Details of the Target

General Information of Target

Target ID LDTP12239
Target Name Non-lysosomal glucosylceramidase (GBA2)
Gene Name GBA2
Gene ID 57704
Synonyms
KIAA1605; SPG46; Non-lysosomal glucosylceramidase; NLGase; EC 3.2.1.45; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; EC 2.4.1.-; Cholesteryl-beta-glucosidase GBA2; EC 3.2.1.-; Glucosylceramidase 2; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; EC 3.2.1.46; Non-lysosomal glycosylceramidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPWGTVYFLGIAQVFSFLFSWWNLEGVMNQADAPRPLNWTIRKLCHAAFLPSVRLLKA
QKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDI
QSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELP
KLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHAS
KSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTT
GKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVAL
IVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV
TIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP
DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRF
LTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYT
RKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFP
FHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNH
NSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQM
LLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEP
EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWF
YTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKV
WLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLG
PYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGE
VFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNT
FFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDER
DYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEV
NEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYI
VRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLES
IFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDID
PLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSD
YTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANF
GVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSS
DSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFS
ISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQSFESKHN
Target Bioclass
Enzyme
Family
Non-lysosomal glucosylceramidase family
Subcellular location
Endoplasmic reticulum membrane
Function
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution. They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties. Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties. Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine) (Probable). May play a role in the metabolism of bile acids. Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers.
Uniprot ID
Q9HCG7
Ensemble ID
ENST00000378094.4
HGNC ID
HGNC:18986
ChEMBL ID
CHEMBL3761

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.D439N; p.Q463H .
HCT15 SNV: p.G707V .
HT115 SNV: p.E93Ter .
JURKAT Deletion: p.P863QfsTer19 .
MCC26 SNV: p.F860L DBIA    Probe Info 
MDAMB453 SNV: p.S143F DBIA    Probe Info 
NCIH358 Deletion: p.Q757RfsTer4 DBIA    Probe Info 
SKNAS SNV: p.A421G DBIA    Probe Info 
TE8 SNV: p.D354H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C511(1.36); C45(1.36)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C511(1.65); C59(1.24); C60(1.24)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C511(1.23); C59(1.38); C60(1.38)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C511(1.52); C59(1.28); C60(1.28)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C511(1.23)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C511(1.15)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C511(1.26)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C511(1.09)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C511(0.90)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C511(1.22)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C511(0.95)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C511(1.02); C59(1.13); C60(1.13)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C511(1.09)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C511(0.99)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C511(1.13)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C511(0.99)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C511(1.05)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C511(1.32)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C511(1.28)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C511(0.96)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C511(1.10); C59(0.96); C60(0.96)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C59(1.03); C60(1.03)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C59(1.02); C60(1.02)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C59(0.95); C60(0.95)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C59(0.93); C60(0.93)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C59(1.00); C60(1.00)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C59(1.44); C60(1.44)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C59(1.21); C60(1.21)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C59(1.27); C60(1.27); C511(1.55)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C59(1.03); C60(1.03)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C59(1.33); C60(1.33)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C59(1.03); C60(1.03)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C59(1.11); C60(1.11)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C59(0.90); C60(0.90)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C59(0.99); C60(0.99)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C59(1.03); C60(1.03)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C59(0.92); C60(0.92)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C867(1.04); C59(1.15); C60(1.15); C511(1.44)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C511(0.90); C867(0.93); C59(1.52); C60(1.52)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C867(1.25); C511(1.25); C59(1.32); C60(1.32)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C59(0.98); C60(0.98); C511(1.38)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C867(0.97); C511(1.13); C59(1.34); C60(1.34)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C511(0.94); C867(1.02); C59(1.26); C60(1.26)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C867(1.07); C511(1.33); C59(1.33); C60(1.33)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C867(1.04); C59(1.07); C60(1.07); C511(1.22)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C867(1.04); C59(1.21); C60(1.21); C511(1.48)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C89(0.95); C511(1.00); C763(1.09)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C89(0.96); C511(0.92)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C89(1.03); C511(0.94); C867(1.13)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C89(0.99); C511(1.05)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C89(0.95); C511(1.04); C867(0.95); C763(0.89)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C59(1.06); C60(1.06); C511(1.25)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C89(0.98); C511(1.02); C30(0.94)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C89(1.02); C511(0.97); C867(0.95); C152(0.97)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C89(1.00); C511(0.94); C867(1.22)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C89(1.04); C511(1.03); C763(1.09)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C89(0.98); C511(1.03)  LDD1534  [5]
 LDCM0296  AC35 HCT 116 C511(0.76)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C511(0.90)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C511(1.05)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C511(0.97)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C511(0.89)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C511(1.27); C59(1.34); C60(1.34)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C511(0.96)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C511(0.88)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C511(1.03)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C511(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C511(1.18)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C511(1.12)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C60(1.09)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C60(1.04)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C60(0.84)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C60(0.95)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C59(1.18); C60(1.18); C511(1.30)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C60(1.09)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C60(1.03)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C60(1.07)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C60(1.05)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C60(1.23)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C60(1.02)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C60(1.08)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C511(1.34)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C511(1.46)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C511(1.61)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C511(1.19); C59(1.70); C60(1.70)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C511(1.25)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C511(1.29)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C511(1.43)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C511(1.22)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C511(1.53)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C511(1.99)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C511(1.77)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C511(1.53)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C60(1.04)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C60(0.88)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C511(1.10); C59(1.33); C60(1.33)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C60(1.21)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C60(0.96)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C60(1.02)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C60(1.33)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C60(1.25)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C60(1.14)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C60(0.94)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C60(1.13)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C60(1.05)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C60(1.06)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C511(1.04); C59(1.20); C60(1.20)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C60(1.31)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C60(1.13)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C60(2.10)  LDD0946  [2]
 LDCM0248  AKOS034007472 HCT 116 C511(1.01); C59(1.16); C60(1.16)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C59(1.09); C60(1.09); C511(1.23)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C511(1.82); C59(2.13); C60(2.13)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 11.57  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C867(1.11); C59(1.14); C60(1.14)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C867(0.96); C59(1.03); C60(1.03)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C511(0.90); C59(1.42); C60(1.42)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C59(1.27); C60(1.27); C511(1.59)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C59(1.13); C60(1.13); C511(1.24)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C59(1.05); C60(1.05); C511(1.21)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C511(1.20); C59(1.30); C60(1.30)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C867(1.09); C59(1.16); C60(1.16); C511(1.40)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C867(0.90); C59(1.27); C60(1.27); C511(1.31)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C867(0.91); C59(1.33); C60(1.33); C511(1.99)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C867(1.06); C59(1.08); C60(1.08); C511(1.39)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C867(0.99); C511(1.10); C59(1.73); C60(1.73)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C867(0.92); C59(1.27); C60(1.27)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C867(1.05); C59(1.28); C60(1.28); C511(1.81)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C511(0.98); C867(1.14); C59(1.30); C60(1.30)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C89(0.95); C511(0.96); C867(0.93)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C89(0.85); C511(0.94)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C89(0.91); C511(1.02); C867(1.05)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C89(1.05); C511(1.12); C152(1.08)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C89(0.93); C511(1.14); C867(1.11)  LDD1590  [5]
 LDCM0387  CL117 HCT 116 C511(1.15)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C511(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C511(0.99)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C867(1.08); C59(1.19); C60(1.19)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C511(1.05)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C60(1.14)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C60(1.21)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C60(1.40)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C60(0.98)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C511(1.09)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C511(0.90)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C511(1.13)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C511(1.38)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C59(0.99); C60(0.99); C867(1.10)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C867(1.09); C59(1.30); C60(1.30)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C59(0.96); C60(0.96); C867(1.03)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C511(0.91)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C867(1.19); C511(1.76)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C867(1.09); C511(1.77)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C867(1.25); C511(1.30)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C867(0.92); C59(1.24); C60(1.24)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C867(1.26); C511(1.71)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C867(1.12); C511(1.80)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C867(1.11); C511(2.25)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C867(1.32); C511(1.33)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C867(1.12); C511(1.74)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C511(1.19); C867(1.05)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C511(1.42); C867(1.27)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C511(1.55); C867(1.36)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C511(1.11); C867(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C511(1.58); C867(1.23)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C59(1.20); C60(1.20); C867(0.95)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C511(1.42); C867(1.37)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C511(0.91); C867(1.10)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C511(1.10)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C511(1.07)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C511(0.99)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C511(1.12)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C511(1.10)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C511(0.99)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C511(0.91)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C59(0.84); C60(0.84); C867(1.03)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C511(0.93)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C511(0.87)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C511(1.06)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C511(0.92)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C511(0.98)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C511(0.97)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C59(0.86); C60(0.86); C867(0.90)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C59(0.90); C60(0.90); C867(1.05)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C59(0.73); C60(0.73); C867(0.86)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C59(1.14); C60(1.14); C867(1.09)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C59(0.97); C60(0.97); C867(0.88)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C59(0.83); C60(0.83); C867(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C59(0.78); C60(0.78); C867(0.90)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C59(0.87); C60(0.87); C867(0.90)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C59(1.05); C60(1.05); C867(0.98)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C59(0.97); C60(0.97); C867(0.83)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C59(1.03); C60(1.03); C867(0.86)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C59(1.06); C60(1.06); C867(0.81)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C59(0.86); C60(0.86); C867(1.19)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C59(0.86); C60(0.86); C867(0.86)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C59(0.98); C60(0.98); C867(0.91)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C59(1.15); C60(1.15); C867(1.18)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C59(0.96); C60(0.96); C867(0.87)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C59(1.17); C60(1.17); C867(1.16)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C59(1.21); C60(1.21); C867(1.11)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C59(1.27); C60(1.27); C867(0.95)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C59(1.59); C60(1.59); C867(1.04)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C59(1.17); C60(1.17); C867(1.00)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C59(1.98); C60(1.98); C867(1.03)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C59(1.45); C60(1.45); C867(0.93)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C59(1.38); C60(1.38); C867(1.38)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C59(1.33); C60(1.33); C867(0.96)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C59(1.34); C60(1.34); C867(1.04)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C59(1.36); C60(1.36); C867(1.11)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C59(1.45); C60(1.45); C867(1.03)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C59(1.03); C60(1.03); C867(1.09)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C59(1.52); C60(1.52); C867(1.10)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C59(1.48); C60(1.48); C867(0.99)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C511(1.02)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C511(0.90)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C511(0.93)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C511(1.26)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C59(1.32); C60(1.32); C867(0.97)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C511(0.93)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C511(1.09)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C511(1.16)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C511(1.05)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C511(1.22)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C511(0.78)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C511(0.91)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C511(1.16)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C511(0.86)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C511(0.88)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C59(1.00); C60(1.00); C867(1.33)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C511(1.00)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C511(1.46); C59(0.86); C60(0.86)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C511(1.31); C59(0.95); C60(0.95)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C511(1.64); C59(0.96); C60(0.96)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C511(1.77); C59(1.18); C60(1.18)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C511(1.82); C59(1.28); C60(1.28)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C511(1.46); C59(1.26); C60(1.26)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C511(1.30); C59(1.40); C60(1.40)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C511(1.59); C59(1.37); C60(1.37)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C511(1.39); C59(1.24); C60(1.24)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C89(1.11); C511(1.07); C152(1.14)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C59(1.37); C60(1.37); C867(0.95)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C511(0.76)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C511(1.36); C45(1.36)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C511(1.38); C45(1.25)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C511(1.66); C45(1.42)  LDD0082  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402