Details of the Target

General Information of Target

Target ID LDTP11926
Target Name Zinc fingers and homeoboxes protein 3 (ZHX3)
Gene Name ZHX3
Gene ID 23051
Synonyms
KIAA0395; TIX1; Zinc fingers and homeoboxes protein 3; Triple homeobox protein 1; Zinc finger and homeodomain protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFL
NPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAF
YQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQ
EICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGK
VHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPK
LLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKP
HDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGT
QTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSS
VSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRS
RLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ
Target Bioclass
Transcription factor
Family
ZHX family
Subcellular location
Nucleus
Function
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
Uniprot ID
Q9H4I2
Ensemble ID
ENST00000309060.7
HGNC ID
HGNC:15935

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.A773S .
EFO27 SNV: p.D956N .
Ishikawa (Heraklio) 02 ER SNV: p.Y827C DBIA    Probe Info 
MCC13 SNV: p.E333K;p.E936K
Substitution: p.P609F		 .
SH4 SNV: p.L552W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K510(6.26)  LDD0277  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [3]
DBIA
 Probe Info  		C335(1.58)  LDD0080  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		C335(0.00); C11(0.00)  LDD2224  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C335(0.75)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C335(0.99)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C335(0.95)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C335(0.89)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C335(0.88)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C335(1.02)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C335(0.98)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C335(1.05)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C335(0.91)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C335(0.83)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C335(0.94)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C335(0.92)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C335(0.99)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C335(0.89)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C335(0.88)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C335(0.82)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C335(0.69)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C335(0.66)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C335(0.71)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C335(0.98)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C335(0.71)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C335(0.69)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C335(0.71)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C335(0.88)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C335(0.89)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C335(0.67)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C335(0.71)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C335(0.56)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C335(0.64)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C335(0.71)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C335(0.71)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C335(0.68)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C335(1.06)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C335(1.25)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C335(1.18)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C335(1.57)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C335(1.34)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C335(1.50)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C335(1.12)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C335(1.23)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C335(0.99)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C335(1.09)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C335(1.05)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C335(1.16)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C335(0.96)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C335(1.16)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C335(1.11)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C335(1.32)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C335(1.14)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C335(1.05)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C335(1.16)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C335(1.25)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C335(1.12)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C335(2.27)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C335(1.68)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C335(1.07)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C335(1.09)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C335(0.91)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C335(1.02)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C335(1.86)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C335(0.87)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C335(1.03)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C335(0.98)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C335(1.08)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C335(1.12)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C335(1.47)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C335(1.18)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C335(0.85)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C335(1.25)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C335(1.19)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C335(1.09)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C335(1.16)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C335(1.04)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C335(1.05)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C335(1.19)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C335(1.27)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C335(1.20)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C335(1.27)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C335(0.76)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C335(1.30)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C335(1.15)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C335(1.44)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C335(1.21)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C335(1.41)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C335(0.74)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C335(0.74)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C335(0.81)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C335(0.85)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C335(0.94)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C335(0.76)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C335(1.18)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C335(0.89)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C335(0.99)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C335(1.04)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C335(1.02)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C335(1.23)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C335(1.08)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C335(0.95)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C335(0.98)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C335(1.00)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C335(0.71)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C335(1.03)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C335(1.11)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C335(1.16)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C335(0.98)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C335(1.24)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C335(1.28)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C335(0.98)  LDD0917  [4]
 LDCM0320  AC57 HCT 116 C335(1.04)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C335(0.97)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C335(1.00)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C335(1.12)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C335(0.98)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C335(1.26)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C335(1.23)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C335(1.20)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C335(1.23)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C335(1.23)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C335(1.25)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C335(1.24)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C335(0.95)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C335(0.95)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C335(1.02)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C335(0.84)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C335(0.86)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C335(0.91)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C335(1.02)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C335(1.12)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C335(1.01)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C335(0.98)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C335(0.98)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C335(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C335(0.94)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C335(1.07)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C335(1.20)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C335(0.88)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C335(1.11)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C335(0.85)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C335(0.82)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C335(0.80)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C335(0.89)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C335(0.79)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C335(0.86)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C335(0.89)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C335(0.86)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C335(0.83)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C335(0.86)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C335(0.77)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C335(0.75)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C335(0.85)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C335(0.69)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C335(0.81)  LDD1243  [4]
 LDCM0365  AC98 HEK-293T C335(0.76)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C335(0.88)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C335(0.99)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C335(1.00)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C335(1.38)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 9.67  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C335(20.00); C11(1.35)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C335(0.86)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C335(0.70)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C335(0.80)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C335(1.15)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C335(0.91)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C335(0.88)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C335(0.97)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C335(1.24)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C335(1.55)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C335(1.53)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C335(1.53)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C335(1.26)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C335(0.74)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C335(1.31)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C335(1.26)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C335(1.05)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C335(1.34)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C335(1.12)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C335(1.27)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C335(1.16)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C335(1.77)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C335(1.00)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C335(1.09)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C335(0.85)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C335(0.88)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C335(1.24)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C335(1.07)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C335(1.30)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C335(1.06)  LDD0993  [4]
 LDCM0396  CL125 HCT 116 C335(1.09)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C335(1.00)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C335(1.01)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C335(1.01)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C335(0.76)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C335(0.85)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C335(0.74)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C335(1.29)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C335(1.30)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C335(1.44)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C335(1.13)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C335(0.87)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C335(1.21)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C335(1.43)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C335(1.66)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C335(1.45)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C335(1.33)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C335(1.33)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C335(1.32)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C335(1.58)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C335(1.79)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C335(1.23)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C335(0.78)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C335(1.52)  LDD1298  [4]
 LDCM0420  CL31 HCT 116 C335(1.01)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C335(1.09)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C335(1.08)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C335(1.15)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C335(1.15)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C335(1.16)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C335(1.26)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C335(1.14)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C335(0.90)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C335(1.25)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C335(1.23)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C335(1.15)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C335(1.21)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C335(1.07)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C335(1.09)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C335(1.14)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C335(1.10)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C335(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C335(1.02)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C335(0.70)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C335(1.04)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C335(1.06)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C335(1.07)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C335(1.18)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C335(1.00)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C335(1.01)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C335(1.05)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C335(1.14)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C335(0.94)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C335(0.98)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C335(0.76)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C335(1.08)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C335(1.12)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C335(1.22)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C335(1.22)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C335(1.44)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C335(1.20)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C335(1.57)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C335(1.48)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C335(1.26)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C335(1.12)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C335(0.74)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C335(1.22)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C335(1.31)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C335(1.21)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C335(1.42)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C335(1.28)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C11(0.99); C335(1.17); C483(1.01)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C11(0.97); C335(0.97); C483(1.19)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C11(0.90); C335(1.00)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C11(1.02); C335(1.05)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C335(1.08)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C11(0.92); C335(0.91)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C11(0.98); C335(0.90)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C11(0.86); C335(1.03); C463(1.23)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C11(0.97); C587(1.04); C335(0.97)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C11(0.99); C335(0.88); C483(1.04)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C11(0.87); C587(0.63); C335(0.90)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C11(0.90); C335(0.96); C483(1.00)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C11(0.95); C335(0.96)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C11(0.94); C335(1.05); C483(1.02)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C11(1.01); C335(1.02); C483(0.99)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C335(0.75)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C11(0.74); C335(0.91)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C335(0.92)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C335(0.96)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C335(0.86)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C335(0.86)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C335(0.84)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C335(0.82)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C335(0.90)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C335(0.90)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C335(0.76)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C11(1.12); C335(0.90)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C11(1.34)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C335(1.20)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C335(1.87)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C335(1.58)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C335(1.41)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C335(1.43)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0226  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase NLK (NLK) CMGC Ser/Thr protein kinase family Q9UBE8
Ataxin-3 (ATXN3) . P54252
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761