular drug D0PU8T
Pz-128 Small molecular drug D2F7JC
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rwj-56110 Small molecular drug D0I2VE
Sch-205831 Small molecular drug D0QK2E
Sch-602539 Small molecular drug D0BV3B
Sr-123781a . DB05361
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fr-171113 Small molecular drug D0Z4NX
Rwj-58259 Small molecular drug D08ELM

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840