Details of the Target

General Information of Target

Target ID LDTP13912
Target Name Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)
Gene Name MAP3K2
Gene ID 10746
Synonyms
MAPKKK2; MEKK2; Mitogen-activated protein kinase kinase kinase 2; EC 2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEVEAAAGATAVPAATVPATAAGVVAVVVPVPAGEPQKGGGAGGGGGAASGPAAGTPSA
PGSRTPGNPATAVSGTPAPPARSQADKPVLAIQVLGTVKWFNVRNGYGFINRNDTKEDVF
VHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEATNVTGPGGVPVKGSRYAPNRRKS
RRFIPRPPSVAPPPMVAEIPSAGTGPGSKGERAEDSGQRPRRWCPPPFFYRRRFVRGPRP
PNQQQPIEGTDRVEPKETAPLEGHQQQGDERVPPPRFRPRYRRPFRPRPRQQPTTEGGDG
ETKPSQGPADGSRPEPQRPRNRPYFQRRRQQAPGPQQAPGPRQPAAPETSAPVNSGDPTT
TILE
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Subcellular location
Cytoplasm
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics.
TTD ID
T76508
Uniprot ID
Q9Y2U5
DrugMap ID
TTK1N5G
Ensemble ID
ENST00000344908.9
HGNC ID
HGNC:6854
ChEMBL ID
CHEMBL5914

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C405(2.09)  LDD0168  [2]
IPM
 Probe Info  		C512(2.40)  LDD1702  [3]
DBIA
 Probe Info  		C373(0.77)  LDD0532  [4]
AMP probe
 Probe Info  		N.A.  LDD0200  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C405(0.00); C373(0.00); C512(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C424(0.00); C373(0.00); C405(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C512(0.00); C373(0.00); C405(0.00); C424(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		C405(0.00); C512(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C405(2.09)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C405(2.84)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C512(1.04); C405(1.13)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C373(0.77)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C424(0.73)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C424(0.62)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C424(0.74)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C424(0.68)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C424(0.86)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C424(0.76)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C424(0.77)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C424(0.98)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C424(1.06)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C424(1.23)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C373(0.88)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C424(0.69)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C424(0.85)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C424(0.74)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C424(0.99)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C424(0.97)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C424(1.10)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C424(0.91)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C424(0.91)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C424(0.89)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C424(1.05)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C373(0.85)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C424(0.95)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C424(0.86)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C424(0.95)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C424(1.28)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C424(0.98)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C424(1.01)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C424(0.92)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C424(0.92)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C424(1.52)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C424(1.17)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C424(1.05)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C424(1.45)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C424(1.10)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C424(1.11)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C424(1.54)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C424(1.19)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C424(1.09)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C424(1.08)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C424(1.81)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C424(1.18)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C373(0.61)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C424(1.26)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C424(1.50)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C424(1.08)  LDD0579  [4]
 LDCM0270  AC15 HCT 116 C373(0.76)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C424(0.88)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C424(0.79)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C424(0.91)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C512(1.12); C405(1.29)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C424(0.74)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C424(0.77)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C424(0.85)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C424(0.81)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C424(0.93)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C373(1.01)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C373(1.03)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C373(1.12)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C373(1.14)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C373(1.17)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C512(1.02); C405(0.90)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C373(1.27)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C373(1.18)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C373(1.18)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C373(0.95)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C373(0.97)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C424(1.05)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C424(0.79)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C424(1.17)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C424(0.68)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C424(0.83)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C512(0.98)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C424(0.71)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C424(1.15)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C424(0.87)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C424(0.81)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C424(1.36)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C424(1.22)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C373(2.09)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C373(1.57)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C373(1.22)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C373(1.04)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C512(1.09)  LDD1551  [11]
 LDCM0313  AC50 HCT 116 C373(1.07)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C373(1.36)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C373(1.64)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C373(1.27)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C373(1.02)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C373(1.35)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C373(1.28)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C424(0.77)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C424(0.81)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C424(0.75)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C373(0.78)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C424(0.81)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C424(0.90)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C424(0.72)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C424(0.84)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C424(1.18)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C424(0.93)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C424(0.86)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C424(0.76)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C424(0.84)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C424(1.05)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C373(0.73)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C424(0.93)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C424(1.11)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C424(0.97)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C424(0.91)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C424(1.18)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C424(0.83)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C424(1.14)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C424(1.14)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C424(1.07)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C424(1.03)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C373(0.99)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C424(1.21)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C424(1.05)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C424(1.05)  LDD0665  [4]
 LDCM0365  AC98 HCT 116 C424(0.69)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C424(0.71)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C373(0.62)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C373(0.64)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C373(0.70)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 14.49  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C424(20.00); C512(0.24)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C373(0.96); C424(0.98)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C373(1.03); C424(1.18)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C512(1.06); C405(0.91)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C373(0.86)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C373(0.65)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C373(0.94)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C373(0.64)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C424(0.84)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C424(0.80)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C424(1.05)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C424(0.85)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C424(0.71)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C373(1.19); C424(1.53)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C424(1.09)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C424(0.85)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C373(0.95)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C373(1.13)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C373(0.97)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C373(1.08)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C373(1.02)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C424(0.68)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C424(0.86)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C424(1.03)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C373(0.89); C424(2.49)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C424(0.90)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C373(1.16)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C373(1.30)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C373(1.44)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C373(0.91)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C424(0.70)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C424(0.73)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C424(0.91)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C424(0.71)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C373(0.88); C424(1.49)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C373(1.19); C424(1.54)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C373(1.16); C424(1.22)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C512(0.95); C405(1.00)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C512(0.93); C405(1.10)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C512(0.98); C405(1.14)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C512(1.02); C405(0.94)  LDD1610  [11]
 LDCM0407  CL2 HCT 116 C424(1.00); C373(1.00)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C512(1.14)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C512(1.16)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C512(1.05); C405(1.16)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C405(1.10)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C512(1.15); C405(1.04)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C512(1.01)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C512(1.03); C405(0.96)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C512(1.00); C405(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C512(1.01); C405(0.92)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C512(1.13); C405(0.98)  LDD1621  [11]
 LDCM0418  CL3 HCT 116 C373(1.05); C424(1.54)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C512(1.05); C405(1.22)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C512(1.10); C405(0.95)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C512(0.98)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C512(1.06)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C512(1.05); C405(0.94)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C405(1.01)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C512(1.00); C405(1.11)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C512(0.95)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C512(1.03); C405(0.91)  LDD1632  [11]
 LDCM0429  CL4 HCT 116 C373(0.90); C424(1.09)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C512(1.06); C405(1.06)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C512(1.03); C405(1.00)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C512(1.04); C405(1.16)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C512(1.21); C405(1.07)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C512(0.96)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C512(1.11)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C373(1.23)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C373(1.10)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C373(1.33)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C373(1.16)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C373(1.18); C424(0.88)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C373(1.45)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C373(1.75)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C373(1.48)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C373(0.81)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C373(1.28)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C373(0.82)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C373(0.88)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C373(1.07)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C373(1.01)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C373(1.13)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C373(1.18); C424(0.90)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C373(1.30)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C373(1.10); C424(0.94)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C373(1.11); C424(0.86)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C373(0.87); C424(0.91)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C373(1.20); C424(0.82)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C373(1.01); C424(1.12)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C373(1.07); C424(0.92)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C373(1.18); C424(1.39)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C373(0.72); C424(1.31)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C373(1.07); C424(0.95)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C373(1.12); C424(0.85)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C373(1.19); C424(1.17)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C373(1.13); C424(1.17)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C373(1.29); C424(1.13)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C373(1.26); C424(1.22)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C373(1.08); C424(1.21)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C373(0.84); C424(1.15)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C373(0.85); C424(1.41)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C373(1.02); C424(0.95)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C373(0.99); C424(0.88)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C373(0.98); C424(0.97)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C373(0.99); C424(1.24)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C373(1.03); C424(1.19)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C373(0.95); C424(0.91)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C373(0.94); C424(0.93)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C373(0.95); C424(1.42)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C373(0.95); C424(1.06)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C373(0.96); C424(1.17)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C373(0.98); C424(1.27)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C373(0.92); C424(1.00)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C373(0.91); C424(1.02)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C373(0.95); C424(0.76)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C373(0.81); C424(1.33)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C512(1.13); C405(0.97)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C512(0.99)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C512(1.05)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C512(0.98); C405(1.00)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C405(0.98)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C512(1.06); C405(0.88)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C512(0.96)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C512(1.02); C405(0.98)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C512(1.07); C405(0.94)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C512(1.03); C405(0.99)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C512(2.40)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C373(1.01); C424(0.90)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C512(1.04); C405(0.93)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C512(1.02); C405(0.96)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C512(0.93); C405(1.05)  LDD1497  [11]
 LDCM0024  KB05 NCI-H1155 C405(2.19)  LDD3342  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) STE Ser/Thr protein kinase family Q13163
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bosutinib Small molecular drug DB06616
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 113858 Antisense drug D0QP0H
Isis 113871 Antisense drug D04LHI
Isis 113872 Antisense drug D0X7DN
Isis 113873 Antisense drug D0Y3OV
Isis 113874 Antisense drug D05AYU
Isis 113902 Antisense drug D07EFO
Isis 113903 Antisense drug D0M9JK
Isis 113904 Antisense drug D0E3AR
Isis 113905 Antisense drug D0V7SZ
Isis 113906 Antisense drug D0D5HE
Isis 113907 Antisense drug D0F9AI
Isis 113908 Antisense drug D05HUP
Isis 113909 Antisense drug D00GKE

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840