Details of the Target

General Information of Target

Target ID LDTP10105
Target Name RAD51-associated protein 1 (RAD51AP1)
Gene Name RAD51AP1
Gene ID 10635
Synonyms
PIR51; RAD51-associated protein 1; HsRAD51AP1; RAD51-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVT
PQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREA
KLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVS
D
Target Bioclass
Other
Subcellular location
Chromosome
Function
Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination. Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination. May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo.
Uniprot ID
Q96B01
Ensemble ID
ENST00000228843.13
HGNC ID
HGNC:16956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.85  LDD0403  [1]
BTD
 Probe Info  		C254(1.22)  LDD2101  [2]
DBIA
 Probe Info  		C254(0.92)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C254(0.00); C85(0.00); C145(0.00)  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C254(0.92)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C254(1.02)  LDD1508  [12]
 LDCM0216  AC100 HEK-293T C254(0.89)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C254(0.97)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C254(0.93)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C254(0.94)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C254(0.98)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C254(1.12)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C254(1.01)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C254(0.87)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C254(0.71)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C254(1.06)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C254(1.12)  LDD1509  [12]
 LDCM0227  AC110 HEK-293T C254(0.89)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C254(1.05)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C254(0.86)  LDD0827  [3]
 LDCM0237  AC12 HEK-293T C254(1.06)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C254(1.04); C85(1.03)  LDD1512  [12]
 LDCM0263  AC143 HCT 116 C254(1.41)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C254(1.03)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C254(1.00)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C254(1.01)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C254(1.20)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C254(0.89)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C254(0.94)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C254(1.14)  LDD1513  [12]
 LDCM0271  AC150 HCT 116 C254(0.92)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C254(0.91)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C254(0.86)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C254(0.87)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C254(1.05)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C254(1.07)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C254(1.18)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C254(1.03)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C254(1.24)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C254(0.90)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C254(1.98)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C254(1.11)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C254(1.07)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C254(1.15)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C254(1.03); C85(0.96)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C254(1.02)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C254(0.99)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C254(1.28)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C254(1.22)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C254(1.01)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C254(1.52)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C254(1.20)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C254(0.88)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C254(1.16)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C254(0.96)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C254(1.07)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C254(1.16)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C254(1.21)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C254(0.73)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C254(0.79)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C254(0.69)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C254(0.98)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C254(0.82)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C254(0.91)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C254(0.83)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C254(1.36)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C254(1.01)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C254(1.06)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C254(0.72)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C254(0.89)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C254(1.04); C85(1.03)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C254(1.03)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C254(1.00)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C254(1.14)  LDD1550  [12]
 LDCM0312  AC5 HCT 116 C254(0.81)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C254(1.00)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C254(1.02)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C254(1.08)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C254(1.12)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C254(1.19); C85(1.05)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C254(1.08)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C254(1.07)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C254(1.04)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C254(0.90)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C254(1.07)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C254(1.08); C85(0.98)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C254(1.05)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C254(1.13)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C254(1.07); C85(1.01)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C254(1.08)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C254(0.98)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C254(1.01)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C254(1.04)  LDD1569  [12]
 LDCM0365  AC98 HEK-293T C254(0.86)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C254(0.67)  LDD0964  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C254(0.88)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C254(1.14)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C254(1.11)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C254(0.99)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 13.85  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C254(1.98)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C254(1.09)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C254(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C254(0.84)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C145(0.96); C254(1.09)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C254(1.06)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C254(1.14)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C254(0.99)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C145(0.95); C254(1.03)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C254(1.09)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C254(1.11)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C254(1.10)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C145(1.08); C254(1.03)  LDD1582  [12]
 LDCM0379  CL11 HCT 116 C254(0.94)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C254(1.06)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C254(1.17)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C254(0.89)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C254(1.17)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C254(1.23)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C254(0.99)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C254(1.11)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C254(0.96)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C254(0.96)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C254(1.24)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C254(1.10)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C254(0.98)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C145(0.96); C254(1.15)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C254(1.07)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C254(1.06)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C254(1.16)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C145(0.74); C254(1.00)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C254(0.91)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C254(0.97)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C254(1.09)  LDD1603  [12]
 LDCM0400  CL13 HCT 116 C254(1.02)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C254(1.18)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C254(0.97)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C254(1.17)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C254(1.13)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C254(0.98)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C254(1.07)  LDD1610  [12]
 LDCM0407  CL2 HCT 116 C254(1.12)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C254(1.06)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C254(1.26)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C254(1.07); C85(1.05)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C254(1.10)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C254(0.94)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C145(0.90); C254(0.96)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C254(1.03)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C254(1.10)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C254(0.98)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C254(1.01)  LDD1621  [12]
 LDCM0418  CL3 HCT 116 C254(1.26)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C254(1.05)  LDD1623  [12]
 LDCM0420  CL31 HCT 116 C254(0.73)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C254(0.76)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C254(0.99)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C254(1.08)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C254(1.17)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C254(1.34)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C254(1.32)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C254(1.13)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C254(1.02)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C254(1.11)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C254(1.21)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C254(1.13)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C254(1.16)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C254(1.05)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C254(0.84)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C254(0.99); C85(1.12)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C254(0.97)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C254(1.13)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C145(0.79); C254(0.98)  LDD1643  [12]
 LDCM0440  CL5 HCT 116 C254(1.10)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C254(0.97)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C254(1.06)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C254(1.15)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C254(0.89)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C254(1.01)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C254(0.99)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C254(1.33)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C254(1.18); C85(1.05)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C254(1.10)  LDD1653  [12]
 LDCM0451  CL6 HCT 116 C254(1.25)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C254(1.04)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C254(1.05)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C254(1.01)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C254(0.88)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C254(0.97)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C254(1.01)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C254(0.86)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C254(1.22)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C254(1.10)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C254(1.14)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C254(1.06)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C254(1.05)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C254(0.98)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C254(1.16)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C254(1.09)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C254(1.08)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C254(0.98)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C254(1.03)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C254(0.98)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C254(0.98)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C254(1.29)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C254(1.02)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C254(1.17)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C254(1.11); C85(1.04)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C254(1.06)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C254(1.10)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C145(0.71); C254(1.09)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C254(1.01)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C254(0.98)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C254(0.95)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C254(0.98)  LDD1686  [12]
 LDCM0484  CL9 HCT 116 C254(1.10)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C254(0.96)  LDD1688  [12]
 LDCM0486  CL91 HCT 116 C254(0.71)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C254(0.72)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C254(0.71)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C254(0.83)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C254(0.91)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C254(0.93)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C254(0.88)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C254(0.91)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C254(0.77)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C254(1.01)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C254(0.97)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C254(2.32)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C254(0.90)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C254(1.12)  LDD1497  [12]
 LDCM0024  KB05 HEK-293T C254(0.92)  LDD1502  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C254(0.54)  LDD2121  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C254(1.22)  LDD2101  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C254(1.37)  LDD2105  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C254(0.64)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C254(1.03)  LDD2120  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C254(1.03)  LDD2128  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C254(0.82)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C254(0.90)  LDD2134  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609
Partner and localizer of BRCA2 (PALB2) . Q86YC2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402