Details of the Target

General Information of Target

Target ID LDTP09205
Target Name RalBP1-associated Eps domain-containing protein 2 (REPS2)
Gene Name REPS2
Gene ID 9185
Synonyms
POB1; RalBP1-associated Eps domain-containing protein 2; Partner of RalBP1; RalBP1-interacting protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEA
ARVAPGTATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQ
SGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDED
KQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSS
SGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSF
ISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGL
PPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDV
TSDDKQALKSTINEALPKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTP
PPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLS
RAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPT
VQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway. By controlling growth factor receptors endocytosis may regulate cell survival. Through ASAP1 may regulate cell adhesion and migration.
Uniprot ID
Q8NFH8
Ensemble ID
ENST00000303843.7
HGNC ID
HGNC:9963

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.R80Q .
G415 SNV: p.Ter661CextTer10 .
IM95 SNV: p.G353S .
MEWO SNV: p.R655C .
PF382 SNV: p.A624T .
RBE SNV: p.D398Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K638(7.14)  LDD0277  [1]
Probe 1
 Probe Info  		Y271(7.48)  LDD3495  [2]
DBIA
 Probe Info  		C380(1.34)  LDD0531  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
CY4
 Probe Info  		N.A.  LDD0247  [5]
NAIA_5
 Probe Info  		C45(0.00); C96(0.00)  LDD2225  [6]
TFBX
 Probe Info  		C45(0.00); C132(0.00)  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C380(1.34)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C380(0.91)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C380(1.38)  LDD0543  [3]
 LDCM0230  AC113 PaTu 8988t C380(1.27)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C380(1.37)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C380(1.00)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C380(1.43)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C380(1.19)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C380(1.22)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C380(1.09)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C380(0.83)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C380(1.19)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C380(1.73)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C380(1.02)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C380(0.99)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C380(1.33)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C380(1.14)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C380(1.22)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C380(1.84)  LDD1124  [3]
 LDCM0246  AC128 HCT 116 C380(0.98)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C380(1.05)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C380(1.01)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C380(1.04)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C380(1.09)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C380(1.11)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C380(1.41)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C380(1.10)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C380(1.18)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C380(1.20)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C380(1.47)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C380(1.31)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C380(0.90)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C380(1.50)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C380(1.52)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C380(1.32)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C380(1.17)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C380(1.09)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C380(1.06)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C380(1.08)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C380(1.04)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C380(1.12)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C380(1.14)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C380(1.22)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C380(1.12)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C380(0.96)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C380(1.03)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C380(1.08)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C380(1.08)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C380(1.14)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C380(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C380(1.04)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C380(0.99)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C380(1.48)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C380(1.00)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C380(1.34)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C380(1.02)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C380(1.06)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C380(0.98)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C380(0.97)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C380(0.97)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C380(0.88)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C380(1.06)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C380(1.08)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C380(1.22)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C380(1.25)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C380(1.25)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C380(1.41)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C380(1.06)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C380(1.42)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C380(1.21)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C380(0.99)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C380(1.13)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C380(1.29)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C380(1.16)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C380(0.91)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C380(0.86)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C380(1.54)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C380(0.66)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C380(0.77)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C380(0.67)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C380(0.83)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C380(0.61)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C380(0.65)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C380(1.19)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C380(0.90)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C380(1.01)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C380(1.03)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C380(1.78)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C380(0.93)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C380(1.02)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C380(0.94)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C380(1.19)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C380(0.78)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C380(1.24)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C380(1.19)  LDD0636  [3]
 LDCM0320  AC57 PaTu 8988t C380(1.26)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C380(1.57)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C380(1.27)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C380(0.95)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C380(1.74)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C380(1.23)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C380(1.46)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C380(1.54)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C380(1.26)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C380(1.36)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C380(1.62)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C380(1.10)  LDD1210  [3]
 LDCM0334  AC7 HCT 116 C380(0.82)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C380(0.82)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C380(1.43)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C380(1.23)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C380(1.17)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C380(1.10)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C380(1.06)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C380(1.17)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C380(1.20)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C380(1.29)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C380(1.41)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C380(1.15)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C380(1.44)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C380(0.92)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C380(1.09)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C380(1.08)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C380(1.19)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C380(0.98)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C380(1.46)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C380(1.61)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C380(1.08)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C380(1.51)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C380(1.37)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C380(1.02)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C380(1.06)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C380(1.14)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C380(1.15)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C380(1.18)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C380(1.43)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C380(1.19)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C380(1.35)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C380(1.23)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C380(1.38)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C380(1.21)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C380(1.23)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C380(1.19)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C380(1.31)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C380(1.52)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C380(1.36)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C380(1.05)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C380(0.53)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C380(1.20)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C380(1.12)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C380(1.53)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C380(1.18)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C380(1.25)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C380(0.94)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C380(1.12)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C380(1.28)  LDD0712  [3]
 LDCM0396  CL125 PaTu 8988t C380(1.62)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C380(1.18)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C380(1.38)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C380(1.17)  LDD1278  [3]
 LDCM0400  CL13 HCT 116 C380(1.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C380(1.38)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C380(1.23)  LDD0719  [3]
 LDCM0407  CL2 HCT 116 C380(1.15)  LDD0724  [3]
 LDCM0418  CL3 HCT 116 C380(0.91)  LDD0735  [3]
 LDCM0420  CL31 HCT 116 C380(1.59)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C380(1.53)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C380(1.34)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C380(1.75)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C380(1.39)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C380(1.82)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C380(1.92)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C380(1.89)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C380(1.26)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C380(2.06)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C380(1.64)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C380(2.71)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C380(1.74)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C380(1.64)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C380(1.80)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C380(0.90)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C380(1.14)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C380(0.93)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C380(1.04)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C380(1.23)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C380(1.14)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C380(0.94)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C380(1.10)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C380(0.89)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C380(1.00)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C380(1.24)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C380(1.53)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C380(1.12)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C380(0.89)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C380(1.06)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C380(1.34)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C380(0.90)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C380(1.48)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C380(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C380(1.43)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C380(2.62)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C380(1.56)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C380(1.68)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C380(1.99)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C380(1.71)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C380(1.27)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C380(1.16)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C380(1.22)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C380(1.23)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C380(2.05)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C380(1.81)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C380(2.95)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C380(1.17)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C380(1.27)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C380(1.44)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C380(1.36)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C380(1.29)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C380(1.55)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C380(1.44)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C380(1.49)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C380(1.28)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C380(1.40)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C380(1.32)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C380(1.56)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C380(1.53)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C380(1.67)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C380(1.29)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C380(1.74)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C380(1.82)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C380(1.25)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C380(1.13)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C380(1.17)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C380(1.43)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C380(1.28)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C380(1.18)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C380(1.99)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C380(1.39)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C380(1.27)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C380(1.14)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C380(2.03)  LDD0744  [3]
 LDCM0022  KB02 BRX211 C45(1.39); C132(1.08)  LDD2268  [8]
 LDCM0023  KB03 BRX211 C45(1.23); C132(1.07)  LDD2685  [8]
 LDCM0024  KB05 NCI-H2291 C45(1.18)  LDD3358  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Myc box-dependent-interacting protein 1 (BIN1) . O00499

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840