Details of the Target

General Information of Target

Target ID LDTP10468
Target Name Spatacsin (SPG11)
Gene Name SPG11
Gene ID 80208
Synonyms
KIAA1840; Spatacsin; Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLS
APGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAG
DAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGI
NAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDA
MRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTI
RRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQ
AQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQR
IMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAE
KQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGS
KESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWS
SAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLS
CFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALR
AAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPS
DGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVL
DGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSS
CLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPA
PSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRL
SLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Uniprot ID
Q96JI7
Ensemble ID
ENST00000261866.12
HGNC ID
HGNC:11226

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.A704T DBIA    Probe Info 
HCT116 Deletion: p.L950WfsTer13 DBIA    Probe Info 
HCT15 SNV: p.D837N .
HKGZCC Deletion: p.S1663AfsTer30 .
HT Deletion: p.L950WfsTer13 DBIA    Probe Info 
HT29 SNV: p.S331F .
IM95 SNV: p.P1185T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Insertion: p.L950FfsTer4 DBIA    Probe Info 
JURKAT SNV: p.P98S; p.I415T; p.W817Ter .
MDAMB453 SNV: p.H1902N; p.P1906S DBIA    Probe Info 
MELJUSO SNV: p.S1340G DBIA    Probe Info 
MEWO SNV: p.H1902Y DBIA    Probe Info 
MFE319 SNV: p.W659Ter .
MOLT4 SNV: p.G495D IA-alkyne    Probe Info 
OVISE SNV: p.S352C DBIA    Probe Info 
SNU478 SNV: p.D146V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1424(3.37)  LDD0080  [1]
IA-alkyne
 Probe Info  		C2291(0.00); C78(0.00)  LDD0162  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		C526(0.00); C1734(0.00)  LDD0148  [5]
AOyne
 Probe Info  		13.20  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C2291(0.86)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C2291(0.51)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C2291(0.52)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C2291(0.74)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C2291(0.61)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C2291(0.75)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C2291(0.61)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C2291(0.62)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C2291(0.58)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C2291(0.39)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C2291(0.95)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C2291(0.66)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C2291(0.49)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C2291(1.14)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C2291(1.04)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C2291(0.43)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C2291(1.02); C298(1.04)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C2291(1.08); C298(1.23)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C2291(1.02); C298(1.21)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C2291(1.06); C298(1.29)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C2291(1.19); C298(1.12)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C2291(1.25); C298(1.09)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C2291(1.18); C298(1.18)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C2291(0.55)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C2291(1.00); C298(1.00)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C2291(1.11); C298(1.01)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C2291(1.21); C298(1.08)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C2291(1.08); C298(1.12)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C2291(1.13); C298(1.10)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C2291(0.90); C298(1.10)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C2291(0.97); C298(1.18)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C2291(1.21); C298(1.16)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C1040(1.04); C1427(1.14); C2291(1.10); C2324(1.18)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C1040(1.11); C1427(1.20); C2291(0.93); C2324(1.05)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C1040(0.77); C1427(0.99); C2291(1.01); C2324(1.15)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C1040(0.85); C1427(1.07); C2291(1.11); C2324(0.95)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C1040(1.06); C1427(1.16); C2291(1.00); C2324(1.27)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C1040(0.82); C1427(1.05); C2291(1.04); C2324(1.34)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C1040(0.86); C1427(1.16); C2291(1.15); C2324(1.38)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C1040(0.75); C1427(1.10); C2291(1.08); C2324(1.54)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C1040(1.02); C1427(1.02); C2291(0.99); C2324(2.34)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C1040(1.18); C1427(1.26); C2291(1.15); C2324(1.51)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C1040(1.14); C1427(1.09); C2291(1.33); C2324(1.24)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C1040(0.91); C1427(1.24); C2291(1.17); C2324(1.07)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C2291(0.52)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C1040(0.82); C1427(1.02); C2291(1.12); C2324(1.07)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C1040(1.06); C1427(1.23); C2291(1.19); C2324(1.28)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C1040(0.99); C1427(1.17); C2291(1.09); C2324(1.26)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C298(1.34)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C298(1.01)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C298(1.19)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C298(0.88)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C298(1.49)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C298(1.82)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C298(1.02)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C2291(0.66)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C298(1.04)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C298(0.88)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C298(1.18)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C298(1.44)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C298(0.96)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C298(1.01)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C298(0.98)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C298(0.80)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C2291(0.84); C298(0.93)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C298(0.80); C2291(1.04)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C2291(0.98); C298(1.07)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C2291(0.87)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C2291(0.74); C298(0.86)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C2291(0.74); C298(0.88)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C298(0.99); C2291(1.00)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C2291(0.69); C298(0.81)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C298(0.87); C2291(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C2291(0.64); C298(1.17)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C2291(0.90); C298(0.93)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C2291(0.86); C298(1.23)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C2291(0.97); C298(1.07)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C2291(0.71); C298(1.03)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C2291(1.07)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C2291(0.91); C298(1.13)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C2291(0.96); C298(0.99)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C2291(0.77); C298(1.13)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C2291(0.92); C298(1.12)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C2291(0.87); C298(1.23)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C298(0.81); C2291(1.47)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C2291(0.77); C298(0.88)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C298(1.01); C2291(1.46)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C2291(0.93); C298(1.16)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C298(0.99); C2291(1.18)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C2291(1.05)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C298(1.12); C2291(1.54)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C298(1.04); C2291(1.11)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C2291(1.08); C298(1.26)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C298(1.14); C2291(1.40)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C298(1.15); C2291(1.45)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C298(1.16); C2291(1.63)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C298(1.00); C2291(1.58)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C298(0.95); C2291(1.43)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C298(1.12); C2291(1.48)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C2291(1.56); C298(1.91)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C2291(1.10)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C298(1.27); C2291(2.26)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C298(0.96); C2291(1.58)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C298(1.01); C2291(1.18)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C298(1.18); C2291(1.39)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C298(1.01); C2291(1.57)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C298(1.28); C2291(1.69)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C298(1.56); C2291(2.09)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C2291(1.18)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C2291(1.38)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C2291(1.49)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C2291(0.61)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C2291(1.09)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C2291(1.16)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C2291(1.38)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C2291(1.38)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C2291(1.34)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C2291(1.21)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C2291(1.49)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C2291(1.42)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C2291(1.10)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C2291(1.30)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C2291(0.62)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C2291(1.38)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C2291(1.40)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C2291(1.35)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C2291(2.04)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C2291(2.23)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C2291(1.84)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C2291(1.34)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C2291(1.14)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C2291(1.57)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C2291(1.44)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C2291(0.44)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C2291(1.46)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C2291(1.63)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C2291(3.09)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C2291(1.65)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C2291(1.25)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C2291(1.51)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C2291(1.60)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C2291(0.93)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C2291(0.85)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C2291(1.39)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C2291(0.81)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C2291(1.24)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C2291(1.28)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C2291(0.91)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C2291(0.68)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C2291(0.80)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C2291(1.15)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C2291(1.03)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C2291(1.06)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C2291(0.55)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C2291(0.46)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C2291(0.62)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C2291(0.66)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C2291(0.86); C931(1.03)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C2291(1.09); C931(1.26)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C2291(1.01)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C2291(0.48)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C2291(0.67)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C2291(0.48)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C2291(0.49)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C298(0.90); C2291(0.93)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C298(0.78); C2291(1.16)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C298(0.82); C2291(0.93)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C298(0.94); C2291(1.03)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C2291(0.93); C298(0.94)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C2291(1.09); C931(1.33)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C298(0.96); C2291(1.20)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C2291(0.92); C298(1.04)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C2291(0.80); C298(0.98)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C2291(0.93); C298(1.13)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C2291(0.81); C298(0.92)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C2291(0.86); C298(1.10)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C2291(0.92); C298(1.09)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C298(1.34); C2291(1.74)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C298(1.10); C2291(1.74)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C298(1.04); C2291(1.27)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C2291(0.89); C931(1.18)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C298(1.01); C2291(1.11)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C298(0.80); C2291(0.87)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C298(1.17); C2291(2.47)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C298(1.22); C2291(1.92)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C298(1.38); C2291(1.40)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C2291(1.03)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C2291(0.87)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C2291(0.99)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C2291(1.06)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C2291(0.81); C931(1.09)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C2291(0.84); C931(1.11)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C2291(0.88); C931(1.21)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C298(0.88); C2291(1.27)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C2291(0.97); C298(1.46)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C298(0.83); C2291(1.16)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C298(1.02); C2291(1.59)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C2291(0.85); C931(1.18)  LDD1005  [1]
 LDCM0408  CL20 HCT 116 C2291(0.98); C298(1.28)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C298(1.22); C2291(1.41)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C298(1.45); C2291(2.21)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C2291(0.95); C298(1.11)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C2291(1.06); C298(1.25)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C2291(0.91); C298(1.38)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C2291(1.32); C298(1.10)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C2291(1.63); C298(1.14)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C2291(0.67); C298(1.06)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C2291(1.03); C298(1.26)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C2291(0.85); C931(0.97)  LDD1016  [1]
 LDCM0419  CL30 HCT 116 C2291(0.72); C298(0.99)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C2291(0.93); C2324(0.79)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C2291(0.85); C2324(0.90)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C2291(0.81); C2324(0.74)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C2291(0.99); C2324(0.95)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C2291(0.79); C2324(0.95)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C2291(0.87); C2324(1.07)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C2291(0.85); C2324(1.07)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C2291(0.94); C2324(1.20)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C2291(0.93); C931(1.04)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C2291(0.74); C2324(1.11)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C2291(0.81); C2324(1.32)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C2291(0.84); C2324(1.33)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C2291(0.86); C2324(1.24)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C2291(0.81); C2324(1.01)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C2291(0.84); C2324(1.10)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C1040(0.80); C1427(0.92); C2291(0.95)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C1040(0.85); C1427(0.87); C2291(1.00)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C1040(0.75); C1427(0.99); C2291(1.03)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C1040(1.07); C1427(0.97); C2291(0.92)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C2291(0.83); C931(1.27)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C1040(1.04); C1427(0.96); C2291(1.06)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C1040(0.82); C1427(0.80); C2291(0.94)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C1040(1.27); C1427(1.06); C2291(1.15)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C1040(0.99); C1427(1.21); C2291(1.19)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C1040(0.84); C1427(0.85); C2291(0.94)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C1040(0.69); C1427(0.92); C2291(0.94)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C1040(0.79); C1427(0.89); C2291(1.04)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C1040(0.80); C1427(0.89); C2291(1.05)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C1040(1.18); C1427(0.84); C2291(0.99)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C1040(0.77); C1427(1.02); C2291(0.93)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C2291(0.90); C931(1.31)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C1040(1.00); C1427(1.15); C2291(1.00)  LDD1050  [1]
 LDCM0453  CL61 HCT 116 C2291(0.87)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C2291(0.98)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C2291(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C2291(0.87)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C2291(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C2291(1.39)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C2291(1.00)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C2291(0.94)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C2291(1.03)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C2291(0.83); C931(0.95)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C2291(0.82)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C2291(0.92)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C2291(0.79)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C2291(0.72)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C2291(0.88)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C2291(1.33)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C2291(1.02)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C2291(1.05)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C2291(1.28)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C2291(1.23); C931(1.15)  LDD1071  [1]
 LDCM0474  CL80 HCT 116 C2291(0.77)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C2291(1.34)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C2291(1.50)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C2291(1.22)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C2291(1.89)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C2291(0.91)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C2291(0.89)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C2291(1.24)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C2291(1.33)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C2291(1.74)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C2291(0.99); C931(1.37)  LDD1082  [1]
 LDCM0485  CL90 HCT 116 C2291(1.17)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C2291(1.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C2291(0.81)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C2291(0.91)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C2291(0.90)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C2291(0.96)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C2291(0.86)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C2291(1.09)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C2291(0.96)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C2291(0.99)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C298(1.13); C1424(0.86); C526(1.09); C2291(1.09)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C2291(0.76)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C2291(0.81); C2324(1.07)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C1424(3.37)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1424(2.17)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1424(3.32)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynamin-1 (DNM1) Dynamin/Fzo/YdjA family Q05193
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402