Details of the Target

General Information of Target

Target ID LDTP00959
Target Name PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1)
Gene Name PHLPP1
Gene ID 23239
Synonyms
KIAA0606; PHLPP; PLEKHE1; SCOP; PH domain leucine-rich repeat-containing protein phosphatase 1; EC 3.1.3.16; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
Target Bioclass
Enzyme
Subcellular location
Cytoplasm; Cell membrane
Function
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylates RAF1 inhibiting its kinase activity. May act as a negative regulator of K-Ras signaling in membrane rafts. Involved in the hippocampus-dependent long-term memory formation. Involved in circadian control by regulating the consolidation of circadian periodicity after resetting. Involved in development and function of regulatory T-cells.
Uniprot ID
O60346
Ensemble ID
ENST00000262719.10
HGNC ID
HGNC:20610
ChEMBL ID
CHEMBL3414405

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.A485T .
CAL148 SNV: p.R1306T .
COLO792 SNV: p.Q509Ter DBIA    Probe Info 
DOTC24510 SNV: p.S317N .
HCT15 SNV: p.A1181T .
HL60 SNV: p.W312G .
HUH7 Deletion: p.V1389RfsTer33 .
IGROV1 SNV: p.A23D; p.S1023G .
LS123 SNV: p.G518A .
LU65 SNV: p.S1373I; p.S1408R .
MELHO SNV: p.E18G .
MEWO SNV: p.L919Q .
MOLT4 SNV: p.D1166H .
NCIH1993 SNV: p.A419D; p.P420T .
NCIH82 SNV: p.Q1407L .
PC9 SNV: p.S279W .
RKO SNV: p.H1086Y; p.P1218S DBIA    Probe Info 
SKNSH SNV: p.E432Ter .
SKOV3 SNV: p.E266Q; p.V306I .
SW756 SNV: p.G113A DBIA    Probe Info 
YSCCC SNV: p.S166L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C1156(20.00)  LDD0168  [2]
DBIA
 Probe Info  		C1516(1.02); C1522(1.02)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1156(20.00)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1156(10.03)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C1189(0.98); C1199(0.98)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C1189(0.85); C1199(0.85)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1189(0.68); C1199(0.68); C1291(0.83); C1296(0.83)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1189(0.58); C1199(0.58); C1291(0.93); C1296(0.93)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1189(0.67); C1199(0.67); C1291(0.82); C1296(0.82)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1189(0.71); C1199(0.71); C1291(0.77); C1296(0.77)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1189(0.76); C1199(0.76); C1291(0.80); C1296(0.80)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1189(0.59); C1199(0.59); C1291(1.06); C1296(1.06)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1189(0.65); C1199(0.65); C1291(1.03); C1296(1.03)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1189(0.64); C1199(0.91); C1291(0.95); C1296(0.95)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1189(0.75); C1199(0.54); C1291(0.74); C1296(0.74)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1189(0.61); C1199(0.56); C1291(0.75); C1296(0.75)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1189(0.83); C1199(0.83)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1189(0.73); C1199(0.44); C1291(0.88); C1296(0.88)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1189(0.61); C1199(0.54); C1291(0.78); C1296(0.78)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1189(0.75); C1199(0.65); C1291(0.71); C1296(0.71)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1189(1.10); C1199(1.10)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1189(1.08); C1199(1.08)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1189(1.14); C1199(1.14)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1189(1.09); C1199(1.09)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1189(0.97); C1199(0.97)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1189(0.87); C1199(0.87)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1189(0.98); C1199(0.98)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1189(0.83); C1199(0.83)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1189(1.12); C1199(1.12)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1189(0.88); C1199(0.88)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1189(0.77); C1199(0.77)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1189(1.05); C1199(1.05)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1189(1.00); C1199(1.00)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1189(0.94); C1199(0.94)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1189(1.05); C1199(1.05)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1189(1.06); C1199(1.06)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1189(1.23); C1199(1.23)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1189(1.36); C1199(1.36)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1189(1.05); C1199(1.05)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1189(1.31); C1199(1.31)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1189(0.89); C1199(0.89)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1189(1.04); C1199(1.04)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1189(1.02); C1199(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1189(1.04); C1199(1.04)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1189(0.95); C1199(0.95)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1189(0.97); C1199(0.97)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1189(1.02); C1199(1.02)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1189(0.97); C1199(0.97)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1189(0.86); C1199(0.86)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1189(1.05); C1199(1.05)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1189(1.03); C1199(1.03)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1189(0.95); C1199(0.95)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1189(0.86); C1199(0.86)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1189(2.07); C1199(2.07)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1189(1.37); C1199(1.37)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1189(1.50); C1199(1.50)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1189(1.33); C1199(1.33)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1189(1.94); C1199(1.94)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1189(1.18); C1199(1.18)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1189(0.78); C1199(0.78)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C1189(1.47); C1199(1.47)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1189(1.03); C1199(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1189(1.49); C1199(1.49)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1189(1.79); C1199(1.79)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1189(1.11); C1199(1.11)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1189(1.12); C1199(1.12)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1189(1.22); C1199(1.22)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1189(2.13); C1199(2.13)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C1296(1.29); C1516(1.29); C1522(0.99); C789(1.04)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C1296(1.11); C1516(1.11); C1522(1.05); C789(1.05)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C1296(1.27); C1516(1.27); C1522(1.08); C789(0.91)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C1189(1.04); C1199(1.04)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C1296(1.13); C1516(1.13); C1522(1.32); C789(1.01)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C1296(1.46); C1516(1.46); C1522(1.09); C789(0.88)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C1296(1.02); C1516(1.02); C1522(0.97); C789(1.03)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C1296(0.98); C1516(0.98); C1522(1.05); C789(0.95)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C1296(0.95); C1516(0.95); C1522(1.37); C789(0.98)  LDD0882  [3]
 LDCM0285  AC25 HCT 116 C1189(0.96); C1199(0.96)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1189(0.93); C1199(0.93)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1189(0.98); C1199(0.98)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1189(0.84); C1199(0.84)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1189(1.11); C1199(1.11)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1189(0.80); C1199(0.80)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1189(1.02); C1199(1.02)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1189(1.06); C1199(1.06)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1189(0.92); C1199(0.92)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1189(1.06); C1199(1.06)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1189(0.92); C1199(0.92)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C1189(0.99); C1199(0.99); C1522(0.72); C938(0.96)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C1189(1.00); C1199(1.00); C1522(0.79); C938(1.05)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C1189(0.93); C1199(0.93); C1522(0.77); C938(0.98)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C1189(0.99); C1199(0.99); C1522(0.81); C938(0.88)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C1189(0.85); C1199(0.85); C1522(0.95); C938(0.89)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C1189(0.99); C1199(0.99)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C1189(0.92); C1199(0.92); C1522(0.85); C938(1.02)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C1189(0.75); C1199(0.75); C1522(0.97); C938(0.90)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C1189(0.78); C1199(0.78); C1522(1.16); C938(0.93)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C1189(0.94); C1199(0.94); C1522(1.25); C938(0.81)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C1189(1.02); C1199(1.02); C1522(0.92); C938(0.94)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C1189(0.88); C1199(0.88); C1522(0.78); C938(0.93)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C1189(1.03); C1199(1.03)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1189(0.95); C1199(0.95)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1189(0.75); C1199(0.75)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1189(1.25); C1199(1.25)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1189(0.96); C1199(0.96)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1189(1.33); C1199(1.33)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1189(0.95); C1199(0.95)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1189(1.13); C1199(1.13)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1189(1.14); C1199(1.14)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1189(1.66); C1199(1.66)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1189(1.57); C1199(1.57)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1189(1.62); C1199(1.62)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1189(0.77); C1199(0.77); C1291(1.04); C1296(1.04)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1189(0.94); C1199(0.94); C1291(1.24); C1296(1.24)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1189(0.86); C1199(0.86); C1291(1.30); C1296(1.30)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C1189(1.06); C1199(1.06)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1189(0.77); C1199(0.77); C1291(1.06); C1296(1.06)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1189(0.83); C1199(0.83); C1291(1.03); C1296(1.03)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1189(1.22); C1199(1.22); C1291(1.29); C1296(1.29)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1189(0.98); C1199(0.98); C1291(1.00); C1296(1.00)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1189(0.93); C1199(0.93); C1291(1.11); C1296(1.11)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1189(0.82); C1199(0.82); C1291(1.40); C1296(1.40)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1189(1.04); C1199(1.04); C1291(1.16); C1296(1.16)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1189(0.89); C1199(0.89); C1291(1.29); C1296(1.29)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1189(0.88); C1199(0.88)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1189(1.00); C1199(1.00)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1189(0.82); C1199(0.82)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1189(0.90); C1199(0.90)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1189(0.93); C1199(0.93)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1189(1.07); C1199(1.07)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1189(1.13); C1199(1.13)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1189(1.16); C1199(1.16)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1189(1.46); C1199(1.46)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1189(1.12); C1199(1.12)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1189(0.92); C1199(0.92)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1189(0.87); C1199(0.87)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1189(0.91); C1199(0.91)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1189(0.79); C1199(0.79)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1189(1.16); C1199(1.16)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1189(1.02); C1199(1.02)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1189(1.15); C1199(1.15)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1291(1.37); C1296(1.37); C1189(1.37); C1199(1.37)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1291(0.84); C1296(0.84); C1189(1.19); C1199(1.19)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1291(0.65); C1296(0.65); C1189(1.09); C1199(1.09)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1291(0.77); C1296(0.77); C1189(1.16); C1199(1.16)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1291(1.08); C1296(1.08); C1189(1.10); C1199(1.10)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1291(1.02); C1296(1.02); C1189(1.13); C1199(1.13)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1291(1.22); C1296(1.22); C1189(1.34); C1199(1.34)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1189(0.94); C1199(0.94); C1291(1.62); C1296(1.62)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1291(1.23); C1296(1.23); C1189(1.41); C1199(1.41)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1291(1.31); C1296(1.31); C1189(1.40); C1199(1.40)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1189(1.04); C1199(1.04); C1291(1.35); C1296(1.35)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1291(0.98); C1296(0.98); C1189(1.13); C1199(1.13)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1189(1.03); C1199(1.03); C1291(1.20); C1296(1.20)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1189(1.24); C1199(1.24); C1291(1.38); C1296(1.38)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1291(0.81); C1296(0.81); C1189(1.24); C1199(1.24)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1189(0.77); C1199(0.77); C1291(0.81); C1296(0.81)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1189(0.68); C1199(0.68); C1291(0.77); C1296(0.77)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1189(0.88); C1199(0.88)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1189(0.78); C1199(0.78)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1189(1.10); C1199(1.10)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1516(1.02); C1522(1.02)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C1189(1.45); C1199(1.45)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1189(1.48); C1199(1.48)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1189(0.86); C1199(0.86)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C1189(0.77); C1199(0.77)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1189(1.05); C1199(1.05)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1189(1.04); C1199(1.04)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1189(0.94); C1199(0.94)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C1296(0.78); C1516(0.78); C1522(1.19); C789(1.11)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C1296(1.12); C1516(1.12); C1522(0.95); C789(1.06)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C1296(1.26); C1516(1.26); C1522(1.29); C789(1.05)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C1296(1.06); C1516(1.06); C1522(1.14); C789(0.92)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C1296(1.47); C1516(1.47); C1522(0.91); C789(0.94)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C1189(1.39); C1199(1.39)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C1296(1.14); C1516(1.14); C1522(1.02); C789(1.11)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C1296(1.19); C1516(1.19); C1522(1.07); C789(1.05)  LDD0979  [3]
 LDCM0382  CL112 HCT 116 C1189(0.94); C1199(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1189(1.02); C1199(1.02)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1189(1.06); C1199(1.06)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1189(0.89); C1199(0.89)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1189(1.00); C1199(1.00)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C1189(0.71); C1199(0.71); C1522(0.75); C938(1.09)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C1189(0.87); C1199(0.87); C1522(0.80); C938(1.11)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C1189(0.76); C1199(0.76); C1522(1.05); C938(0.87)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C1189(1.59); C1199(1.59)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C1189(0.93); C1199(0.93); C1522(1.02); C938(0.98)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C1189(2.54); C1199(2.54)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1189(1.09); C1199(1.09)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1189(1.78); C1199(1.78)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1189(1.47); C1199(1.47)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C1189(0.79); C1199(0.79); C1291(0.90); C1296(0.90)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1189(0.61); C1199(0.61); C1291(0.92); C1296(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1189(0.79); C1199(0.79); C1291(0.95); C1296(0.95)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1189(0.88); C1199(0.88); C1291(1.42); C1296(1.42)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1189(1.13); C1199(1.13)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1189(1.46); C1199(1.46)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1189(1.24); C1199(1.24)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1189(1.20); C1199(1.20)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1189(1.38); C1199(1.38)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1189(0.98); C1199(0.98)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1189(1.16); C1199(1.16)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C1189(1.02); C1199(1.02)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1189(1.27); C1199(1.27)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1189(1.42); C1199(1.42)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1189(1.72); C1199(1.72)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1189(1.31); C1199(1.31)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1189(1.46); C1199(1.46)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1189(1.31); C1199(1.31)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1189(1.11); C1199(1.11)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1189(1.07); C1199(1.07)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1189(1.25); C1199(1.25)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1189(1.15); C1199(1.15)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1189(1.68); C1199(1.68)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1189(1.13); C1199(1.13)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C1522(1.10)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C1522(0.97)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C1522(0.98)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C1522(0.86)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C1522(0.93)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C1522(0.94)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C1522(0.89)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C1522(0.88)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C1189(1.16); C1199(1.16)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C1522(0.81)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C1522(0.87)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C1522(0.73)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C1522(0.76)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C1522(0.99)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C1522(0.68)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C1291(1.22); C1296(1.22)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1291(0.88); C1296(0.88)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1291(0.94); C1296(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1291(1.01); C1296(1.01)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1189(1.02); C1199(1.02)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1291(1.05); C1296(1.05)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1291(1.09); C1296(1.09)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1291(1.02); C1296(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1291(0.99); C1296(0.99)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1291(1.03); C1296(1.03)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1291(0.91); C1296(0.91)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1291(0.94); C1296(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1291(1.05); C1296(1.05)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1291(0.99); C1296(0.99)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1291(1.13); C1296(1.13)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1189(1.49); C1199(1.49)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1291(0.99); C1296(0.99)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C1189(1.15); C1199(1.15); C1296(1.15); C1516(1.09)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C1189(0.84); C1199(0.84); C1296(0.96); C1516(0.93)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C1189(1.07); C1199(1.07); C1296(1.08); C1516(1.14)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C1189(1.46); C1199(1.46); C1296(1.30); C1516(1.13)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C1189(0.91); C1199(0.91); C1296(1.26); C1516(1.08)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C1189(1.04); C1199(1.04); C1296(1.08); C1516(0.89)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C1189(1.54); C1199(1.54); C1296(1.15); C1516(0.99)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C1189(0.90); C1199(0.90); C1296(1.00); C1516(0.94)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C1189(1.32); C1199(1.32); C1296(1.09); C1516(0.91)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C1189(1.07); C1199(1.07)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C1189(0.95); C1199(0.95); C1296(1.09); C1516(1.07)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C1189(1.02); C1199(1.02); C1296(1.17); C1516(1.25)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C1189(0.91); C1199(0.91); C1296(1.26); C1516(1.50)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C1189(1.22); C1199(1.22); C1296(1.28); C1516(0.99)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C1189(0.73); C1199(0.73); C1296(1.22); C1516(1.43)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C1189(1.02); C1199(1.02); C1291(0.91); C1296(0.91)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C1189(1.00); C1199(1.00); C1291(1.07); C1296(1.07)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C1189(0.88); C1199(0.88); C1291(0.96); C1296(0.96)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C1189(1.41); C1199(1.41); C1291(1.00); C1296(1.00)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C1189(2.32); C1199(2.32)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C1189(1.59); C1199(1.59); C1291(1.18); C1296(1.18)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C1189(0.97); C1199(0.97); C1291(0.99); C1296(0.99)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C1189(1.37); C1199(1.37); C1291(1.33); C1296(1.33)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C1189(1.05); C1199(1.05); C1291(1.25); C1296(1.25)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C1189(1.42); C1199(1.42); C1291(0.97); C1296(0.97)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C1189(1.05); C1199(1.05); C1291(0.90); C1296(0.90)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C1189(1.09); C1199(1.09); C1291(0.95); C1296(0.95)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C1189(1.05); C1199(1.05); C1291(0.92); C1296(0.92)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C1189(1.07); C1199(1.07); C1291(1.13); C1296(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C1189(1.59); C1199(1.59); C1291(1.13); C1296(1.13)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C1189(1.26); C1199(1.26)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C1189(1.54); C1199(1.54); C1291(1.31); C1296(1.31)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C1189(0.74); C1199(0.74)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1189(0.86); C1199(0.86)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1189(1.02); C1199(1.02)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1189(1.09); C1199(1.09)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1189(0.88); C1199(0.88)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1189(0.96); C1199(0.96)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1189(0.97); C1199(0.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1189(0.89); C1199(0.89)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1189(0.92); C1199(0.92)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C938(1.09)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C1189(1.35); C1199(1.35); C1296(1.31); C1516(1.20)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C1522(0.72)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C435(1.10)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C938(9.89)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C938(3.42)  LDD3310  [8]
 LDCM0021  THZ1 HCT 116 C1516(1.17); C1522(1.17)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) . O14745
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein scribble homolog (SCRIB) LAP (LRR and PDZ) protein family Q14160

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840