Details of the Target

General Information of Target

Target ID LDTP07084
Target Name Tumor protein p63-regulated gene 1-like protein (TPRG1L)
Gene Name TPRG1L
Gene ID 127262
Synonyms
FAM79A; MOVER; Tumor protein p63-regulated gene 1-like protein; Mossy fiber terminal-associated vertebrate-specific presynaptic protein; Protein FAM79A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQLRDSVDSAGTSPTAVLAAGEEVGAGGGPGGGRPGAGTPLRQTLWPLSIHDPTRRARV
KEYFVFRPGSIEQAVEEIRVVVRPVEDGEIQGVWLLTEVDHWNNEKERLVLVTEQSLLIC
KYDFISLQCQQVVRIALNAVDTISYGEFQFPPKSLNKREGFGIRIQWDKQSRPSFINRWN
PWSTNVPYATFTEHPMAGADEKTASLCQLESFKALLIQAVKKAQKESPLPGQANGVLILE
RPLLIETYVGLMSFINNEAKLGYSMTRGKIGF
Target Bioclass
Other
Family
TPRG1 family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.
Uniprot ID
Q5T0D9
Ensemble ID
ENST00000344579.5
HGNC ID
HGNC:27007

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.H101R DBIA    Probe Info 
NCIH196 SNV: p.E105Q .
SW1116 Substitution: p.L111G .
WM1552C SNV: p.G12A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C207(1.76)  LDD2119  [1]
IPM
 Probe Info  		C207(2.50)  LDD1702  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C207(0.94)  LDD0625  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C207(1.03); C129(1.19); C120(0.96)  LDD1507  [7]
 LDCM0215  AC10 PaTu 8988t C207(0.85)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C207(0.76)  LDD1105  [3]
 LDCM0237  AC12 PaTu 8988t C207(0.49)  LDD1116  [3]
 LDCM0246  AC128 PaTu 8988t C207(0.91)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C207(0.73)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C207(0.78)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C207(0.81)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C207(0.91)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C207(0.47)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C207(0.55)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C207(0.44)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C207(0.64)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C207(0.50)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C207(0.70)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C207(0.70)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C207(1.24)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C207(0.84)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C207(0.84)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C207(0.73)  LDD1141  [3]
 LDCM0263  AC143 PaTu 8988t C207(0.84)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C207(0.93)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C207(0.84)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C207(1.01)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C207(0.95)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C207(0.81)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C207(0.89)  LDD1148  [3]
 LDCM0270  AC15 PaTu 8988t C207(1.08)  LDD1149  [3]
 LDCM0271  AC150 PaTu 8988t C207(1.00)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C207(0.95)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C207(0.97)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C207(0.86)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C207(0.87)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C207(0.87)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C207(0.95)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C207(1.03)  LDD2169  [3]
 LDCM0276  AC17 PaTu 8988t C207(0.76)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C207(0.52)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C207(0.68)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C207(1.09)  LDD1518  [7]
 LDCM0280  AC20 PaTu 8988t C207(0.70)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C207(0.49)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C207(0.47)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C207(0.53)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C207(0.61)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C207(0.93); C129(1.05); C120(1.01)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C207(1.11)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C207(1.00)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C207(0.95)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C129(1.07)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C207(1.01)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C207(1.02); C129(1.03)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C207(1.01)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C207(1.00); C129(1.19)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C207(0.99); C129(1.16); C120(1.04)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C207(1.07)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C207(0.99)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C207(0.94)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C129(1.05)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C207(1.16); C129(1.29)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C207(0.99)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C207(0.94)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C207(1.11); C129(1.25)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C207(0.94); C129(1.19); C120(0.94)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C207(0.98)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C207(0.98)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C207(0.89)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C129(1.06)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C207(0.94)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C207(0.92)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C207(1.02)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C207(0.53)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C129(1.03)  LDD1551  [7]
 LDCM0313  AC50 HCT 116 C207(0.60)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C207(1.19)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C207(0.98)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C207(0.73)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C207(0.73)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C207(0.57)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C207(0.43)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C207(0.52)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C207(0.55)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C207(1.44)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C207(0.80)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C207(0.73)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C207(0.67)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C207(0.68)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C207(0.76)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C207(0.58)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C207(0.85)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C207(1.03)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C207(0.47)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C207(0.93)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C207(0.57)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C207(0.95)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C207(0.44)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C207(1.13)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C207(0.81)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C207(0.36)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C207(0.39)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C207(0.33)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C207(0.64)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C207(0.63)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C207(0.92)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C207(0.89)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C207(1.06)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C207(0.68)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C207(0.80)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C207(0.31)  LDD0665  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C207(1.11)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C207(0.60)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C207(0.74)  LDD1154  [3]
 LDCM0367  CL1 HEK-293T C207(1.07)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C207(0.92); C129(1.45)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C207(0.98); C129(0.96)  LDD1573  [7]
 LDCM0370  CL101 PaTu 8988t C207(0.82)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C207(0.86)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C207(0.59)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C207(0.89)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C207(0.76)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C207(0.63)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C207(0.78)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C207(0.76)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C207(0.73)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C207(0.97)  LDD1583  [7]
 LDCM0380  CL110 PaTu 8988t C207(0.69)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C207(0.48)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C207(0.98); C129(0.99)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C207(1.08)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C207(0.95)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C207(1.03); C129(0.97)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C207(1.02); C129(1.14)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C207(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C207(0.98)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C207(1.09); C129(1.15)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C207(1.05); C129(1.60)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C207(0.98); C129(1.18)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C207(0.60)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C207(0.79)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C207(0.72)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C207(0.67)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C207(0.52)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C207(0.80)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C207(1.53)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C207(0.92)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C207(1.04)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C207(1.00)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C207(1.08); C129(1.13)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C207(0.81)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C207(0.71)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C207(0.65)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C207(0.71)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C207(1.05)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C207(0.73)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C207(0.46)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C207(0.31)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C207(0.63)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C207(0.51)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C207(0.57)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C207(0.71)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C207(0.85)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C207(0.59)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C207(0.58)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C207(1.08); C129(1.01)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C207(0.77)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C207(0.83)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C207(0.67)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C207(1.17)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C207(0.62)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C207(0.64)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C207(0.75)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C207(0.45)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C207(0.64)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C207(0.89); C129(1.20)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C207(0.60)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C207(0.73)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C207(0.35)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C207(0.45)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C207(0.72)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C207(0.54)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C207(1.10); C129(1.30)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C207(1.07)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C207(1.09); C129(1.24)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C207(1.12)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C207(1.07); C129(1.19); C120(0.97)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C207(1.03)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C207(1.02); C129(1.09)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C207(1.01); C129(1.53); C120(0.95)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C207(1.06)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C207(1.02)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C207(1.03)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C129(1.41)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C207(1.26); C129(1.91)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C207(0.97)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C207(1.05)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C207(1.01); C129(1.49)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C207(1.02)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C207(1.02)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C207(1.04); C129(0.97)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C207(1.02); C129(1.34)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C207(0.94); C129(1.06); C120(1.07)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C207(1.03)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C207(1.03)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C207(1.03)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C129(1.28)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C207(1.09)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C207(1.09); C129(1.68)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C207(1.09)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C207(0.96); C129(1.19)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C207(1.13)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C207(0.93)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C207(1.03); C129(1.19)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C207(0.98); C129(2.17); C120(0.98)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C207(1.09)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C207(1.07)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C207(0.87)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C207(1.10)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C129(1.29)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C207(1.12); C129(1.51)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C207(1.04)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C207(0.95); C129(1.29)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C207(1.03)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C207(1.01)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C207(1.06); C129(0.90)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C207(0.96); C129(1.10)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C207(1.01); C129(1.12); C120(0.95)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C129(1.54)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C207(1.08)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C207(1.12)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C207(1.02)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C129(1.30)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C207(1.10); C129(1.39)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C207(0.96)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C207(0.98); C129(1.30)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C207(0.98)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C207(1.00)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C207(1.01); C129(1.01)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C207(1.02); C129(1.05)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C207(2.50)  LDD1702  [1]
 LDCM0625  F8 Ramos C207(1.08)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C207(0.93)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C207(0.47)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C207(0.92)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C207(0.97)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C207(0.55)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C207(1.09)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C207(0.90)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C207(0.56)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C207(0.94)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C207(0.72)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C207(0.89)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C207(0.72)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C207(0.93)  LDD2201  [8]
 LDCM0468  Fragment33 HEK-293T C207(0.96); C129(0.99)  LDD1671  [7]
 LDCM0596  Fragment38 Ramos C207(0.76)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C207(0.97)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C207(0.44)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C207(1.17)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C207(1.38)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C207(0.96)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C207(1.08)  LDD2188  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C207(0.90); C129(0.88)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C207(0.95); C129(0.93)  LDD1497  [7]
 LDCM0024  KB05 MOLM-16 C207(1.77)  LDD3334  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C207(1.76)  LDD2119  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C207(1.16)  LDD2123  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C207(1.22)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C207(0.93)  LDD2136  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840