Details of the Target

General Information of Target

Target ID LDTP06856
Target Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)
Gene Name PLCH1
Gene ID 23007
Synonyms
KIAA1069; PLCL3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; EC 3.1.4.11; Phosphoinositide phospholipase C-eta-1; Phospholipase C-eta-1; PLC-eta-1; Phospholipase C-like protein 3; PLC-L3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE
KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI
TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR
RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL
KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD
MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG
YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS
VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN
GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG
KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE
LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY
RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP
FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR
VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY
LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS
SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT
TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLN
FNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCP
SKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEG
NRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALI
GQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIA
LSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPT
KGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREG
TSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGA
GFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTS
EDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQV
LYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPS
APTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPS
SDDKPEIYFLLRL
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Uniprot ID
Q4KWH8
Ensemble ID
ENST00000334686.6
HGNC ID
HGNC:29185

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K61(1.89)  LDD0277  [1]
Probe 1
 Probe Info  		Y566(7.42)  LDD3495  [2]
DBIA
 Probe Info  		C1074(3.83); C1079(3.83)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
AOyne
 Probe Info  		12.40  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1074(0.94); C1079(0.98)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C1074(1.01); C1079(0.97)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C1074(0.83); C1079(0.83)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1074(0.78); C1079(0.78)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1074(0.87); C1079(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1074(1.34); C1079(1.34)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1074(0.96); C1079(0.96)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1074(1.02); C1079(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1074(0.90); C1079(0.90)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1074(0.94); C1079(1.02)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1074(0.87); C1079(0.74)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1074(0.72); C1079(0.75)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C1074(1.15); C1079(1.15)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C1074(0.76); C1079(0.88)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1074(0.85); C1079(0.78)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1074(0.93); C1079(0.94)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C1074(1.07); C1079(1.16)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C1074(1.01); C1079(1.10)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C1074(0.95); C1079(0.95)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C1074(1.06); C1079(0.92)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C1074(0.96); C1079(0.88)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C1074(0.98); C1079(0.87)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C1074(1.10); C1079(0.93)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C1074(1.11); C1079(1.14)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C1074(1.07); C1079(1.04)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C1074(1.30); C1079(1.19)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C1074(1.29); C1079(1.02)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C1074(1.29); C1079(1.10)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C1074(1.33); C1079(1.41)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C1074(1.10); C1079(1.00)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C1074(1.55); C1079(1.34)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C1074(1.50); C1079(1.16)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C1074(1.00); C1079(1.00)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1074(0.75); C1079(0.75)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1074(0.98); C1079(0.98)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1074(0.87); C1079(0.87)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1074(0.64); C1079(0.64)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1074(0.81); C1079(0.81)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1074(0.86); C1079(0.86)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1074(0.80); C1079(0.80)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1074(0.74); C1079(0.74)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1074(0.66); C1079(0.66)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1074(0.66); C1079(0.66)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1074(0.68); C1079(0.68)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C1074(1.13); C1079(1.04)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C1074(0.75); C1079(0.75)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1074(0.71); C1079(0.71)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1074(0.79); C1079(0.79)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1074(1.34); C1079(1.34)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1074(1.39); C1079(1.39)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1074(1.43); C1079(1.43)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1074(1.90); C1079(1.90)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1074(1.57); C1079(1.57)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1074(2.08); C1079(2.08)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1074(2.00); C1079(2.00)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C1074(1.15); C1079(1.09)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C1074(1.81); C1079(1.81)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1074(1.41); C1079(1.41)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1074(2.00); C1079(2.00)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1074(2.75); C1079(2.75)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1074(1.60); C1079(1.60)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1074(2.20); C1079(2.20)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1074(1.32); C1079(1.32)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1074(2.22); C1079(2.22)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1074(1.39); C1079(1.39)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1074(2.18); C1079(2.18)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1074(1.70); C1079(1.70)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C1074(1.33); C1079(1.29)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C1074(1.19); C1079(1.19)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1074(1.50); C1079(1.50)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1074(1.54); C1079(1.54)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1074(1.01); C1079(1.01)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1074(1.31); C1079(1.31)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1074(0.84); C1079(0.84)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1074(1.07); C1079(1.07)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1074(1.15); C1079(1.15)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1074(1.09); C1079(1.09)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1074(1.26); C1079(1.26)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C1074(0.97); C1079(0.92)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C1074(1.22); C1079(1.22)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1074(0.75); C1079(0.75)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1074(1.29); C1079(1.29)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1074(1.54); C1079(1.54)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1074(1.42); C1079(1.42)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C1074(1.12); C1079(1.12)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C1074(1.11); C1079(1.11)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C1074(0.93); C1079(0.93)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C1074(1.32); C1079(1.32)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C1074(1.12); C1079(1.12)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C1074(0.89); C1079(0.88)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C1074(1.24); C1079(1.24)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C1074(1.07); C1079(1.07)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C1074(0.87); C1079(0.87)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C1074(1.24); C1079(1.24)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C1074(0.91); C1079(0.91)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C1074(1.36); C1079(1.36)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C1074(0.81); C1079(1.24)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C1074(0.91); C1079(1.17)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C1074(0.97); C1079(1.26)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C1074(1.05); C1079(1.09)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C1074(1.03); C1079(1.08)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C1074(1.08); C1079(1.35)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C1074(1.39); C1079(1.69)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C1074(1.20); C1079(1.58)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C1074(1.48); C1079(1.68)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C1074(1.22); C1079(1.42)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C1074(1.19); C1079(1.30)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C1074(0.98); C1079(1.37)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C1074(0.94); C1079(0.94)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C1074(1.11); C1079(1.11)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1074(1.18); C1079(1.18)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C1074(0.97); C1079(0.77)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C1074(1.01); C1079(1.01)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1074(0.96); C1079(0.96)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1074(1.23); C1079(1.23)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1074(1.05); C1079(1.05)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1074(1.36); C1079(1.36)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1074(0.69); C1079(0.69)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1074(0.63); C1079(0.63)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1074(0.92); C1079(0.92)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1074(1.01); C1079(1.01)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1074(1.07); C1079(1.07)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C1074(1.04); C1079(0.92)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C1074(1.15); C1079(1.15)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1074(0.84); C1079(0.84)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1074(1.30); C1079(1.30)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1074(1.84); C1079(1.84)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1074(1.56); C1079(1.56)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1074(2.33); C1079(2.33)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1074(1.37); C1079(1.37)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1074(1.29); C1079(1.29)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1074(1.08); C1079(1.08)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1074(1.00); C1079(1.00)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C1074(1.10); C1079(1.04)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C1074(1.34); C1079(1.34)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1074(1.16); C1079(1.16)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1074(2.08); C1079(2.08)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1074(2.07); C1079(2.07)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1074(1.59); C1079(1.59)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C1074(1.39); C1079(1.39)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1074(1.33); C1079(1.33)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1074(1.15); C1079(1.15)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1074(1.37); C1079(1.37)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1074(1.87); C1079(1.87)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C1074(0.92); C1079(0.92)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1074(2.00); C1079(2.00)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1074(2.01); C1079(2.01)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1074(1.40); C1079(1.40)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1074(1.60); C1079(1.60)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C1074(1.29); C1079(1.29)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1074(1.89); C1079(1.89)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1074(2.26); C1079(2.26)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1074(1.69); C1079(1.69)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1074(0.71); C1079(0.71)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C1074(1.01); C1079(0.94)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C1074(1.16); C1079(1.08)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C1074(1.20); C1079(1.17)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C1074(0.94); C1079(0.94)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1074(1.51); C1079(1.51)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C1074(1.33); C1079(1.02)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C1074(1.48); C1079(1.14)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C1074(2.29); C1079(1.58)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C1074(1.18); C1079(1.00)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C1074(1.16); C1079(0.93)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C1074(1.48); C1079(1.48)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1074(1.73); C1079(1.73)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1074(1.31); C1079(1.31)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1074(1.41); C1079(1.41)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1074(1.88); C1079(1.88)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C1074(1.31); C1079(1.31)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C1074(1.88); C1079(1.88)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1074(1.36); C1079(1.36)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1074(0.90); C1079(0.90)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1074(1.44); C1079(1.44)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1074(0.82); C1079(0.82)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1074(2.75); C1079(2.75)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1074(0.81); C1079(0.81)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C1074(1.05); C1079(1.05)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C1074(0.85); C1079(0.85)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C1074(0.80); C1079(0.80)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C1074(1.81); C1079(1.81)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C1074(0.98); C1079(0.98)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C1074(1.23); C1079(1.31)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C1074(1.28); C1079(1.43)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C1074(2.16); C1079(1.76)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C1074(1.31); C1079(1.27)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C1074(0.89); C1079(0.89)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C1074(0.88); C1079(0.88)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1074(1.04); C1079(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1074(1.13); C1079(1.13)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1074(1.28); C1079(1.28)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1074(0.79); C1079(0.79)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1074(1.07); C1079(1.07)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1074(0.87); C1079(0.87)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C1074(1.70); C1079(1.76)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C1074(1.49); C1079(1.57)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C1074(1.24); C1079(1.07)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C1074(0.68); C1079(0.68)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C1074(0.87); C1079(1.16)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C1074(1.81); C1079(2.30)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C1074(1.18); C1079(1.64)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C1074(0.86); C1079(1.11)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C1074(1.14); C1079(1.33)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C1074(1.41); C1079(1.53)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C1074(0.79); C1079(1.19)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C1074(1.10); C1079(1.30)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C1074(1.06); C1079(1.34)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C1074(1.03); C1079(1.50)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C1074(0.64); C1079(0.64)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C1074(1.13); C1079(1.51)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C1074(1.18); C1079(1.18)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C1074(1.09); C1079(1.09)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1074(0.91); C1079(0.91)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1074(1.03); C1079(1.03)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1074(0.92); C1079(0.92)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1074(0.88); C1079(0.88)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1074(1.21); C1079(1.21)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1074(0.82); C1079(0.82)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1074(0.82); C1079(0.82)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1074(1.23); C1079(1.23)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1074(0.98); C1079(0.98)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1074(0.59); C1079(0.59)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1074(1.15); C1079(1.15)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1074(0.91); C1079(0.91)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1074(0.69); C1079(0.69)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C1074(0.47); C1079(0.47)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C1074(0.47); C1079(0.47)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C1074(0.67); C1079(0.67)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C1074(0.78); C1079(0.78)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C1074(0.91); C1079(0.91)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C1074(0.65); C1079(0.65)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C1074(0.64); C1079(0.64)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C1074(0.72); C1079(0.72)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C1074(0.95); C1079(0.95)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C1074(0.59); C1079(0.59)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C1074(0.49); C1079(0.49)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C1074(0.65); C1079(0.65)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C1074(0.54); C1079(0.54)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C1074(0.78); C1079(0.78)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C1074(0.69); C1079(0.69)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C1074(0.91); C1079(0.91)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C1074(0.53); C1079(0.53)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1074(1.14); C1079(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1074(1.00); C1079(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1074(1.04); C1079(1.04)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1074(1.07); C1079(1.07)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1074(1.14); C1079(1.14)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1074(1.14); C1079(1.14)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1074(1.02); C1079(1.02)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1074(1.11); C1079(1.11)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1074(1.06); C1079(1.06)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C1074(1.01); C1079(1.01)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1074(1.06); C1079(1.06)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1074(0.98); C1079(0.98)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1074(1.30); C1079(1.30)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1074(1.07); C1079(1.07)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1074(1.24); C1079(1.24)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C1074(1.11); C1079(1.11)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C1074(1.54); C1079(1.54)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C1074(0.98); C1079(0.98)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C1074(0.91); C1079(0.91)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C1074(2.55); C1079(2.55)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C1074(0.99); C1079(0.99)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C1074(1.15); C1079(1.15)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C1074(0.85); C1079(0.85)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C1074(0.96); C1079(0.96)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C1074(1.35); C1079(1.35)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C1074(1.23); C1079(1.23)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C1074(1.27); C1079(1.27)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C1074(1.14); C1079(1.14)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C1074(1.33); C1079(1.33)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C1074(0.99); C1079(0.99)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C1074(0.81); C1079(0.81)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C1074(2.31); C1079(2.31)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C1074(1.00); C1079(0.85)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C1074(1.11); C1079(1.02)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C1074(1.14); C1079(0.96)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C1074(1.58); C1079(1.10)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C1074(2.96); C1079(1.73)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C1074(1.13); C1079(0.96)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C1074(1.24); C1079(1.06)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C1074(1.17); C1079(1.09)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C1074(1.24); C1079(1.13)  LDD1092  [3]
 LDCM0468  Fragment33 HCT 116 C1074(1.00); C1079(1.00)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C1074(0.88); C1079(0.88)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C1074(3.83); C1079(3.83)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C1074(1.82); C1079(1.82)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C1074(2.12); C1079(2.12)  LDD0082  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264