Details of the Target

General Information of Target

Target ID LDTP08806
Target Name Latent-transforming growth factor beta-binding protein 4 (LTBP4)
Gene Name LTBP4
Gene ID 8425
Synonyms
Latent-transforming growth factor beta-binding protein 4; LTBP-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQT
SRRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARA
LLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFC
QLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERV
SGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECAS
PLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDE
CATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSL
PILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLG
QEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIP
ESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAP
GRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY
QAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPP
CGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCP
MGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSS
GAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGS
FACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCL
DVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQ
RCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGY
EGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAG
TFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARN
VTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLF
RDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYH
CTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYG
EAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPE
LYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPY
RSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCF
DGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPA
RPRA
Target Bioclass
Other
Family
LTBP family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Uniprot ID
Q8N2S1
Ensemble ID
ENST00000308370.11
HGNC ID
HGNC:6717

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C367(0.92); C372(0.92)  LDD0078  [1]
IPM
 Probe Info  		C344(0.00); C372(0.00); C367(0.00)  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C372(1.13); C612(1.05); C750(1.05)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C87(1.24); C372(0.99); C612(0.88); C860(1.04)  LDD1508  [3]
 LDCM0216  AC100 HCT 116 C1183(0.75); C1193(0.75)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C1183(0.54); C1193(0.54)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C1183(0.54); C1193(0.54)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C1183(0.38); C1193(0.38)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C1183(0.50); C1193(0.50)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C1183(0.56); C1193(0.56)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C1183(0.45); C1193(0.45)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C1183(0.52); C1193(0.52)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C1183(0.36); C1193(0.36)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C1183(0.32); C1193(0.32)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C612(0.94); C860(0.88)  LDD1509  [3]
 LDCM0227  AC110 HCT 116 C1183(0.45); C1193(0.45)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C1183(0.34); C1193(0.34)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C1183(0.48); C1193(0.48)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C324(1.21); C327(1.21)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C324(1.41); C327(1.41)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C324(1.44); C327(1.44)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C324(1.25); C327(1.25)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C324(1.24); C327(1.24)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C324(1.31); C327(1.31)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C324(1.06); C327(1.06)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C87(1.00); C298(1.00); C612(1.02); C860(1.09)  LDD1510  [3]
 LDCM0238  AC120 HCT 116 C324(1.17); C327(1.17)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C324(0.96); C327(0.96)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C324(0.97); C327(0.97)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C324(1.05); C327(1.05)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C324(1.04); C327(1.04)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C324(1.39); C327(1.39)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C324(1.71); C327(1.71)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C324(1.09); C327(1.09)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C324(1.08); C327(1.08)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C324(0.98); C327(0.98)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C324(1.00); C327(1.00)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C324(0.79); C327(0.79)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C324(0.85); C327(0.85)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C324(0.91); C327(0.91)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C324(1.07); C327(1.07)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C324(0.94); C327(0.94)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C324(0.89); C327(0.89)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C324(0.92); C327(0.92)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C324(0.69); C327(0.69)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C324(0.81); C327(0.81)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C418(0.98); C640(1.28); C372(1.13); C612(1.16)  LDD1512  [3]
 LDCM0260  AC140 HCT 116 C324(0.87); C327(0.87)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C324(0.89); C327(0.89)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C324(0.76); C327(0.76)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C367(0.84); C372(0.84)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C367(1.50); C372(1.50)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C367(1.00); C372(1.00)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C367(1.10); C372(1.10)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C367(1.31); C372(1.31)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C367(1.77); C372(1.77)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C367(1.39); C372(1.39)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C87(1.26); C612(0.96); C860(1.22)  LDD1513  [3]
 LDCM0271  AC150 HCT 116 C367(0.90); C372(0.90)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C367(1.01); C372(1.01)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C367(1.11); C372(1.11)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C367(2.03); C372(2.03)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C367(2.07); C372(2.07)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C367(1.41); C372(1.41)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C367(1.13); C372(1.13)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C367(1.12); C372(1.12)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C372(1.16); C612(1.15); C750(1.26)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C87(1.34); C372(1.02); C612(1.06); C860(0.81)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C612(2.13); C860(1.24)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C87(1.23); C372(0.93); C612(1.06); C860(1.23)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C87(1.59); C298(0.86); C612(1.10); C860(1.03)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C87(0.87); C973(1.08); C612(0.61); C860(0.94)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C418(0.92); C640(1.09); C372(0.95); C612(1.02)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C87(1.38); C612(0.87); C860(0.94)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C87(1.05); C973(1.07); C640(0.89); C372(0.88)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C372(1.15); C612(0.96); C750(0.95)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C87(1.75); C372(1.37); C612(1.02); C860(0.96)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C612(1.18); C860(0.85)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C87(0.93); C298(0.89); C612(0.92); C860(0.99)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C87(0.91); C973(1.05); C612(0.83); C860(1.09)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C612(0.94); C860(0.89)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C418(1.12); C640(1.09); C372(1.06); C612(0.81)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C87(1.24); C612(1.22); C860(1.18)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C87(0.91); C973(1.08); C640(0.87); C372(1.05)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C372(1.55); C612(1.14); C750(1.04)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C87(1.13); C372(0.96); C612(1.13); C860(0.88)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C612(0.82); C860(1.00)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C87(0.91); C298(1.02); C612(1.17); C860(0.99)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C87(1.01); C973(0.93); C612(1.07); C860(0.85)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C418(0.98); C640(1.03); C372(1.37); C612(0.95)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C87(1.14); C612(0.91); C860(1.01)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C87(1.04); C298(0.87); C612(1.22); C860(1.09)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C87(0.92); C973(1.09); C640(0.82); C372(1.20)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C372(1.17); C612(0.97); C750(1.02)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C87(1.04); C372(0.98); C612(0.92); C860(1.05)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C612(1.07); C860(0.92)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C87(1.43); C298(1.01); C612(1.07); C860(1.15)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C87(0.91); C973(1.09); C612(0.85); C860(1.23)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C418(0.98); C640(1.10); C372(1.18); C612(1.18)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C87(1.18); C612(0.99); C860(1.13)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C87(1.08); C973(1.09); C640(0.75); C372(1.11)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C372(1.13); C612(1.42); C750(1.05)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C87(0.99); C973(0.95); C612(0.96); C860(0.88)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C87(1.35); C372(0.99); C612(1.13); C860(1.05)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C612(0.95); C860(0.96)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C87(1.26); C298(0.84); C612(1.12); C860(1.10)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C87(1.05); C973(1.00); C612(0.58); C860(0.90)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C418(1.08); C640(1.15); C372(1.04); C612(1.28)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C87(1.01); C612(1.16); C860(1.34)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C87(0.98); C973(1.16); C640(0.96); C372(1.18)  LDD1558  [3]
 LDCM0320  AC57 HCT 116 C324(1.32); C327(1.32)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C324(1.11); C327(1.11)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C324(1.43); C327(1.43)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C418(1.03); C640(1.15); C372(1.28); C612(0.99)  LDD1562  [3]
 LDCM0324  AC60 HCT 116 C324(1.17); C327(1.17)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C324(1.70); C327(1.70)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C324(1.58); C327(1.58)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C324(0.93); C327(0.93)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C324(1.28); C327(1.28)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C324(0.58); C327(0.58)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C324(0.62); C327(0.62)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C324(0.74); C327(0.74)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C324(0.90); C327(0.90); C367(1.25); C372(1.25)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C367(1.07); C372(1.07); C324(1.08); C327(1.08)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C87(1.24); C612(1.01); C860(1.14)  LDD1568  [3]
 LDCM0335  AC70 HCT 116 C324(1.25); C327(1.25); C367(1.56); C372(1.56)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C324(0.83); C327(0.83); C367(1.00); C372(1.00)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C367(1.03); C372(1.03); C324(1.18); C327(1.18)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C367(1.44); C372(1.44); C324(1.50); C327(1.50)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C367(1.40); C372(1.40); C324(1.44); C327(1.44)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C324(1.67); C327(1.67); C367(1.68); C372(1.68)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C324(1.02); C327(1.02); C367(1.16); C372(1.16)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C324(1.11); C327(1.11); C367(1.12); C372(1.12)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C324(0.96); C327(0.96); C367(1.01); C372(1.01)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C324(0.85); C327(0.85); C367(1.06); C372(1.06)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C87(0.95); C973(0.97); C640(1.01); C372(1.22)  LDD1569  [3]
 LDCM0346  AC80 HCT 116 C367(1.00); C372(1.00); C324(1.12); C327(1.12)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C324(0.80); C327(0.80); C367(1.00); C372(1.00)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C324(1.58); C327(1.58); C367(1.69); C372(1.69)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C1183(1.78); C1193(1.78); C367(1.93); C372(1.93)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C367(1.30); C372(1.30); C1183(1.64); C1193(1.64)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C367(0.99); C372(0.99); C1183(1.17); C1193(1.17)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1183(1.39); C1193(1.39); C367(1.62); C372(1.62)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C367(1.30); C372(1.30); C1183(1.39); C1193(1.39)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C367(1.22); C372(1.22); C1183(1.50); C1193(1.50)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1183(1.67); C1193(1.67); C367(2.16); C372(2.16)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1183(0.98); C1193(0.98); C367(1.22); C372(1.22)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1183(2.05); C1193(2.05); C367(2.22); C372(2.22)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C367(1.73); C372(1.73); C1183(2.16); C1193(2.16)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C367(1.03); C372(1.03); C1183(1.60); C1193(1.60)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C367(1.06); C372(1.06); C1183(1.48); C1193(1.48)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1183(1.24); C1193(1.24); C367(1.51); C372(1.51)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C367(1.44); C372(1.44); C1183(1.79); C1193(1.79)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1183(1.51); C1193(1.51); C367(2.05); C372(2.05)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C1183(0.49); C1193(0.49)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C1183(0.39); C1193(0.39)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C87(0.90); C973(1.00); C612(0.89); C860(0.95)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C372(1.28); C612(1.08); C750(1.24)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C87(0.95); C973(1.01); C640(0.84); C372(1.12)  LDD1514  [3]
 LDCM0020  ARS-1620 HCC44 C367(0.92); C372(0.92)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C1183(1.08); C1193(1.08)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1183(0.91); C1193(0.91)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C418(0.79); C612(0.73); C860(0.94)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C298(1.09); C612(1.11); C860(1.00); C55(0.96)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C87(1.14); C973(1.06); C372(1.12); C612(1.20)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C87(1.09); C372(0.95); C860(1.08)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C418(0.93); C612(0.66); C860(1.15)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C298(0.97); C612(1.01); C860(0.96); C55(1.04)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C87(0.93); C973(1.06); C372(1.05); C612(1.02)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C87(0.99); C372(1.01); C860(1.14)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C418(0.82); C612(0.64); C860(0.96)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C298(0.90); C612(0.91); C860(0.98); C55(0.93)  LDD1582  [3]
 LDCM0379  CL11 HCT 116 C1183(1.09); C1193(1.09)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C87(0.90); C973(1.11); C372(0.89); C612(1.02)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C87(1.21); C372(1.07); C860(1.12)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C418(0.97); C612(0.65); C860(1.09)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C298(1.00); C612(0.88); C860(1.13); C55(1.07)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C87(0.98); C973(1.01); C372(1.09); C612(1.12)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C87(1.17); C372(0.87); C860(1.22)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C418(1.03); C612(0.79); C860(1.13)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C298(0.92); C612(0.91); C860(1.04); C55(1.16)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C87(1.08); C973(1.13); C372(1.17); C612(1.10)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C87(1.10); C372(0.85); C860(1.21)  LDD1593  [3]
 LDCM0390  CL12 HCT 116 C1183(1.12); C1193(1.12)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C418(0.94); C612(0.81); C860(0.99)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C298(0.99); C612(1.04); C860(0.98); C55(0.93)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C87(1.07); C973(1.15); C372(1.00); C612(1.30)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C87(1.00); C372(0.94); C860(1.00)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C418(0.87); C612(1.02); C860(0.90)  LDD1599  [3]
 LDCM0396  CL125 HCT 116 C324(0.86); C327(0.86)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C324(0.99); C327(0.99)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C324(0.64); C327(0.64)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C324(1.35); C327(1.35)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C1183(0.92); C1193(0.92)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1183(1.03); C1193(1.03)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1183(0.91); C1193(0.91)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C1183(0.94); C1193(0.94); C324(0.97); C327(1.27)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1183(0.76); C1193(0.76); C327(1.26)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C1183(1.20); C1193(1.20); C327(1.43)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C327(0.98); C1183(1.18); C1193(1.18)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C1183(1.02); C1193(1.02)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C327(1.08); C1183(1.17); C1193(1.17)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C1183(0.88); C1193(0.88); C327(1.29)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C1183(0.77); C1193(0.77); C327(1.69)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C327(0.90); C1183(1.24); C1193(1.24)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C327(1.23); C1183(1.53); C1193(1.53)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1183(0.88); C1193(0.88); C327(1.08)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1183(1.41); C1193(1.41); C327(1.30)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1183(1.08); C1193(1.08); C327(1.34)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1183(0.96); C1193(0.96); C327(0.94)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1183(1.09); C1193(1.09); C327(1.17)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C1183(0.97); C1193(0.97)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C1183(1.02); C1193(1.02); C327(1.21)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C612(0.91); C860(1.18)  LDD1624  [3]
 LDCM0421  CL32 HCT 116 C1183(0.82); C1193(0.82); C324(1.25); C327(1.25)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1183(1.06); C1193(1.06); C324(1.16); C327(1.16)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1183(0.65); C1193(0.65); C324(1.34); C327(1.34)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1183(0.74); C1193(0.74); C324(1.30); C327(1.30)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1183(0.71); C1193(0.71); C324(1.15); C327(1.15)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1183(0.65); C1193(0.65); C324(1.56); C327(1.56)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1183(0.58); C1193(0.58); C324(1.02); C327(1.02)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C1183(1.02); C1193(1.02)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C1183(0.64); C1193(0.64); C324(1.54); C327(1.54)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1183(1.09); C1193(1.09); C324(1.06); C327(1.06)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1183(1.26); C1193(1.26); C324(1.04); C327(1.04)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1183(1.07); C1193(1.07); C324(1.36); C327(1.36)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1183(0.70); C1193(0.70); C324(1.23); C327(1.23)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1183(0.89); C1193(0.89); C324(1.30); C327(1.30)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C1183(0.92); C1193(0.92); C367(0.97); C372(0.97)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1183(0.91); C1193(0.91); C367(0.91); C372(0.91)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1183(0.77); C1193(0.77); C367(1.00); C372(1.00)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1183(0.69); C1193(0.69); C367(0.80); C372(0.80)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C1183(0.95); C1193(0.95)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C1183(0.95); C1193(0.95); C367(0.94); C372(0.94)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1183(0.85); C1193(0.85); C367(0.92); C372(0.92)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1183(0.81); C1193(0.81); C367(0.96); C372(0.96)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1183(1.03); C1193(1.03); C367(0.97); C372(0.97)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1183(0.75); C1193(0.75); C367(1.02); C372(1.02)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1183(1.00); C1193(1.00); C367(1.11); C372(1.11)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1183(0.77); C1193(0.77); C367(1.01); C372(1.01)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1183(0.72); C1193(0.72); C367(0.82); C372(0.82)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1183(0.77); C1193(0.77); C367(0.97); C372(0.97)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1183(0.89); C1193(0.89); C367(0.87); C372(0.87)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C1183(0.84); C1193(0.84)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C1183(0.82); C1193(0.82); C367(1.02); C372(1.02)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C367(1.33); C372(1.33)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C367(0.90); C372(0.90)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C367(0.86); C372(0.86)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C367(1.00); C372(1.00)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C367(0.83); C372(0.83)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C367(0.82); C372(0.82)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C367(0.88); C372(0.88)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C367(0.82); C372(0.82)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C367(0.85); C372(0.85)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C1183(0.81); C1193(0.81)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C367(0.86); C372(0.86)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C367(0.89); C372(0.89)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C367(0.87); C372(0.87)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C367(0.80); C372(0.80)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C367(0.84); C372(0.84)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C418(1.03); C612(1.17); C860(1.14)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C372(1.14); C612(0.93); C750(1.27)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C87(1.24); C372(1.45); C612(0.88); C860(1.20)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C612(0.92); C860(0.84)  LDD1675  [3]
 LDCM0473  CL8 HCT 116 C1183(1.81); C1193(1.81)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C87(1.18); C298(1.00); C612(0.93); C860(0.97)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C87(0.98); C973(1.08); C612(0.89); C860(1.19)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C418(1.23); C640(1.19); C372(1.32); C612(0.79)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C87(1.30); C612(1.36); C860(1.27)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C87(0.90); C973(1.05); C640(1.08); C372(1.04)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C298(0.86); C612(0.71); C860(0.94); C55(0.97)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C87(0.83); C973(1.09); C372(1.18); C612(1.11)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C87(0.89); C372(0.77); C860(1.05)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C418(0.98); C612(0.68); C860(1.07)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C372(1.21); C612(1.02); C750(0.96)  LDD1686  [3]
 LDCM0484  CL9 HCT 116 C1183(0.86); C1193(0.86)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C87(0.97); C372(1.25); C612(1.25); C860(1.20)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C612(0.83); C860(1.04)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C87(1.19); C298(0.97); C612(1.05); C860(1.03)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C87(1.16); C973(1.11); C612(0.89); C860(1.11)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C418(1.17); C640(1.53); C372(1.17); C612(1.03)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C87(1.10); C612(0.79); C860(1.07)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C87(0.96); C973(1.10); C640(0.89); C372(1.02)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C298(0.93); C612(0.88); C860(0.95); C55(0.87)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C87(0.90); C973(1.01); C372(0.81); C612(0.96)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C87(0.99); C372(0.98); C860(1.15)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C87(1.34); C372(0.83); C860(1.19)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C367(0.97); C372(0.97)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C1183(0.58); C1193(0.58); C324(1.16); C327(1.16)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C367(4.47); C372(4.47)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C367(3.16); C372(3.16)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C367(2.88); C372(2.88)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C367(0.87); C372(0.87); C1183(0.96); C1193(0.96)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) Calcium channel alpha-1 subunit (TC 1.A.1.11) family O00555
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-7 (ATXN7) Ataxin-7 family O15265

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402