Details of the Target

General Information of Target

Target ID LDTP00330
Target Name E3 ubiquitin-protein ligase TRIM38 (TRIM38)
Gene Name TRIM38
Gene ID 10475
Synonyms
RNF15; RORET; E3 ubiquitin-protein ligase TRIM38; EC 2.3.2.27; RING finger protein 15; Tripartite motif-containing protein 38; Zinc finger protein RoRet
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP
QCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQ
HKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIR
SDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGS
AQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDT
AHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWD
LGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEA
GVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters.
Uniprot ID
O00635
Ensemble ID
ENST00000357085.5
HGNC ID
HGNC:10059

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C58(1.10); C59(0.94); C62(0.94)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C237(0.00); C188(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C58(1.19); C59(1.19); C62(1.19)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C237(1.05); C58(1.05); C59(1.05); C62(1.05)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C58(1.00); C59(1.00); C62(1.00)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C58(1.16); C59(1.16); C62(1.16)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C58(1.11); C59(1.11); C62(1.11)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C58(0.88); C59(0.88); C62(0.88)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C58(0.98); C59(0.98); C62(0.98)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C58(1.11); C59(1.11); C62(1.11)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C58(1.20); C59(1.20); C62(1.20)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C58(0.77); C59(0.91); C62(0.98)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C58(1.38); C59(0.89); C62(0.85)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C58(1.16); C59(0.93); C62(0.91)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C237(1.10); C58(1.13); C59(1.13); C62(1.13)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C58(0.97); C59(0.93); C62(0.88)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C58(1.01); C59(1.12); C62(0.92)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C58(1.09); C59(0.90); C62(1.00)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C335(1.12); C339(1.12); C58(0.77); C59(0.77)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C335(0.63); C339(0.63); C58(0.85); C59(0.85)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C335(0.42); C339(0.42); C58(0.97); C59(0.97)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C335(0.39); C339(0.39); C58(0.69); C59(0.69)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C335(0.76); C339(0.76); C58(1.06); C59(1.06)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C335(0.87); C339(0.87); C58(0.71); C59(0.71)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C335(0.58); C339(0.58); C58(0.83); C59(0.83)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C237(1.37); C58(0.91); C59(0.91); C62(0.91)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C335(0.56); C339(0.56); C58(0.72); C59(0.72)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C335(0.87); C339(0.87); C58(0.85); C59(0.85)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C335(0.88); C339(0.88); C58(0.70); C59(0.70)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C335(0.89); C339(0.89); C58(0.98); C59(0.98)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C335(1.12); C339(1.12); C58(1.15); C59(1.15)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C335(0.78); C339(0.78); C58(0.88); C59(0.88)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C335(0.58); C339(0.58); C58(0.68); C59(0.68)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C335(0.45); C339(0.45); C58(0.64); C59(0.64)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C58(0.72); C59(0.72); C62(0.72)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C58(0.63); C59(0.63); C62(0.63)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C58(0.80); C59(0.80); C62(0.80)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C58(0.82); C59(0.82); C62(0.82)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C58(0.88); C59(0.88); C62(0.88)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C58(0.75); C59(0.75); C62(0.75)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C58(0.66); C59(0.66); C62(0.66)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C58(0.83); C59(0.83); C62(0.83)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C58(0.73); C59(0.73); C62(0.73)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C58(0.68); C59(0.68); C62(0.68)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C58(0.66); C59(0.66); C62(0.66)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C58(0.77); C59(0.77); C62(0.77)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C237(1.42); C58(1.25); C59(1.25); C62(1.25)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C58(0.72); C59(0.72); C62(0.72)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C58(0.73); C59(0.73); C62(0.73)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C58(0.73); C59(0.73); C62(0.73)  LDD0579  [3]
 LDCM0263  AC143 PaTu 8988t C335(0.54); C339(0.54); C237(0.97)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C335(0.99); C339(0.99); C237(0.83)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C335(0.87); C339(0.87); C237(0.83)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C335(0.91); C339(0.91); C237(0.72)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C335(0.73); C339(0.73); C237(1.25)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C335(0.50); C339(0.50); C237(0.86)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C335(0.44); C339(0.44); C237(0.74)  LDD1148  [3]
 LDCM0270  AC15 HCT 116 C58(1.12); C59(1.12); C62(1.12); C237(1.15)  LDD0587  [3]
 LDCM0271  AC150 PaTu 8988t C335(1.05); C339(1.05); C237(0.57)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C335(0.60); C339(0.60); C237(1.23)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C335(0.63); C339(0.63); C237(0.94)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C335(0.44); C339(0.44); C237(1.01)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C335(0.63); C339(0.63); C237(0.75)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C335(0.97); C339(0.97); C237(1.02)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C335(0.56); C339(0.56); C237(1.07)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C335(1.20); C339(1.20); C237(0.95)  LDD2169  [3]
 LDCM0276  AC17 HCT 116 C188(0.76); C237(0.88)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C188(0.70); C237(0.88)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C188(0.63); C237(1.05)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C58(1.40); C59(1.40); C62(1.40)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C188(0.71); C237(1.25)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C188(0.52); C237(1.25)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C188(0.60); C237(1.12)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C188(0.53); C237(0.94)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C188(0.50); C237(0.71)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C335(0.67); C339(0.67)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C335(0.60); C339(0.60)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C335(0.61); C339(0.61)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C335(0.47); C339(0.47)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C335(0.64); C339(0.64)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C58(1.28); C59(1.28); C62(1.28)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C335(0.66); C339(0.66)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C335(0.70); C339(0.70)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C335(0.36); C339(0.36)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C335(0.46); C339(0.46)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C335(0.36); C339(0.36)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C58(0.89); C59(0.89); C62(0.89); C335(1.35)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C58(1.12); C59(1.12); C62(1.12); C335(1.36)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C58(0.93); C59(0.93); C62(0.93); C335(1.53)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C58(1.00); C59(1.00); C62(1.00); C335(1.57)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C58(1.02); C59(1.02); C62(1.02); C335(1.29)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C58(1.21); C59(1.21); C62(1.21)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C335(0.81); C339(0.81); C58(0.83); C59(0.83)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C58(1.02); C59(1.02); C62(1.02); C335(1.19)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C335(0.87); C339(0.87); C58(1.16); C59(1.16)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C335(1.05); C339(1.05); C58(1.28); C59(1.28)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C335(0.96); C339(0.96); C58(1.00); C59(1.00)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C335(0.63); C339(0.63); C58(0.77); C59(0.77)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C58(0.70); C59(0.70); C62(0.70); C335(1.19)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C58(0.63); C59(0.63); C62(0.63); C335(1.08)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C58(0.84); C59(0.84); C62(0.84); C188(1.12)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C335(0.56); C339(0.56); C58(0.69); C59(0.69)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C58(1.48); C59(1.48); C62(1.48)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C335(0.53); C339(0.53); C58(0.76); C59(0.76)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C58(1.06); C59(1.06); C62(1.06); C188(1.07)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C58(0.81); C59(0.81); C62(0.81); C188(1.16)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C335(0.67); C339(0.67); C58(0.80); C59(0.80)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C335(0.69); C339(0.69); C58(0.86); C59(0.86)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C335(0.54); C339(0.54); C58(0.91); C59(0.91)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C335(0.51); C339(0.51); C58(0.73); C59(0.73)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C335(0.41); C339(0.41); C58(0.90); C59(0.90)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C335(0.39); C339(0.39); C58(0.84); C59(0.84)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C335(0.28); C339(0.28); C58(1.08); C59(1.08)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C237(0.96); C58(1.15); C59(1.15); C62(1.15)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C335(0.47); C339(0.47); C58(0.91); C59(0.91)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C335(0.76); C339(0.76); C58(0.87); C59(0.87)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C335(0.29); C339(0.29); C58(0.83); C59(0.83)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C335(0.33); C339(0.33); C58(0.77); C59(0.77)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C335(0.29); C339(0.29); C58(0.62); C59(0.62)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C335(0.37); C339(0.37); C58(0.70); C59(0.70)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C335(0.41); C339(0.41); C58(0.65); C59(0.65)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C335(0.18); C339(0.18); C58(0.49); C59(0.49)  LDD0648  [3]
 LDCM0332  AC68 PaTu 8988t C62(0.82); C59(0.82); C112(1.05); C104(1.05)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C62(1.02); C59(1.02); C112(0.88); C104(0.88)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C58(0.98); C59(0.98); C62(0.98); C237(1.01)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C62(0.99); C59(0.99); C112(1.13); C104(1.13)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C62(0.94); C59(0.94); C112(0.88); C104(0.88)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C62(0.79); C59(0.79); C112(1.35); C104(1.35)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C62(0.71); C59(0.71); C112(1.10); C104(1.10)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C62(0.88); C59(0.88); C112(0.92); C104(0.92)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C62(0.96); C59(0.96); C112(0.88); C104(0.88)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C62(0.96); C59(0.96); C112(1.26); C104(1.26)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C62(0.87); C59(0.87); C112(0.96); C104(0.96)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C62(0.77); C59(0.77); C112(1.59); C104(1.59)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C62(0.84); C59(0.84); C112(0.95); C104(0.95)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C237(0.90); C58(1.08); C59(1.08); C62(1.08)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C62(0.99); C59(0.99); C112(1.05); C104(1.05)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C62(0.89); C59(0.89); C112(1.02); C104(1.02)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C62(0.77); C59(0.77); C112(1.07); C104(1.07)  LDD1227  [3]
 LDCM0349  AC83 HCT 116 C59(0.81); C62(0.81); C237(0.92); C58(1.25)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C237(0.72); C59(0.90); C62(0.90); C58(1.13)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C237(0.68); C59(0.89); C62(0.89); C58(1.05)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C237(0.83); C58(1.13); C59(1.15); C62(1.15)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C237(0.66); C59(0.78); C62(0.78); C58(0.83)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C237(0.68); C59(1.07); C62(1.07); C58(1.10)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C237(1.00); C59(1.08); C62(1.08); C58(1.26)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C58(0.92); C237(0.98); C59(1.15); C62(1.15)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C237(0.93); C59(1.02); C62(1.02); C58(1.41)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C237(1.07); C59(1.13); C62(1.13); C58(1.23)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C237(0.70); C58(1.07); C59(1.07); C62(1.07)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C59(0.99); C62(0.99); C58(1.01); C237(1.01)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C59(0.81); C62(0.81); C237(0.87); C58(0.93)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C237(0.82); C59(1.12); C62(1.12); C58(1.18)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C237(0.76); C59(0.99); C62(0.99); C58(1.18)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C58(0.84); C59(0.84); C62(0.84)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C58(0.78); C59(0.78); C62(0.78)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C237(1.23); C58(1.05); C59(1.05); C62(1.05)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C58(0.93); C59(0.93); C62(0.93); C237(0.99)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C237(0.99); C58(1.20); C59(1.20); C62(1.20)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 10.64  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C58(1.10); C59(0.94); C62(0.94)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C335(0.83); C339(0.83); C188(0.84); C58(1.21)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C335(0.38); C339(0.38); C188(1.14); C58(2.07)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C58(1.19); C59(1.19); C62(1.19)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C237(1.18); C58(1.61); C59(1.61); C62(1.61)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C58(1.04); C59(1.04); C62(1.04); C237(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C237(0.98); C58(1.05); C59(1.05); C62(1.05)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C58(1.12); C59(1.12); C62(1.12); C237(1.45)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C237(0.68); C188(0.78)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C237(0.75); C188(0.85)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C188(0.97); C237(1.15)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C237(0.88); C188(0.95)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C188(0.77); C237(1.02)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C335(0.33); C339(0.33); C188(0.90); C58(1.18)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C188(0.60); C237(0.84)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C188(0.65); C237(0.94)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C335(0.69); C339(0.69)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C335(0.46); C339(0.46)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C335(0.45); C339(0.45)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C335(0.61); C339(0.61)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C335(0.61); C339(0.61)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C335(0.46); C339(0.46); C58(1.31); C59(1.31)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C58(0.99); C59(0.99); C62(0.99); C335(1.04)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C335(0.89); C339(0.89); C58(1.70); C59(1.70)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C335(0.35); C339(0.35); C188(1.03); C58(1.81)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C58(1.08); C59(1.08); C62(1.08); C335(1.34)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C335(0.91); C339(0.91); C188(0.98); C58(1.82)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C58(0.59); C59(0.59); C62(0.59); C188(0.90)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C335(0.55); C339(0.55); C58(0.57); C59(0.57)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C335(0.46); C339(0.46); C58(0.66); C59(0.66)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C58(0.91); C59(0.91); C62(0.91); C335(0.92)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C335(0.66); C339(0.66); C58(1.39); C59(1.39)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C58(0.85); C59(0.85); C62(0.85); C335(0.97)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C335(0.35); C339(0.35); C58(1.10); C59(1.10)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C335(0.53); C339(0.53); C188(1.03); C58(1.16)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C335(0.65); C339(0.65); C188(0.94); C58(1.51)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C335(0.68); C339(0.68); C188(1.13); C58(1.20)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C335(0.71); C339(0.71); C188(1.12); C58(1.28)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C335(0.58); C339(0.58); C188(0.78); C58(0.85)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C188(0.96); C58(1.11); C59(1.11); C62(1.11)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C335(0.74); C339(0.74); C188(0.86); C58(1.18)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C188(0.89); C335(1.17); C339(1.17); C58(1.37)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C335(0.45); C339(0.45); C188(0.85); C58(1.21)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C335(0.27); C339(0.27); C188(0.83); C58(1.05)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C335(0.29); C339(0.29); C188(1.03); C58(1.10)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C335(0.60); C339(0.60); C188(1.06); C58(1.22)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C188(1.13); C335(0.34); C339(0.34); C58(1.50)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C188(1.01); C335(0.31); C339(0.31); C58(1.32)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C188(1.18); C335(0.66); C339(0.66); C58(1.26)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C188(1.05); C335(0.77); C339(0.77); C58(1.52)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C188(1.01); C335(0.42); C339(0.42); C58(1.23)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C188(0.94); C335(0.57); C339(0.57); C58(1.86)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C188(0.86); C335(0.99); C339(0.99); C58(1.46)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C188(0.95); C335(0.79); C339(0.79); C58(1.49)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C58(0.85); C59(0.85); C62(0.85)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C58(0.99); C59(0.99); C62(0.99)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C58(0.85); C59(0.85); C62(0.85)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C58(0.99); C59(0.99); C62(0.99)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C58(0.91); C59(0.91); C62(0.91)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C58(0.94); C59(0.94); C62(0.94)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C58(0.94); C59(0.94); C62(0.94)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C58(0.99); C59(0.99); C62(0.99)  LDD1026  [3]
 LDCM0429  CL4 HCT 116 C188(0.90); C335(0.65); C339(0.65); C58(1.42)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C58(0.88); C59(0.88); C62(0.88)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C58(0.83); C59(0.83); C62(0.83)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C58(0.95); C59(0.95); C62(0.95)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C58(1.08); C59(1.08); C62(1.08)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C58(0.98); C59(0.98); C62(0.98)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C58(0.97); C59(0.97); C62(0.97)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C188(0.86)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C188(1.05)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C188(1.00)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C188(0.87)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C188(1.08); C335(0.82); C339(0.82); C58(1.43)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C188(0.90)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C188(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C188(0.90)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C188(0.92)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C188(0.79)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C188(0.76)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C188(0.67)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C188(0.80)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C188(0.75)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C188(0.91)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C188(0.94); C335(0.69); C339(0.69); C58(1.53)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C188(0.77)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C237(1.24); C335(0.88); C339(0.88); C59(0.84)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C237(1.52); C335(0.78); C339(0.78); C59(0.93)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C237(1.52); C335(0.64); C339(0.64); C59(0.97)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C237(1.50); C335(0.40); C339(0.40); C59(0.86)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C237(1.51); C335(0.92); C339(0.92); C59(1.01)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C237(0.88); C335(0.27); C339(0.27); C59(0.93)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C237(1.08); C335(0.53); C339(0.53); C59(0.86)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C237(0.92); C335(0.57); C339(0.57); C59(1.07)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C237(1.02); C335(0.97); C339(0.97); C59(1.00)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C188(1.00); C335(0.58); C339(0.58); C58(1.45)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C237(1.40); C335(0.73); C339(0.73); C59(0.95)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C237(1.29); C335(0.45); C339(0.45); C59(0.90)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C237(1.03); C335(0.83); C339(0.83); C59(0.91)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C237(1.11); C335(0.49); C339(0.49); C59(0.99)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C237(1.16); C335(0.54); C339(0.54); C59(1.05)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C188(0.99); C335(0.91); C339(0.91); C59(0.93)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C188(1.06); C335(0.57); C339(0.57); C59(0.82)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C188(1.31); C335(0.67); C339(0.67); C59(1.11)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C188(1.34); C335(0.40); C339(0.40); C59(1.46)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C188(1.03); C335(0.30); C339(0.30); C58(1.01)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C188(1.03); C335(1.37); C339(1.37); C59(1.33)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C188(1.01); C335(0.70); C339(0.70); C59(1.57)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C188(1.11); C335(0.27); C339(0.27); C59(1.48)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C188(1.20); C335(0.30); C339(0.30); C59(0.81)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C188(1.09); C335(0.24); C339(0.24); C59(1.16)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C188(1.07); C335(0.59); C339(0.59); C59(1.01)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C188(1.02); C335(0.80); C339(0.80); C59(1.20)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C188(1.18); C335(0.45); C339(0.45); C59(1.40)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C188(1.21); C335(0.35); C339(0.35); C59(1.39)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C188(1.52); C335(0.28); C339(0.28); C59(1.25)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C188(1.09); C335(0.61); C339(0.61); C58(1.40)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C188(0.97); C335(0.66); C339(0.66); C59(1.21)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C58(1.24); C59(1.24); C62(1.24)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C58(1.65); C59(1.65); C62(1.65)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C58(1.11); C59(1.11); C62(1.11)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C58(1.21); C59(1.21); C62(1.21)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C58(0.88); C59(0.88); C62(0.88)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C58(1.44); C59(1.44); C62(1.44)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C58(1.23); C59(1.23); C62(1.23)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C58(1.11); C59(1.11); C62(1.11)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C58(1.41); C59(1.41); C62(1.41)  LDD1092  [3]
 LDCM0572  Fragment10 Ramos C237(0.17)  LDD2189  [6]
 LDCM0574  Fragment12 Ramos C237(0.22)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C237(0.48)  LDD2192  [6]
 LDCM0579  Fragment20 Ramos C237(0.21)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C237(0.20)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C237(0.29)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C237(0.28)  LDD2197  [6]
 LDCM0589  Fragment31 Ramos C237(0.25)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C237(0.04)  LDD2201  [6]
 LDCM0468  Fragment33 HCT 116 C237(1.44); C335(0.50); C339(0.50); C59(1.02)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C237(0.30)  LDD2203  [6]
 LDCM0427  Fragment51 HEK-293T C58(0.81); C59(0.81); C62(0.81)  LDD1025  [3]
 LDCM0022  KB02 42-MG-BA C188(1.65)  LDD2244  [7]
 LDCM0023  KB03 42-MG-BA C188(2.37)  LDD2661  [7]
 LDCM0024  KB05 IGR37 C188(1.45)  LDD3314  [7]
 LDCM0021  THZ1 HCT 116 C237(1.28); C335(1.05); C339(1.05)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication factor C subunit 5 (RFC5) Activator 1 small subunits family P40937
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Proteasome subunit alpha type-4 (PSMA4) Peptidase T1A family P25789
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-binding protein 1 (STXBP1) STXBP/unc-18/SEC1 family P61764
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Bystin (BYSL) Bystin family Q13895
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Heat shock 70 kDa protein 1-like (HSPA1L) Heat shock protein 70 family P34931
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Maturin (MTURN) MTURN family Q8N3F0
Testis-specific Y-encoded-like protein 4 (TSPYL4) Nucleosome assembly protein (NAP) family Q9UJ04
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840