Details of the Target

General Information of Target

Target ID LDTP08982
Target Name Mitochondrial basic amino acids transporter (SLC25A29)
Gene Name SLC25A29
Gene ID 123096
Synonyms
C14orf69; ORNT3; Mitochondrial basic amino acids transporter; Carnitine/acylcarnitine translocase-like; CACT-like; Mitochondrial carnitine/acylcarnitine carrier protein CACL; Mitochondrial ornithine transporter 3; Solute carrier family 25 member 29
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYK
GLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRL
QLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALG
CEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYR
AEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAAPAGPALAQP
SSL
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation.
Uniprot ID
Q8N8R3
Ensemble ID
ENST00000359232.8
HGNC ID
HGNC:20116

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.A219V .
IGROV1 SNV: p.W204Ter .
KPL1 SNV: p.P37L .
MCF7 SNV: p.P37L .
SKNSH SNV: p.P112H .
SNGM SNV: p.A264T DBIA    Probe Info 
SW1783 SNV: p.T42M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C181(1.02)  LDD0531  [1]
CY-1
 Probe Info  		N.A.  LDD0246  [2]
CY4
 Probe Info  		N.A.  LDD0247  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C137(0.00); C9(0.00)  LDD0165  [4]
IPM
 Probe Info  		C137(0.00); C234(0.00)  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C181(0.00); C234(0.00); C137(0.00); C9(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C181(1.02)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C45(1.03)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C181(0.40)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C181(0.45)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C181(0.40)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C181(0.40)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C181(0.42)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C181(0.37)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C181(0.40)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C181(0.41)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C181(0.47)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C181(0.38)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C45(1.14)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C181(0.52)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C181(0.38)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C181(0.45)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C181(1.15)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C181(1.49)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C181(1.50)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C181(0.97)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C181(0.83)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C181(1.01)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C181(0.94)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C45(1.10)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C181(1.14)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C181(1.02)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C181(0.83)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C181(0.83)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C181(0.88)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C181(1.19)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C181(0.93)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C181(1.04)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C45(1.08)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C45(0.84)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C45(0.83)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C45(0.93)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C45(0.97)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C45(1.01)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C45(0.85)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C45(0.94)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C45(1.05)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C45(0.96)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C45(0.92)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C45(0.99)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C45(1.21)  LDD0857  [1]
 LDCM0260  AC140 HCT 116 C45(0.99)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C45(0.98)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C45(0.78)  LDD0579  [1]
 LDCM0270  AC15 HEK-293T C45(0.99)  LDD0868  [1]
 LDCM0276  AC17 HCT 116 C181(1.08)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C181(1.08)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C181(1.09)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C181(1.18)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C181(1.04)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C181(1.11)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C181(1.09)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C181(1.21)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C181(1.10)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C45(1.16)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C45(1.21)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C45(1.07)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C45(1.00)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C45(1.00)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C181(1.14)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C45(0.91)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C45(1.29)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C45(0.83)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C45(0.77)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C45(0.63)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C45(1.11)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C45(1.22)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C45(1.11)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C45(1.07)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C45(1.10)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C181(1.01)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C45(1.06)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C45(0.96)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C45(0.94)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C45(1.00)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C45(0.80)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C45(0.83)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C45(0.94)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C45(0.98)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C45(0.83)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C45(1.02)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C181(1.01)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C45(0.87)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C45(1.05)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C45(0.89)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C45(0.95)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C45(0.94)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C45(0.92)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C45(0.96)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C45(1.08)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C45(1.09)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C45(0.89)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C45(1.00)  LDD0921  [1]
 LDCM0324  AC60 HCT 116 C45(0.81)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C45(0.89)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C45(0.83)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C45(0.84)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C45(0.87)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C45(0.80)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C45(0.80)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C45(0.70)  LDD0648  [1]
 LDCM0332  AC68 HEK-293T C45(0.77)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C45(0.96)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C45(0.97)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C45(1.00)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C45(0.82)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C45(0.83)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C45(0.76)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C45(0.82)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C45(0.72)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C45(0.70)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C45(0.91)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C45(0.70)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C45(0.65)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C45(1.43)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C45(0.69)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C45(0.67)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C45(0.76)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C45(1.14)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C45(1.12)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C45(0.97)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C45(1.20)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C45(1.01)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C45(1.06)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C45(1.23)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C45(1.10)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C45(1.09)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C45(1.32)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C45(1.10)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C45(1.13)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C45(1.10)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C45(1.18)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C45(1.12)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C181(0.27)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C181(0.57)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C45(1.14)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C45(1.15)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C45(1.03)  LDD0873  [1]
 LDCM0367  CL1 HCT 116 C181(1.11)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C181(1.20)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C181(0.89)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C45(1.10)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C45(0.94)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C45(1.00)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C45(1.06)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C181(0.97)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C181(1.14)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C181(0.99)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C181(1.18)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C181(0.93)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C181(1.12)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C181(0.86)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C181(0.80)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C45(1.18)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C45(0.86)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C45(0.81)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C45(0.76)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C45(0.63)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C45(1.08)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C45(1.20)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C45(1.20)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C181(1.27)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C45(1.01)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C45(0.77)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C45(0.90)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C45(1.00)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C45(0.94)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C45(1.00)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C45(0.98)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C45(0.88)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C45(1.01)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C181(1.26)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C181(1.03)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C181(1.43)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C45(1.01); C137(1.01)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C45(1.41); C137(1.20); C181(1.00)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C45(1.01); C137(1.06); C181(1.00); C234(1.08)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C45(0.97); C137(1.28); C181(1.11)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C181(1.17)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C45(1.04); C137(1.10)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C45(1.38); C137(1.29)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C45(1.19); C137(1.14); C181(1.05)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C45(1.10); C137(1.26)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C45(1.37); C137(1.23); C181(1.05)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C45(1.29); C137(1.25)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C45(1.03); C137(1.01); C181(1.00)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C45(0.97); C137(1.02)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C45(0.93); C137(1.00)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C45(0.97); C137(1.14); C181(1.09)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C181(1.18)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C45(1.02); C137(0.99); C181(1.12); C234(1.08)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C45(1.44)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C45(1.11)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C45(1.59)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C45(1.18)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C45(1.10)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C45(1.08)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C45(1.03)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C45(1.27)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C181(1.24)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C45(1.16)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C45(1.27)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C45(1.28)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C45(1.13)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C45(1.15)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C45(1.34)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C45(0.89)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C45(1.01)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C45(0.82)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C45(1.01)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C181(1.12)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C45(0.77)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C45(1.05)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C45(0.93)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C45(0.89)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C45(0.97)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C45(0.92)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C45(0.86)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C45(0.91)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C45(0.98)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C45(0.98)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C181(1.23)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C45(0.86)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C45(1.04)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C45(1.14)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C45(1.03)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C45(1.04)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C45(1.29)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C45(1.21)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C45(1.07)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C45(0.99)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C45(0.90)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C181(1.28)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C45(0.96)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C45(0.87)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C45(0.84)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C45(0.81)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C45(0.85)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C45(0.99)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C45(1.04)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C45(1.04)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C45(0.88)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C181(1.32)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C45(0.99)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C45(0.87)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C45(0.88)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C45(0.76)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C45(0.78)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C45(0.89)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C45(0.83)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C45(0.66)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C45(0.75)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C45(0.82)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C181(1.08)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C45(0.82)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C181(0.90)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C181(0.96)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C181(0.88)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C181(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C181(1.21)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C181(1.01)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C181(0.96)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C181(1.02)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C181(1.00)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C45(1.12); C137(1.13)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C137(0.95)  LDD1702  [10]
 LDCM0575  Fragment13 Ramos C234(1.07)  LDD2192  [11]
 LDCM0580  Fragment21 Ramos C234(1.50)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C234(1.20)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C234(1.43)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C234(1.07)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C234(3.41)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C234(1.09)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C45(0.77)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C45(0.95)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C181(0.92); C45(0.83)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C181(1.02); C45(0.91)  LDD1497  [9]
 LDCM0024  KB05 UACC257 C181(2.04); C71(3.59)  LDD3325  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Levocarnitine Small molecular drug DB00583

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840