Details of the Target

General Information of Target

Target ID LDTP09323
Target Name Ras and Rab interactor 3 (RIN3)
Gene Name RIN3
Gene ID 79890
Synonyms
Ras and Rab interactor 3; Ras interaction/interference protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTC
PVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEE
KSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFW
DSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFI
EDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVL
PALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMK
PGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSD
GPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLEN
AELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGV
SVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRK
LYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTE
LKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVIL
ATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGK
PYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSY
DKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADT
QAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVY
RPLDGGGGGGGGSPPCLVVREPNFL
Target Bioclass
Other
Family
RIN (Ras interaction/interference) family
Subcellular location
Cytoplasm
Function Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
Uniprot ID
Q8TB24
Ensemble ID
ENST00000216487.12
HGNC ID
HGNC:18751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.N218D; p.Y550C .
ICC10 Substitution: p.A308P .
JURKAT SNV: p.P361S .
KMRC20 SNV: p.V371A .
MCC13 SNV: p.P264L; p.P367S .
MCC26 SNV: p.R645C .
MEWO SNV: p.P402S .
MFE319 SNV: p.A268V; p.H957Q .
NCIH446 SNV: p.Y793N .
RKO Deletion: p.G203DfsTer4
SNV: p.C942G		 DBIA    Probe Info 
RL952 Deletion: p.L206Ter .
SW1271 SNV: p.G496C .
SW403 Insertion: p.P285_V286insPLPP DBIA    Probe Info 
TE4 SNV: p.S245R .
TE8 SNV: p.A817D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C43(1.10)  LDD2125  [1]
AHL-Pu-1
 Probe Info  		C484(2.90)  LDD0170  [2]
IA-alkyne
 Probe Info  		C931, C942, C943(17.04)  LDD1705  [3]
IPM
 Probe Info  		C43(2.98)  LDD1701  [1]
DBIA
 Probe Info  		C906(0.83); C909(0.83)  LDD0531  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C484(2.90)  LDD0170  [2]
 LDCM0214  AC1 HCT 116 C906(0.83); C909(0.83)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C931(0.96); C942(0.96)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C931(0.80); C942(0.80)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C931(1.04); C942(1.04)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C931(0.80); C942(0.80)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C931(0.91); C942(0.91)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C931(0.84); C942(0.84)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C931(0.92); C942(0.92)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C931(0.90); C942(0.90)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C931(0.86); C942(0.86)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C931(0.77); C942(0.77)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C931(1.02); C942(1.02)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C931(1.31); C942(1.31)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C931(0.98); C942(0.98)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C931(1.03); C942(1.03)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C931(0.90); C942(0.90)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C931(1.29); C942(1.29)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C931(1.05); C942(1.05)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C931(0.90); C942(0.90)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C906(1.07); C909(1.07)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C906(0.64); C909(0.64)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C906(0.87); C909(0.87)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C906(1.05); C909(1.05)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C906(1.49); C909(1.49)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C906(0.98); C909(0.98)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C906(1.66); C909(1.66)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C906(1.18); C909(1.18)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C906(1.10); C909(1.10)  LDD0601  [4]
 LDCM0286  AC26 HEK-293T C484(0.86)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C698(0.99)  LDD1526  [5]
 LDCM0290  AC3 HCT 116 C906(1.21); C909(1.21)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C698(0.97)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C698(1.13)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C698(1.57)  LDD1532  [5]
 LDCM0295  AC34 HEK-293T C484(0.88)  LDD1534  [5]
 LDCM0296  AC35 HCT 116 C931(0.82); C942(0.82); C906(1.02); C909(1.02)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C931(0.95); C942(0.95); C906(1.17); C909(1.17)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C931(0.76); C942(0.76); C906(1.00); C909(1.00)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C931(0.92); C942(0.92); C906(1.27); C909(1.27)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C931(0.79); C942(0.79); C906(1.13); C909(1.13)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C906(0.91); C909(0.91)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C906(1.31); C909(1.31); C931(1.39); C942(1.39)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C906(0.97); C909(0.97); C931(1.32); C942(1.32)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C906(1.09); C909(1.09); C931(1.16); C942(1.16)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C906(0.80); C909(0.80); C931(1.23); C942(1.23)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C906(0.97); C909(0.97); C931(1.43); C942(1.43)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C906(0.88); C909(0.88); C931(1.45); C942(1.45)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C931(1.11); C942(1.11)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C931(1.00); C942(1.00)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C931(1.16); C942(1.16)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C931(1.38); C942(1.38)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C906(0.95); C909(0.95)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C931(1.22); C942(1.22)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C931(1.24); C942(1.24)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C931(0.96); C942(0.96)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C931(1.18); C942(1.18)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C931(1.29); C942(1.29)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C931(1.29); C942(1.29)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C931(0.84); C942(0.84)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C931(1.17); C942(1.17)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C931(1.24); C942(1.24)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C931(1.10); C942(1.10)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C931(1.21); C942(1.21)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C931(1.29); C942(1.29)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C931(1.30); C942(1.30)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C931(1.42); C942(1.42)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C931(1.19); C942(1.19)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C931(1.44); C942(1.44)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C931(1.19); C942(1.19)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C931(1.09); C942(1.09)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C931(1.26); C942(1.26)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C931(1.65); C942(1.65)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C931(1.03); C942(1.03)  LDD0662  [4]
 LDCM0365  AC98 HCT 116 C931(1.13); C942(1.13)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C931(0.87); C942(0.87)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C931(1.01); C942(1.01)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C931(1.38); C942(1.38)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C931(1.60); C942(1.60)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C881(0.92); C906(1.49); C909(1.49); C931(1.64)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C881(0.89); C906(0.93); C909(0.93); C931(1.68)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C906(0.90); C909(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C931(1.18); C942(1.18)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C931(1.87); C942(1.87)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C931(1.69); C942(1.69)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C931(1.22); C942(1.22)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C906(0.72); C909(0.72)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C906(0.78); C909(0.78)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C906(0.61); C909(0.61)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C906(0.64); C909(0.64)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C906(0.94); C909(0.94)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C906(0.89); C909(0.89); C881(0.92); C931(1.40)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C906(0.72); C909(0.72)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C906(0.88); C909(0.88)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C698(1.00)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C484(1.03)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C698(1.10)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C698(1.14)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C698(1.14)  LDD1590  [5]
 LDCM0387  CL117 HCT 116 C906(1.17); C909(1.17); C931(1.36); C942(1.36)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C906(0.92); C909(0.92); C931(0.98); C942(0.98)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C931(0.95); C942(0.95); C906(1.07); C909(1.07)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C906(0.87); C909(0.87); C881(1.03); C931(1.75)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C931(1.08); C942(1.08); C906(1.14); C909(1.14)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C931(0.44); C942(0.44)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C931(1.30); C942(1.30)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C931(1.00); C942(1.00)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C931(1.45); C942(1.45)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C931(1.14); C942(1.14)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C931(0.91); C942(0.91)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C931(1.04); C942(1.04)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C931(1.13); C942(1.13)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C906(0.88); C909(0.88); C881(1.05); C931(1.33)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C906(1.08); C909(1.08); C881(1.19); C931(1.62)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C881(0.97); C906(1.18); C909(1.18); C931(1.73)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C698(1.01)  LDD1607  [5]
 LDCM0404  CL17 HCT 116 C931(1.25); C942(1.25)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C931(0.91); C942(0.91)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C931(1.06); C942(1.06)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C881(0.96); C931(1.15); C942(1.15); C906(1.33)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C931(1.17); C942(1.17)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C931(1.34); C942(1.34)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C931(1.62); C942(1.62)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C931(1.01); C942(1.01)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C931(1.04); C942(1.04)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C931(1.06); C942(1.06)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C931(1.06); C942(1.06)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C931(1.21); C942(1.21)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C931(1.51); C942(1.51)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C931(1.16); C942(1.16)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C881(1.11); C906(0.95); C909(0.95); C931(1.14)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C931(0.98); C942(0.98)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C881(1.03); C931(1.05); C942(1.05)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C881(0.83)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C881(0.98)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C881(1.00)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C881(1.05)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C881(1.07)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C881(1.11)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C881(1.04)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C881(0.90); C906(1.01); C909(1.01); C931(1.12)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C881(0.92)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C881(1.21)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C881(1.15)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C881(0.98)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C881(0.95)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C881(0.85)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C881(0.95)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C881(0.89)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C881(0.88)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C881(0.88)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C881(1.10); C906(0.96); C909(0.96); C931(1.06)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C881(0.88)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C881(0.98)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C881(1.00)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C881(1.25)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C881(0.95)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C881(0.88)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C881(0.95)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C881(0.95)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C881(0.94)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C881(0.91)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C881(1.22); C906(0.95); C909(0.95); C931(1.38)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C881(0.89)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C484(1.19)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C698(1.17)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C698(1.10)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C698(1.01)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C484(0.98)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C698(0.90)  LDD1662  [5]
 LDCM0462  CL7 HCT 116 C881(1.27); C906(0.86); C909(0.86); C931(1.23)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C698(1.02)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C698(0.75)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C698(1.11)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C484(0.79)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C698(1.04)  LDD1670  [5]
 LDCM0469  CL76 HCT 116 C881(0.97); C906(0.91)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C881(1.14); C906(1.04)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C881(1.14); C906(0.80)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C881(0.96); C906(1.14)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C881(1.04); C906(0.73); C909(0.73); C931(1.71)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C881(1.00); C906(1.14)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C881(1.13); C906(1.30)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C881(1.03); C906(1.26)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C881(1.06); C906(0.94)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C881(0.98); C906(1.09)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C881(0.99); C906(0.72)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C881(1.04); C906(0.79)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C881(1.13); C906(1.60)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C881(1.09); C906(0.46)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C881(1.06); C906(0.57)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C881(1.03); C906(0.89); C909(0.89); C931(1.22)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C881(1.11); C906(1.60)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C906(1.11); C909(1.11)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C906(1.21); C909(1.21)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C906(0.83); C909(0.83)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C906(0.80); C909(0.80)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C906(0.78); C909(0.78)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C906(1.15); C909(1.15)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C906(0.97); C909(0.97)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C906(0.90); C909(0.90)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C906(0.88); C909(0.88)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C698(1.09)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C346(1.12)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C698(0.90)  LDD1671  [5]
 LDCM0427  Fragment51 HCT 116 C881(1.10)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C698(1.05)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C698(1.08)  LDD1497  [5]
 LDCM0024  KB05 MV4-11 C698(3.43)  LDD3338  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C43(1.10)  LDD2125  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD2-associated protein (CD2AP) . Q9Y5K6
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Myc box-dependent-interacting protein 1 (BIN1) . O00499
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840