Details of the Target

General Information of Target

Target ID LDTP15888
Target Name tRNA (adenine(37)-N6)-methyltransferase (TRMO)
Gene Name TRMO
Gene ID 51531
Synonyms
C9orf156; tRNA; adenine(37)-N6)-methyltransferase; EC 2.1.1.-; tRNA methyltransferase O
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSRLPRQLFLQGVAAVFMFAFASLYTQIPGLYGPEGILPARRTLRPQGKGRWQQLWET
PTLLWEAPRLGLDTAQGLELLSLLGALVALGALLLSPLRHPVIYLLLWAAYLSACQVGQV
FLYFQWDSLLLETGFLAVLVAPLRPASHRKEAPQGRQAGALPHEDLPFWLVRWLLFRLMF
ASGVVKLTSRCPAWWGLTALTYHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVP
PLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNLMTLVLTTALLDDQHLAAEPGHGSR
KKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRTIHSRTTFTFHQFSQW
LKTLTLPTVWLGVASLVWELLSALWRWTQVRGWLRKLSAVVQLSLVGTATVALFLISLVP
YSYVEPGTHGRLWTGAHRLFGAVEHLQLANSYGLFRRMTGLGGRPEVVLEGSYDGHHWTE
IEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGPHTHSPWFTSLVLRLLQGKEPVIRLV
QSQVARYPFHKQPPTYVRAQRYKYWFSQPGEQGQWWRRQWVEEFFPSVSLGDPTLETLLR
QFGLQEKSPPRTRSANSTLAQALHWTRSQLSPLEAPALLWGLLMAVGAVRFVQALLAPCS
LRSSPLAPVSGEKRRPASQKDSGAASEQATAAPNPCSSSSRTTRRKK
Target Bioclass
Enzyme
Family
TRNA methyltransferase O family
Function
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability.
Uniprot ID
Q9BU70
Ensemble ID
ENST00000375119.8
HGNC ID
HGNC:30967

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C16(0.93); C18(0.93)  LDD0532  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C198(0.98)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C16(0.93); C18(0.93)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C198(1.11); C53(0.83)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C198(1.00); C53(0.88)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C198(1.00); C53(0.86)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C198(0.86); C53(0.68)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C198(0.89); C53(0.87)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C198(1.52); C53(0.87)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C198(1.44); C53(0.98)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C198(1.02); C53(0.88)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C198(1.48); C53(0.92)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C198(1.31); C53(0.87)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C16(1.17); C18(1.17)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C198(0.95); C53(0.93)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C198(1.08); C53(0.82)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C198(1.14); C53(0.82)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C198(0.65)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C198(0.92)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C198(0.98)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C198(0.99)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C198(1.00)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C198(0.91)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C198(1.10)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C16(1.11); C18(1.11)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C198(0.82)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C198(0.98)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C198(1.54)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C198(0.87)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C198(0.80)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C198(1.11)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C198(1.01)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C198(0.76)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C16(0.56); C18(0.56)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C16(0.59); C18(0.59)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C16(0.62); C18(0.62)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C16(0.64); C18(0.64)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C16(0.67); C18(0.67)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C16(0.70); C18(0.70)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C16(0.71); C18(0.71)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C16(0.67); C18(0.67)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C16(0.66); C18(0.66)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C16(0.67); C18(0.67)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C16(0.77); C18(0.77)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C16(0.81); C18(0.81)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C16(1.21); C18(1.21)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C16(0.80); C18(0.80)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C16(0.83); C18(0.83)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C16(0.68); C18(0.68)  LDD0579  [1]
 LDCM0263  AC143 HEK-293T C198(1.26); C53(0.77)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C198(1.10); C53(0.99)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C198(1.15); C53(0.69)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C198(1.25); C53(0.77)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C198(1.18); C53(0.77)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C198(1.33); C53(0.68)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C198(1.29); C53(0.91)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C16(0.98); C18(0.98)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C198(1.78); C53(0.70)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C198(1.19); C53(0.76)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C198(1.58); C53(1.07)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C198(1.32); C53(1.02)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C198(0.88); C53(1.01)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C198(1.21); C53(1.24)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C198(1.31); C53(0.94)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C198(1.42); C53(0.96)  LDD2165  [1]
 LDCM0279  AC2 HEK-293T C198(0.88)  LDD0877  [1]
 LDCM0281  AC21 HEK-293T C312(1.01)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C312(0.99)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C198(1.31)  LDD0888  [1]
 LDCM0296  AC35 HEK-293T C198(1.21)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C198(0.91)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C198(0.81)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C198(0.85)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C198(1.42)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C198(1.83)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C198(0.86)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C198(0.92)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C198(1.12)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C198(1.37)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C198(0.86)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C198(0.96)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C198(1.02)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C198(0.94)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C198(0.88)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C198(0.65)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C198(1.07)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C198(0.80)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C198(0.64)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C198(0.58)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C198(0.93)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C198(0.71)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C198(0.90)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C198(0.94)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C198(1.29)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C198(1.49)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C198(1.55)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C16(1.04); C18(1.04)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C198(1.29)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C198(1.19)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C198(1.67)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C198(1.35)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C198(1.52)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C198(1.39)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C198(1.43)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C198(1.79)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C198(0.96)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C198(0.83)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C16(1.05); C18(1.05)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C198(1.21)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C198(0.83)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C198(1.31)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C198(1.31)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C198(0.87)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C198(1.07)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C198(0.98)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C198(1.07)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C198(1.10)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C198(0.90)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C16(1.07); C18(1.07)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C198(1.53)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C198(1.15)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C198(1.02)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C198(1.44)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C198(1.08)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C198(0.97)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C198(1.07)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C198(1.08)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C198(0.84)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C198(1.14)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C198(0.85)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C198(1.19)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C198(1.41)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C198(0.84)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C198(1.13)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C198(0.89)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C198(1.03)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C198(0.98)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C198(1.06); C53(0.79)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C198(1.36); C53(0.72)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C16(1.10); C18(1.10)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C16(1.47); C18(1.47)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C16(1.12); C18(1.12)  LDD0592  [1]
 LDCM0369  CL100 HEK-293T C198(1.14)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C16(1.05); C18(1.05)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C16(1.05); C18(1.05)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C16(0.98); C18(0.98)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C16(1.08); C18(1.08)  LDD0690  [1]
 LDCM0387  CL117 HEK-293T C198(1.05)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C198(1.00)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C198(0.85)  LDD0987  [1]
 LDCM0391  CL120 HEK-293T C198(1.10)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C198(0.79)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C198(0.77)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C198(0.82)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C198(0.76)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C198(1.18)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C198(1.28)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C198(1.12)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C198(1.25)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C16(1.14); C18(1.14)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C16(0.99); C18(0.99); C198(1.20)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C198(0.83); C16(0.95); C18(0.95)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C198(0.94); C16(0.98); C18(0.98)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C16(0.98); C18(0.98); C198(1.09)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C16(0.98); C18(0.98); C198(1.27)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C198(0.98); C16(1.09); C18(1.09)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C198(0.88); C16(1.10); C18(1.10)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C198(0.94); C16(0.99); C18(0.99)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C16(1.02); C18(1.02); C198(0.85)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C16(1.22); C18(1.22); C198(0.79)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C16(1.01); C18(1.01); C198(0.89)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C16(1.04); C18(1.04); C198(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C16(1.10); C18(1.10); C198(0.94)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C16(1.05); C18(1.05); C198(0.87)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C198(0.93)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C198(0.93)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C198(1.16)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C198(1.28)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C198(1.05)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C198(1.12)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C198(1.08)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C198(0.91)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C198(1.33)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C198(1.16)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C198(1.12)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C198(0.94)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C198(1.14)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C198(1.06)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C16(0.99); C18(0.99); C198(1.31)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C16(0.92); C18(0.92); C198(1.33)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C16(0.87); C18(0.87); C198(1.50)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C16(1.04); C18(1.04); C198(1.43)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C16(0.97); C18(0.97); C198(1.36)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C16(0.92); C18(0.92); C198(1.64)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C16(1.02); C18(1.02); C198(1.58)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C16(0.95); C18(0.95); C198(1.36)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C16(0.84); C18(0.84); C198(1.23)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C16(0.83); C18(0.83); C198(1.05)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C16(0.78); C18(0.78); C198(1.17)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C16(0.83); C18(0.83); C198(1.40)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C16(0.80); C18(0.80); C198(1.22)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C16(0.83); C18(0.83); C198(1.52)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C16(0.93); C18(0.93); C198(1.48)  LDD0769  [1]
 LDCM0461  CL69 HEK-293T C312(1.09)  LDD1664  [4]
 LDCM0469  CL76 HEK-293T C198(1.24)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C198(1.04)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C198(1.59)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C198(1.24)  LDD1070  [1]
 LDCM0474  CL80 HEK-293T C198(1.11)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C198(1.20)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C198(0.95)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C198(0.94)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C198(1.08)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C198(1.05)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C198(1.85)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C198(1.00)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C198(1.08)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C198(1.25)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C312(0.98)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C198(0.81)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C198(1.25)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C198(1.10)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C198(0.91)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C198(0.92)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C198(1.31)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C198(1.48)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C198(1.03)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C198(1.41)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C198(1.16)  LDD1092  [1]
 LDCM0427  Fragment51 HCT 116 C198(1.11)  LDD0744  [1]
 LDCM0022  KB02 IGR-37 C312(1.61)  LDD2396  [5]
 LDCM0023  KB03 Hs 936.T C312(1.44)  LDD2780  [5]
 LDCM0024  KB05 SK-MEL-28 C312(1.18)  LDD3427  [5]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840