Details of the Target

General Information of Target

Target ID LDTP10480
Target Name Protein fem-1 homolog C (FEM1C)
Gene Name FEM1C
Gene ID 56929
Synonyms
KIAA1785; Protein fem-1 homolog C; FEM1c; FEM1-gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV
ISALLWCWWAETSS
Target Bioclass
Other
Family
Fem-1 family
Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Promotes ubiquitination and degradation of SLBP.
Uniprot ID
Q96JP0
Ensemble ID
ENST00000274457.5
HGNC ID
HGNC:16933

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K21(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C205(44.22)  LDD0209  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C496(1.09)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C496(1.28)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C496(1.03)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C496(1.02)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C496(1.24)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C496(1.25)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C496(1.25)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C496(1.04)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C496(1.34)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C496(1.20)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C496(1.09)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C496(1.07)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C496(1.04)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C496(1.04)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C496(0.86)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C496(0.78)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C496(0.97)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C496(1.35)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C496(0.89)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C496(0.54)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C496(0.60)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C496(0.61)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C496(0.64)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C496(0.81)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C496(0.57)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C496(0.83)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C496(0.66)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C496(0.54)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C496(0.76)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C496(0.68)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C496(0.95)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C496(0.98)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C496(1.14)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C496(0.81)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C496(0.70)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C496(1.00)  LDD0587  [3]
 LDCM0279  AC2 HCT 116 C496(1.16)  LDD0596  [3]
 LDCM0285  AC25 HCT 116 C496(0.92)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C496(1.00)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C496(1.48)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C496(1.09)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C496(1.34)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C496(1.29)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C496(1.43)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C496(0.96)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C496(1.32)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C496(1.05)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C496(0.92)  LDD0612  [3]
 LDCM0301  AC4 HCT 116 C496(1.09)  LDD0618  [3]
 LDCM0308  AC46 HCT 116 C496(1.31)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C496(0.96)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C496(1.07)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C496(1.20)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C496(1.18)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C496(1.12)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C496(1.19)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C496(1.07)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C496(1.02)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C496(1.09)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C496(1.31)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C496(0.90)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C496(1.14)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C496(1.07)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C496(1.27)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C496(1.15)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C496(1.24)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C496(1.13)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C496(1.34)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C496(1.35)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C496(1.50)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C496(1.30)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C496(1.31)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C496(1.31)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C496(0.83)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C496(1.22)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C496(1.70)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C496(1.18)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C496(0.93)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C496(1.36)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C496(1.31)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C496(0.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C496(1.51)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C496(1.06)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C496(1.10)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C496(1.15)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C496(1.12)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C496(1.37)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C496(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C496(1.13)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C496(1.10)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C496(1.32)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C496(1.09)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C496(1.13)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C496(1.34)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C496(1.69)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C496(1.40)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C496(1.28)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C496(1.27)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C496(0.90)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C496(1.34)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C496(1.28)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C496(1.26)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C496(1.15)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C496(1.18)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C496(1.46)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C496(1.09)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C496(1.25)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C496(1.13)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C496(1.21)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C496(0.77)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C496(1.45)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C496(1.19)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C496(1.38)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C496(1.43)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C496(1.25)  LDD0690  [3]
 LDCM0379  CL11 HCT 116 C496(0.96)  LDD0696  [3]
 LDCM0382  CL112 HCT 116 C496(1.34)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C496(1.48)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C496(2.30)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C496(1.48)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C496(1.23)  LDD0703  [3]
 LDCM0390  CL12 HCT 116 C496(0.96)  LDD0707  [3]
 LDCM0392  CL121 HCT 116 C496(1.18)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C496(1.06)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C496(1.50)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C496(1.26)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C496(1.24)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C496(1.22)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C496(1.22)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C496(1.20)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C496(0.79)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C496(0.68)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C496(1.00)  LDD0719  [3]
 LDCM0407  CL2 HCT 116 C496(0.92)  LDD0724  [3]
 LDCM0418  CL3 HCT 116 C496(1.38)  LDD0735  [3]
 LDCM0420  CL31 HCT 116 C496(1.53)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C496(1.39)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C496(1.41)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C496(1.25)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C496(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C496(1.24)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C496(1.43)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C496(1.24)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C496(1.86)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C496(1.86)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C496(1.20)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C496(1.51)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C496(1.30)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C496(1.50)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C496(1.43)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C496(1.59)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C496(1.85)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C496(1.29)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C496(1.23)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C496(0.92)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C496(1.43)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C496(1.94)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C496(1.62)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C496(1.09)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C496(1.74)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C496(1.23)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C496(1.22)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C496(1.82)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C496(1.83)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C496(1.20)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C496(1.13)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C496(1.33)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C496(1.09)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C496(1.15)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C496(1.48)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C496(1.29)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C496(1.06)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C496(1.63)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C496(1.08)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C496(1.36)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C496(1.62)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C496(0.99)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C496(0.94)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C496(1.23)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C496(1.02)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C496(1.54)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C496(1.18)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C496(0.85)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C496(1.53)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C496(0.98)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C496(1.24)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C496(0.93)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C496(1.07)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C496(1.08)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C496(0.86)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C496(1.21)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C496(1.24)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C496(0.95)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C496(0.85)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C496(1.21)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C496(0.90)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C496(0.91)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C496(1.30)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C496(1.55)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C496(1.09)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C496(1.11)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C496(1.21)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C496(1.31)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C496(1.28)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C496(1.17)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C496(1.52)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C496(1.50)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C496(1.28)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C496(1.14)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C496(1.99)  LDD0744  [3]
 LDCM0022  KB02 A101D C416(1.47); C496(2.50)  LDD2250  [4]
 LDCM0023  KB03 Jurkat C205(44.22)  LDD0209  [2]
 LDCM0024  KB05 WM266-4 C496(2.98)  LDD3328  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840