Details of the Target

General Information of Target

Target ID LDTP08323
Target Name Lon protease homolog 2, peroxisomal (LONP2)
Gene Name LONP2
Gene ID 83752
Synonyms
LONP; Lon protease homolog 2, peroxisomal; EC 3.4.21.53; Lon protease-like protein 2; Lon protease 2; Peroxisomal Lon protease; pLon
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSVSPIQIPSRLPLLLTHEGVLLPGSTMRTSVDSARNLQLVRSRLLKGTSLQSTILGVI
PNTPDPASDAQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLITGLCRFQIVQVLKEKPYP
IAEVEQLDRLEEFPNTCKMREELGELSEQFYKYAVQLVEMLDMSVPAVAKLRRLLDSLPR
EALPDILTSIIRTSNKEKLQILDAVSLEERFKMTIPLLVRQIEGLKLLQKTRKPKQDDDK
RVIAIRPIRRITHISGTLEDEDEDEDNDDIVMLEKKIRTSSMPEQAHKVCVKEIKRLKKM
PQSMPEYALTRNYLELMVELPWNKSTTDRLDIRAARILLDNDHYAMEKLKKRVLEYLAVR
QLKNNLKGPILCFVGPPGVGKTSVGRSVAKTLGREFHRIALGGVCDQSDIRGHRRTYVGS
MPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHNFTDHYLNVAF
DLSQVLFIATANTTATIPAALLDRMEIIQVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQ
IQIPQVTTLDIITRYTREAGVRSLDRKLGAICRAVAVKVAEGQHKEAKLDRSDVTEREGC
REHILEDEKPESISDTTDLALPPEMPILIDFHALKDILGPPMYEMEVSQRLSQPGVAIGL
AWTPLGGEIMFVEASRMDGEGQLTLTGQLGDVMKESAHLAISWLRSNAKKYQLTNAFGSF
DLLDNTDIHLHFPAGAVTKDGPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPV
GGIKDKVLAAHRAGLKQVIIPRRNEKDLEGIPGNVRQDLSFVTASCLDEVLNAAFDGGFT
VKTRPGLLNSKL
Target Bioclass
Enzyme
Family
Peptidase S16 family
Subcellular location
Peroxisome matrix
Function
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {|HAMAP-Rule:MF_03121}.
Uniprot ID
Q86WA8
Ensemble ID
ENST00000285737.9
HGNC ID
HGNC:20598

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G428V DBIA    Probe Info 
CCK81 SNV: p.R43W DBIA    Probe Info 
COLO792 SNV: p.R705C DBIA    Probe Info 
DU145 SNV: p.G512V DBIA    Probe Info 
EFO21 SNV: p.I251L DBIA    Probe Info 
EGI1 SNV: p.D185H DBIA    Probe Info 
HELA SNV: p.D65A .
JURKAT SNV: p.D203N Compound 10    Probe Info 
MCC13 Substitution: p.P61F DBIA    Probe Info 
NCIH716 SNV: p.A697P .
OPM2 SNV: p.R562H DBIA    Probe Info 
OVK18 Insertion: p.G639WfsTer6
SNV: p.E208D		 DBIA    Probe Info 
PC9 SNV: p.D342E .
RKO SNV: p.S383N DBIA    Probe Info 
SHP77 SNV: p.R43W DBIA    Probe Info 
SNU449 Deletion: p.K739RfsTer5 DBIA    Probe Info 
YSCCC Insertion: . .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C137(2.17)  LDD0171  [1]
DBIA
 Probe Info  		C372(0.49)  LDD0533  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C372(0.00); C751(0.00)  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
ENE
 Probe Info  		N.A.  LDD0006  [6]
TFBX
 Probe Info  		C405(0.00); C137(0.00)  LDD0148  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		12.40  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.04  LDD1752  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C137(2.17)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C137(0.97)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C137(1.00)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C372(0.49)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C372(0.51)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C372(0.57)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C372(0.41)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C372(0.43)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C372(0.46)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C372(0.43)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C372(0.38)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C372(0.53)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C372(0.48)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C137(0.97); C405(1.00)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C372(0.50)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C372(0.54)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C372(0.45)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C137(1.02)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C137(1.08)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C137(1.05)  LDD1513  [11]
 LDCM0276  AC17 HCT 116 C137(1.00)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C137(1.34)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C137(1.19)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C137(0.93)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C137(1.03)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C137(1.18)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C137(1.06)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C137(1.27)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C137(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C137(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C137(0.96)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C137(0.91)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C137(0.91)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C137(0.96)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C137(1.00); C405(0.96)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C137(0.92)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C137(1.02)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C137(0.85)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C137(0.79)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C137(0.83)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C372(1.00)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C372(1.02)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C372(1.00)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C372(1.05)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C372(0.99)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C137(1.01)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C372(0.98)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C372(1.03)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C372(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C372(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C372(1.16)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C372(1.04)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C137(1.00)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C137(1.03)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C137(0.97)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C137(1.01)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C137(0.95)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C137(0.93)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C137(1.01); C405(1.01)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C137(0.98)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C137(0.95)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C137(0.98)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C137(1.06)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C137(1.02)  LDD1558  [11]
 LDCM0320  AC57 HCT 116 C372(0.65)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C372(0.62)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C372(0.64)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C137(0.89)  LDD1562  [11]
 LDCM0324  AC60 HCT 116 C372(0.66)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C372(0.76)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C372(0.62)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C372(0.62)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C372(0.67)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C372(0.81)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C372(0.81)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C372(0.63)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C137(0.41)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C137(0.48)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C137(1.05)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C137(0.79)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C137(0.58)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C137(0.72)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C137(0.59)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C137(0.54)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C137(0.46)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C137(0.63)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C137(0.59)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C137(0.53)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C137(0.63)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C137(1.10)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C137(0.54)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C137(0.93)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C137(0.71)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C372(0.31)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C372(0.50)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C137(1.04)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C137(1.03)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C137(1.17)  LDD1514  [11]
 LDCM0367  CL1 HEK-293T C137(0.85)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C137(1.73)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C137(1.31); C405(0.85)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C137(0.89)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C137(1.03)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C137(1.05)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C137(1.42); C405(0.88)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C137(1.28)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C137(1.55)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C137(2.08)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C137(1.62)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C137(1.31)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C137(1.55)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C137(1.69)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C137(1.21)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C137(0.83)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C137(0.86)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C137(1.22)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C137(1.05)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C137(1.00)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C372(1.02)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C372(1.05)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C372(0.90)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C137(1.00)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C372(1.02)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C137(1.07)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C137(0.96)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C137(1.15)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C137(1.08); C405(0.97)  LDD1599  [11]
 LDCM0396  CL125 HCT 116 C372(0.98)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C372(0.75)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C372(0.74)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C372(0.66)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C137(0.99)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C137(1.00)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C137(1.10)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C372(0.78)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C372(0.74)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C372(0.65)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C372(0.76)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C137(1.00)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C372(0.65)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C372(0.65)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C372(0.64)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C372(0.62)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C372(0.64)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C372(0.60)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C372(0.60)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C372(0.70)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C372(0.61)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C372(0.62)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C137(0.88)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C372(0.68)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C137(1.25); C405(1.09)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C137(1.42)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C137(1.41)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C137(1.39)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C137(1.55)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C137(1.01)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C137(0.91)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C137(1.10)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C137(1.37); C405(1.08)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C137(1.29); C405(0.99)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C137(1.21)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C137(1.09)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C137(1.21); C405(1.05)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C137(1.24)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C137(1.51)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C137(1.19); C372(1.03)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C137(0.94); C372(0.98)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C137(0.95); C372(1.17)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C137(1.14); C372(0.99)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C137(1.06)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C137(0.83); C372(1.13)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C137(1.04); C372(1.09)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C137(0.97); C372(0.98)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C137(0.82); C372(1.08)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C137(0.83); C372(0.95)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C137(0.97); C372(1.03)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C137(0.76); C372(1.10)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C137(0.76); C372(1.00)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C137(1.01); C372(1.03)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C137(0.84); C372(0.99)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C137(1.14)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C137(0.78); C372(1.08)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C372(1.03)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C372(0.90)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C372(0.78)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C372(0.73)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C372(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C372(0.85)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C372(0.73)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C372(0.80)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C372(0.87)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C137(1.23); C405(1.11)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C372(0.79)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C372(0.87)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C372(1.11)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C372(0.90)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C372(0.83)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C137(1.02)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C137(0.96)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C137(1.37)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C137(0.96)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C137(1.38)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C137(0.99)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C137(1.00)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C137(1.04)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C137(0.98)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C137(0.97)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C137(1.00)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C137(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C137(1.06)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C137(1.13)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C137(1.02)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C137(1.37)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C137(1.89)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C137(1.08); C405(0.97)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C137(1.13)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C137(1.17)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C137(1.24)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C137(1.28)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C137(1.18)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C137(0.91)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C137(1.01)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C137(0.86)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C137(0.97)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C137(0.80)  LDD1702  [12]
 LDCM0468  Fragment33 HCT 116 C372(0.84)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C137(0.87)  LDD1631  [11]
 LDCM0022  KB02 22RV1 C137(3.00); C372(1.77); C405(2.17)  LDD2243  [13]
 LDCM0023  KB03 22RV1 C137(3.71); C372(3.34); C405(3.12)  LDD2660  [13]
 LDCM0024  KB05 COLO792 C137(2.37); C372(2.02)  LDD3310  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Radial spoke head protein 9 homolog (RSPH9) Flagellar radial spoke RSP9 family Q9H1X1
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840