Details of the Target

General Information of Target

Target ID LDTP06752
Target Name Echinoderm microtubule-associated protein-like 3 (EML3)
Gene Name EML3
Gene ID 256364
Synonyms
Echinoderm microtubule-associated protein-like 3; EMAP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA
PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQ
SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANL
LVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP
SGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH
YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER
GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC
IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG
NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQ
WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL
WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG
RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG
RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVL
GFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGS
HVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV
Target Bioclass
Other
Family
WD repeat EMAP family
Subcellular location
Cytoplasm, cytoskeleton
Function
Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation. Required for proper alignnment of chromosomes during metaphase.
Uniprot ID
Q32P44
Ensemble ID
ENST00000394773.7
HGNC ID
HGNC:26666

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C816(0.84)  LDD0533  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C310(0.00); C825(0.00); C816(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C310(0.00); C464(0.00); C615(0.00); C825(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C310(0.00); C615(0.00); C825(0.00); C816(0.00)  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
VSF
 Probe Info  		N.A.  LDD0007  [3]
Acrolein
 Probe Info  		C816(0.00); C420(0.00)  LDD0217  [4]
NAIA_5
 Probe Info  		C615(0.00); C307(0.00); C825(0.00)  LDD2223  [5]
HHS-475
 Probe Info  		Y228(0.67)  LDD2238  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C825(1.11)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C615(1.04)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C816(0.84)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C816(0.85)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C816(0.82)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C816(1.02)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C816(0.90)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C816(0.93)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C816(0.99)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C816(1.06)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C816(0.75)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C816(0.72)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C615(1.08)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C816(0.88)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C816(0.88)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C816(0.87)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C615(1.21); C816(1.15)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C615(1.14); C816(1.13)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C615(1.07); C816(1.18)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C615(1.16); C816(1.18)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C615(1.08); C816(1.15)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C615(1.29); C816(1.37)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C615(1.07); C816(1.22)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C615(0.96)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C615(1.19); C816(0.99)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C615(1.12); C816(1.12)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C615(1.19); C816(1.14)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C615(1.18); C816(1.15)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C615(1.13); C816(0.97)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C615(1.13); C816(1.18)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C615(1.06); C816(1.26)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C615(1.31); C816(1.27)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C816(1.31)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C816(1.10)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C816(1.20)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C816(1.18)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C816(1.17)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C816(1.23)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C816(1.34)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C816(1.23)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C816(1.18)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C816(1.07)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C816(1.22)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C816(1.36)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C615(1.02)  LDD0857  [1]
 LDCM0260  AC140 HCT 116 C816(1.33)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C816(1.22)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C816(1.23)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C816(0.98)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C816(1.11)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C816(0.95)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C816(1.15)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C816(1.16)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C816(1.20)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C816(1.15)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C615(0.94)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C816(0.89)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C816(0.88)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C816(1.03)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C816(1.03)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C816(1.07)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C816(1.01)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C816(1.03)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C816(0.95)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C615(0.83)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C615(1.01)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C615(0.96)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C825(0.98)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C615(0.92)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C615(0.88)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C615(0.93)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C615(0.77)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C615(0.95)  LDD0882  [1]
 LDCM0285  AC25 PaTu 8988t C816(1.20)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C816(1.04)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C816(1.03)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C816(0.94)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C816(0.92)  LDD1168  [1]
 LDCM0290  AC3 HEK-293T C825(0.86)  LDD0888  [1]
 LDCM0291  AC30 PaTu 8988t C816(1.08)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C816(1.12)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C816(0.98)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C816(0.92)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C816(0.89)  LDD1174  [1]
 LDCM0296  AC35 HEK-293T C615(0.91); C825(2.01)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C615(0.89); C825(2.01)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C615(0.80); C825(1.68)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C615(0.87); C825(1.64)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C615(0.86); C825(1.10)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C825(0.77)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C615(0.82); C825(1.41)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C615(0.92); C825(1.30)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C615(0.90); C825(1.30)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C615(0.89); C825(1.24)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C615(0.91); C825(1.42)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C615(0.81); C825(2.05)  LDD0905  [1]
 LDCM0308  AC46 HCT 116 C816(0.94)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C816(1.02)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C816(1.29)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C816(0.98)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C825(0.80)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C816(0.99)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C816(1.04)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C816(1.08)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C816(1.08)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C816(0.96)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C816(0.98)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C816(0.87)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C825(1.11)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C825(1.18)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C825(1.09)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C615(1.14)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C825(1.21)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C825(1.66)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C825(1.64)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C825(1.55)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C825(1.50)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C825(2.03)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C825(1.34)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C825(1.56)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C816(1.23)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C816(1.04)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C615(1.11)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C816(0.80)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C816(1.01)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C816(1.05)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C816(0.92)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C816(0.90)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C816(0.76)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C816(1.03)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C816(1.05)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C816(1.25)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C816(1.08)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C615(1.09)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C816(1.07)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C816(1.14)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C816(0.63)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C816(1.03)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C816(1.05)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C816(0.99)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C816(1.01)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C816(1.09)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C816(0.95)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C816(1.02)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C816(0.95)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C816(0.97)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C816(1.06)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C816(1.03)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C816(0.94)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C816(1.39)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C816(1.00)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C816(0.93)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C816(0.67)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C816(0.78)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C615(0.99)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C615(0.98)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C615(0.98)  LDD0873  [1]
 LDCM0108  Chloroacetamide HeLa C420(0.00); C816(0.00)  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C615(0.94)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C615(1.12)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C825(0.85)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C615(1.04)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C615(1.02)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C615(1.05)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C615(1.11)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C615(0.95)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C615(1.05)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C615(1.01)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C615(1.06)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C615(0.90)  LDD0976  [1]
 LDCM0379  CL11 HCT 116 C615(1.07)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C615(0.83)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C615(0.86)  LDD0979  [1]
 LDCM0382  CL112 PaTu 8988t C816(1.24)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C816(1.03)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C816(0.94)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C816(1.06)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C816(1.91)  LDD1265  [1]
 LDCM0387  CL117 HEK-293T C615(0.81); C825(2.14)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C615(0.73); C825(1.77)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C615(0.92); C825(1.30)  LDD0987  [1]
 LDCM0390  CL12 HCT 116 C615(1.10)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C615(0.93); C825(1.14)  LDD0989  [1]
 LDCM0392  CL121 HCT 116 C816(0.87)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C816(0.95)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C816(0.97)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C816(0.97)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C825(1.11)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C825(1.00)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C825(0.93)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C825(1.09)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C615(1.12)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C615(1.10)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C615(1.16)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C615(0.92)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C615(0.90)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C615(1.17)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C615(0.90)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C615(1.03)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C615(0.80)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C615(0.79)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C615(0.77)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C615(0.85)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C615(0.89)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C615(0.87)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C615(0.78)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C615(0.93)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C615(0.85)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C615(0.90)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C615(1.04)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C615(0.90)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C615(0.91)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C615(1.31)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C615(1.18)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C615(0.89)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C615(0.81)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C615(0.94)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C615(0.88)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C615(0.99)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C615(1.06)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C615(0.83)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C615(1.11)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C615(0.77)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C615(1.01)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C615(1.03)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C615(1.06)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C615(0.93)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C615(0.86)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C615(0.87)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C615(0.79)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C615(1.07)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C615(0.90)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C615(0.89)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C615(0.94)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C615(0.84)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C615(0.81)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C615(0.85)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C615(0.81)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C615(0.89)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C615(0.90)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C615(0.91)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C615(1.20)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C615(0.87)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C825(1.09)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C825(1.05)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C825(0.80)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C825(0.75)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C825(0.62)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C825(0.99)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C825(0.95)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C825(1.19)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C825(1.14)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C615(1.08)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C825(1.10)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C825(1.16)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C825(1.40)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C825(1.23)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C825(2.12)  LDD1065  [1]
 LDCM0469  CL76 PaTu 8988t C759(2.03); C310(0.89); C816(0.93)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C759(1.10); C310(0.69); C816(0.81)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C759(1.21); C310(0.79); C816(0.81)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C759(1.46); C310(0.72); C816(0.81)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C615(1.15)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C759(1.60); C310(0.80); C816(0.97)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C759(1.13); C310(0.73); C816(0.76)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C759(1.14); C310(0.89); C816(0.76)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C759(1.17); C310(1.13); C816(0.75)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C759(1.23); C310(0.72); C816(0.68)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C759(1.23); C310(0.66); C816(0.83)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C759(1.17); C310(0.67); C816(0.75)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C759(1.14); C310(0.95); C816(0.77)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C759(1.02); C310(0.79); C816(0.69)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C759(1.15); C310(0.79); C816(0.69)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C615(1.06)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C759(1.03); C310(0.72); C816(0.67)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C825(0.49)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C825(0.51)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C825(0.87)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C825(0.82)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C825(1.87)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C825(0.98)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C825(0.75)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C825(0.69)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C825(0.63)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C307(1.06)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C825(1.95)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C825(1.27)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C615(0.89)  LDD0744  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 22RV1 C759(2.22)  LDD2243  [9]
 LDCM0023  KB03 22RV1 C759(2.78)  LDD2660  [9]
 LDCM0024  KB05 COLO792 C615(2.91); C759(1.59)  LDD3310  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840