Details of the Target

General Information of Target

Target ID LDTP11658
Target Name WW domain-containing transcription regulator protein 1 (WWTR1)
Gene Name WWTR1
Gene ID 25937
Synonyms
TAZ; WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELG
KEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK
Target Bioclass
Other
Subcellular location
Nucleus
Function
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Uniprot ID
Q9GZV5
Ensemble ID
ENST00000360632.8
HGNC ID
HGNC:24042

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.21  LDD0403  [1]
BTD
 Probe Info  		C262(1.12)  LDD2120  [2]
AHL-Pu-1
 Probe Info  		C262(2.19)  LDD0171  [3]
HHS-475
 Probe Info  		Y141(0.94)  LDD0264  [4]
IA-alkyne
 Probe Info  		C363(1.35)  LDD2214  [5]
DBIA
 Probe Info  		C262(1.28)  LDD0078  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C262(2.19)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C262(1.01)  LDD0531  [6]
 LDCM0215  AC10 PaTu 8988t C262(2.58)  LDD1094  [6]
 LDCM0216  AC100 HCT 116 C262(1.20)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C262(1.28)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C262(1.08)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C262(1.32)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C262(1.04)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C262(1.31)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C262(1.38)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C262(1.23)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C262(1.26)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C262(0.94)  LDD0542  [6]
 LDCM0226  AC11 PaTu 8988t C262(1.90)  LDD1105  [6]
 LDCM0227  AC110 HCT 116 C262(1.29)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C262(1.58)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C262(1.18)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C262(0.87)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C262(1.24)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C262(1.32)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C262(1.45)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C262(1.30)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C262(1.10)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C262(1.35)  LDD0553  [6]
 LDCM0237  AC12 PaTu 8988t C262(1.05)  LDD1116  [6]
 LDCM0238  AC120 HCT 116 C262(1.19)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C262(0.97)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C262(1.18)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C262(0.95)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C262(1.13)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C262(1.05)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C262(1.41)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C262(1.26)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C262(1.72)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C262(0.94)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C262(1.23)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C262(0.97)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C262(1.01)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C262(1.41)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C262(1.39)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C262(1.26)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C262(1.08)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C262(1.12)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C262(1.14)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C262(1.21)  LDD0575  [6]
 LDCM0259  AC14 PaTu 8988t C262(1.98)  LDD1138  [6]
 LDCM0260  AC140 HCT 116 C262(1.17)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C262(1.20)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C262(0.98)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C262(1.19)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C262(0.96)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C262(1.03)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C262(1.10)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C262(0.98)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C262(1.02)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C262(1.02)  LDD0586  [6]
 LDCM0270  AC15 PaTu 8988t C262(1.95)  LDD1149  [6]
 LDCM0271  AC150 HCT 116 C262(0.95)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C262(0.94)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C262(0.96)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C262(1.18)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C262(0.98)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C262(0.94)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C262(0.99)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C262(0.84)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C262(0.88)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C262(0.87)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C262(0.73)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C262(1.00)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C262(0.86)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C262(0.87)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C262(0.91)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C262(0.75)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C262(1.02)  LDD0601  [6]
 LDCM0290  AC3 HCT 116 C262(1.07)  LDD0607  [6]
 LDCM0296  AC35 PaTu 8988t C262(1.36)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C262(1.91)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C262(1.27)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C262(1.54)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C262(1.91)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C262(0.86)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C262(1.88)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C262(1.08)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C262(1.30)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C262(1.49)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C262(1.54)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C262(1.35)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C262(1.14)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C262(1.33)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C262(1.48)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C262(1.52)  LDD1190  [6]
 LDCM0312  AC5 HCT 116 C262(0.92)  LDD0629  [6]
 LDCM0313  AC50 PaTu 8988t C262(1.51)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C262(0.76)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C262(1.54)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C262(2.25)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C262(2.74)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C262(1.54)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C262(1.59)  LDD1198  [6]
 LDCM0323  AC6 PaTu 8988t C262(1.11)  LDD1202  [6]
 LDCM0334  AC7 PaTu 8988t C262(1.11)  LDD1213  [6]
 LDCM0345  AC8 PaTu 8988t C262(1.01)  LDD1224  [6]
 LDCM0349  AC83 HCT 116 C262(1.76)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C262(1.50)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C262(1.28)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C262(1.21)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C262(1.12)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C262(1.13)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C262(1.52)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C262(1.00)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C262(2.26)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C262(1.79)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C262(1.23)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C262(1.26)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C262(1.24)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C262(1.56)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C262(1.55)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C262(1.35)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C262(1.13)  LDD0683  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C262(1.98)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C262(1.49)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C262(1.68)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 9.21  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C262(1.28)  LDD0078  [6]
 LDCM0630  CCW28-3 231MFP C363(1.35)  LDD2214  [5]
 LDCM0369  CL100 HCT 116 C262(1.01)  LDD0686  [6]
 LDCM0370  CL101 PaTu 8988t C262(1.01)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C262(1.29)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C262(2.69)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C262(1.44)  LDD1252  [6]
 LDCM0374  CL105 HCT 116 C262(0.90)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C262(0.70)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C262(0.96)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C262(1.03)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C262(0.91)  LDD0695  [6]
 LDCM0380  CL110 HCT 116 C262(0.75)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C262(0.65)  LDD0698  [6]
 LDCM0387  CL117 PaTu 8988t C262(1.11)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C262(0.98)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C262(1.34)  LDD1268  [6]
 LDCM0391  CL120 PaTu 8988t C262(1.69)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C262(1.49)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C262(1.34)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C262(2.60)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C262(1.72)  LDD1274  [6]
 LDCM0403  CL16 HCT 116 C262(0.91)  LDD0720  [6]
 LDCM0404  CL17 PaTu 8988t C262(0.78)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C262(1.22)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C262(0.95)  LDD1285  [6]
 LDCM0408  CL20 PaTu 8988t C262(0.79)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C262(1.38)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C262(2.52)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C262(0.91)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C262(1.06)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C262(1.65)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C262(1.51)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C262(1.46)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C262(1.70)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C262(0.95)  LDD1296  [6]
 LDCM0419  CL30 PaTu 8988t C262(1.08)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C262(1.41)  LDD1299  [6]
 LDCM0421  CL32 HCT 116 C262(1.16)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C262(1.03)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C262(1.36)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C262(1.46)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C262(1.21)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C262(1.49)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C262(1.07)  LDD0745  [6]
 LDCM0430  CL40 HCT 116 C262(0.96)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C262(1.13)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C262(0.80)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C262(1.61)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C262(1.54)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C262(1.38)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C262(0.64)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C262(0.73)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C262(0.78)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C262(0.79)  LDD0756  [6]
 LDCM0441  CL50 HCT 116 C262(0.76)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C262(0.76)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C262(1.10)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C262(0.80)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C262(0.95)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C262(0.80)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C262(0.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C262(0.68)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C262(0.90)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C262(0.81)  LDD0767  [6]
 LDCM0452  CL60 HCT 116 C262(0.73)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C262(0.94)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C262(0.87)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C262(0.88)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C262(0.84)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C262(0.89)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C262(0.94)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C262(0.80)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C262(0.75)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C262(0.92)  LDD0778  [6]
 LDCM0463  CL70 HCT 116 C262(0.84)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C262(0.91)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C262(0.86)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C262(0.96)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C262(0.91)  LDD0784  [6]
 LDCM0486  CL91 HCT 116 C262(0.99)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C262(0.76)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C262(0.90)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C262(0.96)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C262(1.05)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C262(0.90)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C262(0.98)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C262(1.11)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C262(0.87)  LDD0811  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C262(2.14)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C262(0.92)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C262(1.03)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y141(0.94)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y141(1.00)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y141(0.95)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y141(0.88)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y141(0.72)  LDD0268  [4]
 LDCM0022  KB02 42-MG-BA C262(1.97)  LDD2244  [9]
 LDCM0023  KB03 769-P C262(1.26)  LDD2663  [9]
 LDCM0024  KB05 COLO792 C262(1.58)  LDD3310  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C262(1.12)  LDD2120  [2]
 LDCM0021  THZ1 HCT 116 C262(1.06)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4) Commissureless family Q9BZD6
Serine/threonine-protein kinase LATS1 (LATS1) AGC Ser/Thr protein kinase family O95835
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) Zinc-containing alcohol dehydrogenase family Q8WWV3
Cell division cycle and apoptosis regulator protein 1 (CCAR1) . Q8IX12
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Transcriptional enhancer factor TEF-5 (TEAD3) . Q99594
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Segment polarity protein dishevelled homolog DVL-1 (DVL1) DSH family O14640
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
Protein scribble homolog (SCRIB) LAP (LRR and PDZ) protein family Q14160
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
UPF0739 protein C1orf74 (C1orf74) UPF0739 family Q96LT6
WW domain-binding protein 2 (WBP2) . Q969T9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840