Details of the Target

General Information of Target

Target ID LDTP12999
Target Name Vacuolar protein sorting-associated protein 54 (VPS54)
Gene Name VPS54
Gene ID 51542
Synonyms
HCC8; Vacuolar protein sorting-associated protein 54; Hepatocellular carcinoma protein 8; Tumor antigen HOM-HCC-8; Tumor antigen SLP-8p
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEAGDLVQPGISFPGPAEEDLDPQY
SWSPTQHFNEERYSPAPRSMKGLSGSRTQPPLCSGHTCGLAPPEDCEHLHHGPDARPPYL
LSPADSCPGGRHRCSPRSSVHSECVMMPVVLGDHVSSSTFPRMHYSSHYDTRDDCAVAHA
GAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAAAEQRSESPGRIRHLVHSVQKLFT
KSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSKRSKSKERKPEGKPRPGMSSWWSSDD
NLDSDSTYRTPSVLNRHHLGPVAHCYPDALQSPFGDLSLKTSKSNNDVKCSACEGLALTP
DAKYLKRSSWSTLTVSQAKEAYRKSSLNLDKPLLHQDAKPALRPCHYLQVPQDEWGGYPT
GGKDEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPKSAILPEPLLKSIGQRPLGEHQT
QTYLQAASDVPVGHSLDPAANYNSPKFRSRNQSYMRAVSTLSQASCVSQVSEAEINGQFE
SVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPMMTPSDITSTIRS
TAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGLY
NSTDSLDSNKAMNLALETAAAQRHLPESQSSSVRTSDKAILVSKAEELLKSRCSSIGIQD
SEFPEHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADL
ELEGFPGHITTEDKGLQFGSSFQRHSEPSTPTQYSAVRTVRTQGLFSYREDYRTQVDTST
LPPPDPWLEPAIDTVETGRMSPCRRDGSWFLKLLHAETKRMEGWCKEMEREAEENDLSEE
ILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSIEDVSM
KFDELQRLRLNDWKMMESPERKEERKVPPPIPKKPPKGKFPITREKSLDLPDRQRQEARR
RLMAAKRAASFRQNSASERADSIEIYIPEAQTRL
Target Bioclass
Other
Family
VPS54 family
Subcellular location
Golgi apparatus, trans-Golgi network
Function
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.
Uniprot ID
Q9P1Q0
Ensemble ID
ENST00000272322.9
HGNC ID
HGNC:18652

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.E132K .
HCC1395 SNV: p.D453H .
HCT15 SNV: p.F902I .
HGC27 SNV: p.P546L .
NCIH1993 SNV: p.E524Ter .
RAMOS SNV: p.G792A .
RT112 SNV: p.D584V .
SKOV3 SNV: p.G13E .
YSCCC SNV: p.H68D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C40(1.58)  LDD2227  [1]
AHL-Pu-1
 Probe Info  		C40(2.50)  LDD0171  [2]
DBIA
 Probe Info  		C547(2.07); C557(2.07)  LDD0080  [3]
CY-1
 Probe Info  		C416(0.00); Q415(0.00)  LDD0246  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [9]
STS-2
 Probe Info  		N.A.  LDD0138  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C40(2.50)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C886(1.24)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C547(1.55); C557(1.55)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C886(1.04)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C886(0.92)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C886(1.12)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C886(1.03)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C886(0.90)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C886(1.10)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C886(0.98)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C886(1.04)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C886(1.11)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C886(1.05)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C547(1.32); C557(1.32)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C886(0.95)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C886(0.96)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C886(0.85)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C547(1.12); C557(1.12)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C547(1.20); C557(1.20)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C547(1.09); C557(1.09)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C547(0.77); C557(0.77)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C547(1.09); C557(1.09)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C547(0.70); C557(0.70)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C547(1.06); C557(1.06)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C547(1.42); C557(1.42)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C547(0.88); C557(0.88)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C547(1.15); C557(1.15)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C547(1.13); C557(1.13)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C547(1.02); C557(1.02)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C547(1.27); C557(1.27)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C547(1.17); C557(1.17)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C547(1.01); C557(1.01)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C547(0.98); C557(0.98)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C886(0.68)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C886(0.97)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C886(1.31)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C886(0.92)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C886(0.95)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C886(0.79)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C886(0.87)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C886(0.87)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C886(0.77)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C886(0.78)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C886(0.65)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C886(0.79)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C547(1.21); C557(1.21)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C886(0.92)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C886(0.97)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C886(0.82)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C547(0.93); C557(0.93)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C547(1.13); C557(1.13)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C547(1.07); C557(1.07)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C547(1.07); C557(1.07)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C547(1.08); C557(1.08)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C547(0.84); C557(0.84)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C547(1.20); C557(1.20)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C547(1.23); C557(1.23)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C547(0.94); C557(0.94)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C547(1.38); C557(1.38)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C547(1.19); C557(1.19)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C547(0.97); C557(0.97)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C547(0.91); C557(0.91)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C547(1.00); C557(1.00)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C547(1.05); C557(1.05)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C547(0.87); C557(0.87)  LDD2165  [3]
 LDCM0276  AC17 PaTu 8988t C547(1.28); C557(1.28); C886(1.07)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C547(1.46); C557(1.46); C886(1.26)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C547(1.38); C557(1.38); C886(1.06)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C886(1.18)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C547(1.39); C557(1.39); C886(1.05)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C547(1.64); C557(1.64); C886(1.28)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C547(1.77); C557(1.77); C886(1.21)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C547(1.60); C557(1.60); C886(1.09)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C547(1.16); C557(1.16); C886(1.08)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C547(0.59); C557(0.59)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C547(0.75); C557(0.75)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C547(0.78); C557(0.78)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C547(0.74); C557(0.74)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C547(0.61); C557(0.61)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C886(1.31)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C547(0.74); C557(0.74)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C547(0.68); C557(0.68)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C547(0.79); C557(0.79)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C547(0.80); C557(0.80)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C547(0.89); C557(0.89)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C886(0.94)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C886(0.79)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C886(0.73)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C886(0.84)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C886(0.75)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C886(1.72)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C886(0.66)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C886(1.05)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C886(0.69)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C886(0.70)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C886(1.20)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C886(0.90)  LDD0624  [3]
 LDCM0308  AC46 PaTu 8988t C886(0.88)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C886(0.87)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C886(0.85)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C886(0.92)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C886(1.68)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C886(1.04)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C886(0.60)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C886(0.94)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C886(0.99)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C886(1.13)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C886(0.86)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C886(0.97)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C547(0.60); C557(0.60)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C547(0.74); C557(0.74)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C547(0.60); C557(0.60)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C547(1.05); C557(1.05)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C547(0.61); C557(0.61)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C547(0.63); C557(0.63)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C547(0.70); C557(0.70)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C547(0.81); C557(0.81)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C547(0.74); C557(0.74)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C547(1.09); C557(1.09)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C547(0.82); C557(0.82)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C547(0.80); C557(0.80)  LDD0929  [3]
 LDCM0332  AC68 PaTu 8988t C886(0.96)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C886(0.80)  LDD1212  [3]
 LDCM0334  AC7 HEK-293T C547(0.92); C557(0.92)  LDD0932  [3]
 LDCM0335  AC70 PaTu 8988t C886(0.90)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C886(0.94)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C886(1.06)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C886(0.99)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C886(1.02)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C886(0.98)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C886(0.96)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C886(0.87)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C886(0.92)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C886(0.98)  LDD1223  [3]
 LDCM0345  AC8 HEK-293T C547(1.23); C557(1.23)  LDD0943  [3]
 LDCM0346  AC80 PaTu 8988t C886(1.00)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C886(1.05)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C886(0.92)  LDD1227  [3]
 LDCM0349  AC83 HEK-293T C547(1.02); C557(1.02); C886(0.86)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C547(1.17); C557(1.17); C886(0.92)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C547(1.13); C557(1.13); C886(0.92)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C547(1.34); C557(1.34); C886(0.96)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C547(1.27); C557(1.27); C886(0.91)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C547(0.88); C557(0.88); C886(0.96)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C547(1.42); C557(1.42); C886(1.04)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C547(1.03); C557(1.03); C886(0.93)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C547(1.37); C557(1.37); C886(0.82)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C547(1.09); C557(1.09); C886(0.84)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C547(1.20); C557(1.20); C886(0.85)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C547(1.38); C557(1.38); C886(0.81)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C547(1.07); C557(1.07); C886(0.93)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C547(1.51); C557(1.51); C886(0.84)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C547(1.22); C557(1.22); C886(0.75)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C886(1.01)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C886(1.08)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C547(1.23); C557(1.23)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C547(1.18); C557(1.18)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C547(1.43); C557(1.43)  LDD0873  [3]
 LDCM0632  CL-Sc Hep-G2 C40(1.58)  LDD2227  [1]
 LDCM0367  CL1 PaTu 8988t C813(0.97); C886(0.97)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C813(0.81); C886(1.07)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C886(1.50)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C547(0.99); C557(0.99)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C547(1.38); C557(1.38)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C547(0.75); C557(0.75)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C547(1.02); C557(1.02)  LDD0971  [3]
 LDCM0374  CL105 PaTu 8988t C547(1.14); C557(1.14); C886(0.88)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C547(1.38); C557(1.38); C886(0.92)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C547(0.90); C557(0.90); C886(1.03)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C547(1.08); C557(1.08); C886(1.14)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C547(1.33); C557(1.33); C886(1.07)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C813(0.66); C886(1.17)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C547(1.41); C557(1.41); C886(0.97)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C547(1.95); C557(1.95); C886(1.21)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C547(0.86); C557(0.86)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C547(0.74); C557(0.74)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C547(0.81); C557(0.81)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C547(0.88); C557(0.88)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C547(0.80); C557(0.80)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C886(0.88)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C886(0.66)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C886(0.92)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C813(0.67); C886(1.01)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C886(0.84)  LDD0708  [3]
 LDCM0392  CL121 PaTu 8988t C886(0.86)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C886(0.92)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C886(0.93)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C886(1.02)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C547(0.82); C557(0.82)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C547(0.63); C557(0.63)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C547(0.80); C557(0.80)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C547(0.67); C557(0.67)  LDD0997  [3]
 LDCM0400  CL13 PaTu 8988t C813(1.16); C886(1.19)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C813(1.27); C886(1.17)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C813(0.85); C886(1.26)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C886(1.28)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C886(1.59)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C886(0.75)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C886(1.23)  LDD1004  [3]
 LDCM0407  CL2 PaTu 8988t C813(0.76); C886(1.15)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C886(0.91)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C886(0.91)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C886(0.94)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C886(0.94)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C886(0.56)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C886(0.74)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C886(0.53)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C886(0.87)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C886(0.71)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C886(0.69)  LDD1015  [3]
 LDCM0418  CL3 PaTu 8988t C813(1.26); C886(1.08)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C886(0.67)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C886(0.95)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C886(0.93)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C886(0.93)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C886(0.81)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C886(0.92)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C886(0.93)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C886(0.87)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C886(1.03)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C813(0.91); C886(1.22)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C886(0.83)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C886(0.90)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C886(0.79)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C886(0.90)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C886(0.92)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C886(0.90)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C886(1.08)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C886(0.96)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C886(1.66)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C886(0.87)  LDD1037  [3]
 LDCM0440  CL5 PaTu 8988t C813(1.17); C886(0.98)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C886(0.57)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C886(0.56)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C886(0.91)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C886(0.69)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C886(0.69)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C886(0.72)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C886(0.79)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C886(0.89)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C886(1.05)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C886(0.81)  LDD1048  [3]
 LDCM0451  CL6 PaTu 8988t C813(0.83); C886(1.00)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C886(0.81)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C886(2.39)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C886(1.82)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C886(1.62)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C886(1.79)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C886(1.99)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C886(2.73)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C886(1.61)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C886(1.99)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C886(2.13)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C813(0.80); C886(1.04)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C886(1.67)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C886(1.77)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C886(1.86)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C886(1.82)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C886(1.81)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C886(1.37)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C886(1.00)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C886(1.42)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C886(2.11)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C813(0.81); C886(0.85)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C886(1.71)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C886(1.18)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C886(1.16)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C886(1.12)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C886(1.40)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C886(1.07)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C886(1.20)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C886(1.40)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C886(1.71)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C886(1.06)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C813(0.75); C886(1.26)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C886(1.32)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C886(0.96)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C886(0.71)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C886(0.75)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C886(0.98)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C886(0.87)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C886(1.01)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C886(1.07)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C886(1.39)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C886(1.74)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C813(0.94); C886(1.17); C40(1.01); C374(1.18)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C886(2.22)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C886(0.90)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C547(2.07); C557(2.07)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C547(1.44); C557(1.44)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C547(1.51); C557(1.51)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Gelsolin (GSN) Villin/gelsolin family P06396
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402