Details of the Target

General Information of Target

Target ID LDTP11339
Target Name Caspase recruitment domain-containing protein 10 (CARD10)
Gene Name CARD10
Gene ID 29775
Synonyms
CARMA3; Caspase recruitment domain-containing protein 10; CARD-containing MAGUK protein 3; Carma 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.
Uniprot ID
Q9BWT7
Ensemble ID
ENST00000251973.10
HGNC ID
HGNC:16422

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A210T DBIA    Probe Info 
DU145 SNV: p.A586T .
FADU SNV: p.R710C .
HCC1806 SNV: p.L290P .
HEC1 SNV: p.C747Y DBIA    Probe Info 
HEC1B SNV: p.C747Y .
HT SNV: p.L225P .
JHH4 SNV: p.A445D .
JURKAT Insertion: p.N862KfsTer87 .
LS180 SNV: p.K918N .
MFE319 SNV: p.L111R .
NALM6 SNV: p.D278G .
OPM2 SNV: p.V875M .
OVKATE SNV: p.R801L .
REH SNV: p.R1005C .
SUPT1 SNV: p.A305V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1020(0.97)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_4
 Probe Info  		C589(0.00); C688(0.00); C725(0.00)  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1020(0.97)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C1020(1.22); C920(0.80)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C1020(1.19); C920(0.91)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C1020(0.99); C920(0.97)  LDD0554  [1]
 LDCM0246  AC128 HCT 116 C920(0.74)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C920(0.89)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C920(0.98)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C920(0.70)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C920(1.17)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C920(0.88)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C920(0.88)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C920(0.96)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C920(0.90)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C920(0.89)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C920(0.92)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C920(1.09)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C1020(1.10); C920(0.80)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C920(1.09)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C920(1.04)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C920(0.90)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C1020(0.95)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C1020(1.08)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C1020(0.93)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C1020(1.11)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C1020(1.08)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C1020(1.50)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C1020(1.10)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C920(0.96); C1020(1.27)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C1020(0.95)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C1020(0.87)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C1020(1.09)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C1020(1.52)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C1020(1.14)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C1020(1.08)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C1020(0.93)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C1020(0.81)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C876(1.13); C887(1.13)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C876(1.08); C887(1.08)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C876(0.89); C887(0.89)  LDD1157  [1]
 LDCM0279  AC2 HCT 116 C1020(0.99)  LDD0596  [1]
 LDCM0280  AC20 PaTu 8988t C876(0.93); C887(0.93)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C876(1.01); C887(1.01)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C876(0.97); C887(0.97)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C876(1.14); C887(1.14)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C876(1.17); C887(1.17)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C920(1.11)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C920(1.81)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C920(1.13)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C920(1.69)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C920(1.21)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C1020(0.96)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C920(1.30)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C920(1.28)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C920(1.63)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C920(0.93)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C920(0.76)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C876(1.04); C887(1.04); C920(0.93)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C876(1.04); C887(1.04); C920(1.05)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C876(1.07); C887(1.07); C920(1.09)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C876(1.16); C887(1.16); C920(1.13)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C876(1.05); C887(1.05); C920(1.05)  LDD1179  [1]
 LDCM0301  AC4 HCT 116 C1020(1.16)  LDD0618  [1]
 LDCM0302  AC40 PaTu 8988t C876(1.12); C887(1.12); C920(1.02)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C876(1.10); C887(1.10); C920(0.87)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C876(1.26); C887(1.26); C920(1.01)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C876(1.15); C887(1.15); C920(1.00)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C876(0.97); C887(0.97); C920(1.08)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C876(1.33); C887(1.33); C920(0.94)  LDD1186  [1]
 LDCM0312  AC5 HCT 116 C1020(0.95)  LDD0629  [1]
 LDCM0323  AC6 HCT 116 C920(1.11); C1020(1.17)  LDD0640  [1]
 LDCM0332  AC68 HCT 116 C1020(0.73)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1020(0.97)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C920(0.97); C1020(1.15)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C1020(1.10)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1020(0.95)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1020(0.94)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1020(1.12)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1020(0.91)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1020(0.86)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1020(1.03)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1020(0.91)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1020(0.95)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1020(0.97)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C920(1.05); C1020(1.13)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C1020(0.95)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1020(0.90)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1020(0.99)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C876(0.96); C887(0.96)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C876(0.87); C887(0.87)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C876(0.84); C887(0.84)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C876(0.83); C887(0.83)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C876(0.78); C887(0.78)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C876(0.82); C887(0.82)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C876(0.82); C887(0.82)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C876(0.84); C887(0.84)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C876(0.93); C887(0.93)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C876(0.89); C887(0.89)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C876(0.71); C887(0.71)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C876(0.85); C887(0.85)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C876(0.93); C887(0.93)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C876(0.82); C887(0.82)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C876(0.88); C887(0.88)  LDD1243  [1]
 LDCM0248  AKOS034007472 HCT 116 C1020(0.97); C920(1.03)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C920(1.05); C1020(1.13)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C920(0.96); C1020(1.44)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C876(1.35); C887(1.35)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C1020(1.05)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1020(0.95)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C1020(0.93)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C920(0.84); C1020(1.28)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C920(0.97); C1020(1.15)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C920(0.81); C1020(1.16)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C920(0.86); C1020(1.19)  LDD0690  [1]
 LDCM0374  CL105 PaTu 8988t C876(0.94); C887(0.94)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C876(0.90); C887(0.90)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C876(0.85); C887(0.85)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C876(1.08); C887(1.08)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C876(1.02); C887(1.02)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C1020(1.05)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C876(1.22); C887(1.22)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C876(1.12); C887(1.12)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C920(0.96)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C920(1.07)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C920(0.99)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C920(0.93)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C920(1.05)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C876(0.96); C887(0.96); C920(0.92)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C876(1.21); C887(1.21); C920(0.91)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C876(0.95); C887(0.95); C920(1.11)  LDD1268  [1]
 LDCM0390  CL12 HCT 116 C1020(0.98)  LDD0707  [1]
 LDCM0391  CL120 PaTu 8988t C876(1.19); C887(1.19); C920(1.07)  LDD1270  [1]
 LDCM0400  CL13 HCT 116 C1020(0.88)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1020(1.00)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1020(1.04)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C1020(0.91); C920(0.96)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1020(0.82); C920(1.01)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C920(0.87); C1020(0.89)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C920(0.92); C1020(1.02)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C1020(1.00)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C920(0.92); C1020(1.08)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C920(1.04); C1020(1.22)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C920(0.84); C1020(1.38)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C920(0.94); C1020(1.00)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C920(0.96); C1020(1.09)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1020(1.15); C920(1.11)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1020(0.95); C920(1.02)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1020(1.03); C920(0.89)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1020(1.05); C920(1.08)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1020(1.06); C920(1.04)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C1020(0.93)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C1020(0.90); C920(1.04)  LDD0736  [1]
 LDCM0420  CL31 PaTu 8988t C920(1.19)  LDD1299  [1]
 LDCM0421  CL32 HCT 116 C1020(1.33); C920(0.80)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1020(1.11); C920(1.00)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1020(0.90); C920(0.96)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1020(1.16); C920(0.95)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1020(1.03); C920(0.97)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1020(1.06); C920(1.01)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1020(1.08); C920(0.91)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C1020(0.95)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C1020(1.47); C920(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1020(1.18); C920(0.83)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1020(0.95); C920(0.76)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1020(1.25); C920(0.84)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1020(1.18); C920(0.95)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1020(1.10); C920(0.95)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C1020(1.03)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1020(0.92)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1020(1.00)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1020(0.96)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C1020(0.90)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C1020(0.89)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1020(0.98)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1020(0.97)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1020(0.96)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1020(0.83)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1020(0.96)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1020(0.90)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1020(0.87)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1020(0.96)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1020(0.86)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C1020(0.90)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C1020(0.97)  LDD0769  [1]
 LDCM0453  CL61 PaTu 8988t C920(1.00)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C920(0.93)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C920(0.89)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C920(1.05)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C920(1.02)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C920(1.01)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C920(1.29)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C920(1.54)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C920(1.33)  LDD1340  [1]
 LDCM0462  CL7 HCT 116 C1020(1.00)  LDD0779  [1]
 LDCM0463  CL70 PaTu 8988t C920(1.12)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C920(0.98)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C920(0.83)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C920(1.29)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C920(1.04)  LDD1346  [1]
 LDCM0469  CL76 HCT 116 C1020(0.92); C920(0.88)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1020(0.86); C920(0.86)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1020(0.76); C920(0.81)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1020(1.00); C920(0.86)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C1020(1.18)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C1020(1.10); C920(0.98)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1020(0.79); C920(0.95)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1020(0.98); C920(0.91)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1020(0.93); C920(1.02)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1020(0.97); C920(1.06)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1020(0.97); C920(0.81)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1020(0.79); C920(0.89)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1020(0.88); C920(0.91)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1020(1.06); C920(0.91)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1020(0.94); C920(0.86)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C1020(1.07)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C1020(0.87); C920(0.85)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C1020(1.10)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C1020(1.00)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C1020(0.88)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C1020(0.96)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C1020(1.10)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C1020(0.97)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C1020(1.17)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C1020(0.88)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C1020(1.01)  LDD0811  [1]
 LDCM0468  Fragment33 PaTu 8988t C920(1.05)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C1020(1.32); C920(1.01)  LDD0744  [1]
 LDCM0022  KB02 786-O C725(1.84); C920(1.95)  LDD2247  [6]
 LDCM0023  KB03 786-O C725(1.89); C920(5.78)  LDD2664  [6]
 LDCM0024  KB05 MKN-1 C920(1.98)  LDD3331  [6]
 LDCM0021  THZ1 HCT 116 C876(1.35); C887(1.35)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prostaglandin-H2 D-isomerase (PTGDS) Lipocalin family P41222
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Putative ATP-dependent RNA helicase DHX57 (DHX57) DEAD box helicase family Q6P158
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Glutathione S-transferase P (GSTP1) Pi family P09211
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Dual specificity protein phosphatase 26 (DUSP26) Protein-tyrosine phosphatase family Q9BV47
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Josephin-1 (JOSD1) . Q15040
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B9 (HOXB9) Abd-B homeobox family P17482
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Zinc finger protein 1 homolog (ZFP1) Krueppel C2H2-type zinc-finger protein family Q6P2D0
Zinc finger protein 10 (ZNF10) Krueppel C2H2-type zinc-finger protein family P21506
Zinc finger protein 12 (ZNF12) Krueppel C2H2-type zinc-finger protein family P17014
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 223 (ZNF223) Krueppel C2H2-type zinc-finger protein family Q9UK11
Zinc finger protein 239 (ZNF239) Krueppel C2H2-type zinc-finger protein family Q16600
Zinc finger protein 285 (ZNF285) Krueppel C2H2-type zinc-finger protein family Q96NJ3
Zinc finger protein 286A (ZNF286A) Krueppel C2H2-type zinc-finger protein family Q9HBT8
Zinc finger protein 32 (ZNF32) Krueppel C2H2-type zinc-finger protein family P17041
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 439 (ZNF439) Krueppel C2H2-type zinc-finger protein family Q8NDP4
Zinc finger protein 440 (ZNF440) Krueppel C2H2-type zinc-finger protein family Q8IYI8
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 559 (ZNF559) Krueppel C2H2-type zinc-finger protein family Q9BR84
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 613 (ZNF613) Krueppel C2H2-type zinc-finger protein family Q6PF04
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein 775 (ZNF775) Krueppel C2H2-type zinc-finger protein family Q96BV0
Zinc finger protein 80 (ZNF80) Krueppel C2H2-type zinc-finger protein family P51504
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Forkhead box protein D4-like 3 (FOXD4L3) . Q6VB84
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Oligodendrocyte transcription factor 3 (OLIG3) . Q7RTU3
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger protein 202 (ZNF202) . O95125
Zinc finger protein 366 (ZNF366) . Q8N895
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM47B (FAM47B) FAM47 family Q8NA70
Hemoglobin subunit zeta (HBZ) Globin family P02008
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Mitochondria-eating protein (SPATA18) MIEAP family Q8TC71
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) PTCD1 family O75127
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Centrosomal protein of 95 kDa (CEP95) . Q96GE4
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 116 (CCDC116) . Q8IYX3
Genetic suppressor element 1 (GSE1) . Q14687
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
MIT domain-containing protein 1 (MITD1) . Q8WV92
Proline-rich protein 35 (PRR35) . P0CG20
Protein SPMIP2 (SPMIP2) . Q96LM5
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840