Details of the Target

General Information of Target

Target ID LDTP06467
Target Name Ras-related protein Rab-30 (RAB30)
Gene Name RAB30
Gene ID 27314
Synonyms
Ras-related protein Rab-30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKL
QIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLV
GNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQNTLV
NNVSSPLPGEGKSISYLTCCNFN
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Membrane
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
Uniprot ID
Q15771
Ensemble ID
ENST00000260056.6
HGNC ID
HGNC:9770

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L85F .
HT SNV: p.T117A DBIA    Probe Info 
PC9 SNV: p.S112R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C93(1.15)  LDD0304  [1]
DBIA
 Probe Info  		C168(1.07)  LDD0078  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C168(0.82)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C168(1.10)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C168(1.22)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C168(1.33)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C168(1.27)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C168(1.23)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C168(1.01)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C168(1.36)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C168(1.62)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C168(1.24)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C168(1.25)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C168(1.13)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C168(1.02)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C168(1.86)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C168(1.29)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C168(1.18)  LDD0827  [2]
 LDCM0237  AC12 HCT 116 C168(0.91)  LDD0554  [2]
 LDCM0246  AC128 HEK-293T C168(0.79)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C168(0.73)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C168(0.71)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C168(0.86)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C168(0.64)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C168(0.78)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C168(0.81)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C168(0.79)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C168(0.87)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C168(0.77)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C168(0.83)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C168(0.85)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C168(1.00)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C168(0.75)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C168(0.80)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C168(0.91)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C168(1.05)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C168(1.07)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C168(1.04)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C168(1.14)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C168(1.03)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C168(0.96)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C168(1.17)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C168(0.92)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C168(1.12)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C168(1.12)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C168(1.16)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C168(1.33)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C168(1.05)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C168(1.25)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C168(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C168(1.13)  LDD2161  [2]
 LDCM0279  AC2 HCT 116 C168(0.88)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C99(0.97)  LDD1519  [5]
 LDCM0283  AC23 HEK-293T C99(1.02)  LDD1522  [5]
 LDCM0288  AC28 HEK-293T C99(0.92)  LDD1527  [5]
 LDCM0290  AC3 HCT 116 C168(0.80)  LDD0607  [2]
 LDCM0292  AC31 HEK-293T C99(0.89)  LDD1531  [5]
 LDCM0297  AC36 HEK-293T C99(0.94)  LDD1536  [5]
 LDCM0300  AC39 HEK-293T C99(0.91)  LDD1539  [5]
 LDCM0301  AC4 HCT 116 C168(0.87)  LDD0618  [2]
 LDCM0306  AC44 HEK-293T C99(0.93)  LDD1545  [5]
 LDCM0309  AC47 HEK-293T C99(1.15)  LDD1548  [5]
 LDCM0312  AC5 HCT 116 C168(0.92)  LDD0629  [2]
 LDCM0315  AC52 HEK-293T C99(1.01)  LDD1554  [5]
 LDCM0318  AC55 HEK-293T C99(1.05)  LDD1557  [5]
 LDCM0323  AC6 HCT 116 C168(1.10)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C99(0.99)  LDD1563  [5]
 LDCM0327  AC63 HEK-293T C99(1.04)  LDD1566  [5]
 LDCM0332  AC68 HEK-293T C168(1.09)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C168(0.98)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C168(1.03)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C168(0.89)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C168(0.98)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C168(1.03)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C168(0.99)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C168(0.80)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C168(0.93)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C168(1.00)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C168(1.07)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C168(0.99)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C168(0.87)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C168(1.17)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C168(0.97)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C168(1.06)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C168(1.07)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C168(0.81)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C168(0.83)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C168(0.79)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C168(1.11)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C168(0.69)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C168(1.06)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C168(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C168(1.19)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C168(1.13)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C168(0.99)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C168(1.09)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C168(1.47)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C168(0.71)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C168(1.31)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C168(1.04)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C168(1.30)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C168(1.02)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C168(1.04)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C168(0.93)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C168(1.25)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C168(1.07)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C168(1.08)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C168(1.19)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C168(0.96)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C168(0.91)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C168(1.16)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C168(0.87)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C168(0.94)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C168(1.02)  LDD0690  [2]
 LDCM0376  CL107 HEK-293T C168(1.04)  LDD1580  [5]
 LDCM0379  CL11 HCT 116 C168(1.26)  LDD0696  [2]
 LDCM0381  CL111 HEK-293T C168(1.16)  LDD1585  [5]
 LDCM0385  CL115 HEK-293T C168(1.33)  LDD1589  [5]
 LDCM0389  CL119 HEK-293T C168(1.19)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C168(0.64)  LDD0707  [2]
 LDCM0394  CL123 HEK-293T C168(1.02)  LDD1598  [5]
 LDCM0398  CL127 HEK-293T C168(1.28)  LDD1602  [5]
 LDCM0400  CL13 HCT 116 C168(1.21)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C168(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C168(1.17)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C168(1.07)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C168(1.06)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C168(1.06)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C168(1.11)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C168(1.09)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C168(1.15)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C168(1.22)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C168(0.95)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C168(1.42)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C168(1.09)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C168(1.17)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C168(1.07)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C168(1.19)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C168(1.19)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C168(1.30)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C168(1.01)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C168(1.07)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C168(0.99)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C168(1.06)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C168(1.08)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C168(1.12)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C168(1.08)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C168(1.12)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C168(1.07)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C168(1.01)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C168(1.00)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C168(1.02)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C168(0.92)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C168(1.03)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C168(1.21)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C168(1.03)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C168(1.02)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C168(0.84)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C168(0.95)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C168(0.87)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C168(0.85)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C168(0.89)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C168(0.86)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C168(0.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C168(0.99)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C168(0.81)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C168(0.79)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C168(0.81)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C168(0.98)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C168(0.90)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C168(0.93)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C168(0.86)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C168(1.07)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C168(0.99)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C168(1.19)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C168(1.24)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C168(1.20)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C168(1.19)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C168(1.24)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C168(1.56)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C168(1.11)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C168(1.26)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C168(1.33)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C168(1.10)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C168(1.22)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C168(1.17)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C168(1.20)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C168(1.43)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C168(1.21)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C168(1.80)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C168(3.75)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C168(1.38)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C168(1.62)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C168(1.15)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C168(1.26)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C168(1.39)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C168(1.25)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C168(1.21)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C168(1.33)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C168(1.43)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C168(1.62)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C168(2.93)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C168(1.42)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C168(1.03)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C168(1.24)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C168(4.68)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C168(1.02)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C168(1.17)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C168(0.97)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C168(1.03)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C168(1.33)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C168(0.96)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C168(1.00)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C168(0.92)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C168(0.86)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C168(1.15)  LDD1698  [5]
 LDCM0625  F8 Ramos C99(1.24); C168(1.00)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C99(3.55); C168(1.91)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C99(0.05)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C99(5.89); C168(2.10)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C99(1.41); C168(0.86)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C99(2.90); C168(1.85)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C99(13.12); C168(2.95)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C99(1.50); C168(1.02)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C99(0.95); C168(1.37)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C99(0.93); C168(0.70)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C99(1.02); C168(0.53)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C99(1.35); C168(0.92)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C99(1.39); C168(1.23)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C99(3.34); C168(1.26)  LDD2201  [6]
 LDCM0468  Fragment33 HCT 116 C168(1.35)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C99(2.05); C168(1.26)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C99(1.90); C168(1.88)  LDD2184  [6]
 LDCM0427  Fragment51 HCT 116 C168(1.19)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C99(2.06); C168(1.04)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C99(1.31); C168(0.91)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C99(2.73); C168(1.38)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C99(7.81); C168(3.14)  LDD2188  [6]
 LDCM0022  KB02 HEK-293T C168(1.19)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C168(1.45)  LDD1497  [5]
 LDCM0024  KB05 G361 C99(2.77)  LDD3311  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C99(0.07)  LDD2207  [8]
 LDCM0131  RA190 MM1.R C93(1.15)  LDD0304  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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