Details of the Target

General Information of Target

Target ID LDTP01958
Target Name Retinol-binding protein 4 (RBP4)
Gene Name RBP4
Gene ID 5950
Synonyms
Retinol-binding protein 4; Plasma retinol-binding protein; PRBP; RBP) [Cleaved into: Plasma retinol-binding protein(1-182; Plasma retinol-binding protein(1-181; Plasma retinol-binding protein(1-179; Plasma retinol-binding protein(1-176)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV
AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND
DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA
RQYRLIVHNGYCDGRSERNLL
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Calycin superfamily, Lipocalin family
Subcellular location
Secreted
Function
Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
TTD ID
T55703
Uniprot ID
P02753
DrugMap ID
TT0C8BY
Ensemble ID
ENST00000371464.8
HGNC ID
HGNC:9922
ChEMBL ID
CHEMBL3100

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K35(0.92)  LDD0274  [1]
DBIA
 Probe Info  		C178(0.85)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C178(0.85)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C178(0.86)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C178(1.07)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C178(0.97)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C178(1.04)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C178(1.04)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C178(1.08)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C178(0.90)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C178(0.91)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C178(1.04)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C178(0.95)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C178(0.97)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C178(0.70)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C178(1.26)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C178(1.49)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C178(1.41)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C178(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C178(1.07)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C178(0.83)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C178(1.05)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C178(1.12)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C178(1.56)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C178(1.22)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C178(0.77)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C178(1.44)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C178(1.14)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C178(0.96)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C178(1.45)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C178(1.07)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C178(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C178(1.24)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C178(1.62)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C178(1.60)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C178(1.88)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C178(1.69)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C178(1.85)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C178(1.91)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C178(1.73)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C178(2.02)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C178(2.18)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C178(2.79)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C178(2.16)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C178(3.23)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C178(2.52)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C178(0.67)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C178(3.44)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C178(3.18)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C178(2.48)  LDD0579  [2]
 LDCM0270  AC15 HCT 116 C178(0.66)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C178(1.01)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C178(0.82)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C178(0.81)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C178(0.61)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C178(0.68)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C178(0.66)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C178(0.96)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C178(0.76)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C178(0.68)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C178(1.82)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C178(1.45)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C178(1.40)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C178(1.44)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C178(1.11)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C178(0.66)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C178(1.00)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C178(1.60)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C178(2.61)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C178(1.64)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C178(0.96)  LDD0612  [2]
 LDCM0301  AC4 HCT 116 C178(0.77)  LDD0618  [2]
 LDCM0308  AC46 HEK-293T C178(1.08)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C178(1.23)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C178(1.24)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C178(1.06)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C178(1.02)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C178(1.18)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C178(1.23)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C178(1.15)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C178(0.94)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C178(1.30)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C178(1.14)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C178(0.99)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C178(1.24)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C178(0.93)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C178(1.03)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C178(0.91)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C178(1.05)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C178(1.10)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C178(1.28)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C178(0.88)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C178(1.16)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C178(1.07)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C178(0.78)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C178(1.13)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C178(0.96)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C178(1.09)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C178(0.90)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C178(1.07)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C178(1.07)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C178(1.07)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C178(1.21)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C178(1.47)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C178(0.94)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C178(1.05)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C178(0.94)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C178(1.01)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C178(0.97)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C178(0.86)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C178(1.21)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C178(0.93)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C178(1.20)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C178(0.99)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C178(1.03)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C178(1.18)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C178(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C178(0.94)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C178(0.84)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C178(0.75)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C178(0.75)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C178(0.97)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C178(0.83)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C178(0.84)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C178(1.47)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C178(1.23)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C178(1.47)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C178(1.36)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C178(1.00)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C178(0.93)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C178(0.68)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C178(0.71)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C178(0.64)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C178(1.07)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C178(1.56)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C178(0.63)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C178(0.74)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C178(0.72)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C178(0.64)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C178(0.68)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C178(0.88)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C178(0.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C178(1.01)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C178(0.94)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C178(0.85)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C178(1.24)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C178(0.89)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C178(0.72)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C178(1.51)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C178(1.76)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C178(2.20)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C178(1.87)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C178(1.38)  LDD0703  [2]
 LDCM0390  CL12 HCT 116 C178(1.55)  LDD0707  [2]
 LDCM0392  CL121 HEK-293T C178(1.15)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C178(1.21)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C178(1.18)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C178(1.13)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C178(1.23)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C178(0.80)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C178(1.01)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C178(1.08)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C178(1.27)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C178(1.45)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C178(1.54)  LDD0719  [2]
 LDCM0407  CL2 HCT 116 C178(1.28)  LDD0724  [2]
 LDCM0418  CL3 HCT 116 C178(1.57)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C178(1.09)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C178(0.81)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C178(0.88)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C178(1.30)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C178(0.98)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C178(0.88)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C178(0.79)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C178(0.93)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C178(1.59)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C178(0.80)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C178(1.25)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C178(1.06)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C178(0.90)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C178(0.86)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C178(1.20)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C178(1.09)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C178(1.06)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C178(0.88)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C178(1.15)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C178(1.22)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C178(1.14)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C178(1.22)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C178(1.03)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C178(0.87)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C178(0.92)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C178(0.76)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C178(0.99)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C178(0.94)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C178(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C178(0.99)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C178(1.28)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C178(1.08)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C178(0.99)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C178(0.88)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C178(1.14)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C178(0.68)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C178(1.12)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C178(0.87)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C178(0.86)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C178(1.00)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C178(0.87)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C178(1.51)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C178(0.99)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C178(1.05)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C178(0.74)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C178(0.91)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C178(0.69)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C178(1.08)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C178(0.75)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C178(0.80)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C178(1.05)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C178(0.95)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C178(0.93)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C178(0.85)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C178(0.86)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C178(0.63)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C178(0.65)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C178(0.76)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C178(0.72)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C178(0.78)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C178(0.96)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C178(0.93)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C178(1.21)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C178(1.26)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C178(0.91)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C178(0.54)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C178(0.82)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C178(0.78)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C178(0.76)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C178(0.77)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C178(0.74)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C178(0.85)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C178(0.75)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C178(0.44)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C178(0.85)  LDD0744  [2]
 LDCM0022  KB02 Hep 3B2.1-7 C192(1.22); C178(1.33)  LDD2353  [3]
 LDCM0023  KB03 Hep 3B2.1-7 C192(1.43); C178(1.56)  LDD2770  [3]
 LDCM0024  KB05 MELHO C192(1.63)  LDD3318  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transthyretin (TTR) Transthyretin family P02766

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tretinoin Small molecular drug DB00755
Vitamin A Small molecular drug DB00162
Patented
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A1-10436 Small molecular drug D01KKC
A1-10438 Small molecular drug D0D5AI
Us8586571, 12 Small molecular drug D08PYU
Us8586571, 36 Small molecular drug D0I1LE
Us8586571, 6 Small molecular drug D0J9YV
Us8853215, 3 Small molecular drug D0IV0E
Us9434727, 120 Small molecular drug D0K0IZ
Us9434727, 153 Small molecular drug D04BAA
Us9434727, 40 Small molecular drug D05AIC
Us9434727, 63 Small molecular drug D0YU9U
Us9434727, 93 Small molecular drug D02TPQ

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840