Details of the Target

General Information of Target

Target ID LDTP08497
Target Name Forkhead box protein P4 (FOXP4)
Gene Name FOXP4
Gene ID 116113
Synonyms
FKHLA; Forkhead box protein P4; Fork head-related protein-like A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAE
LLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVPVSVAMMSPQMLTPQQMQQ
ILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQQQAGKPQPKEALGNKQLAFQ
QQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLPQAAVCPTDLPQLWKGEGAPGQP
AEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSSSHEETPGS
HPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKES
ERLQAMMAHLHMRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHPPTSAAAPVT
PLRPPGLGSASLHGGGPARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAI
LETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDE
REYQKRRPPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSL
LPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPS
ASGPPEDRDLEEELPGEELS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional repressor that represses lung-specific expression.
Uniprot ID
Q8IVH2
Ensemble ID
ENST00000307972.10
HGNC ID
HGNC:20842

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.L272SfsTer95 .
COLO800 SNV: p.P115Q .
DU145 SNV: p.P412L .
HCC1143 SNV: p.A464T .
HCT15 SNV: p.E8V; p.Q341K .
HEC1B SNV: p.D465N .
LS180 Deletion: p.L272SfsTer95 .
MOLT4 SNV: p.P418L .
RL952 Deletion: p.L272SfsTer95 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
BTD
 Probe Info  		C342(1.50)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C223(7.73)  LDD0170  [3]
DBIA
 Probe Info  		C342(6.52)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		12.60  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C342(1.03)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C342(1.21)  LDD2152  [2]
 LDCM0025  4SU-RNA DM93 C223(7.73)  LDD0170  [3]
 LDCM0215  AC10 HCT 116 C314(0.70); C318(0.70)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C447(0.73)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C447(0.82)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C447(0.60)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C447(1.04)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C447(0.83)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C447(0.76)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C447(0.78)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C447(0.99)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C447(0.61)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C447(1.06)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C314(0.63); C318(0.63)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C447(0.68)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C447(0.63)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C447(0.74)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C314(1.18); C318(1.18)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C314(1.33); C318(1.33)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C314(1.22); C318(1.22)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C314(1.05); C318(1.05)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C314(1.20); C318(1.20)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C314(1.27); C318(1.27)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C314(1.02); C318(1.02)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C314(0.75); C318(0.75)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C314(1.47); C318(1.47)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C314(1.32); C318(1.32)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C314(1.32); C318(1.32)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C314(1.06); C318(1.06)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C314(1.29); C318(1.29)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C314(1.17); C318(1.17)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C314(1.44); C318(1.44)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C314(1.40); C318(1.40)  LDD0562  [10]
 LDCM0246  AC128 PaTu 8988t C314(0.91); C318(0.91)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C314(0.99); C318(0.99)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C314(0.69); C318(0.69)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C314(0.82); C318(0.82)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C314(0.89); C318(0.89)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C314(0.89); C318(0.89)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C314(0.74); C318(0.74)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C314(1.08); C318(1.08)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C314(0.97); C318(0.97)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C314(0.94); C318(0.94)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C314(0.87); C318(0.87)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C314(0.97); C318(0.97)  LDD1137  [10]
 LDCM0259  AC14 HCT 116 C314(0.75); C318(0.75)  LDD0576  [10]
 LDCM0260  AC140 PaTu 8988t C314(1.01); C318(1.01)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C314(0.79); C318(0.79)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C314(0.87); C318(0.87)  LDD1141  [10]
 LDCM0270  AC15 HCT 116 C314(0.59); C318(0.59)  LDD0587  [10]
 LDCM0276  AC17 HCT 116 C447(0.69)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C447(0.50)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C447(0.61)  LDD0595  [10]
 LDCM0280  AC20 HCT 116 C447(0.68)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C447(0.57)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C447(0.62)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C447(0.66)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C447(0.72)  LDD0601  [10]
 LDCM0288  AC28 HEK-293T C447(1.08)  LDD1527  [11]
 LDCM0291  AC30 HEK-293T C223(0.91)  LDD1530  [11]
 LDCM0293  AC32 HEK-293T C447(0.99)  LDD1532  [11]
 LDCM0296  AC35 HCT 116 C314(0.92); C318(0.92)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C314(0.98); C318(0.98)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C314(1.32); C318(1.32)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C314(1.75); C318(1.75)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C314(1.35); C318(1.35)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C447(1.04)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C314(1.22); C318(1.22)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C314(1.15); C318(1.15)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C314(1.21); C318(1.21)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C314(1.37); C318(1.37)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C314(1.28); C318(1.28)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C314(1.38); C318(1.38)  LDD0624  [10]
 LDCM0308  AC46 PaTu 8988t C314(1.01); C318(1.01)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C314(0.92); C318(0.92)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C314(0.96); C318(0.96)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C314(1.01); C318(1.01)  LDD1190  [10]
 LDCM0313  AC50 PaTu 8988t C314(0.98); C318(0.98)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C314(1.00); C318(1.00)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C314(0.96); C318(0.96)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C314(1.04); C318(1.04)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C314(1.09); C318(1.09)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C314(0.94); C318(0.94)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C314(1.00); C318(1.00)  LDD1198  [10]
 LDCM0323  AC6 HCT 116 C314(0.65); C318(0.65)  LDD0640  [10]
 LDCM0324  AC60 HEK-293T C447(1.05)  LDD1563  [11]
 LDCM0326  AC62 HEK-293T C223(0.85)  LDD1565  [11]
 LDCM0328  AC64 HEK-293T C447(1.10)  LDD1567  [11]
 LDCM0332  AC68 HEK-293T C447(1.10)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C447(1.18)  LDD0931  [10]
 LDCM0334  AC7 HCT 116 C314(0.78); C318(0.78)  LDD0651  [10]
 LDCM0335  AC70 HEK-293T C447(1.37)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C447(0.85)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C447(1.27)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C447(1.29)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C447(1.89)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C447(1.38)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C447(1.50)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C447(1.19)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C447(1.63)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C447(1.05)  LDD0942  [10]
 LDCM0345  AC8 HCT 116 C314(0.71); C318(0.71)  LDD0662  [10]
 LDCM0346  AC80 HEK-293T C447(1.20)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C447(1.25)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C447(1.37)  LDD0946  [10]
 LDCM0349  AC83 HCT 116 C447(1.38)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C447(1.56)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C447(1.32)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C447(1.16)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C447(0.74)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C447(0.90)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C447(1.50)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C447(0.84)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C447(1.43)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C447(1.67)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C447(1.11)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C447(1.22)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C447(0.86)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C447(1.01)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C447(1.38)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C447(0.89)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C447(0.58)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C314(0.69); C318(0.69)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C314(1.08); C318(1.08)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C314(0.63); C318(0.63)  LDD0592  [10]
 LDCM0632  CL-Sc Hep-G2 C447(20.00); C223(20.00); C447(0.91)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C314(0.79); C318(0.79)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C314(1.44); C318(1.44)  LDD0685  [10]
 LDCM0370  CL101 HCT 116 C314(0.79); C318(0.79)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C314(0.76); C318(0.76)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C314(0.82); C318(0.82)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C314(0.69); C318(0.69)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C447(0.63)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C447(0.59)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C447(0.57)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C447(0.63)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C447(0.68)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C314(1.04); C318(1.04)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C447(0.74)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C447(0.90)  LDD0698  [10]
 LDCM0387  CL117 HCT 116 C314(1.65); C318(1.65)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C314(1.18); C318(1.18)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C314(1.13); C318(1.13)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C314(0.96); C318(0.96)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C314(1.17); C318(1.17)  LDD0708  [10]
 LDCM0392  CL121 PaTu 8988t C314(1.00); C318(1.00)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C314(0.94); C318(0.94)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C314(1.20); C318(1.20)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C314(1.02); C318(1.02)  LDD1274  [10]
 LDCM0400  CL13 HCT 116 C314(1.17); C318(1.17)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C314(0.94); C318(0.94)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C314(1.04); C318(1.04)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C314(1.15); C318(1.15)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C314(1.27); C318(1.27)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C314(0.97); C318(0.97)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C314(1.18); C318(1.18)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C314(0.84); C318(0.84)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C314(0.79); C318(0.79)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C314(0.89); C318(0.89)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C314(1.30); C318(1.30)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C314(0.88); C318(0.88)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C314(0.80); C318(0.80)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C314(0.99); C318(0.99)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C314(0.84); C318(0.84)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C314(0.99); C318(0.99)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C314(1.12); C318(1.12)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C314(1.00); C318(1.00)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C314(1.05); C318(1.05)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C314(0.93); C318(0.93)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C447(1.09)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C447(1.03)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C447(1.09)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C447(0.95)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C447(1.28)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C447(1.29)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C447(1.45)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C447(1.06)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C314(1.21); C318(1.21)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C447(1.48)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C447(1.22)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C447(1.08)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C447(1.12)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C447(1.08)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C447(1.17)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C447(0.68)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C447(0.88)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C447(0.79)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C447(1.01)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C314(0.95); C318(0.95)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C447(0.78)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C447(0.81)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C447(0.86)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C447(0.89)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C447(0.78)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C447(0.68)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C447(1.06)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C447(0.74)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C447(0.85)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C447(1.04)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C314(1.05); C318(1.05)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C447(1.03)  LDD0769  [10]
 LDCM0453  CL61 HEK-293T C447(1.04)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C447(1.10)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C447(1.18)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C447(1.03)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C447(1.22)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C447(1.16)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C447(1.25)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C447(1.26)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C447(1.26)  LDD1059  [10]
 LDCM0462  CL7 HCT 116 C314(0.86); C318(0.86)  LDD0779  [10]
 LDCM0463  CL70 HEK-293T C447(1.10)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C447(1.24)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C447(1.20)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C447(1.34)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C447(1.65)  LDD1065  [10]
 LDCM0469  CL76 PaTu 8988t C314(1.00); C318(1.00)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C314(1.01); C318(1.01)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C314(0.72); C318(0.72)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C314(0.80); C318(0.80)  LDD1351  [10]
 LDCM0473  CL8 HCT 116 C314(0.92); C318(0.92)  LDD0790  [10]
 LDCM0474  CL80 PaTu 8988t C314(1.07); C318(1.07)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C314(0.85); C318(0.85)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C314(0.91); C318(0.91)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C314(0.89); C318(0.89)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C314(0.85); C318(0.85)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C314(0.73); C318(0.73)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C314(0.85); C318(0.85)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C314(1.01); C318(1.01)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C314(0.82); C318(0.82)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C314(0.84); C318(0.84)  LDD1362  [10]
 LDCM0484  CL9 HCT 116 C314(1.08); C318(1.08)  LDD0801  [10]
 LDCM0485  CL90 PaTu 8988t C314(0.83); C318(0.83)  LDD1364  [10]
 LDCM0487  CL92 HEK-293T C447(0.93)  LDD1690  [11]
 LDCM0489  CL94 HEK-293T C223(0.89)  LDD1692  [11]
 LDCM0491  CL96 HEK-293T C447(1.10)  LDD1694  [11]
 LDCM0468  Fragment33 HEK-293T C447(1.66)  LDD1066  [10]
 LDCM0427  Fragment51 HCT 116 C447(1.39)  LDD0744  [10]
 LDCM0022  KB02 A-375 C447(1.95)  LDD2255  [12]
 LDCM0023  KB03 Jurkat C342(6.52)  LDD0209  [4]
 LDCM0024  KB05 NCI-N87 C223(2.18)  LDD3364  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C342(0.96)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C342(0.83)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C342(1.03)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C342(0.57)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C342(0.82)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C342(1.02)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C342(0.69)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C342(0.83)  LDD2127  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C342(1.22)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C342(1.50)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C342(0.57)  LDD2140  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C342(5.81)  LDD2143  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C342(0.95)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C342(3.13)  LDD2148  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein P1 (FOXP1) . Q9H334
Forkhead box protein P2 (FOXP2) . O15409

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840