Details of the Target

General Information of Target

Target ID LDTP06730
Target Name CWF19-like protein 2 (CWF19L2)
Gene Name CWF19L2
Gene ID 143884
Synonyms
CWF19-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWML
PDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWV
EAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMRKI
EQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRM
KEQAEKQSRNFEDIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQ
ESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQEFS
FGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWS
RSDGRGDKKHSNQKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSP
ERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGVEN
EDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLN
DLVKNEKMGTAENQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKK
AIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHR
AATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDM
APIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHK
FPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY
Target Bioclass
Other
Family
CWF19 family
Uniprot ID
Q2TBE0
Ensemble ID
ENST00000282251.10
HGNC ID
HGNC:26508

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P842T .
HT115 SNV: p.E92D; p.A394T .
KELLY SNV: p.S86A DBIA    Probe Info 
LS180 Insertion: p.S536IfsTer6 DBIA    Probe Info 
MDAMB231 SNV: p.R720I .
NCIH1048 Deletion: p.L754WfsTer5 DBIA    Probe Info 
NCIH1650 SNV: p.D491N DBIA    Probe Info 
OVK18 Deletion: p.L754WfsTer5 DBIA    Probe Info 
SW1573 SNV: p.R658W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K499(0.43)  LDD0274  [1]
STPyne
 Probe Info  		K499(5.36)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C299(4.39)  LDD0168  [2]
DBIA
 Probe Info  		C299(1.05)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C299(0.00); C347(0.00)  LDD0037  [4]
Compound 10
 Probe Info  		C299(0.00); C402(0.00)  LDD2216  [5]
Compound 11
 Probe Info  		C299(0.00); C402(0.00)  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		12.50  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C299(4.39)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C299(10.52)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C299(1.05)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C299(1.04); C675(0.78); C678(1.29)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C299(1.18); C347(0.82); C675(0.87); C678(1.18)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C299(1.10); C347(1.03); C675(0.94); C678(1.15)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C299(1.14); C347(0.92); C675(0.97); C678(1.17)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C299(1.15); C347(0.87); C675(0.98); C678(1.26)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C299(1.10); C347(0.89); C675(1.10); C678(1.19)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C299(1.00); C347(1.18); C675(0.89); C678(1.04)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C299(0.95); C347(0.92); C675(1.00); C678(0.98)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C299(1.11); C347(0.94); C675(1.17); C678(1.13)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C299(1.02); C347(1.12); C675(0.95); C678(0.97)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C299(1.05); C347(0.92); C675(1.00); C678(0.95)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C299(0.98); C675(0.79); C678(1.14)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C299(1.57); C347(1.00); C675(1.06); C678(1.52)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C299(1.95); C347(1.27); C675(1.19); C678(1.89)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C299(1.57); C347(0.94); C675(1.15); C678(1.59)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C299(0.95); C347(0.86); C675(1.17); C678(1.06)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C299(0.92); C347(0.97); C675(1.37); C678(1.00)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C299(0.93); C347(0.88); C675(1.11); C678(1.02)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C299(0.96); C347(0.86); C675(0.97); C678(0.95)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C299(1.12); C347(0.75); C675(1.19); C678(1.10)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C299(1.13); C347(0.72); C675(1.37); C678(1.18)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C299(1.12); C347(0.75); C675(1.40); C678(1.25)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C299(0.95); C675(0.78); C678(1.27)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C299(1.14); C347(0.79); C675(1.44); C678(1.14)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C299(1.18); C347(0.61); C675(1.38); C678(1.32)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C299(1.51); C347(0.86); C675(1.58); C678(1.44)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C299(1.45); C347(0.79); C675(1.59); C678(1.51)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C299(1.16); C347(0.79); C675(1.32); C678(1.13)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C299(1.16); C347(0.76); C675(1.57); C678(1.37)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C299(1.73); C347(0.87); C675(2.18); C678(1.35)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C299(1.90); C347(1.09); C675(1.72); C678(1.81)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C347(1.08); C402(0.91); C675(0.90); C699(1.08)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C347(1.02); C402(0.61); C675(1.02); C699(1.02)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C347(0.93); C402(0.72); C675(0.96); C699(0.93)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C347(1.00); C402(1.25); C675(0.94); C699(1.00)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C347(0.84); C402(0.89); C675(0.86); C699(0.84)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C347(0.83); C402(0.78); C675(0.92); C699(0.83)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C347(0.86); C402(0.66); C675(0.89); C699(0.86)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C347(0.92); C402(0.75); C675(1.19); C699(0.92)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C347(0.84); C402(0.78); C675(1.10); C699(0.84)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C347(0.87); C402(0.68); C675(1.24); C699(0.87)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C347(1.01); C402(0.78); C675(1.38); C699(1.01)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C347(0.95); C402(0.67); C675(1.46); C699(0.95)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C299(1.08); C675(0.76); C678(1.35)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C347(0.87); C402(0.71); C675(1.00); C699(0.87)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C347(0.91); C402(0.74); C675(1.10); C699(0.91)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C347(0.89); C402(0.72); C675(1.12); C699(0.89)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C299(0.99)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C299(0.99)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C299(1.33)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C299(1.17)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C299(1.08)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C299(0.91)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C299(0.98)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C299(1.16); C675(0.82); C678(1.37)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C299(1.54)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C299(0.94)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C299(0.91)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C299(1.04)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C299(1.47)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C299(0.95)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C299(1.25)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C299(0.99)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C299(0.41)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C299(0.35)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C299(0.27)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C299(1.14)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C299(0.39)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C299(0.30)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C299(0.25)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C299(0.24)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C299(0.31)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C299(1.12); C347(0.76); C402(0.78); C675(1.17)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C299(1.30); C347(0.75); C402(0.68); C675(1.15)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C299(1.18); C347(0.62); C402(0.58); C675(1.07)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C299(0.68); C347(0.80); C402(0.47); C675(0.96)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C299(1.05); C347(0.81); C402(0.64); C675(0.91)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C299(1.00)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C299(1.19); C347(0.77); C402(0.55); C675(1.03)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C299(0.90); C347(0.87); C402(0.62); C675(1.06)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C299(1.09); C347(0.77); C402(0.64); C675(1.05)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C299(1.05); C347(0.79); C402(0.62); C675(0.98)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C299(0.94); C347(0.96); C402(0.73); C675(1.10)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C347(0.89); C402(1.02); C675(0.99); C678(0.99)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C347(0.88); C402(1.15); C675(1.00); C678(1.00)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C347(0.74); C402(0.98); C675(1.00); C678(1.00)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C347(0.79); C402(0.78); C675(0.99); C678(0.99)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C347(0.87); C402(1.02); C675(0.90); C678(0.90)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C299(1.04)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C347(1.08); C402(0.93); C675(0.99); C678(0.99)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C347(0.98); C402(0.98); C675(1.01); C678(1.01)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C347(1.02); C402(0.76); C675(0.93); C678(0.93)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C347(1.09); C402(0.99); C675(0.92); C678(0.92)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C347(0.82); C402(0.77); C675(0.97); C678(0.97)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C347(0.76); C402(0.93); C675(0.86); C678(0.86)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C299(1.05); C402(1.36); C675(0.79); C678(0.94)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C299(1.07); C402(1.15); C675(0.81); C678(1.02)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C299(1.12); C402(1.19); C675(0.74); C678(0.92)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C299(1.14); C402(0.93); C675(0.92); C678(1.01)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C299(0.94)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C299(1.23); C402(1.06); C675(0.88); C678(0.96)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C299(1.30); C402(1.02); C675(0.95); C678(0.93)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C299(1.18); C402(0.78); C675(0.96); C678(1.07)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C299(0.97); C402(1.05); C675(0.81); C678(0.90)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C299(1.29); C402(0.94); C675(0.90); C678(0.98)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C299(1.17); C402(0.93); C675(0.83); C678(0.94)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C299(1.21); C402(1.05); C675(1.01); C678(1.11)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C299(0.78); C347(0.89); C402(1.29); C699(0.89)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C299(1.15); C347(0.88); C402(1.15); C699(0.88)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C299(0.82); C347(0.98); C402(1.27); C699(0.98)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C299(0.81); C675(1.07); C678(1.17)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C299(0.76); C347(1.09); C402(0.97); C699(1.09)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C299(0.89); C347(0.71); C402(1.15); C699(0.71)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C299(0.99); C347(0.70); C402(1.28); C699(0.70)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C299(0.78); C347(0.65); C402(1.04); C699(0.65)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C299(0.79); C347(0.70); C402(1.10); C699(0.70)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C299(0.83); C347(0.57); C402(1.03); C699(0.57)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C299(0.73); C347(0.67); C402(1.01); C699(0.67)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C299(0.85); C347(0.59); C402(1.00); C699(0.59)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C299(1.01); C347(0.97); C402(0.86); C678(1.15)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C299(0.98); C347(1.08); C402(0.73); C678(1.17)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C299(0.77); C675(0.87); C678(1.35)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C299(1.04); C347(1.17); C402(0.64); C678(1.16)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C299(1.22); C347(0.91); C402(0.97); C678(1.26)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C299(1.06); C347(1.01); C402(1.01); C678(1.24)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C299(1.20); C347(1.17); C402(1.00); C678(1.36)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C299(1.22); C347(1.05); C402(0.77); C678(1.37)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C299(1.24); C347(0.98); C402(0.74); C678(1.34)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C299(1.06); C347(1.01); C402(0.80); C678(1.29)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C299(1.04); C347(1.11); C402(0.95); C678(1.21)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C299(0.98); C347(0.99); C402(0.82); C678(1.27)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C299(1.13); C347(0.88); C402(0.70); C678(1.17)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C299(1.05); C675(0.90); C678(1.37)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C299(1.26); C347(1.15); C402(1.29); C678(1.32)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C299(1.03); C347(1.16); C402(0.87); C678(1.22)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C299(1.28); C347(1.57); C402(0.66); C678(1.72)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C347(0.91); C402(0.73); C675(0.94); C678(1.10)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C347(0.66); C402(0.85); C675(0.92); C678(1.16)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C347(0.63); C402(0.87); C675(0.77); C678(1.24)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C347(0.57); C402(0.83); C675(0.88); C678(1.09)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C347(0.65); C402(0.89); C675(0.75); C678(1.13)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C347(0.55); C402(0.75); C675(0.81); C678(1.27)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C347(0.57); C402(0.75); C675(0.80); C678(1.31)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C347(0.71); C402(0.84); C675(0.96); C678(1.15)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C347(0.70); C402(0.79); C675(0.89); C678(1.24)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C347(0.70); C402(0.75); C675(0.89); C678(1.17)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C347(0.74); C402(0.90); C675(2.12); C678(1.29)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C347(0.61); C402(0.70); C675(0.85); C678(1.20)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C347(0.58); C402(0.69); C675(0.79); C678(1.27)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C347(0.80); C402(0.80); C675(1.01); C678(1.42)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C347(0.79); C402(0.89); C675(1.21); C678(1.71)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C299(0.99); C347(0.92); C675(0.96); C678(1.10)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C299(1.04); C347(0.85); C675(2.26); C678(1.04)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C299(0.87); C675(0.86); C678(1.26)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C299(1.15); C675(0.81); C678(1.44)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C299(0.99); C675(0.83); C678(1.18)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C299(0.81)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C299(0.84)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C299(1.08)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C299(1.17); C675(1.13); C678(1.17)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C299(1.19); C675(0.75); C678(1.25)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C299(0.97); C675(1.00); C678(1.34)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C299(1.12); C675(1.00); C678(1.40)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C299(0.31)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C299(0.29)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C299(0.24)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C299(0.29)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C299(0.39)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C299(0.59)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C299(0.41)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C299(0.42)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C299(1.16); C347(0.75); C402(0.67); C675(1.00)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C299(1.10); C347(0.76); C402(0.69); C675(1.06)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C299(1.46); C347(0.90); C402(0.50); C675(1.04)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C299(1.30); C347(0.85); C402(0.57); C675(1.09)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C299(1.31); C347(0.75); C402(0.57); C675(1.09)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C347(0.99); C402(1.06); C675(0.90); C678(0.90)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C347(0.82); C402(1.15); C675(1.18); C678(1.18)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C347(0.88); C402(1.09); C675(1.30); C678(1.30)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C299(0.79)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C347(0.90); C402(1.05); C675(1.13); C678(1.13)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C299(1.26); C402(0.95); C675(0.77); C678(0.88)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C299(1.14); C402(1.09); C675(0.90); C678(1.01)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C299(1.10); C402(0.96); C675(0.76); C678(0.82)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C299(1.07); C402(0.92); C675(0.81); C678(0.91)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C299(0.84); C347(0.95); C402(1.10); C699(0.95)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C299(1.00); C347(0.73); C402(1.43); C699(0.73)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C299(0.79); C347(0.91); C402(1.32); C699(0.91)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C299(0.96); C347(0.78); C402(1.38); C699(0.78)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C299(0.69)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C299(1.01)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C299(0.85)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C299(1.03)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C299(0.98); C675(0.98)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C299(1.07); C675(1.27)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C299(1.10); C675(1.22)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C299(0.83)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C299(1.04); C675(1.15)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C299(1.51); C675(1.05)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C299(1.17); C675(1.21)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C299(1.07); C675(1.24)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C299(0.86); C675(1.64)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C299(1.14); C675(0.89)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C299(0.94); C675(1.20)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C299(1.08); C675(1.14)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C299(0.98); C675(1.07)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C299(1.01); C675(1.09)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C299(0.55)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C299(1.26); C675(1.29)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C299(1.14); C347(1.13); C402(0.73); C699(1.13)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C299(1.10)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C299(1.21)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C299(0.90)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C299(1.07)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C299(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C299(1.14)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C299(0.93)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C299(0.76)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C299(1.34)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C299(1.11)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C299(0.75)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C299(0.87)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C299(1.06)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C299(1.00)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C347(0.91); C675(1.15); C678(1.08); C699(0.91)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C347(0.85); C675(1.12); C678(1.21); C699(0.85)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C347(0.85); C675(1.14); C678(1.19); C699(0.85)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C347(0.73); C675(1.05); C678(1.19); C699(0.73)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C299(0.84)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C347(0.87); C675(1.02); C678(1.25); C699(0.87)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C347(0.84); C675(0.93); C678(1.02); C699(0.84)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C347(1.12); C675(1.05); C678(1.00); C699(1.12)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C347(1.12); C675(0.91); C678(1.00); C699(1.12)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C347(0.73); C675(0.86); C678(1.09); C699(0.73)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C347(0.78); C675(1.28); C678(1.22); C699(0.78)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C347(0.93); C675(1.31); C678(1.08); C699(0.93)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C347(0.97); C675(0.99); C678(1.12); C699(0.97)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C347(0.94); C675(1.01); C678(1.13); C699(0.94)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C347(0.78); C675(1.01); C678(1.07); C699(0.78)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C299(1.10)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C347(0.89); C675(0.92); C678(1.24); C699(0.89)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C675(1.15)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C675(1.12)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C675(1.46)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C675(1.39)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C675(1.28)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C675(1.30)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C675(1.10)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C675(0.98)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C675(1.14)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C299(0.56)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C675(0.97)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C675(0.91)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C675(1.16)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C675(0.74)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C675(1.32)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C347(1.35); C402(1.01); C699(1.35)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C347(0.92); C402(0.88); C699(0.92)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C347(1.28); C402(0.67); C699(1.28)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C347(1.39); C402(0.65); C699(1.39)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C299(1.18)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C347(1.06); C402(0.88); C699(1.06)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C347(1.27); C402(0.79); C699(1.27)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C347(0.88); C402(0.82); C699(0.88)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C347(0.94); C402(0.84); C699(0.94)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C347(1.62); C402(0.73); C699(1.62)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C347(1.11); C402(0.77); C699(1.11)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C347(1.06); C402(0.64); C699(1.06)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C347(0.97); C402(0.59); C699(0.97)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C347(0.83); C402(0.65); C699(0.83)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C347(1.05); C402(0.82); C699(1.05)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C299(0.60)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C347(0.95); C402(0.79); C699(0.95)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C299(0.97)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C299(0.91)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C299(0.81)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C299(1.13)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C299(0.85)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C299(0.81)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C299(1.08)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C299(1.12)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C299(0.79)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C299(0.96); C347(1.00); C402(1.10)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C675(1.29)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C299(1.10)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C299(0.91); C347(0.93); C214(1.07); C699(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C299(0.97); C347(0.97); C214(1.13); C699(1.11)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C699(2.78)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
E3 ubiquitin-protein ligase TRIM9 (TRIM9) TRIM/RBCC family Q9C026
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Homeobox protein MOX-1 (MEOX1) . P50221
LIM/homeobox protein Lhx9 (LHX9) . Q9NQ69
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 47 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) CALCOCO family Q9P1Z2
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
CWF19-like protein 1 (CWF19L1) CWF19 family Q69YN2
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Protein Hook homolog 2 (HOOK2) Hook family Q96ED9
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Vimentin (VIM) Intermediate filament family P08670
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Axin-2 (AXIN2) . Q9Y2T1
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Centrobin (CNTROB) . Q8N137
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Meiosis 1 arrest protein (M1AP) . Q8TC57
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Protein KASH5 (KASH5) . Q8N6L0
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840