Details of the Target

General Information of Target

Target ID LDTP08515
Target Name Kinase suppressor of Ras 1 (KSR1)
Gene Name KSR1
Gene ID 8844
Synonyms
KSR; Kinase suppressor of Ras 1; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Function
Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown.
Uniprot ID
Q8IVT5
Ensemble ID
ENST00000398988.7
HGNC ID
HGNC:6465
ChEMBL ID
CHEMBL1938215

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C251(2.34)  LDD0168  [1]
DBIA
 Probe Info  		C164(1.84); C148(5.38); C155(5.38)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		C62(0.00); C251(0.00)  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C251(2.34)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C251(6.42)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C62(1.07); C166(0.89)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C148(0.45); C155(0.45)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C148(0.35); C155(0.35)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C148(0.44); C155(0.44)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C164(0.85)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C164(1.12)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C164(1.13)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C164(1.10)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C164(1.26)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C164(1.14)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C164(1.18)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C164(1.20)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C164(1.12)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C164(1.12)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C164(1.32)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C164(1.21)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C148(0.45); C155(0.45)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C164(1.29)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C164(1.36)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C164(1.06)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C148(1.15); C155(1.15)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C148(0.97); C155(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C148(1.09); C155(1.09)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C148(0.97); C155(0.97)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C148(0.84); C155(0.84)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C148(0.91); C155(0.91)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C148(0.90); C155(0.90)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C148(0.28); C155(0.28)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C148(0.94); C155(0.94)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C148(1.87); C155(1.87)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C148(0.81); C155(0.81)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C148(0.97); C155(0.97)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C148(1.22); C155(1.22)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C148(0.81); C155(0.81)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C148(1.47); C155(1.47)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C148(1.65); C155(1.65)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C164(1.32)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C164(1.07)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C164(1.20)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C166(0.89); C251(1.42)  LDD1518  [9]
 LDCM0280  AC20 HCT 116 C164(1.14)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C164(1.09)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C164(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C164(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C164(1.13)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C148(0.75); C155(0.75)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C148(0.61); C155(0.61)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C148(0.80); C155(0.80)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C148(0.39); C155(0.39)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C148(0.64); C155(0.64)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C62(0.94); C166(1.00)  LDD1529  [9]
 LDCM0291  AC30 HCT 116 C148(0.71); C155(0.71)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C148(0.71); C155(0.71)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C148(0.45); C155(0.45)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C148(0.71); C155(0.71)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C148(0.55); C155(0.55)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C148(0.83); C155(0.83); C164(1.02)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C164(1.13); C148(2.18); C155(2.18)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C148(0.82); C155(0.82); C164(1.12)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C148(0.87); C155(0.87); C164(1.18)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C148(0.87); C155(0.87); C164(1.39)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C62(0.92); C166(1.03)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C148(0.56); C155(0.56); C164(1.32)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C148(0.74); C155(0.74); C164(1.43)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C148(0.71); C155(0.71); C164(1.33)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C148(1.06); C155(1.06); C164(1.24)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C148(0.90); C155(0.90); C164(1.34)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C148(0.91); C155(0.91); C164(1.22)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C155(1.12)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C155(1.17)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C155(1.23)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C155(1.07)  LDD1190  [2]
 LDCM0312  AC5 HEK-293T C62(0.95); C166(0.94)  LDD1551  [9]
 LDCM0313  AC50 PaTu 8988t C155(1.09)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C155(1.33)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C155(0.74)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C155(1.69)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C155(1.25)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C155(1.31)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C155(1.17)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C148(0.62); C155(0.62)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C148(0.71); C155(0.71)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C148(0.61); C155(0.61)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C148(0.38); C155(0.38)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C148(0.63); C155(0.63)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C148(1.20); C155(1.20)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C148(0.62); C155(0.62)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C148(0.65); C155(0.65)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C148(0.58); C155(0.58)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C148(0.49); C155(0.49)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C148(0.47); C155(0.47)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C148(0.40); C155(0.40)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C148(0.32); C155(0.32)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C148(0.26); C155(0.26)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C148(0.87); C155(0.87)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C148(0.75); C155(0.75)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C148(0.74); C155(0.74)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C148(0.86); C155(0.86)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C148(0.92); C155(0.92)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C148(0.85); C155(0.85)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C148(0.80); C155(0.80)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C148(1.36); C155(1.36)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C148(0.84); C155(0.84)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C148(0.96); C155(0.96)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C148(0.92); C155(0.92)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C148(0.71); C155(0.71)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C148(0.98); C155(0.98)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C148(0.96); C155(0.96)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C148(0.63); C155(0.63)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C148(0.46); C155(0.46)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C148(0.38); C155(0.38)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C148(0.30); C155(0.30)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C148(1.03); C155(1.03)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C148(0.66); C155(0.66)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C62(1.07); C166(0.91); C777(1.04)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C148(0.37); C155(0.37)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C148(0.54); C155(0.54)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C148(0.40); C155(0.40)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C148(0.42); C155(0.42)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C164(1.13)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C164(0.95)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C164(0.91)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C164(1.13)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C164(1.01)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C148(0.90); C155(0.90)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C164(1.40)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C164(1.00)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C148(0.61); C155(0.61)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C148(0.52); C155(0.52)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C148(0.67); C155(0.67)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C148(0.67); C155(0.67)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C148(0.81); C155(0.81)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C148(0.65); C155(0.65); C164(1.21)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C148(0.77); C155(0.77); C164(1.21)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C148(0.57); C155(0.57); C164(1.25)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C148(0.96); C155(0.96)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C148(0.94); C155(0.94); C164(1.19)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C155(1.41)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C155(1.05)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C155(1.37)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C155(0.77)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C148(0.61); C155(0.61)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C148(0.87); C155(0.87)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C148(0.71); C155(0.71)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C148(0.51); C155(0.51)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C148(0.87); C155(0.87)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C148(1.15); C155(1.15)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C148(1.43); C155(1.43)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C62(1.02); C166(0.94); C777(0.90)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C62(1.08); C166(1.01)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C166(0.94); C251(1.24)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C62(1.13); C166(0.96)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C148(2.27); C155(2.27)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C62(1.12); C166(1.04)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C62(1.11); C166(0.95)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C62(1.01); C166(0.82)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C62(1.04); C166(1.07)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C62(1.10); C166(0.96); C777(0.84)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C62(0.87); C166(0.96)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C62(1.04); C166(0.95)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C62(1.02); C166(0.90)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C62(1.08); C166(0.88); C777(0.84)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C62(1.05); C166(0.95)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C148(0.97); C155(0.97)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C166(0.93); C251(1.00)  LDD1623  [9]
 LDCM0420  CL31 HCT 116 C164(0.93)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C164(1.03)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C164(1.19)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C164(1.24)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C164(1.00)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C164(1.03)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C164(0.95)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C164(0.95)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C148(1.11); C155(1.11)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C164(0.87)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C164(0.89)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C164(0.82)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C164(0.98)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C164(1.06)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C164(1.28)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C164(0.98)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C164(0.89)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C164(0.86)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C164(0.88)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C148(0.90); C155(0.90)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C164(0.81)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C164(0.92)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C164(0.84)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C164(0.84)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C164(0.81)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C164(0.85)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C164(0.78)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C164(1.06)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C164(0.92)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C164(0.99)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C148(1.06); C155(1.06)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C164(0.85)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C164(1.24)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C164(1.24)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C164(1.15)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C164(1.36)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C164(1.29)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C164(1.08)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C164(1.05)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C164(0.97)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C164(1.31)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C148(1.24); C155(1.24)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C164(1.18)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C164(1.06)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C164(0.99)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C164(1.23)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C164(1.06)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C62(1.16); C166(0.93); C777(1.13)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C62(1.13); C166(0.92)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C166(0.98); C251(1.15)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C62(1.04); C166(0.99)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C148(0.95); C155(0.95)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C62(0.97); C166(0.95)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C62(1.06); C166(0.98)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C62(0.99); C166(0.86)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C62(1.18); C166(0.99)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C62(1.22); C166(0.98); C777(0.77)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C62(0.93); C166(1.00)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C62(1.12); C166(1.10)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C62(1.12); C166(1.00)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C62(0.97); C166(0.96); C777(1.11)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C62(0.99); C166(0.96)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C148(1.41); C155(1.41)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C166(0.94); C251(1.18)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C62(1.02); C166(0.96)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C62(0.95); C166(1.06)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C62(0.76); C166(0.99)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C62(1.04); C166(0.88)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C62(1.06); C166(1.08)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C62(1.11); C166(0.95); C777(0.90)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C62(0.93); C166(0.94)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C62(1.05); C166(0.81)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C62(0.96); C166(0.95)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C62(0.90); C166(1.12)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C164(1.41)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C164(0.93)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C164(1.84); C148(5.38); C155(5.38)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C164(1.49); C148(10.30); C155(10.30)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C164(3.45); C148(3.11); C155(3.11)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase VRK2 (VRK2) CK1 Ser/Thr protein kinase family Q86Y07
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) STE Ser/Thr protein kinase family P36507

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402