Details of the Target

General Information of Target

Target ID LDTP10956
Target Name Mothers against decapentaplegic homolog 5 (SMAD5)
Gene Name SMAD5
Gene ID 4090
Synonyms
MADH5; Mothers against decapentaplegic homolog 5; MAD homolog 5; Mothers against DPP homolog 5; JV5-1; SMAD family member 5; SMAD 5; Smad5; hSmad5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSRLPPALAALGAALLLSSIEAEVDPPSDLNFKIIDENTVHMSWAKPVDPIVGYRITVD
PTTDGPTKEFTLSASTTETLLSELVPETEYVVTITSYDEVEESVPVIGQLTIQTGSSTKP
VEKKPGKTEIQKCSVSAWTDLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVG
VVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVG
FPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVA
NFDAIVDIQNEIISQVCSGVDEQLGELVSGEEVVEPPSNLIAMEVSSKYVKLNWNPSPSP
VTGYKVILTPMTAGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIME
KTQPMKVQVECSRGVDIKADIVFLVDGSYSIGIANFVKVRAFLEVLVKSFEISPNRVQIS
LVQYSRDPHTEFTLKKFTKVEDIIEAINTFPYRGGSTNTGKAMTYVREKIFVPSKGSRSN
VPKVMILITDGKSSDAFRDPAIKLRNSDVEIFAVGVKDAVRSELEAIASPPAETHVFTVE
DFDAFQRISFELTQSICLRIEQELAAIKKKAYVPPKDLSFSEVTSYGFKTNWSPAGENVF
SYHITYKEAAGDDEVTVVEPASSTSVVLSSLKPETLYLVNVTAEYEDGFSIPLAGEETTE
EVKGAPRNLKVTDETTDSFKITWTQAPGRVLRYRIIYRPVAGGESREVTTPPNQRRRTLE
NLIPDTKYEVSVIPEYFSGPGTPLTGNAATEEVRGNPRDLRVSDPTTSTMKLSWSGAPGK
VKQYLVTYTPVAGGETQEVTVRGDTTNTVLQGLKEGTQYALSVTALYASGAGDALFGEGT
TLEERGSPQDLVTKDITDTSIGAYWTSAPGMVRGYRVSWKSLYDDVDTGEKNLPEDAIHT
MIENLQPETKYRISVFATYSSGEGEPLTGDATTELSQDSKTLKVDEETENTMRVTWKPAP
GKVVNYRVVYRPHGRGKQMVAKVPPTVTSTVLKRLQPQTTYDITVLPIYKMGEGKLRQGS
GTTASRFKSPRNLKTSDPTMSSFRVTWEPAPGEVKGYKVTFHPTGDDRRLGELVVGPYDN
TVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGMECLTRAEADI
VLLVDGSWSIGRANFRTVRSFISRIVEVFDIGPKRVQIALAQYSGDPRTEWQLNAHRDKK
SLLQAVANLPYKGGNTLTGMALNFIRQQNFRTQAGMRPRARKIGVLITDGKSQDDVEAPS
KKLKDEGVELFAIGIKNADEVELKMIATDPDDTHAYNVADFESLSRIVDDLTINLCNSVK
GPGDLEAPSNLVISERTHRSFRVSWTPPSDSVDRYKVEYYPVSGGKRQEFYVSRMETSTV
LKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYDVGPTTMHVQWQPVGGA
TGYILSYKPVKDTEPTRPKEVRLGPTVNDMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVR
EVTLPLPRPQDLKLRDVTHSTMNVFWEPVPGKVRKYIVRYKTPEEDVKEVEVDRSETSTS
LKDLFSQTLYTVSVSAVHDEGESPPVTAQETTRPVPAPTNLKITEVTSEGFRGTWDHGAS
DVSLYRITWAPFGSSDKMETILNGDENTLVFENLNPNTIYEVSITAIYPDESESDDLIGS
ERTLPILTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTT
IGGRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKPLNTVRNLRVYDPSTSTL
NVRWDHAEGNPRQYKLFYAPAAGGPEELVPIPGNTNYAILRNLQPDTSYTVTVVPVYTEG
DGGRTSDTGRTLMRGLARNVQVYNPTPNSLDVRWDPAPGPVLQYRVVYSPVDGTRPSESI
VVPGNTRMVHLERLIPDTLYSVNLVALYSDGEGNPSPAQGRTLPRSGPRNLRVFGETTNS
LSVAWDHADGPVQQYRIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIAVYE
DGDGGHLTGNGRTVGLLPPQNIHISDEWYTRFRVSWDPSPSPVLGYKIVYKPVGSNEPME
AFVGEMTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTLYLNVTDLKTYQIGWDTF
CVKWSPHRAATSYRLKLSPADGTRGQEITVRGSETSHCFTGLSPDTDYGVTVFVQTPNLE
GPGVSVKEHTTVKPTEAPTEPPTPPPPPTIPPARDVCKGAKADIVFLTDASWSIGDDNFN
KVVKFIFNTVGGFDEISPAGIQVSFVQYSDEVKSEFKLNTYNDKALALGALQNIRYRGGN
TRTGKALTFIKEKVLTWESGMRKNVPKVLVVVTDGRSQDEVKKAALVIQQSGFSVFVVGV
ADVDYNELANIASKPSERHVFIVDDFESFEKIEDNLITFVCETATSSCPLIYLDGYTSPG
FKMLEAYNLTEKNFASVQGVSLESGSFPSYSAYRIQKNAFVNQPTADLHPNGLPPSYTII
LLFRLLPETPSDPFAIWQITDRDYKPQVGVIADPSSKTLSFFNKDTRGEVQTVTFDTEEV
KTLFYGSFHKVHIVVTSKSVKIYIDCYEIIEKDIKEAGNITTDGYEILGKLLKGERKSAA
FQIQSFDIVCSPVWTSRDRCCDIPSRRDEGKCPAFPNSCTCTQDSVGPPGPPGPAGGPGA
KGPRGERGISGAIGPPGPRGDIGPPGPQGPPGPQGPNGLSIPGEQGRQGMKGDAGEPGLP
GRTGTPGLPGPPGPMGPPGDRGFTGKDGAMGPRGPPGPPGSPGSPGVTGPSGKPGKPGDH
GRPGPSGLKGEKGDRGDIASQNMMRAVARQVCEQLISGQMNRFNQMLNQIPNDYQSSRNQ
PGPPGPPGPPGSAGARGEPGPGGRPGFPGTPGMQGPPGERGLPGEKGERGTGSSGPRGLP
GPPGPQGESRTGPPGSTGSRGPPGPPGRPGNSGIRGPPGPPGYCDSSQCASIPYNGQGYP
GSG
Target Bioclass
Transcription factor
Family
Dwarfin/SMAD family
Subcellular location
Cytoplasm
Function
Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis.
Uniprot ID
Q99717
Ensemble ID
ENST00000509297.6
HGNC ID
HGNC:6771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K16(3.85)  LDD0277  [1]
BTD
 Probe Info  		C65(0.37)  LDD2091  [2]
IPM
 Probe Info  		C378(3.05); C65(2.10)  LDD1701  [2]
DBIA
 Probe Info  		C378(0.86)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
Lodoacetamide azide
 Probe Info  		C122(0.00); C378(0.00)  LDD0037  [5]
TFBX
 Probe Info  		C65(0.00); C90(0.00)  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C65(2.81); C122(3.02)  LDD0371  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C65(9.16)  LDD0372  [7]
 LDCM0214  AC1 HCT 116 C378(0.86)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C378(1.04)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C360(0.59); C372(0.59)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C360(0.73); C372(0.73)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C360(0.84); C372(0.84)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C360(0.79); C372(0.79)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C360(0.90); C372(0.90)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C360(0.71); C372(0.71)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C360(0.66); C372(0.66)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C360(0.68); C372(0.68)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C360(0.64); C372(0.64)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C360(0.97); C372(0.97)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C378(0.99)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C360(0.73); C372(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C360(0.64); C372(0.64)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C360(0.75); C372(0.75)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C378(0.91)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C378(1.03)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C378(1.18)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C378(1.11)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C378(1.08)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C378(0.98)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C378(1.26)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C378(1.09)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C378(1.10)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C378(0.87)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C378(1.14)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C378(1.07)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C378(0.88)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C378(1.06)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C378(1.14)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C378(0.98)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C378(1.02)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C360(0.97); C372(0.97); C378(1.20)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C360(0.65); C372(0.65); C378(0.97)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C360(0.94); C372(0.94); C378(1.04)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C360(0.63); C372(0.63); C378(1.20)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C360(0.60); C372(0.60); C378(1.02)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C360(0.33); C372(0.33); C378(1.41)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C360(0.53); C372(0.53); C378(1.30)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C378(1.14)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C360(1.04); C372(1.04); C378(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C360(0.75); C372(0.75); C378(1.30)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C360(0.65); C372(0.65); C378(1.13)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C360(0.32); C372(0.32); C378(1.50)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C360(0.78); C372(0.78); C378(1.27)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C360(0.87); C372(0.87); C378(1.45)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C360(1.05); C372(1.05); C378(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C360(0.92); C372(0.92); C378(1.18)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C378(1.00)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C378(0.87)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C378(0.99)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C378(1.02)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C378(0.89)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C378(0.80)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C378(0.90)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C378(0.87)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C378(0.92)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C378(0.90); C360(1.06)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C378(1.00); C360(0.96)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C378(1.10); C360(0.94)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C378(0.90)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C378(0.96); C360(0.76)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C378(0.96)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C378(1.05); C360(1.01)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C378(1.02); C360(0.97)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C378(1.04); C360(1.07)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C378(0.87); C360(1.08)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C378(1.01); C360(0.99)  LDD1534  [8]
 LDCM0296  AC35 HCT 116 C378(0.87)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C378(0.79)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C378(0.86)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C378(0.93)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C378(0.85)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C378(0.94)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C378(0.91)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C378(1.03)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C378(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C378(0.98)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C378(1.10)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C378(1.08)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C110(0.63); C360(0.63); C372(0.63)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C110(0.87); C360(0.87); C372(0.87)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C110(1.05); C360(1.05); C372(1.05)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C110(0.86); C360(0.86); C372(0.86)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C378(1.06)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C110(0.78); C360(0.78); C372(0.78)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C110(0.84); C360(0.84); C372(0.84)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C110(0.78); C360(0.78); C372(0.78)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C110(1.02); C360(1.02); C372(1.02)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C110(0.81); C360(0.81); C372(0.81)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C110(0.86); C360(0.86); C372(0.86)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C110(0.90); C360(0.90); C372(0.90)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C378(0.92)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C378(0.97)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C378(1.05)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C378(1.17)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C378(1.01)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C378(0.89)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C378(1.02)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C378(1.04)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C378(1.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C378(0.96)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C378(0.86)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C378(0.99)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C360(0.75); C372(0.75)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C360(0.63); C372(0.63)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C378(1.06)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C360(0.54); C372(0.54)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C360(0.85); C372(0.85)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C360(0.80); C372(0.80)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C360(0.43); C372(0.43)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C360(0.45); C372(0.45)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C360(0.49); C372(0.49)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C360(0.57); C372(0.57)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C360(0.58); C372(0.58)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C360(0.57); C372(0.57)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C360(1.05); C372(1.05)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C378(1.14)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C360(0.80); C372(0.80)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C360(0.92); C372(0.92)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C360(0.58); C372(0.58)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C360(0.93); C372(0.93); C378(1.06)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C360(0.85); C372(0.85); C378(1.02)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C360(0.61); C372(0.61); C378(1.07)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C360(0.81); C372(0.81); C378(1.04)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C378(0.89); C360(0.96); C372(0.96)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C378(0.91); C360(1.15); C372(1.15)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C360(0.78); C372(0.78); C378(1.03)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C360(0.87); C372(0.87); C378(0.97)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C360(0.68); C372(0.68); C378(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C360(0.91); C372(0.91); C378(1.09)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C360(0.75); C372(0.75); C378(1.00)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C360(0.75); C372(0.75); C378(1.06)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C360(0.97); C372(0.97); C378(0.98)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C360(0.66); C372(0.66); C378(0.97)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C360(0.68); C372(0.68); C378(1.02)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C360(0.66); C372(0.66)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C360(0.86); C372(0.86)  LDD0683  [3]
 LDCM0545  Acetamide MDA-MB-231 C65(0.38)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C378(1.13)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C378(0.88)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C378(1.12)  LDD0592  [3]
 LDCM0498  BS-3668 MDA-MB-231 C65(0.37)  LDD2091  [2]
 LDCM0367  CL1 HCT 116 C378(0.91)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C378(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C378(0.91)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C378(1.16)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C378(0.85)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C378(0.92)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C378(0.93)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C378(0.85)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C378(0.74)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C378(0.81)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C378(0.89)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C378(0.79)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C378(0.98)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C378(1.01)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C378(1.16)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C378(0.91); C360(1.25)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C378(0.95); C360(1.09)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C378(0.84); C360(1.04)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C378(0.93)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C378(0.91); C360(1.17)  LDD1590  [8]
 LDCM0387  CL117 HCT 116 C378(0.75)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C378(0.94)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C378(0.91)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C378(1.02)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C378(0.91)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C110(0.79); C360(0.79); C372(0.79)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C110(0.75); C360(0.75); C372(0.75)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C110(0.85); C360(0.85); C372(0.85)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C110(0.86); C360(0.86); C372(0.86)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C378(0.99)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C378(0.85)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C378(1.00)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C378(0.97)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C378(0.96)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C378(0.95)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C378(0.80)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C360(0.74); C372(0.74)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C360(0.62); C372(0.62)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C360(0.51); C372(0.51)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C360(0.64); C372(0.64)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C378(0.95)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C360(0.70); C372(0.70)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C360(0.44); C372(0.44)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C360(0.39); C372(0.39)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C360(0.71); C372(0.71)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C360(0.54); C372(0.54)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C360(0.49); C372(0.49)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C360(0.76); C372(0.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C360(0.65); C372(0.65)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C360(0.56); C372(0.56)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C360(0.60); C372(0.60)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C378(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C360(0.73); C372(0.73)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C378(1.01)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C378(1.12)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C378(0.96)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C378(1.04)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C378(1.06)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C378(1.04)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C378(1.06)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C378(1.06)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C378(0.83)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C378(0.91)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C378(1.00)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C378(0.86)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C378(0.87)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C378(0.93)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C378(1.03)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C110(0.89); C360(0.89); C372(0.89)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C110(1.02); C360(1.02); C372(1.02)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C110(1.18); C360(1.18); C372(1.18)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C110(1.10); C360(1.10); C372(1.10)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C378(0.86)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C110(1.19); C360(1.19); C372(1.19)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C110(1.08); C360(1.08); C372(1.08)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C110(1.27); C360(1.27); C372(1.27)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C110(0.87); C360(0.87); C372(0.87)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C110(0.94); C360(0.94); C372(0.94)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C110(0.96); C360(0.96); C372(0.96)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C110(1.22); C360(1.22); C372(1.22)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C110(0.81); C360(0.81); C372(0.81)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C110(1.19); C360(1.19); C372(1.19)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C110(1.10); C360(1.10); C372(1.10)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C378(0.83)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C110(1.15); C360(1.15); C372(1.15)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C360(0.69); C372(0.69)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C360(0.66); C372(0.66)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C360(0.83); C372(0.83)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C360(0.77); C372(0.77)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C360(1.08); C372(1.08)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C360(0.71); C372(0.71)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C360(0.93); C372(0.93)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C360(1.15); C372(1.15)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C360(0.55); C372(0.55)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C378(0.93)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C360(0.83); C372(0.83)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C360(0.83); C372(0.83)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C360(0.53); C372(0.53)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C360(0.74); C372(0.74)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C360(0.85); C372(0.85)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C378(0.99); C360(0.97)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C378(0.80); C360(0.86)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C378(0.94); C360(0.96)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C378(1.19); C360(1.18)  LDD1675  [8]
 LDCM0473  CL8 HCT 116 C378(0.83)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C378(0.99)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C378(1.04); C360(0.79)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C378(1.10); C360(1.09)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C378(1.05); C360(0.80)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C378(1.01); C360(0.90)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C378(0.96); C360(0.86)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C378(0.96); C360(0.69)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C378(0.90)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C378(0.91); C360(0.71)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C378(0.88); C360(0.62)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C378(1.01)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C378(0.75); C360(0.58)  LDD1688  [8]
 LDCM0486  CL91 HCT 116 C378(0.99)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C378(1.00)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C378(0.90)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C378(0.81)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C378(0.82)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C378(0.87)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C378(1.00)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C378(0.98)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C378(1.01)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C378(0.99)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C378(2.45); C65(1.70)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C360(0.67); C372(0.67)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C378(0.93)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C360(1.04)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C360(0.95)  LDD1497  [8]
 LDCM0024  KB05 UACC257 C122(1.76)  LDD3325  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C65(0.66)  LDD2123  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C65(1.02)  LDD2146  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX5 (DDX5) DEAD box helicase family P17844
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
WW domain-binding protein 2 (WBP2) . Q969T9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840