Details of the Target

General Information of Target

Target ID LDTP07231
Target Name Ubiquitin thioesterase OTU1 (YOD1)
Gene Name YOD1
Gene ID 55432
Synonyms
DUBA8; HIN7; OTUD2; Ubiquitin thioesterase OTU1; EC 3.4.19.12; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVL
QGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLII
EEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAP
EMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVD
TQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALEL
ADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.
TTD ID
T65084
Uniprot ID
Q5VVQ6
DrugMap ID
TTFSH0K
Ensemble ID
ENST00000315927.9
HGNC ID
HGNC:25035
ChEMBL ID
CHEMBL4630833

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RL952 Deletion: p.S288del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(0.80)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
MPP-AC
 Probe Info  		N.A.  LDD0428  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C97(2.04)  LDD0372  [4]
 LDCM0214  AC1 HCT 116 C210(0.80)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C210(0.95)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C210(0.88)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C210(0.74)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C210(0.77)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C210(0.75)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C210(0.93)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C210(0.77)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C210(0.72)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C210(0.78)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C210(0.86)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C210(1.09)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C210(0.96)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C210(0.80)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C210(0.72)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C210(0.77)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C210(0.92)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C210(0.86)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C210(0.88)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C210(1.02)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C210(0.91)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C210(0.91)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C210(0.83)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C210(0.84)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C210(0.75)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C210(1.00)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C210(0.95)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C210(1.08)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C210(1.07)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C210(1.05)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C210(0.99)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C210(0.95)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C210(0.90)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C210(1.08)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C210(0.96)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C210(0.89)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C210(0.92)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C210(1.08)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C210(1.02)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C210(1.04)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C210(1.00)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C210(1.07)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C210(0.93)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C210(0.99)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C210(0.75)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C210(1.26)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C210(1.34)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C210(1.03)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C210(0.62)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C210(1.06)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C210(1.03)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C210(0.60)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C210(1.06)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C210(0.53)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C210(0.65)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C210(0.95)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C210(0.96)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C210(0.86)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C210(0.76)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C210(0.45)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C210(0.82)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C210(0.60)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C210(0.78)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C210(0.56)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C210(1.33)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C210(1.16)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C210(1.28)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C210(0.81)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C210(1.20)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C210(1.19)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C210(1.15)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C210(1.32)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C210(1.33)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C210(0.92)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C210(0.76)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C210(0.79)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C210(0.85)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C210(0.68)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C210(0.82)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C210(0.61)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C210(0.95)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C210(0.64)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C210(0.70)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C210(0.71)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C210(1.20)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C210(0.89)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C210(0.98)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C210(0.84)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C210(1.10)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C210(1.24)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C210(0.86)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C210(0.76)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C210(0.92)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C210(0.74)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C210(1.08)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C210(1.00)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C210(0.73)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C210(0.89)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C210(0.89)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C210(0.77)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C210(1.08)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C210(0.87)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C210(1.05)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C210(0.88)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C210(0.72)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C210(1.10)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C210(0.56)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C210(0.71)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C210(1.15)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C210(1.25)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C210(0.78)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C210(0.99)  LDD0921  [1]
 LDCM0324  AC60 HCT 116 C210(0.61)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C210(1.01)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C210(0.75)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C210(0.75)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C210(0.80)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C210(0.80)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C210(1.11)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C210(0.62)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C210(0.90)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C210(1.08)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C210(1.13)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C210(0.87)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C210(1.22)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C210(0.88)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C210(0.83)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C210(1.22)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C210(0.89)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C210(1.19)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C210(0.89)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C210(0.93)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C210(0.92)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C210(0.81)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C210(1.12)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C210(1.05)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C210(1.02)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C210(1.08)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C210(1.15)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C210(1.06)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C210(1.02)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C210(1.12)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C210(1.12)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C210(1.11)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C210(1.08)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C210(1.20)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C210(1.20)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C210(1.27)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C210(1.20)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C210(1.54)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C210(1.31)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C210(2.06)  LDD0962  [1]
 LDCM0365  AC98 HCT 116 C210(0.66)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C210(0.77)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C210(0.88)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C210(0.98)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C210(0.73)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C210(0.76)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C210(0.70)  LDD0966  [1]
 LDCM0369  CL100 HCT 116 C210(0.71)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C210(0.96)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C210(0.73)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C210(1.18)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C210(1.43)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C210(1.23)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C210(1.63)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C210(1.13)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C210(1.58)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C210(0.97)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C210(1.14)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C210(1.48)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C210(0.96)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C210(0.85)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C210(0.71)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C210(0.57)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C210(0.65)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C210(0.66)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C210(0.93)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C210(0.85)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C210(0.87)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C210(0.96)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C210(0.80)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C210(0.62)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C210(0.76)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C210(0.90)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C210(0.77)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C210(0.80)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C210(0.84)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C210(0.72)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C210(1.13)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C210(1.63)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C210(0.91)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C210(0.91)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C210(0.62)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C210(1.53)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C210(1.08)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C210(1.14)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C210(0.89)  LDD1005  [1]
 LDCM0408  CL20 HCT 116 C210(1.11)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C210(1.56)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C210(1.11)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C210(0.77)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C210(0.90)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C210(0.73)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C210(0.67)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C210(1.13)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C210(0.74)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C210(1.03)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C210(0.91)  LDD1016  [1]
 LDCM0419  CL30 HCT 116 C210(0.93)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C210(1.02)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C210(0.99)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C210(0.92)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C210(1.05)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C210(1.02)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C210(0.98)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C210(1.00)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C210(1.14)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C210(0.88)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C210(1.13)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C210(1.18)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C210(1.36)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C210(1.33)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C210(1.19)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C210(1.32)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C97(1.01); C160(1.25); C320(0.74)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C97(0.91); C160(1.24)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C97(0.96); C320(0.97)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C97(0.98); C210(0.80); C160(1.07)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C210(0.96)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C160(1.38); C320(0.90)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C97(1.08); C160(1.02); C320(0.87)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C97(0.98); C210(1.17)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C97(0.90); C210(1.15); C160(0.81)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C97(0.83); C210(0.97); C160(0.87); C320(1.17)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C97(0.95); C210(1.11); C160(1.04); C320(0.89)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C97(1.17); C210(1.20); C160(1.00)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C97(1.13); C160(1.22); C320(0.86)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C97(0.96); C160(1.25)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C210(0.76)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C97(0.87); C320(0.93)  LDD1655  [5]
 LDCM0453  CL61 HCT 116 C210(0.72)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C210(0.69)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C210(0.67)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C210(0.74)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C210(0.92)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C210(0.96)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C210(0.89)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C210(0.67)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C210(0.63)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C210(1.85)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C210(0.76)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C210(0.76)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C210(0.64)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C210(0.74)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C210(0.82)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C210(0.91)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C210(0.89)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C210(0.86)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C210(1.00)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C210(0.83)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C210(0.85)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C210(0.92)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C210(1.05)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C210(1.07)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C210(0.74)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C210(0.81)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C210(0.75)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C210(0.93)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C210(0.89)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C210(0.86)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C210(0.84)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C210(0.76)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C210(0.97)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C210(1.14)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C210(1.37)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C210(0.74)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C210(1.19)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C210(0.98)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C210(0.83)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C210(0.79)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C210(0.88)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C97(1.08); C210(1.12); C160(0.97); C320(0.83)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C210(0.63)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C210(1.29)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C97(1.03); C320(0.94)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C97(0.86); C320(1.02)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C97(1.05); C320(0.92)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Proteasome subunit alpha type-7 (PSMA7) Peptidase T1A family O14818
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
E3 ubiquitin-protein ligase makorin-1 (MKRN1) . Q9UHC7
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-box transcription factor TBX22 (TBX22) . Q9Y458
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
Neugrin (NGRN) Neugrin family Q9NPE2
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
DAZ-associated protein 2 (DAZAP2) . Q15038
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Spartin (SPART) . Q8N0X7
UBX domain-containing protein 6 (UBXN6) . Q9BZV1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402