Details of the Target

General Information of Target

Target ID LDTP11313
Target Name Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)
Gene Name KATNAL1
Gene ID 84056
Synonyms
Katanin p60 ATPase-containing subunit A-like 1; Katanin p60 subunit A-like 1; EC 5.6.1.1; p60 katanin-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQIIVTEKTNILLRYLH
QQWDKKNAAKKRDQEQVELEGESSAPPRKVARTDSPDMHEDT
Target Bioclass
Enzyme
Family
AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 1 sub-subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. Has microtubule-severing activity in vitro.
Uniprot ID
Q9BW62
Ensemble ID
ENST00000380615.8
HGNC ID
HGNC:28361

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		C40(0.97)  LDD1702  [2]
DBIA
 Probe Info  		C424(0.98)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C313(0.00); C424(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
AOyne
 Probe Info  		13.60  LDD0443  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C424(0.98)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C265(0.62); C424(0.84)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C424(0.54)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C424(0.64)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C424(0.56)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C424(0.65)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C424(0.49)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C424(0.69)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C424(0.45)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C424(0.58)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C424(0.51)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C424(0.40)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C265(0.61); C424(0.72)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C424(0.51)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C424(0.42)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C424(0.49)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C424(0.89)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C424(0.93)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C424(0.92)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C424(0.87)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C424(0.84)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C424(0.82)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C424(0.72)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C265(0.79); C424(0.82)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C424(0.74)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C424(0.63)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C424(0.65)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C424(0.67)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C424(0.79)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C424(0.69)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C424(0.55)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C424(0.44)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C424(0.86)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C424(1.02)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C424(1.00)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C424(0.98)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C424(1.38)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C424(1.04)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C424(1.14)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C424(1.17)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C424(1.14)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C424(1.15)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C424(1.24)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C424(1.25)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C265(0.66); C424(0.97)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C424(1.39)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C424(1.43)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C424(1.14)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C424(0.79)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C424(0.96)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C424(1.13)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C424(1.04)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C424(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C424(1.13)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C424(1.17)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C265(0.76); C424(1.09)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C424(0.96)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C424(0.89)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C424(0.91)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C424(1.15)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C424(1.04)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C424(1.08)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C424(1.15)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C424(1.14)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C265(1.33)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C265(0.99)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C265(1.16)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C424(1.03)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C265(0.92)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C265(1.07)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C265(1.19)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C265(0.98)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C265(1.17)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C265(0.71)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C265(0.85)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C265(0.58)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C265(0.46)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C265(0.89)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C424(0.99)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C265(0.60)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C265(0.52)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C265(0.56)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C265(0.73)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C265(0.64)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C424(0.86)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C424(0.93)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C424(0.84)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C424(1.08)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C424(0.98)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C424(1.10)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C424(0.82)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C424(1.19)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C424(1.25)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C424(2.20)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C424(0.79)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C424(0.75)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C265(1.05); C424(1.15)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C265(0.83); C424(0.94)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C265(0.80); C424(1.08)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C265(0.98); C424(1.03)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C424(1.11)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C265(0.88); C424(1.02)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C424(0.93); C265(1.18)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C265(0.90); C424(1.17)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C265(0.91); C424(0.94)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C265(0.84); C424(0.99)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C265(0.94); C424(1.00)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C424(1.07); C265(1.09)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C265(0.61); C424(0.96)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C265(0.78); C424(0.88)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C265(0.57); C424(1.12)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C265(0.71); C424(0.91)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C265(0.60); C424(1.00)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C265(0.60); C424(1.14)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C265(0.72); C424(1.07)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C265(0.64); C424(1.01)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C265(0.60); C424(0.90)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C265(0.52); C424(1.05)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C265(0.59); C424(1.31)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C265(0.57); C424(1.01)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C424(1.34)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C424(0.99)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C265(0.79); C424(0.90)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C424(1.20)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C424(1.20)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C424(1.00)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C424(1.02)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C424(1.21)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C424(0.99)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C424(1.16)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C424(0.97)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C424(0.98)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C424(1.05)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C265(0.75); C424(0.94)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C424(0.92)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C424(1.16)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C424(1.09)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C424(0.70)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C424(0.71)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C424(0.79)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C424(0.98)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C424(0.87)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C424(1.01)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C424(0.76)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C424(1.27)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C424(0.88)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C424(0.71)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C424(0.73)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C424(0.86)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C424(0.84)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C424(0.70)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C424(0.78)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C424(0.75)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C424(0.42)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C265(0.83); C424(0.93)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C265(0.72); C424(0.93)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C265(0.64); C424(1.02)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 12.34  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C7(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C313(1.41)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C313(0.96)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C424(1.07)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C265(0.71); C424(0.95)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C265(0.72); C424(0.81)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C265(0.73); C424(0.80)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C265(0.82); C424(0.93)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C265(0.95)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C265(0.79)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C265(0.88)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C265(0.99)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C265(0.94)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C313(1.10)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C265(0.87)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C265(0.96)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C265(0.79)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C265(0.51)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C265(0.68)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C265(0.63)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C265(0.62)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C424(1.16)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C424(1.36)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C424(1.38)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C313(1.41)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C424(1.23)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C265(0.56); C424(1.03)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C265(0.79); C424(1.04)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C265(1.04); C424(1.04)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C265(0.83); C424(1.14)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C265(0.91); C424(1.09)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C265(0.69); C424(1.09)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C265(0.70); C424(1.06)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C265(0.59); C424(1.00)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C313(0.96)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C313(0.91)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C313(0.92); C88(0.81)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C424(1.09)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C265(0.99)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C265(1.07)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C265(1.29)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C313(0.95)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C265(1.07)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C265(1.03)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C265(1.06)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C265(1.05)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C265(0.96)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C265(0.77)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C265(0.98)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C265(0.98)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C265(1.18)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C265(0.92)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C313(0.80); C88(0.86)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C265(1.48)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C424(0.69)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C424(1.00)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C424(0.87)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C424(1.29)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C424(1.16)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C424(1.00)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C424(0.93)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C424(1.02)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C313(1.03); C88(0.99)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C424(1.00)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C424(1.04)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C424(1.13)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C424(1.00)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C424(1.05)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C424(0.94)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C424(0.93)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C424(0.85)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C424(0.96)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C424(1.15)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C313(0.84); C88(1.16)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C424(1.12)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C424(1.06)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C424(0.91)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C424(0.71)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C424(0.99)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C424(1.03)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C424(0.92)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C424(1.04)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C424(1.00)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C424(1.04)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C313(0.87)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C424(1.09)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C265(0.82); C313(1.10)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C265(0.97); C313(0.95)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C265(0.94); C313(0.42)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C265(0.94); C313(0.77)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C265(0.91); C313(0.43)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C265(0.91); C313(0.59)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C265(1.04); C313(0.61)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C265(0.75); C313(0.68)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C265(0.92); C313(0.95)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C313(0.73)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C265(0.95); C313(1.31)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C265(1.02); C313(1.00)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C265(0.88); C313(1.20)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C265(0.82); C313(0.96)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C265(0.81); C313(0.57)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C265(0.68)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C265(0.55)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C265(0.46)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C265(0.48)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C313(0.74)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C265(0.62)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C265(0.55)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C265(0.69)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C265(0.65)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C265(0.48)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C265(0.54)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C265(0.45)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C265(0.50)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C265(0.54)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C265(0.54)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C313(1.21); C88(0.84)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C265(0.59)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C424(0.92)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C424(1.03)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C424(1.04)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C424(0.94)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C424(1.04)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C424(0.94)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C424(0.91)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C424(1.07)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C424(1.04)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C313(1.07); C88(1.07)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C40(0.97)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C265(0.68); C313(0.41)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C424(0.92)  LDD0744  [3]
 LDCM0022  KB02 A-172 C313(1.28)  LDD2251  [8]
 LDCM0023  KB03 A-172 C313(3.14)  LDD2668  [8]
 LDCM0024  KB05 MKN-1 C313(1.60)  LDD3331  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 4B (VPS4B) AAA ATPase family O75351
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) AAA ATPase family Q9BW62
Phosphoglycerate mutase 2 (PGAM2) Phosphoglycerate mutase family P15259
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 69 (ZNF69) Krueppel C2H2-type zinc-finger protein family Q9UC07
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Activating signal cointegrator 1 complex subunit 2 (ASCC2) ASCC2 family Q9H1I8
Bystin (BYSL) Bystin family Q13895
Cytochrome c oxidase copper chaperone (COX17) COX17 family Q14061
Kinesin light chain 4 (KLC4) Kinesin light chain family Q9NSK0
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Katanin p80 WD40 repeat-containing subunit B1 (KATNB1) WD repeat KATNB1 family Q9BVA0
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Guanylyl cyclase-activating protein 1 (GUCA1A) . P43080
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
KATNB1-like protein 1 (KATNBL1) . Q9H079

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840