Details of the Target

General Information of Target

Target ID LDTP06837
Target Name Histone-lysine N-methyltransferase KMT5B (KMT5B)
Gene Name KMT5B
Gene ID 51111
Synonyms
SUV420H1; Histone-lysine N-methyltransferase KMT5B; Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B; Suppressor of variegation 4-20 homolog 1; Su(var)4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; EC 2.1.1.362; [histone H4]-lysine20 N-methyltransferase KMT5B; EC 2.1.1.361
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKWLGESKNMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGKNAVERRSNRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQEKNNATSNRKSSVGVKKNSKSRTLTRQSMSRIPA
SSNSTSSKLTHINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRKLEMGNLVLKEP
KVVLYKNLPIKKDKEPEGPAQAAVASGCLTRHAAREHRQNPVRGAHSQGESSPCTYITRR
SVRTRTNLKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEA
KCHKSDTGMSKKKSRQGKLVKQFAKIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVG
VPVSYTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTL
RRRHDSSSKTNDQENDGMNSSKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQ
LKRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDD
YDDDFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
TTD ID
T05164
Uniprot ID
Q4FZB7
DrugMap ID
TTJGV7F
Ensemble ID
ENST00000304363.9
HGNC ID
HGNC:24283
ChEMBL ID
CHEMBL2321645

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S713A .
CAL33 SNV: p.K2T .
HT115 SNV: p.K439N .
Ishikawa (Heraklio) 02 ER SNV: p.L263P .
KYSE30 SNV: p.E516Q .
SKMEL2 Deletion: p.F281LfsTer11
SNV: p.Y185C		 .
SUPT1 SNV: p.I861L .
SW1783 SNV: p.R395Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0221  [1]
DBIA
 Probe Info  		C156(0.74)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C156(0.74)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C260(1.08)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C260(0.76); C275(0.76); C279(0.76)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C260(0.66); C275(0.66); C279(0.66)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C260(0.80); C275(0.80); C279(0.80)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C260(0.76); C275(0.76); C279(0.76)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C260(1.01); C275(1.01); C279(1.01)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C260(0.64); C275(0.64); C279(0.64)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C260(0.75); C275(0.75); C279(0.75)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C260(0.73); C275(0.73); C279(0.73)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C260(0.78); C275(0.78); C279(0.78)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C260(0.83); C275(0.83); C279(0.83)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C260(1.36)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C260(0.72); C275(0.72); C279(0.72)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C260(0.80); C275(0.80); C279(0.80)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C260(0.78); C275(0.78); C279(0.78)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C156(1.02); C260(0.99)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C156(0.92); C260(0.79)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C156(0.99); C260(0.81)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C156(1.31); C260(0.78)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C156(0.98); C260(0.90)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C156(1.01); C260(0.69)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C156(0.99); C260(0.77)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C260(1.23)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C156(0.98); C260(1.15)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C156(0.93); C260(0.68)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C156(0.91); C260(0.78)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C156(1.19); C260(0.72)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C156(1.08); C260(0.55)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C156(1.17); C260(0.71)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C156(1.09); C260(0.64)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C156(1.17); C260(0.72)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C260(1.56); C279(1.56)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C260(1.44); C279(1.44)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C260(1.48); C279(1.48)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C260(1.60); C279(1.60)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C260(1.44); C279(1.44)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C260(1.23); C279(1.23)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C260(1.41); C279(1.41)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C260(1.29); C279(1.29)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C260(1.07); C279(1.07)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C260(1.13); C279(1.13)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C260(1.68); C279(1.68)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C260(1.79); C279(1.79)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C260(1.25)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C260(1.44); C279(1.44)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C260(2.05); C279(2.05)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C260(2.23); C279(2.23)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C260(1.30); C275(1.30); C279(1.30)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C260(0.91); C275(0.91); C279(0.91)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C260(1.51); C275(1.51); C279(1.51)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C260(1.41); C275(1.41); C279(1.41)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C260(1.47); C275(1.47); C279(1.47)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C260(1.39); C275(1.39); C279(1.39)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C260(1.45); C275(1.45); C279(1.45)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C260(1.27)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C260(1.34); C275(1.34); C279(1.34)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C260(1.78); C275(1.78); C279(1.78)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C260(1.22); C275(1.22); C279(1.22)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C260(1.18); C275(1.18); C279(1.18)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C260(0.98); C275(0.98); C279(0.98)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C260(1.37); C275(1.37); C279(1.37)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C260(1.24); C275(1.24); C279(1.24)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C260(1.15); C275(1.15); C279(1.15)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C260(1.40); C275(1.40); C279(1.40)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C260(1.21); C275(1.21); C279(1.21)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C260(1.13); C275(1.13); C279(1.13)  LDD0876  [2]
 LDCM0279  AC2 HCT 116 C156(0.90)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C260(1.08); C275(1.08); C279(1.08)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C260(1.08); C275(1.08); C279(1.08)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C260(0.95); C275(0.95); C279(0.95)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C260(1.25); C275(1.25); C279(1.25)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C260(1.00); C275(1.00); C279(1.00)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C156(1.18)  LDD1524  [6]
 LDCM0289  AC29 HEK-293T C156(0.93)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C156(0.78)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C156(0.92)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C156(1.02)  LDD1531  [6]
 LDCM0294  AC33 HEK-293T C156(0.98)  LDD1533  [6]
 LDCM0296  AC35 HEK-293T C260(1.21); C279(1.21)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C260(1.11); C279(1.11)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C260(1.14); C279(1.14)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C260(1.26); C279(1.26)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C260(1.16); C279(1.16)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C156(0.73)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C260(1.07); C279(1.07)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C260(1.01); C279(1.01)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C260(0.98); C279(0.98)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C260(1.05); C279(1.05)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C260(1.00); C279(1.00)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C260(1.18); C279(1.18)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C156(1.31)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C156(0.93)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C156(0.97)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C156(1.13)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C156(0.82)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C156(1.13)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C156(0.99)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C156(1.11)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C156(0.86)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C156(1.08)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C156(1.00)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C156(1.20)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C156(1.24)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C156(0.85)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C156(0.95)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C260(1.12)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C156(0.98)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C156(1.29)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C156(1.10)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C156(0.97)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C156(1.12)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C156(1.13)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C156(1.01)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C156(1.03)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C156(0.97)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C156(1.06)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C260(1.00)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C156(0.87)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C156(0.91)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C156(1.17)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C156(1.11)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C156(1.06)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C156(0.99)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C156(1.07)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C156(1.00)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C156(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C156(1.05)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C260(1.14)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C156(1.06)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C156(1.18)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C156(1.15)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C260(0.93)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C260(1.30)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C260(1.22)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C260(1.01)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C260(1.07)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C260(1.14)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C260(1.01)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C260(1.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C260(0.61)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C260(1.03)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C260(0.89)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C260(0.65)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C260(1.32)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C260(0.64)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C260(1.04)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C260(0.79); C275(0.79); C279(0.79)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C260(0.84); C275(0.84); C279(0.84)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C260(1.37)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C260(1.02)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C260(1.20)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C156(0.75)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C156(1.34)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C156(0.80)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C260(1.09)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C260(0.96)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C260(1.12)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C260(0.98)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C260(0.95); C275(0.95); C279(0.95)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C260(1.07); C275(1.07); C279(1.07)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C260(1.11); C275(1.11); C279(1.11)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C260(1.25); C275(1.25); C279(1.25)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C260(1.10); C275(1.10); C279(1.10)  LDD0976  [2]
 LDCM0379  CL11 HCT 116 C156(1.16)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C260(1.16); C275(1.16); C279(1.16)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C260(0.90); C275(0.90); C279(0.90)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C156(0.89)  LDD1586  [6]
 LDCM0386  CL116 HEK-293T C156(1.19)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C260(0.91); C279(0.91)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C260(0.94); C279(0.94)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C260(1.01); C279(1.01)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C156(1.95)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C260(1.02); C279(1.02)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C156(0.96)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C156(1.10)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C156(0.79)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C156(0.95)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C156(1.41)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C156(0.78)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C156(1.02)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C156(1.02)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C156(0.91)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C156(1.04)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C156(1.23)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C260(0.93)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C156(0.91)  LDD1608  [6]
 LDCM0407  CL2 HCT 116 C156(1.00)  LDD0724  [2]
 LDCM0409  CL21 HEK-293T C156(0.87)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C156(1.19)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C156(1.21)  LDD1615  [6]
 LDCM0416  CL28 HEK-293T C156(1.29)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C156(1.00)  LDD1621  [6]
 LDCM0418  CL3 HCT 116 C156(2.13)  LDD0735  [2]
 LDCM0420  CL31 HCT 116 C156(1.01)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C156(0.94); C260(0.92)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C156(0.96); C260(1.01)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C156(1.13); C260(0.91)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C156(1.08); C260(0.95)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C156(0.96); C260(0.97)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C156(0.98); C260(0.79)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C156(1.03); C260(1.28)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C156(1.04)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C156(0.95); C260(0.92)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C156(0.93); C260(0.99)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C156(0.86); C260(0.90)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C156(0.95); C260(0.98)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C156(0.99); C260(0.83)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C156(1.42); C260(0.79)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C156(1.07)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C156(1.00)  LDD1641  [6]
 LDCM0440  CL5 HCT 116 C156(1.48)  LDD0757  [2]
 LDCM0443  CL52 HEK-293T C156(0.79)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C156(0.99)  LDD1647  [6]
 LDCM0448  CL57 HEK-293T C156(0.96)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C156(1.20)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C156(0.73)  LDD1653  [6]
 LDCM0451  CL6 HCT 116 C156(0.73)  LDD0768  [2]
 LDCM0453  CL61 HEK-293T C260(0.83); C275(0.83); C279(0.83)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C260(0.87); C275(0.87); C279(0.87)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C260(0.67); C275(0.67); C279(0.67)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C260(0.75); C275(0.75); C279(0.75)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C260(0.90); C275(0.90); C279(0.90)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C260(0.76); C275(0.76); C279(0.76)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C260(0.75); C275(0.75); C279(0.75)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C260(0.73); C275(0.73); C279(0.73)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C260(0.73); C275(0.73); C279(0.73)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C156(1.00)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C260(0.72); C275(0.72); C279(0.72)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C260(0.69); C275(0.69); C279(0.69)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C260(0.86); C275(0.86); C279(0.86)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C260(0.76); C275(0.76); C279(0.76)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C260(0.83); C275(0.83); C279(0.83)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C156(1.26)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C156(0.99)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C156(1.31)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C156(1.45)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C156(1.46)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C156(0.90)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C156(1.16)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C156(1.14)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C156(1.42)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C156(1.22)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C156(0.97)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C156(1.18)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C156(1.18)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C156(1.37)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C156(1.21)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C156(1.25)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C156(0.85)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C156(0.94)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C156(0.89)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C156(0.65)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C156(1.11)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C156(0.80)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C156(0.84)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C156(0.81)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C156(0.72)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C156(0.90)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C260(1.01); C275(1.01); C279(1.01)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C156(0.73); C260(1.20)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0022  KB02 BRX211 C156(2.09)  LDD2268  [7]
 LDCM0023  KB03 BRX211 C156(2.55)  LDD2685  [7]
 LDCM0024  KB05 OAW-42 C156(4.75)  LDD3369  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A-196 Small molecular drug D0P2EH

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840