Details of the Target

General Information of Target

Target ID LDTP10736
Target Name Rab-3A-interacting protein (RAB3IP)
Gene Name RAB3IP
Gene ID 117177
Synonyms
RABIN8; Rab-3A-interacting protein; Rab3A-interacting protein; Rabin-3; Rabin8; SSX2-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGSVLFTAGERWRCFLTPSRSSLYWALHNFCCRKKSTTPKKITPNVTFCDENAKEPENA
LDKLFSSEQQASILHVLNTASTKELEAFRLLRGRRSINIVEHRENFGPFQNLESLMNVPL
FKYKSTVQVCNSILCPKTGREKRKSPENRFLRKLLKPDIERERLKAVNSIISIVFGTRRI
AWAHLDRKLTVLDWQQSDRWSLMRGIYSSSVYLEEISSIISKMPKADFYVLEKTGLSIQN
SSLFPILLHFHIMEAMLYALLNKTFAQDGQHQVLSMNRNAVGKHFELMIGDSRTSGKELV
KQFLFDSILKADPRVFFPSDKIVHYRQMFLSTELQRVEELYDSLLQAIAFYELAVFDSQP
Target Bioclass
Other
Family
SEC2 family
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation.
Uniprot ID
Q96QF0
Ensemble ID
ENST00000247833.12
HGNC ID
HGNC:16508

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
m-APA
 Probe Info  		12.40  LDD0403  [2]
DBIA
 Probe Info  		C334(176.03)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C389(0.00); C395(0.00); C195(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C395(0.00); C431(0.00)  LDD0037  [4]
NAIA_5
 Probe Info  		C389(0.00); C431(0.00); C395(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C431(1.27)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C431(1.32)  LDD1094  [6]
 LDCM0216  AC100 PaTu 8988t C431(0.90)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C431(1.02)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C431(1.26)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C431(1.08)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C431(1.05)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C431(1.01)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C431(1.19)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C431(1.03)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C431(1.11)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C431(1.09)  LDD1104  [6]
 LDCM0226  AC11 PaTu 8988t C431(1.33)  LDD1105  [6]
 LDCM0227  AC110 PaTu 8988t C431(1.27)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C431(1.22)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C431(1.01)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C431(1.08)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C431(1.12)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C431(1.07)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C431(0.98)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C431(0.99)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C431(1.22)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C431(1.09)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C431(1.32)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C431(1.18)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C431(1.23)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C431(1.14)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C431(0.99)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C431(1.30)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C431(1.20)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C431(1.02)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C431(1.07)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C431(0.96)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C431(1.05)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C431(1.04)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C431(1.12)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C431(1.03)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C431(1.01)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C431(1.10)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C431(1.03)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C431(1.03)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C431(0.95)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C431(1.01)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C431(1.01)  LDD1137  [6]
 LDCM0259  AC14 PaTu 8988t C431(0.88)  LDD1138  [6]
 LDCM0260  AC140 PaTu 8988t C431(1.09)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C431(0.95)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C431(1.02)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C431(0.96)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C431(0.95)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C431(0.92)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C431(1.47)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C431(1.07)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C431(1.07)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C431(1.04)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C431(1.00)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C431(1.08)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C431(1.16)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C431(0.96)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C431(1.10)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C431(1.16)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C431(1.01)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C431(0.90)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C431(1.01)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C431(0.95)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C431(0.94)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C431(0.91)  LDD1157  [6]
 LDCM0279  AC2 PaTu 8988t C431(1.06)  LDD1158  [6]
 LDCM0280  AC20 PaTu 8988t C431(0.90)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C431(0.93)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C431(0.98)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C431(1.03)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C431(0.95)  LDD1163  [6]
 LDCM0285  AC25 HCT 116 C431(1.28)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C431(1.39)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C431(1.24)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C431(1.08)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C431(1.31)  LDD0606  [6]
 LDCM0290  AC3 PaTu 8988t C431(1.25)  LDD1169  [6]
 LDCM0291  AC30 HCT 116 C431(1.30)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C431(1.18)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C431(1.30)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C431(1.27)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C431(1.28)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C431(0.82)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C431(0.89)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C431(0.90)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C431(1.02)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C431(0.85)  LDD0617  [6]
 LDCM0301  AC4 PaTu 8988t C431(1.12)  LDD1180  [6]
 LDCM0302  AC40 HCT 116 C431(0.92)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C431(0.80)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C431(0.99)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C431(0.91)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C431(1.06)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C431(0.98)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C431(1.08)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C431(1.01)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C431(0.91)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C431(0.93)  LDD0628  [6]
 LDCM0312  AC5 PaTu 8988t C431(1.34)  LDD1191  [6]
 LDCM0313  AC50 HCT 116 C431(0.84)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C431(1.12)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C431(1.05)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C431(0.98)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C431(0.99)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C431(1.02)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C431(0.87)  LDD0636  [6]
 LDCM0320  AC57 PaTu 8988t C431(1.03)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C431(0.94)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C431(0.95)  LDD1201  [6]
 LDCM0323  AC6 PaTu 8988t C431(1.02)  LDD1202  [6]
 LDCM0324  AC60 PaTu 8988t C431(0.97)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C431(1.01)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C431(1.02)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C431(1.03)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C431(1.02)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C431(0.99)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C431(1.07)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C431(0.91)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C431(0.92)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C431(0.96)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C431(1.18)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C431(0.97)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C431(1.01)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C431(0.88)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C431(0.89)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C431(1.03)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C431(0.97)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C431(1.03)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C431(0.92)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C431(0.95)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C431(0.96)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C431(1.17)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C431(0.90)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C431(0.87)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C431(1.03)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C431(0.99)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C431(1.15)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C431(1.27)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C431(1.18)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C431(1.13)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C431(1.09)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C431(1.20)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C431(1.07)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C431(1.11)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C431(1.20)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C431(0.96)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C431(1.12)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C431(1.09)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C431(0.98)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C431(1.10)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C431(1.16)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C431(1.10)  LDD1245  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C431(0.88)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C431(1.17)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C431(1.10)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 12.40  LDD0403  [2]
 LDCM0367  CL1 PaTu 8988t C431(0.91)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C431(1.06)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C431(1.05)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C431(1.09)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C431(1.37)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C431(1.25)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C431(1.51)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C431(0.91)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C431(0.88)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C431(1.03)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C431(1.13)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C431(0.93)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C431(0.93)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C431(0.99)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C431(1.00)  LDD1260  [6]
 LDCM0382  CL112 HCT 116 C431(0.86)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C431(1.18)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C431(1.00)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C431(1.13)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C431(1.36)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C431(1.03)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C431(0.98)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C431(0.98)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C431(1.14)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C431(0.82)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C431(0.73)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C431(0.99)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C431(1.08)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C431(0.96)  LDD0712  [6]
 LDCM0396  CL125 PaTu 8988t C431(0.93)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C431(1.12)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C431(0.96)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C431(1.06)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C431(1.46)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C431(1.61)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C431(1.03)  LDD1281  [6]
 LDCM0403  CL16 HCT 116 C431(1.21)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C431(1.01)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C431(1.40)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C431(1.13)  LDD0723  [6]
 LDCM0407  CL2 PaTu 8988t C431(1.05)  LDD1286  [6]
 LDCM0408  CL20 HCT 116 C431(1.23)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C431(1.21)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C431(1.74)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C431(1.54)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C431(1.27)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C431(1.34)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C431(1.35)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C431(1.19)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C431(1.25)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C431(1.22)  LDD0734  [6]
 LDCM0418  CL3 PaTu 8988t C431(1.05)  LDD1297  [6]
 LDCM0419  CL30 HCT 116 C431(1.23)  LDD0736  [6]
 LDCM0420  CL31 PaTu 8988t C431(1.01)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C431(1.03)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C431(1.07)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C431(1.06)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C431(1.12)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C431(0.73)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C431(1.06)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C431(1.06)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C431(1.15)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C431(1.01)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C431(1.11)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C431(1.14)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C431(1.23)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C431(1.23)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C431(1.10)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C431(1.13)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C431(1.03)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C431(1.17)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C431(1.06)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C431(1.38)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C431(1.13)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C431(0.97)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C431(1.16)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C431(1.05)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C431(1.04)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C431(1.12)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C431(0.72)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C431(1.29)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C431(1.30)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C431(1.45)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C431(1.30)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C431(1.38)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C431(0.81)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C431(1.18)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C431(1.07)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C431(0.91)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C431(1.11)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C431(1.05)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C431(0.98)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C431(0.97)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C431(0.93)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C431(1.33)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C431(0.79)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C431(0.92)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C431(0.89)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C431(1.19)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C431(1.10)  LDD1346  [6]
 LDCM0469  CL76 HCT 116 C431(1.08)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C431(2.06)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C431(1.09)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C431(1.44)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C431(1.04)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C431(1.51)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C431(1.21)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C431(1.23)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C431(1.15)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C431(1.14)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C431(1.19)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C431(1.07)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C431(1.54)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C431(1.47)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C431(1.04)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C431(1.11)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C431(0.90)  LDD0802  [6]
 LDCM0486  CL91 PaTu 8988t C431(1.13)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C431(1.00)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C431(1.07)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C431(1.24)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C431(1.06)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C431(1.07)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C431(1.13)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C431(1.36)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C431(1.13)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C389(1.01); C395(0.81); C334(1.11); C195(0.90)  LDD1698  [7]
 LDCM0625  F8 Ramos C195(1.48); C389(1.66)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C195(0.77); C389(0.47)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C195(0.85); C389(3.34)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C389(0.33)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C195(0.96)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C195(1.12); C389(1.03)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C195(0.75)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C195(1.57); C389(0.56)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C389(0.72)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C195(1.08)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C195(0.48); C389(0.85)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C195(1.25)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C195(0.72); C389(0.66)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C389(0.54)  LDD2201  [8]
 LDCM0468  Fragment33 PaTu 8988t C431(1.14)  LDD1347  [6]
 LDCM0596  Fragment38 Ramos C195(0.88); C389(0.31)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C195(0.67)  LDD2184  [8]
 LDCM0427  Fragment51 PaTu 8988t C431(1.08)  LDD1306  [6]
 LDCM0610  Fragment52 Ramos C195(3.59)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C195(1.44)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C195(0.69); C389(0.74)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C195(2.22); C389(0.37)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C195(0.91); C389(0.99); C395(0.97); C431(0.96)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C334(176.03)  LDD0209  [3]
 LDCM0024  KB05 HMCB C389(2.12); C334(2.72)  LDD3312  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Nucleotidyltransferase MB21D2 (MB21D2) Mab-21 family Q8IYB1
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Ras-related protein Rab-11A (RAB11A) Rab family P62491
Ras-related protein Rab-3A (RAB3A) Rab family P20336
Ras-related protein Rab-3D (RAB3D) Rab family O95716
Ras-related protein Rab-8A (RAB8A) Rab family P61006
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) . O60568
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Bardet-Biedl syndrome 1 protein (BBS1) . Q8NFJ9
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Zinc finger protein 410 (ZNF410) . Q86VK4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Protein FAM124A (FAM124A) FAM124 family Q86V42
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Periplakin (PPL) Plakin or cytolinker family O60437
Guanine nucleotide exchange factor for Rab-3A (RAB3IL1) SEC2 family Q8TBN0
Protein SSX2 (SSX2; SSX2B) SSX family Q16385
Trafficking protein particle complex subunit 6A (TRAPPC6A) TRAPP small subunits family O75865
Trafficking protein particle complex subunit 10 (TRAPPC10) TRAPPC10 family P48553
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
RUN and FYVE domain-containing protein 1 (RUFY1) . Q96T51
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TBC1 domain family member 21 (TBC1D21) . Q8IYX1

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840