Details of the Target

General Information of Target

Target ID LDTP08410
Target Name G-protein-signaling modulator 1 (GPSM1)
Gene Name GPSM1
Gene ID 26086
Synonyms
AGS3; G-protein-signaling modulator 1; Activator of G-protein signaling 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLL
RLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRV
HVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFF
NMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGA
GGPPEPQQQCQPGAS
Target Bioclass
Other
Family
GPSM family
Subcellular location
Cytoplasm, cytosol
Function
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Uniprot ID
Q86YR5
Ensemble ID
ENST00000291775.3
HGNC ID
HGNC:17858

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K117(8.33); K90(1.72)  LDD0277  [1]
HHS-465
 Probe Info  		Y150(5.49)  LDD2237  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C128(14.31); C129(14.31)  LDD0080  [4]
IA-alkyne
 Probe Info  		C28(0.00); C332(0.00); C497(0.00)  LDD0165  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NAIA_4
 Probe Info  		C497(0.00); C515(0.00)  LDD2226  [7]
VSF
 Probe Info  		C515(0.00); C670(0.00)  LDD0007  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
AOyne
 Probe Info  		13.80  LDD0443  [9]
NAIA_5
 Probe Info  		C332(0.00); C497(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C128(1.09); C332(1.09)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C128(0.87)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C128(1.25); C332(1.25)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C128(1.20); C332(1.20)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C128(1.20); C332(1.20)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C128(1.38); C332(1.38)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C128(1.50); C332(1.50)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C128(1.25); C332(1.25)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C128(1.39); C332(1.39)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C128(1.23); C332(1.23)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C128(1.09); C332(1.09)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C128(1.23); C332(1.23)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C128(0.92)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C128(2.38); C332(2.38)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C128(2.50); C332(2.50)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C128(2.00); C332(2.00)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C128(0.89)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C128(0.90)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C128(0.92)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C128(0.95)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C128(1.24)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C128(1.05)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C128(0.95)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C128(0.92)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C128(1.24)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C128(0.56)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C128(0.71)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C128(0.54)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C128(1.05)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C128(0.73)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C128(0.93)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C128(0.76)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C128(0.75); C129(0.75)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C128(0.78); C129(0.78)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C128(0.85); C129(0.85)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C128(0.82); C129(0.82)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C128(0.89); C129(0.89)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C128(0.89); C129(0.89)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C128(0.79); C129(0.79)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C128(0.89); C129(0.89)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C128(0.92); C129(0.92)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C128(0.78); C129(0.78)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C128(0.76); C129(0.76)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C128(0.94); C129(0.94)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C128(0.91)  LDD0857  [4]
 LDCM0260  AC140 HCT 116 C128(0.93); C129(0.93)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C128(0.93); C129(0.93)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C128(0.90); C129(0.90)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C128(0.98); C129(0.98)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C128(1.46); C129(1.46)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C128(1.91); C129(1.91)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C128(1.10); C129(1.10)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C128(1.06); C129(1.06)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C128(1.17); C129(1.17)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C128(0.93); C129(0.93)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C128(0.87)  LDD0868  [4]
 LDCM0271  AC150 PaTu 8988t C128(1.14); C129(1.14)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C128(1.00); C129(1.00)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C128(1.06); C129(1.06)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C128(1.14); C129(1.14)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C128(1.34); C129(1.34)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C128(1.12); C129(1.12)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C128(1.02); C129(1.02)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C128(1.09); C129(1.09)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C128(1.00)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C128(0.88)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C128(0.83)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C128(0.92); C332(0.92)  LDD0877  [4]
 LDCM0280  AC20 HCT 116 C128(0.93)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C128(0.82)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C128(0.93)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C128(0.78)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C128(1.10)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C128(1.06); C129(1.06)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C128(0.96); C129(0.96)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C128(1.06); C129(1.06)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C128(1.00); C129(1.00)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C128(1.02); C129(1.02)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C128(1.02); C332(1.02)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C128(1.02); C129(1.02)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C128(0.87); C129(0.87)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C128(0.94); C129(0.94)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C128(0.95); C129(0.95)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C128(0.87); C129(0.87)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C128(1.00); C129(1.00)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C128(0.96); C129(0.96)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C128(0.95); C129(0.95)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C128(0.84); C129(0.84)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C128(1.07); C129(1.07)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C128(0.78); C332(0.78)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C128(1.08); C129(1.08)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C128(1.94); C129(1.94)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C128(0.94); C129(0.94)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C128(1.11); C129(1.11)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C128(0.94); C129(0.94)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C128(1.06); C129(1.06)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C128(1.03); C129(1.03)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C128(1.05); C129(1.05)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C128(1.18); C129(1.18)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C128(1.02); C129(1.02)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C128(1.01); C332(1.01)  LDD0910  [4]
 LDCM0313  AC50 HCT 116 C128(1.27); C129(1.27)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C128(1.05); C129(1.05)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C128(0.95); C129(0.95)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C128(0.96); C129(0.96)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C128(1.17); C129(1.17)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C128(1.06); C129(1.06)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C128(1.47); C129(1.47)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C128(0.85); C129(0.89)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C128(0.94); C129(0.89)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C128(0.87); C129(0.84)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C128(0.93)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C128(0.90); C129(0.81)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C128(0.78); C129(0.76)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C128(0.74); C129(0.74)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C128(0.77); C129(0.80)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C128(0.79); C129(0.70)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C128(0.99); C129(0.69)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C128(0.81); C129(0.68)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C128(0.75); C129(0.69)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C128(1.00); C129(1.00)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C128(0.91); C129(0.91)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C128(0.96)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C128(0.85); C129(0.85)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C128(0.99); C129(0.99)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C128(0.86); C129(0.86)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C128(1.14); C129(1.14)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C128(0.97); C129(0.97)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C128(1.13); C129(1.13)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C128(0.79); C129(0.79)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C128(0.79); C129(0.79)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C128(0.72); C129(0.72)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C128(0.76); C129(0.76)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C128(0.94)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C128(0.69); C129(0.69)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C128(0.78); C129(0.78)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C128(0.98); C129(0.98)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C128(1.00); C129(1.00)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C128(0.92); C129(0.92)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C128(1.09); C129(1.09)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C128(1.05); C129(1.05)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C128(1.13); C129(1.13)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C128(0.93); C129(0.93)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C128(0.88); C129(0.88)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C128(1.00); C129(1.00)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C128(1.10); C129(1.10)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C128(0.97); C129(0.97)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C128(1.00); C129(1.00)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C128(0.85); C129(0.85)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C128(0.91); C129(0.91)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C128(1.20); C129(1.20)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C128(0.98); C129(0.98)  LDD1243  [4]
 LDCM0365  AC98 HEK-293T C128(1.48); C332(1.48)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C128(1.37); C332(1.37)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C128(0.85)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C128(0.99)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C128(0.64)  LDD0873  [4]
 LDCM0108  Chloroacetamide HeLa C129(0.00); C128(0.00)  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C497(0.66)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C128(1.32); C129(1.32)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C128(1.08); C129(1.08)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C128(0.88); C332(0.88)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C128(1.40)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C128(0.90)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C128(1.61)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C128(1.25)  LDD0971  [4]
 LDCM0374  CL105 HCT 116 C128(0.88)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C128(0.71)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C128(0.84)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C128(0.74)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C128(1.15)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C128(1.00); C129(1.00)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C128(0.91)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C128(0.80)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C128(0.87); C129(0.87)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C128(0.92); C129(0.92)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C128(0.93); C129(0.93)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C128(1.05); C129(1.05)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C128(0.88); C129(0.88)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C128(1.29); C129(1.29)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C128(0.72); C129(0.72)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C128(0.84); C129(0.84)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C128(1.12); C129(1.12)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C128(0.86); C129(0.86)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C128(2.15); C129(2.15)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C128(0.99); C129(0.99)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C128(1.37); C129(1.37)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C128(1.17); C129(1.17)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C128(0.85); C129(0.92)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C128(1.08); C129(1.01)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C128(0.91); C129(1.02)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C128(1.25); C129(1.02)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C128(1.05); C129(1.05)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C128(0.95); C129(0.95)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C128(1.03); C129(1.03)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C128(0.88); C129(0.88)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C128(0.85); C129(0.85)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C128(0.86); C129(0.86)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C128(1.04); C129(1.04)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C128(1.10); C129(1.10)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C128(0.93); C129(0.93)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C128(0.96); C129(0.96)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C128(1.01); C129(1.01)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C128(0.91); C129(0.91)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C128(0.98); C129(0.98)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C128(0.93); C129(0.93)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C128(1.01); C129(1.01)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C128(0.89); C129(0.89)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C128(0.80); C129(0.80)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C128(0.94); C129(0.94)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C128(0.85); C129(0.85)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C128(0.95); C129(0.95)  LDD1017  [4]
 LDCM0420  CL31 HCT 116 C128(0.69)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C128(0.96)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C128(1.23)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C128(1.16)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C128(1.23)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C128(1.24)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C128(1.24)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C128(1.10)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C128(1.04); C129(1.04)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C128(1.00)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C128(1.02)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C128(1.12)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C128(1.03)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C128(1.05)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C128(0.99)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C128(0.86); C129(0.86)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C128(0.99); C129(0.99)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C128(0.91); C129(0.91)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C128(0.94); C129(0.94)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C128(1.06); C129(1.06)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C128(0.90); C129(0.90)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C128(0.76); C129(0.76)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C128(0.86); C129(0.86)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C128(0.80); C129(0.80)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C128(0.68); C129(0.68)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C128(0.69); C129(0.69)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C128(0.82); C129(0.82)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C128(0.82); C129(0.82)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C128(0.76); C129(0.76)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C128(0.83); C129(0.83)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C128(0.97); C129(0.97)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C128(0.70); C129(0.70)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C128(0.93); C129(0.93)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C128(0.86); C129(0.86)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C128(0.79); C129(0.79)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C128(0.81); C129(0.81)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C128(0.76); C129(0.76)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C128(0.83); C129(0.83)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C128(0.71); C129(0.71)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C128(0.84); C129(0.84)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C128(1.40); C129(1.40)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C128(1.09); C129(1.09)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C128(0.90); C129(0.90)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C128(0.93); C129(0.93)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C128(1.00); C129(1.00)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C128(0.68); C129(0.68)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C128(0.79); C129(0.79)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C129(1.40)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C129(1.46)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C129(1.65)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C129(1.35)  LDD1070  [4]
 LDCM0473  CL8 HCT 116 C128(1.25); C129(1.25)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C129(1.28)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C129(1.44)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C129(1.07)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C129(1.08)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C129(1.77)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C129(1.04)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C129(1.70)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C129(1.23)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C129(1.34)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C129(1.31)  LDD1081  [4]
 LDCM0484  CL9 HCT 116 C128(0.98); C129(0.98)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C129(1.49)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C128(0.72); C332(0.72)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C128(0.90); C332(0.90)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C128(0.84); C332(0.84)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C128(1.16); C332(1.16)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C128(1.34); C332(1.34)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C128(0.95); C332(0.95)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C128(0.90); C332(0.90)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C128(0.96); C332(0.96)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C128(1.14); C332(1.14)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C497(1.25)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C128(0.79); C129(0.79)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C128(1.28)  LDD0744  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C128(14.31); C129(14.31)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C128(2.66); C129(2.66)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C128(5.40); C129(5.40)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
DDB1- and CUL4-associated factor 11 (DCAF11) . Q8TEB1
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Chorion-specific transcription factor GCMb (GCM2) . O75603
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM83A (FAM83A) FAM83 family Q86UY5
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tektin-4 (TEKT4) Tektin family Q8WW24
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402