Details of the Target

General Information of Target

Target ID LDTP12550
Target Name 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
Gene Name AGPAT4
Gene ID 56895
Synonyms
1-acyl-sn-glycerol-3-phosphate acyltransferase delta; EC 2.3.1.51; 1-acylglycerol-3-phosphate O-acyltransferase 4; 1-AGP acyltransferase 4; 1-AGPAT 4; Lysophosphatidic acid acyltransferase delta; LPAAT-delta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSWNSLFCLNSSRPPGHIVYPKHQAGHTGKQADHLGSQAFYPGRQHDYLVPPAGTAGIP
VQNQPGRPEGVPWMPAPPPPLNCPPGLEYLSQIDMILIHQQIELLEVLFSFESSNMYEIK
NSFGQRIYFAAEDTNFCIRNCCGRSRPFTLRITDNVGREVITLERPLRCNCCCCPCCLQE
IEIQAPPGVPVGYVTQTWHPCLTKFTIKNQKREDVLKISGPCIVCSCIAGVDFEITSLDE
QIVVGRISKHWSGFLREAFTDADNFGIQFPRDLDVKMKAVMIGACFLIDYMFFERTR
Target Bioclass
Enzyme
Family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA).
Uniprot ID
Q9NRZ5
Ensemble ID
ENST00000320285.9
HGNC ID
HGNC:20885

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.K247N; p.F313L .
KNS81FD SNV: p.I131V .
MDAMB436 SNV: p.H185Q .
NCIH1993 Substitution: p.S58K .
SKMEL28 SNV: p.E296D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K201(8.52)  LDD0277  [1]
DBIA
 Probe Info  		C175(1.30)  LDD0531  [2]
IA-alkyne
 Probe Info  		C175(0.00); C270(0.00)  LDD0165  [3]
IPM
 Probe Info  		C175(0.00); C270(0.00)  LDD2156  [4]
AOyne
 Probe Info  		14.60  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		4.39  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C175(1.30)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C175(0.99); C228(1.04)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C175(0.98)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C175(0.88)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C175(0.92)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C175(1.03)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C175(1.03)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C175(0.97)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C175(0.99)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C175(1.09)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C175(0.84)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C175(0.88)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C175(0.87); C228(0.91)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C175(0.93)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C175(0.98)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C175(0.87)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C175(0.99)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C175(1.06)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C175(1.00)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C175(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C175(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C175(1.11)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C175(0.89)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C175(0.94); C228(1.08)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C175(1.18)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C175(1.12)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C175(1.20)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C175(1.16)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C175(1.03)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C175(1.12)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C175(1.32)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C175(1.08)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C175(1.06)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C175(0.96)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C175(0.93)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C175(0.89)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C175(1.01)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C175(1.14)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C175(0.98)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C175(1.03)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C175(1.04)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C175(0.95)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C175(1.17)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C175(1.14)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C175(0.95); C228(0.82)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C175(1.16)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C175(1.04)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C175(0.95)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C175(0.77)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C175(0.85)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C175(0.89)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C175(0.95)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C175(0.94)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C175(1.11)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C175(0.95)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C175(0.82); C228(0.93)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C175(0.94)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C175(0.85)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C175(1.13)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C175(1.32)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C175(0.86)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C175(0.89)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C175(0.96)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C175(0.91)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C175(0.96)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C175(0.90)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C175(0.96)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C175(1.39)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C175(1.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C175(0.92)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C175(0.90)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C175(0.95)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C175(0.87)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C175(1.24)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C175(2.24)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C175(1.40)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C175(3.34)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C175(1.56)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C175(1.52)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C175(1.93)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C175(2.11)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C175(2.76)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C175(1.18)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C175(0.60)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C175(0.83); C228(1.01)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C175(1.12); C228(0.73)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C175(1.12); C228(0.95)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C175(1.13); C228(0.74)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C175(0.94); C228(0.86)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C175(1.41)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C175(0.94); C228(0.74)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C175(1.06); C228(0.86)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C175(1.22); C228(0.88)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C175(0.91); C228(0.67)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C175(1.08); C228(0.76)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C175(0.89); C228(0.84)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C175(0.97)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C175(1.65)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C175(1.29)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C175(1.32)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C175(1.37)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C175(1.46)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C175(1.17)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C175(1.48)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C175(1.29)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C175(1.93)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C175(1.15)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C175(1.92)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C175(1.29)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C175(1.26)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C175(1.32)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C175(1.08); C228(1.04)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C175(1.28)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C175(1.25)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C175(1.16)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C175(1.36)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C175(1.18)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C175(1.48)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C175(1.47)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C175(1.32)  LDD0648  [2]
 LDCM0334  AC7 HEK-293T C175(0.98); C228(1.10)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C175(1.01); C228(1.01)  LDD0943  [2]
 LDCM0365  AC98 HCT 116 C175(0.85)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C175(0.82)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C175(0.83); C228(0.87)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C175(0.91); C228(0.92)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C175(0.88); C228(0.87)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C175(0.89)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C175(0.91); C228(1.04)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C175(0.78); C228(1.36)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C175(1.35)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C175(0.92); C228(0.86)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C175(0.80); C228(0.76)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C175(1.06); C228(1.09)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C175(1.01); C228(1.45)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C175(0.91)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C175(1.04)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C175(0.97)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C175(0.95)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C175(1.00)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C175(1.02); C228(1.22)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C175(1.04)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C175(1.05)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C175(2.00)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C175(1.01)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C175(1.08)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C175(1.03)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C175(1.04)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C175(1.01); C228(0.73)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C175(1.47); C228(0.95)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C175(1.22); C228(1.07)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C175(1.03); C228(1.07)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C175(0.98); C228(0.97)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C175(1.68)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C175(1.04)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C175(0.89)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C175(1.25)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C175(1.19)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C175(1.06)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C175(1.17)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C175(1.20)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C175(1.09); C228(1.05)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C175(0.85); C228(1.09)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C175(0.92); C228(1.72)  LDD1000  [2]
 LDCM0403  CL16 PaTu 8988t C175(1.67)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C175(1.80)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C175(1.56)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C175(1.95)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C175(0.95); C228(0.95)  LDD1005  [2]
 LDCM0408  CL20 PaTu 8988t C175(1.36)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C175(1.06)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C175(1.45)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C175(1.72)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C175(1.52)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C175(1.56)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C175(1.61)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C175(1.34)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C175(1.49)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C175(1.92)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C175(1.09); C228(1.09)  LDD1016  [2]
 LDCM0419  CL30 PaTu 8988t C175(1.40)  LDD1298  [2]
 LDCM0420  CL31 HEK-293T C175(1.06); C270(0.99); C228(1.12); C104(0.95)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C175(1.14); C270(1.08); C228(1.20); C104(1.18)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C175(1.66); C270(0.98); C228(1.49); C104(0.95)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C175(1.05); C270(1.35); C228(1.18); C104(1.35)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C175(1.15); C270(0.90); C228(1.18); C104(1.43)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C175(1.26); C270(1.29); C228(0.95); C104(1.08)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C175(1.04); C270(1.02); C228(0.96); C104(1.05)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C175(1.01); C270(1.02); C228(1.22); C104(1.03)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C175(0.96); C228(1.00)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C175(0.98); C270(0.94); C228(0.94); C104(0.67)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C175(0.96); C270(1.09); C228(1.07); C104(1.35)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C175(0.97); C270(1.03); C228(1.07); C104(1.09)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C175(1.01); C270(0.96); C228(1.07); C104(0.96)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C175(1.09); C270(1.25); C228(1.13); C104(1.14)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C175(1.25); C270(0.94); C228(1.11); C104(0.87)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C175(0.83)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C175(0.82)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C175(0.73)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C175(0.83)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C175(0.88); C228(1.18)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C175(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C175(0.83)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C175(0.89)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C175(0.79)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C175(0.71)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C175(0.79)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C175(0.80)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C175(0.76)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C175(0.83)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C175(0.85)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C175(0.88); C228(1.05)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C175(0.85)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C175(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C175(0.90)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C175(0.88)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C175(0.91)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C175(0.91)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C175(0.92)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C175(1.02)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C175(0.81)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C175(0.73)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C175(1.10); C228(1.09)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C175(0.97)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C175(0.97)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C175(0.88)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C175(0.87)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C175(0.91)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C175(0.78)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C175(0.71)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C175(0.89)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C175(0.86)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C175(1.63); C270(1.35); C228(1.45); C104(1.88)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C175(0.80)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C175(0.78)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C175(1.00)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C175(0.78)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C175(0.96)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C175(0.85)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C175(0.83)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C175(0.87)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C175(0.88)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C175(1.19)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C175(1.21); C270(1.00); C228(1.18); C104(0.98)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C175(0.49)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C175(1.14)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C175(1.01)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C175(1.32)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C175(0.98)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C175(0.95)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C175(1.31)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C175(1.34)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C175(1.49)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C175(1.38)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C175(0.92); C270(0.97); C228(1.10); C104(1.32)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C175(0.98)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C175(0.91); C270(1.00); C228(1.04); C104(0.98)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C175(0.89); C270(0.96); C104(0.82); C228(0.98)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C175(0.93); C270(0.97); C104(1.00); C228(0.76)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C175(2.81)  LDD3310  [8]
 LDCM0021  THZ1 HCT 116 C175(0.89)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
Proto-oncogene c-Rel (REL) . Q04864
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cannabinoid receptor 2 (CNR2) G-protein coupled receptor 1 family P34972
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
Sperm acrosome membrane-associated protein 1 (SPACA1) . Q9HBV2

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840