Details of the Target

General Information of Target

Target ID LDTP12499
Target Name PRKCA-binding protein (PICK1)
Gene Name PICK1
Gene ID 9463
Synonyms
PRKCABP; PRKCA-binding protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLR
EGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAH
GTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCT
YQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQ
YWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Uniprot ID
Q9NRD5
Ensemble ID
ENST00000356976.8
HGNC ID
HGNC:9394

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1143 SNV: p.R312H .
IM95 SNV: p.R295H .
JURKAT SNV: p.K27T .
LS123 SNV: p.E320D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C348(1.23)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
AOyne
 Probe Info  		11.20  LDD0443  [6]
NAIA_5
 Probe Info  		C145(0.00); C348(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C348(1.23)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C348(1.05)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C348(1.40)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C348(0.81)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C348(1.15)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C348(1.02)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C348(1.24)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C348(1.31)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C348(0.94)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C348(0.90)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C348(1.33)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C348(0.81)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C348(0.80)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C348(0.95)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C348(1.12)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C348(1.46)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C348(0.89)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C348(0.82)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C348(0.88)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C348(0.78)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C348(0.72)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C348(1.05)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C348(0.84)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C348(0.87)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C348(0.86)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C348(1.40)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C348(0.82)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C348(1.62)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C348(0.91)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C348(0.99)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C348(1.30)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C348(1.02)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C348(0.77)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C348(0.79)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C348(0.71)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C348(0.91)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C348(1.16)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C348(1.23)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C348(1.00)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C348(0.91)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C348(0.98)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C348(0.88)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C348(0.80)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C348(0.86)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C348(0.72)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C348(1.00)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C348(0.92)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C348(0.69)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C348(1.05)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C348(0.64)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C348(0.85)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C348(1.08)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C348(0.92)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C348(0.82)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C348(1.02)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C348(0.87)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C348(1.02)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C348(0.76)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C348(0.70)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C348(0.78)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C348(0.76)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C348(0.73)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C348(0.92)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C348(0.87)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C348(1.23)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C348(0.84)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C348(1.14)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C348(1.14)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C348(1.73)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C348(1.07)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C348(1.56)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C348(0.73)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C348(1.15)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C348(1.24)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C348(1.12)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C348(1.10)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C348(1.21)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C348(1.53)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C348(1.12)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C348(1.14)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C348(1.39)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C348(1.34)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C348(1.26)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C348(1.22)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C348(1.23)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C348(0.89)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C348(1.11)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C348(0.85)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C348(0.98)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C348(1.28)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C348(1.35)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C348(1.00)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C348(0.94)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C348(1.03)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C348(0.97)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C348(1.17)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C348(1.06)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C348(1.24)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C348(0.96)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C348(1.59)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C348(1.15)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C348(1.32)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C348(1.18)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C348(1.03)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C348(1.28)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C348(1.56)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C348(1.40)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C348(1.58)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C348(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C348(1.09)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C348(1.03)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C348(1.06)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C348(0.96)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C348(0.98)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C348(0.91)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C348(0.88)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C348(1.05)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C348(1.30)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C348(1.18)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C348(1.06)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C348(0.91)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C348(1.18)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C348(1.25)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C348(0.85)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C348(0.99)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C348(0.93)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C348(1.01)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C348(1.16)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C348(1.14)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C348(1.03)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C348(0.73)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C348(1.05)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C348(1.01)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C348(1.08)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C348(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C348(0.98)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C348(1.33)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C348(1.00)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C348(1.96)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C348(0.98)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C348(1.12)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C348(1.14)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C348(0.95)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C348(0.91)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C348(1.12)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C348(1.04)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C348(0.83)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C348(0.92)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C348(0.73)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C348(0.86)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C348(1.06)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C348(0.97)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C348(1.21)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C348(1.16)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C348(0.85)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C348(0.88)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C348(1.28)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C264(1.01); C145(0.70); C145(0.39)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C348(0.86); C413(1.10)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C348(0.69); C413(1.16)  LDD0966  [2]
 LDCM0369  CL100 HCT 116 C348(1.05)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C348(1.18)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C348(1.49)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C348(1.00)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C348(1.58)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C348(0.78)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C348(1.06)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C348(1.07)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C348(1.38)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C348(1.14)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C348(0.92); C413(0.94)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C348(0.99)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C348(1.04)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C348(1.03)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C348(1.18)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C348(1.39)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C348(1.35)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C348(1.09)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C348(1.25)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C348(0.91)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C348(1.15)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C348(1.04); C413(1.05)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C348(0.92)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C348(1.27)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C348(1.28)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C348(1.31)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C348(1.27)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C348(0.88)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C348(1.01)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C348(1.00)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C348(0.92)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C348(0.92); C413(1.09)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C348(0.90); C413(1.15)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C348(0.93); C413(1.15)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C348(1.10)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C348(0.91)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C348(0.99)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C348(0.92)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C348(1.07); C413(1.16)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C348(0.96)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C348(1.09)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C348(1.15)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C348(0.84)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C348(1.07)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C348(0.96)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C348(1.02)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C348(0.96)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C348(1.02)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C348(1.04)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C348(0.89); C413(0.86)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C348(0.98)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C348(0.90)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C413(0.93)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C413(1.11)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C413(0.94)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C413(0.97)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C413(1.00)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C413(0.90)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C413(1.08)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C348(0.96); C413(0.95)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C413(0.96)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C413(1.04)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C413(0.95)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C413(0.97)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C413(0.99)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C413(1.03)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C348(0.70)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C348(0.56)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C348(0.48)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C348(0.77)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C348(1.12); C413(1.24)  LDD1038  [2]
 LDCM0441  CL50 PaTu 8988t C348(0.77)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C348(0.65)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C348(0.61)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C348(0.82)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C348(0.66)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C348(0.67)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C348(0.91)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C348(0.79)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C348(0.73)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C348(0.85)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C348(0.84); C413(1.09)  LDD1049  [2]
 LDCM0452  CL60 PaTu 8988t C348(0.78)  LDD1331  [2]
 LDCM0453  CL61 HEK-293T C413(0.99)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C413(0.89)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C413(0.84)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C413(1.06)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C413(1.03)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C413(0.83)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C413(1.07)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C413(0.93)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C413(0.88)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C348(0.89); C413(0.82)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C413(0.98)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C413(0.90)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C413(0.91)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C413(0.93)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C413(0.86)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C348(0.50)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C348(0.48)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C348(0.39)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C348(0.63)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C348(1.62); C413(0.66)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C348(0.49)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C348(0.57)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C348(0.75)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C348(0.64)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C348(0.74)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C348(0.42)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C348(0.60)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C348(0.54)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C348(0.51)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C348(0.83)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C348(1.25); C413(0.86)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C348(0.79)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C348(1.10)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C348(1.22)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C348(1.12)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C348(1.05)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C348(1.15)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C348(1.17)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C348(1.13)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C348(0.85)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C348(1.24)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C145(1.03); C277(1.08); C348(1.09)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C413(0.94)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C413(1.01)  LDD1025  [2]
 LDCM0022  KB02 A101D C145(2.35)  LDD2250  [9]
 LDCM0023  KB03 A101D C145(6.30)  LDD2667  [9]
 LDCM0024  KB05 HMCB C145(4.13)  LDD3312  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 71 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) GDSL lipolytic enzyme family Q15102
Lysocardiolipin acyltransferase 1 (LCLAT1) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q6UWP7
N-acetyltransferase ESCO2 (ESCO2) Acetyltransferase family Q56NI9
Replication factor C subunit 3 (RFC3) Activator 1 small subunits family P40938
DNA (cytosine-5)-methyltransferase 1 (DNMT1) C5-methyltransferase family P26358
Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) EEF2KMT family Q96G04
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) RNA M5U methyltransferase family Q8IZ69
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
ATP-dependent RNA helicase DDX55 (DDX55) DEAD box helicase family Q8NHQ9
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Thioredoxin-like protein 4B (TXNL4B) DIM1 family Q9NX01
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Cryptochrome-2 (CRY2) DNA photolyase class-1 family Q49AN0
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Glutaredoxin domain-containing cysteine-rich protein 1 (GRXCR1) GRXCR1 family A8MXD5
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Porphobilinogen deaminase (HMBS) HMBS family P08397
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Inositol hexakisphosphate kinase 1 (IP6K1) Inositol phosphokinase (IPK) family Q92551
Ribosomal RNA-processing protein 8 (RRP8) RRP8 family O43159
Mitochondrial genome maintenance exonuclease 1 (MGME1) MGME1 family Q9BQP7
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Cathepsin G (CTSG) Peptidase S1 family P08311
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
RNA-binding protein PNO1 (PNO1) PNO1 family Q9NRX1
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
RAC-beta serine/threonine-protein kinase (AKT2) AGC Ser/Thr protein kinase family P31751
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Casein kinase II subunit alpha' (CSNK2A2) Ser/Thr protein kinase family P19784
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) STE Ser/Thr protein kinase family P52564
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
Peptidyl-tRNA hydrolase (PTRH1) PTH family Q86Y79
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Probable global transcription activator SNF2L2 (SMARCA2) SNF2/RAD54 helicase family P51531
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Mitochondrial ribosome-associated GTPase 1 (MTG1) TRAFAC class YlqF/YawG GTPase family Q9BT17
Translin (TSN) Translin family Q15631
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
tRNA wybutosine-synthesizing protein 3 homolog (TYW3) TYW3 family Q6IPR3
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Protein yippee-like 2 (YPEL2) Yippee family Q96QA6
ADP-ribose glycohydrolase OARD1 (OARD1) . Q9Y530
DCN1-like protein 5 (DCUN1D5) . Q9BTE7
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
F-box/LRR-repeat protein 3 (FBXL3) . Q9UKT7
F-box/LRR-repeat protein 8 (FBXL8) . Q96CD0
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Tripartite motif-containing protein 44 (TRIM44) . Q96DX7
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Acid-sensing ion channel 1 (ASIC1) Amiloride-sensitive sodium channel (TC 1.A.6) family P78348
Acid-sensing ion channel 2 (ASIC2) Amiloride-sensitive sodium channel family Q16515
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) Calcium channel alpha-1 subunit (TC 1.A.1.11) family Q13936
Copper homeostasis protein cutC homolog (CUTC) CutC family Q9NTM9
Eukaryotic translation initiation factor 5A-1 (EIF5A) EIF-5A family P63241
Huntingtin (HTT) Huntingtin family P42858
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Dystrophin (DMD) . P11532
Optineurin (OPTN) . Q96CV9
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A5 (HOXA5) Antp homeobox family P20719
Heat shock factor protein 2 (HSF2) HSF family Q03933
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
Transcriptional repressor RHIT (ZNF205) Krueppel C2H2-type zinc-finger protein family O95201
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and BTB domain-containing protein 49 (ZBTB49) Krueppel C2H2-type zinc-finger protein family Q6ZSB9
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) Krueppel C2H2-type zinc-finger protein family Q3MJ62
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 17 (ZNF17) Krueppel C2H2-type zinc-finger protein family P17021
Zinc finger protein 264 (ZNF264) Krueppel C2H2-type zinc-finger protein family O43296
Zinc finger protein 286A (ZNF286A) Krueppel C2H2-type zinc-finger protein family Q9HBT8
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Zinc finger protein 576 (ZNF576) Krueppel C2H2-type zinc-finger protein family Q9H609
Zinc finger protein 624 (ZNF624) Krueppel C2H2-type zinc-finger protein family Q9P2J8
Zinc finger protein 691 (ZNF691) Krueppel C2H2-type zinc-finger protein family Q5VV52
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein ZFP2 (ZFP2) Krueppel C2H2-type zinc-finger protein family Q6ZN57
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Retinoic acid receptor RXR-beta (RXRB) Nuclear hormone receptor family P28702
Retinoic acid receptor RXR-gamma (RXRG) Nuclear hormone receptor family P48443
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein ARX (ARX) Paired homeobox family Q96QS3
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Zinc finger protein 593 (ZNF593) ZNF593/BUD20 C2H2-type zinc-finger protein family O00488
Bromodomain-containing protein 1 (BRD1) . O95696
Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) . Q9H147
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
High mobility group protein 20A (HMG20A) . Q9NP66
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Homeodomain-only protein (HOPX) . Q9BPY8
Metastasis-associated protein MTA1 (MTA1) . Q13330
THAP domain-containing protein 6 (THAP6) . Q8TBB0
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger and BTB domain-containing protein 2 (ZBTB2) . Q8N680
Zinc finger protein 276 (ZNF276) . Q8N554
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 138 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) Bcl-2 family Q9BZR8
Protein BEX1 (BEX1) BEX family Q9HBH7
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) BLOC1S2 family Q6QNY1
BolA-like protein 3 (BOLA3) BolA/IbaG family Q53S33
Cdc42 effector protein 2 (CDC42EP2) BORG/CEP family O14613
Protein BUD31 homolog (BUD31) BUD31 (G10) family P41223
Bystin (BYSL) Bystin family Q13895
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Nucleolar complex protein 4 homolog (NOC4L) CBF/MAK21 family Q9BVI4
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Parafibromin (CDC73) CDC73 family Q6P1J9
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) CDK2AP family O14519
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) CDKN2 cyclin-dependent kinase inhibitor family P42772
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Coilin (COIL) Coilin family P38432
Copine-2 (CPNE2) Copine family Q96FN4
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cyclin-H (CCNH) Cyclin family P51946
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) EIF4E-binding protein family Q13541
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
Activator of basal transcription 1 (ABT1) ESF2/ABP1 family Q9ULW3
Armadillo repeat-containing X-linked protein 1 (ARMCX1) Eutherian X-chromosome-specific Armcx family Q9P291
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM219B (FAM219B) FAM219 family Q5XKK7
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Glypican-4 (GPC4) Glypican family O75487
Fibroblast growth factor 16 (FGF16) Heparin-binding growth factors family O43320
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Meiosis-specific nuclear structural protein 1 (MNS1) MNS1 family Q8NEH6
MOB kinase activator 3C (MOB3C) MOB1/phocein family Q70IA8
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
Protein NATD1 (NATD1) NATD1 family Q8N6N6
Iron-sulfur cluster assembly enzyme ISCU (ISCU) NifU family Q9H1K1
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Programmed cell death protein 5 (PDCD5) PDCD5 family O14737
Phosphatidylethanolamine-binding protein 1 (PEBP1) Phosphatidylethanolamine-binding protein family P30086
Periplakin (PPL) Plakin or cytolinker family O60437
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Zinc finger protein ubi-d4 (DPF2) Requiem/DPF family Q92785
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
U2 small nuclear ribonucleoprotein B'' (SNRPB2) RRM U1 A/B'' family P08579
Something about silencing protein 10 (UTP3) SAS10 family Q9NQZ2
Ribosome biogenesis protein SLX9 homolog (SLX9) SLX9 family Q9NSI2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Charged multivesicular body protein 1b (CHMP1B) SNF7 family Q7LBR1
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Transcription elongation factor A N-terminal and central domain-containing protein 2 (TCEANC2) TCEANC2 family Q96MN5
Transcription initiation factor IIE subunit beta (GTF2E2) TFIIE beta subunit family P29084
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Tropomyosin alpha-4 chain (TPM4) Tropomyosin family P67936
U2 small nuclear ribonucleoprotein A' (SNRPA1) U2 small nuclear ribonucleoprotein A family P09661
UPF0488 protein C8orf33 (C8orf33) UPF0488 family Q9H7E9
Vacuolar protein-sorting-associated protein 25 (VPS25) VPS25 family Q9BRG1
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
Arginine vasopressin-induced protein 1 (AVPI1) . Q5T686
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 290 kDa (CEP290) . O15078
Centrosomal protein of 95 kDa (CEP95) . Q96GE4
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Deoxynucleotidyltransferase terminal-interacting protein 2 (DNTTIP2) . Q5QJE6
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) . Q4VC44
Hamartin (TSC1) . Q92574
Heat shock factor 2-binding protein (HSF2BP) . O75031
INO80 complex subunit B (INO80B) . Q9C086
INO80 complex subunit E (INO80E) . Q8NBZ0
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Interleukin enhancer-binding factor 2 (ILF2) . Q12905
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Leucine-rich repeat-containing protein 73 (LRRC73) . Q5JTD7
Melanoma-associated antigen 4 (MAGEA4) . P43358
Melanoma-associated antigen B4 (MAGEB4) . O15481
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Placental protein 13-like (LGALS14) . Q8TCE9
PRKCA-binding protein (PICK1) . Q9NRD5
Protein hinderin (KIAA1328) . Q86T90
Putative protein MSS51 homolog, mitochondrial (MSS51) . Q4VC12
RAS protein activator like-3 (RASAL3) . Q86YV0
Regulating synaptic membrane exocytosis protein 3 (RIMS3) . Q9UJD0
Renal cancer differentiation gene 1 protein (C4orf46) . Q504U0
Rho guanine nucleotide exchange factor 3 (ARHGEF3) . Q9NR81
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
Rhombotin-1 (LMO1) . P25800
SCAN domain-containing protein 1 (SCAND1) . P57086
SERPINE1 mRNA-binding protein 1 (SERBP1) . Q8NC51
SERTA domain-containing protein 1 (SERTAD1) . Q9UHV2
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) . Q9GZT3
Talin rod domain-containing protein 1 (TLNRD1) . Q9H1K6
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
TBC1 domain family member 7 (TBC1D7) . Q9P0N9
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Tetratricopeptide repeat protein 23-like (TTC23L) . Q6PF05
Thioredoxin domain-containing protein 9 (TXNDC9) . O14530
Tuberin (TSC2) . P49815
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) . Q9BV90
YTH domain-containing protein 1 (YTHDC1) . Q96MU7
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1
ZZ-type zinc finger-containing protein 3 (ZZZ3) . Q8IYH5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840