Details of the Target

General Information of Target

Target ID LDTP09597
Target Name E3 ubiquitin-protein ligase TRIM41 (TRIM41)
Gene Name TRIM41
Gene ID 90933
Synonyms
RINCK; E3 ubiquitin-protein ligase TRIM41; EC 2.3.2.27; RING finger-interacting protein with C kinase; RINCK; Tripartite motif-containing protein 41
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELD
REEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNM
DYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRC
FTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEV
DEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVT
ELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQL
SRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRK
MSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQG
FRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLP
QQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAH
VHTFSAAFLGERVFPFFRVLSKGTRIKLCP
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm
Function
E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.
Uniprot ID
Q8WV44
Ensemble ID
ENST00000315073.10
HGNC ID
HGNC:19013

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.E384D .
EFO21 SNV: p.R485L .
HCT116 Deletion: p.G517VfsTer54 DBIA    Probe Info 
HEC1 SNV: p.R482H .
JURKAT SNV: p.S401F .
MDAMB231 Deletion: p.E596DfsTer58 .
RKO SNV: p.M86T .
SNGM SNV: p.A358V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C180(1.40)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C180(1.13)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C180(1.15)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C180(1.11); C426(1.15)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C180(1.23); C426(0.86)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C180(1.14); C426(1.05)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C180(1.62); C426(0.93)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C180(1.12); C426(1.11)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C180(1.51); C426(0.75)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C180(1.73); C426(0.98)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C180(1.67); C426(0.95)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C180(1.49); C426(1.01)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C180(1.01); C426(0.94)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C180(1.30)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C180(1.24); C426(1.17)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C180(1.18); C426(1.02)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C180(1.27); C426(1.17)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C180(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C180(1.41)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C180(1.28)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C180(1.51)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C180(1.33)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C180(1.47)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C180(1.39)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C180(0.81)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C180(1.35)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C180(1.09)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C180(1.56)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C180(1.76)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C180(1.31)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C180(1.23)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C180(1.37)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C180(1.55)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C389(1.12); C405(1.27); C426(0.99)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C389(1.23); C405(1.24); C426(1.86)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C389(1.33); C405(1.55); C426(1.83)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C389(1.02); C405(0.91); C426(1.56)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C389(1.17); C405(1.32); C426(1.25)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C389(1.04); C405(0.82); C426(1.55)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C389(1.31); C405(1.42); C426(1.92)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C389(1.07); C405(0.91); C426(1.86)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C389(1.08); C405(1.11); C426(1.31)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C389(1.34); C405(1.21); C426(1.95)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C389(1.41); C405(1.22); C426(1.98)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C389(1.48); C405(1.35); C426(1.95)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C180(1.01)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C389(1.21); C405(1.19); C426(1.46)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C389(1.36); C405(1.18); C426(2.01)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C389(1.45); C405(1.56); C426(2.15)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C180(1.21)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C180(1.40)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C180(1.38)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C180(1.34)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C180(1.64)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C180(1.74)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C180(1.50)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C180(1.05)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C180(1.34)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C180(1.17)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C180(1.33)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C180(2.49)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C180(1.48)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C180(1.53)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C180(1.12)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C180(1.16)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C180(0.34); C426(1.42)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C180(0.58); C426(1.01)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C180(0.55); C426(1.13)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C180(1.41)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C180(0.50); C426(1.01)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C180(0.42); C426(0.87)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C180(0.59); C426(0.90)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C180(0.53); C426(0.86)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C180(0.59); C426(0.93)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C426(1.47)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C426(1.56)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C426(1.51)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C426(2.16)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C426(1.56)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C180(1.26)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C426(1.69)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C426(1.42)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C426(1.61)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C426(1.84)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C426(1.93)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C426(0.83)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C426(0.94)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C426(0.92)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C426(1.03)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C426(0.92)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C180(1.18)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C426(1.06)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C426(0.77)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C426(0.87)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C426(0.85)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C426(0.76)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C426(0.94)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C180(0.91); C389(0.85); C426(0.83)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C180(0.86); C389(0.86); C426(0.79)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C180(1.13); C389(1.08); C426(0.72)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C180(1.29); C389(1.05); C426(1.19)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C180(1.08)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C180(1.14); C389(1.18); C426(1.04)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C180(1.51); C389(0.99); C426(1.12)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C180(1.42); C389(0.89); C426(1.46)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C180(1.09); C389(0.97); C426(1.09)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C180(1.10); C389(0.89); C426(1.00)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C180(1.01); C389(0.83); C426(0.94)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C180(1.02); C389(0.97); C426(1.24)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C389(0.76); C405(0.76); C426(1.03)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C389(1.07); C405(1.07); C426(0.87)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C389(1.02); C405(1.02); C426(1.10)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C180(0.89)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C389(0.74); C405(0.74); C426(1.00)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C389(0.88); C405(0.88); C426(1.00)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C389(1.12); C405(1.12); C426(0.77)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C389(1.09); C405(1.09); C426(0.99)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C389(0.99); C405(0.99); C426(0.86)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C389(0.99); C405(0.99); C426(1.06)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C389(0.98); C405(0.98); C426(0.87)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C389(1.23); C405(1.23); C426(1.09)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C180(1.62)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C180(1.94)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C180(1.16)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C180(2.09)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C180(1.68)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C180(1.73)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C180(2.47)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C180(2.27)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C180(4.18)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C180(2.20)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C180(2.02)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C180(1.65)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C180(1.90)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C180(1.38)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C180(2.77)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C180(1.15)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C180(3.46)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C180(2.29)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C180(2.01)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C180(1.41)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C180(1.76)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C180(1.51)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C180(1.40)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C180(2.18)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C180(1.08)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C180(2.52)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C180(2.06)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C180(1.23)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C180(1.15)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C180(1.70)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C180(2.40)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C180(2.03)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C426(1.32); C180(2.64)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C180(0.99); C426(1.01)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C180(1.19)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C180(1.25)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C180(1.47)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C180(1.40)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C426(0.76); C180(1.06)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C426(0.54); C180(1.59)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C180(1.25)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C180(0.65)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C180(0.79)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C180(0.77)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C180(0.93)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C180(0.52); C426(1.14)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C180(0.51); C426(1.09)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C180(0.94); C426(1.06)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C180(0.65); C426(1.08)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C180(0.67); C426(0.98)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C426(0.53); C180(1.30)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C180(0.61); C426(0.97)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C180(0.73); C426(0.95)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C426(1.61)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C426(1.83)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C426(2.00)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C426(1.71)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C426(1.91)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C426(1.22)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C426(0.88)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C426(0.92)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C426(0.53); C180(1.59)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C426(0.92)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C180(1.72); C389(0.92); C426(1.08)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C180(1.16); C389(0.96); C426(0.97)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C180(0.95); C389(0.74); C426(0.71)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C180(1.26); C389(0.97); C426(0.89)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C389(0.90); C405(0.90); C426(1.03)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C389(0.67); C405(0.67); C426(0.88)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C389(0.92); C405(0.92); C426(0.77)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C389(0.73); C405(0.73); C426(0.91)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C426(0.66); C180(1.23)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C426(0.64); C180(1.32)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C426(0.59); C180(1.08)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C180(1.33)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C180(0.85)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C180(1.28)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C180(1.16)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C426(0.62); C180(1.11)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C180(1.39)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C180(1.04)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C180(1.16)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C180(1.21)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C180(1.50)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C180(1.41)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C180(1.57)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C180(1.51)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C180(1.56)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C180(1.47)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C180(1.16); C426(0.54)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C180(1.50)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C426(2.01)  LDD1018  [1]
 LDCM0421  CL32 HCT 116 C180(2.00)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C180(1.51)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C180(3.21)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C180(2.09)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C180(1.32)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C180(1.87)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C180(0.94)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C180(0.88); C426(0.63)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C180(0.85)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C180(1.58)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C180(0.80)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C180(1.20)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C180(1.72)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C180(1.17)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C180(0.78)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C180(0.75)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C180(1.22)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C180(1.03)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C180(1.07); C426(0.79)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C180(0.96)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C180(0.97)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C180(1.23)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C180(1.07)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C180(1.57)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C180(0.89)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C180(0.96)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C180(0.32)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C180(0.92)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C180(1.42)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C180(1.14); C426(0.83)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C180(1.08)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C180(0.73); C426(1.18)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C180(0.73); C426(1.39)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C180(1.14); C426(1.11)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C180(0.71); C426(1.28)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C180(0.95); C426(1.34)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C180(0.61); C426(1.80)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C180(0.66); C426(1.81)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C180(0.68); C426(1.65)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C180(0.77); C426(1.49)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C180(1.23); C426(0.87)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C180(0.94); C426(1.42)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C180(0.61); C426(1.48)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C180(0.70); C426(1.42)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C180(0.70); C426(1.85)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C180(0.93); C426(1.27)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C180(1.12); C426(1.40)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C180(1.05); C426(1.02)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C180(1.94); C426(2.50)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C180(1.57); C426(1.69)  LDD1070  [1]
 LDCM0473  CL8 HCT 116 C180(1.44); C426(0.70)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C180(1.21); C426(1.37)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C180(1.15); C426(1.21)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C180(0.82); C426(0.72)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C180(0.86); C426(0.99)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C180(1.54); C426(2.10)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C180(1.57); C426(1.92)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C180(1.73); C426(1.90)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C180(1.45); C426(1.45)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C180(1.30); C426(1.36)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C180(1.32); C426(1.72)  LDD1081  [1]
 LDCM0484  CL9 HCT 116 C180(1.23); C426(0.61)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C180(1.13); C426(0.98)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C180(0.94)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C180(0.99)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C180(1.13)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C180(1.18)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C180(1.12)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C180(1.11)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C180(1.24)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C180(1.44)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C180(0.92)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C551(1.24); C180(1.11)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C180(0.81); C426(2.03)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C180(1.15)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C180(1.86)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C180(1.47)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C180(1.67)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C180(1.12); C183(1.12); C186(1.12)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Casein kinase II subunit alpha' (CSNK2A2) Ser/Thr protein kinase family P19784
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) Protein-tyrosine phosphatase family P26045
Pseudouridylate synthase PUS7L (PUS7L) Pseudouridine synthase TruD family Q9H0K6
Chromodomain-helicase-DNA-binding protein 2 (CHD2) SNF2/RAD54 helicase family O14647
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
E3 ubiquitin-protein ligase TRIM17 (TRIM17) TRIM/RBCC family Q9Y577
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 60 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and BTB domain-containing protein 39 (ZBTB39) Krueppel C2H2-type zinc-finger protein family O15060
Zinc finger and SCAN domain-containing protein 16 (ZSCAN16) Krueppel C2H2-type zinc-finger protein family Q9H4T2
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger protein 1 homolog (ZFP1) Krueppel C2H2-type zinc-finger protein family Q6P2D0
Zinc finger protein 121 (ZNF121) Krueppel C2H2-type zinc-finger protein family P58317
Zinc finger protein 134 (ZNF134) Krueppel C2H2-type zinc-finger protein family P52741
Zinc finger protein 138 (ZNF138) Krueppel C2H2-type zinc-finger protein family P52744
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 2 (ZNF2) Krueppel C2H2-type zinc-finger protein family Q9BSG1
Zinc finger protein 219 (ZNF219) Krueppel C2H2-type zinc-finger protein family Q9P2Y4
Zinc finger protein 251 (ZNF251) Krueppel C2H2-type zinc-finger protein family Q9BRH9
Zinc finger protein 26 (ZNF26) Krueppel C2H2-type zinc-finger protein family P17031
Zinc finger protein 263 (ZNF263) Krueppel C2H2-type zinc-finger protein family O14978
Zinc finger protein 264 (ZNF264) Krueppel C2H2-type zinc-finger protein family O43296
Zinc finger protein 266 (ZNF266) Krueppel C2H2-type zinc-finger protein family Q14584
Zinc finger protein 275 (ZNF275) Krueppel C2H2-type zinc-finger protein family Q9NSD4
Zinc finger protein 286A (ZNF286A) Krueppel C2H2-type zinc-finger protein family Q9HBT8
Zinc finger protein 319 (ZNF319) Krueppel C2H2-type zinc-finger protein family Q9P2F9
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 439 (ZNF439) Krueppel C2H2-type zinc-finger protein family Q8NDP4
Zinc finger protein 460 (ZNF460) Krueppel C2H2-type zinc-finger protein family Q14592
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Zinc finger protein 490 (ZNF490) Krueppel C2H2-type zinc-finger protein family Q9ULM2
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 629 (ZNF629) Krueppel C2H2-type zinc-finger protein family Q9UEG4
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 653 (ZNF653) Krueppel C2H2-type zinc-finger protein family Q96CK0
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein 691 (ZNF691) Krueppel C2H2-type zinc-finger protein family Q5VV52
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 773 (ZNF773) Krueppel C2H2-type zinc-finger protein family Q6PK81
Zinc finger protein 780A (ZNF780A) Krueppel C2H2-type zinc-finger protein family O75290
Zinc finger protein 784 (ZNF784) Krueppel C2H2-type zinc-finger protein family Q8NCA9
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Zinc finger protein ZFP2 (ZFP2) Krueppel C2H2-type zinc-finger protein family Q6ZN57
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox protein MOX-2 (MEOX2) . P50222
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger and SCAN domain-containing protein 26 (ZSCAN26) . Q16670
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic immunoglobulin-like variable motif-containing protein (BIVM) BIVM family Q86UB2
Bystin (BYSL) Bystin family Q13895
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein FAM124A (FAM124A) FAM124 family Q86V42
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Syntaxin-11 (STX11) Syntaxin family O75558
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
UPF0488 protein C8orf33 (C8orf33) UPF0488 family Q9H7E9
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Cytoplasmic protein NCK2 (NCK2) . O43639
EZH inhibitory protein (EZHIP) . Q86X51
G patch domain-containing protein 2-like (GPATCH2L) . Q9NWQ4
KATNB1-like protein 1 (KATNBL1) . Q9H079
Melanoma-associated antigen H1 (MAGEH1) . Q9H213
Microspherule protein 1 (MCRS1) . Q96EZ8
Mortality factor 4-like protein 1 (MORF4L1) . Q9UBU8
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
PHD finger protein 11 (PHF11) . Q9UIL8
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Vinexin (SORBS3) . O60504
Zinc finger CCHC domain-containing protein 7 (ZCCHC7) . Q8N3Z6
Zinc finger matrin-type protein 5 (ZMAT5) . Q9UDW3

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402