Details of the Target

General Information of Target

Target ID LDTP06437
Target Name Probable JmjC domain-containing histone demethylation protein 2C (JMJD1C)
Gene Name JMJD1C
Gene ID 221037
Synonyms
JHDM2C; KIAA1380; TRIP8; Probable JmjC domain-containing histone demethylation protein 2C; EC 1.14.11.-; Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVETRAELVGKRFLCVAVGDEARSERWESGRGWRSWRAGVIRAVSHRDSRNPDLAVYVE
FDDLEWDKREWVKVYEDFSTFLVEYHLIWAKRNDPSQTQGSKSKQIQWPALTFKPLVERN
IPSSVTAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLHEEVKVWVKEQKVQE
IFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQM
TFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRPAMNSQAAVPKQNT
HQQQQQRSIRPNKRKGSDSSIPDEEKMKEEKYDYISRGENPKGKNKHLMNKRRKPEEDEK
KLNMKRLRTDNVSDFSESSDSENSNKRIIDNSSEQKPENELKNKNTSKINGEEGKPHNNE
KAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDTQLQEDMIIHSSEQSTVSDHNSNDLLP
QECNMDKTHTMELLPKEKFVSRPPTPKCVIDITNDTNLEKVAQENSSTFGLQTLQKMDPN
VSDSKHSIANAKFLETAKKDSDQSWVSDVVKVDLTQSSVTNASSGNDHLNMEKEKYVSYI
SPLSAVSVMEDKLHKRSPPPETIKSKLNTSVDTHKIKSSPSPEVVKPKITHSPDSVKSKA
TYVNSQATGERRLANKIEHELSRCSFHPIPTRSSTLETTKSPLIIDKNEHFTVYRDPALI
GSETGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTH
PLTSGPHHAVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQ
SPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNS
PSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKITAHSSPPLTKTLVDHHKEELER
KAFMEPLRSVASTSAKNDLDLNRSQTGKDCHLHRHFVDPVLNQLQRPPQETGERLNKYKE
EHRRILQESIDVAPFTTKIKGLEGERENYSRVASSSSSPKSHIIKQDMDVERSVSDLYKM
KHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEVSNIYGDKQSNALAAAAANPQTLTSFI
TSLSKPPPLIKHQPESEGLVGKIPEHLPHQIASHSVTTFRNDCRSPTHLTVSSTNTLRSM
PALHRAPVFHPPIHHSLERKEGSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDS
QANFKSSSEQSLTEMWRPNNNLSKEKTEWHVEKSSGKLQAAMASVIVRPSSSTKTDSMPA
MQLASKDRVSERSSAGAHKTDCLKLAEAGETGRIILPNVNSDSVHTKSEKNFQAVSQGSV
PSSVMSAVNTMCNTKTDVITSAADTTSVSSWGGSEVISSLSNTILASTSSECVSSKSVSQ
PVAQKQECKVSTTAPVTLASSKTGSVVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNAS
ETEPNAIKNQTLSASLPLDSTVICSTINKANSVGNGQASQTSQPNYHTKLKKAWLTRHSE
EDKNTNKMENSGNSVSEIIKPCSVNLIASTSSDIQNSVDSKIIVDKYVKDDKVNRRKAKR
TYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEIEEDLKPNGVLSRSAKE
RSKLKLQSNSNTGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSK
KGEEPAHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENFEDDELDIE
TSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVC
QKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAM
HTLREKYGIKSHCHCTNKQNLQVGNFPTMNGVSQVLQNVLNHSNKISLCMPESQQQNTPP
KSEKNGGSSPESDVGTDNKLTPPESQSPLHWLADLAEQKAREEKKENKELTLENQIKEER
EQDNSESPNGRTSPLVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGAPSSK
SGRTMPNILDDIIASVVENKIPPSKTSKINVKPELKEEPEESIISAVDENNKLYSDIPHS
WICEKHILWLKDYKNSSNWKLFKECWKQGQPAVVSGVHKKMNISLWKAESISLDFGDHQA
DLLNCKDSIISNANVKEFWDGFEEVSKRQKNKSGETVVLKLKDWPSGEDFKTMMPARYED
LLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVVAAKDHDIGTTNLHIEVS
DVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVD
KIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVRTCTLIQFLGDAIVL
PAGALHQVQNFHSCIQVTEDFVSPEHLVESFHLTQELRLLKEEINYDDKLQVKNILYHAV
KEMVRALKIHEDEVEDMEEN
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
JHDM2 histone demethylase family
Subcellular location
Nucleus
Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
TTD ID
T75792
Uniprot ID
Q15652
DrugMap ID
TTBISK4
Ensemble ID
ENST00000399262.7
HGNC ID
HGNC:12313
ChEMBL ID
CHEMBL3792271

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.A90S .
CAL51 SNV: p.A1033V DBIA    Probe Info 
CASKI SNV: p.L958I .
COLO792 SNV: p.L758S DBIA    Probe Info 
COLO800 SNV: p.P2090L DBIA    Probe Info 
DU145 SNV: p.Q563H DBIA    Probe Info 
ETK1 Substitution: p.S880P DBIA    Probe Info 
G361 SNV: p.E2416K DBIA    Probe Info 
G415 SNV: p.Y1093F .
HCT15 Insertion: p.D560RfsTer3
SNV: p.K1612N;p.L2170F		 .
HEC1 SNV: p.S1430L; p.E2489G DBIA    Probe Info 
HEC1B SNV: p.S1430L .
HT SNV: p.N2034T; p.Y2517C .
HT115 SNV: p.N1531H .
HT1197 SNV: p.S734R .
IM95 SNV: p.V158I; p.D1882Y DBIA    Probe Info 
KATOIII SNV: p.Q2427K .
KYSE510 SNV: p.Q2006L .
LNCaP clone FGC SNV: p.A2089V DBIA    Probe Info 
LOXIMVI SNV: p.K1659R DBIA    Probe Info 
MFE296 Deletion: p.P1980RfsTer15 DBIA    Probe Info 
MFE319 SNV: p.T513A DBIA    Probe Info 
MKN1 SNV: p.V572L .
MOLT4 Deletion: p.E2026KfsTer45 .
NALM6 Deletion: p.E2026KfsTer45 DBIA    Probe Info 
NCIH1048 Deletion: p.E2026KfsTer45 .
ONS76 Substitution: p.S880P DBIA    Probe Info 
OVK18 Deletion: p.N429IfsTer32;p.E2026KfsTer45
Substitution: p.S880P		 DBIA    Probe Info 
OVTOKO Substitution: p.S880P DBIA    Probe Info 
RKN Substitution: p.S880P DBIA    Probe Info 
SBC5 SNV: p.W565C .
SKHEP1 SNV: p.I1117M DBIA    Probe Info 
SKMEL2 SNV: p.S2007P DBIA    Probe Info 
SSP25 Substitution: p.S880P DBIA    Probe Info 
SW948 Deletion: p.A1530_S1532del DBIA    Probe Info 
TOV21G SNV: p.P53Q DBIA    Probe Info 
YSCCC SNV: p.S1513L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K351(1.27)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C1524(7.97)  LDD0170  [3]
Acrolein
 Probe Info  		N.A.  LDD0226  [4]
DBIA
 Probe Info  		C1814(0.88)  LDD0563  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
IPM
 Probe Info  		C508(0.00); C990(0.00); C1342(0.00); C684(0.00)  LDD0147  [10]
TFBX
 Probe Info  		C684(0.00); C2291(0.00)  LDD0148  [10]
YN-1
 Probe Info  		N.A.  LDD0447  [11]
Phosphinate-6
 Probe Info  		C1342(0.00); C1448(0.00); C990(0.00)  LDD0018  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1524(7.97)  LDD0170  [3]
 LDCM0214  AC1 HEK-293T C2225(0.90); C1814(0.87); C508(0.80); C1524(1.21)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C2225(1.03); C2317(0.94)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C2225(1.06); C508(1.01)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C2225(1.11); C508(1.02); C1524(0.99)  LDD1510  [14]
 LDCM0246  AC128 HCT 116 C1814(0.88)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1814(0.98)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1814(0.74)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1814(0.53)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1814(1.05)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1814(0.61)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1814(0.76)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1814(0.90)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1814(1.01)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1814(0.61)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1814(1.29)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1814(0.78)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C2225(0.93)  LDD1512  [14]
 LDCM0260  AC140 HCT 116 C1814(0.96)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1814(0.68)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1814(0.65)  LDD0579  [5]
 LDCM0270  AC15 HEK-293T C2225(1.13); C1814(1.15); C508(0.95); C1524(0.96)  LDD1513  [14]
 LDCM0276  AC17 HCT 116 C1814(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1814(0.95)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1814(0.96)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C2225(1.34); C2317(1.04)  LDD1518  [14]
 LDCM0280  AC20 HCT 116 C1814(0.93)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1814(1.01)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1814(0.96)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1814(0.89)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1814(1.02)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1814(0.97); C1863(1.08); C1868(1.08); C1871(1.08)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1863(0.81); C1868(0.81); C1871(0.81); C1814(1.14)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1863(1.02); C1868(1.02); C1871(1.02); C1814(1.36)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1863(0.94); C1868(0.94); C1871(0.94); C1814(1.00)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1863(1.08); C1868(1.08); C1871(1.08); C1814(1.25)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C2225(0.98); C508(1.08)  LDD1529  [14]
 LDCM0291  AC30 HCT 116 C1863(1.13); C1868(1.13); C1871(1.13); C1814(1.26)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1863(1.03); C1868(1.03); C1871(1.03); C1814(1.15)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1863(0.97); C1868(0.97); C1871(0.97); C1814(1.18)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1863(1.12); C1868(1.12); C1871(1.12); C1814(1.21)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1863(0.97); C1868(0.97); C1871(0.97); C1814(1.35)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C1863(0.70); C1868(0.70); C1871(0.70); C1814(1.18)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1863(0.98); C1868(0.98); C1871(0.98); C1814(1.21)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1863(0.94); C1868(0.94); C1871(0.94); C1814(1.24)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1863(0.93); C1868(0.93); C1871(0.93); C1814(1.08)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1863(0.90); C1868(0.90); C1871(0.90); C1814(0.97)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C2225(1.12); C508(1.12); C1524(0.94)  LDD1540  [14]
 LDCM0302  AC40 HCT 116 C1863(1.01); C1868(1.01); C1871(1.01); C1814(1.16)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1863(0.88); C1868(0.88); C1871(0.88); C1814(1.29)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1863(0.92); C1868(0.92); C1871(0.92); C1814(0.98)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1863(0.91); C1868(0.91); C1871(0.91); C1814(1.27)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1863(1.06); C1868(1.06); C1871(1.06); C1814(1.25)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1863(0.97); C1868(0.97); C1871(0.97); C1814(1.25)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1863(0.87); C1868(0.87); C1871(0.87)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1863(1.14); C1868(1.14); C1871(1.14)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C1863(0.97); C1868(0.97); C1871(0.97)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1863(0.99); C1868(0.99); C1871(0.99)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C2225(1.14); C1935(1.02)  LDD1551  [14]
 LDCM0313  AC50 HCT 116 C1863(1.04); C1868(1.04); C1871(1.04)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1863(1.06); C1868(1.06); C1871(1.06)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1863(1.10); C1868(1.10); C1871(1.10)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C1863(1.03); C1868(1.03); C1871(1.03)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C1863(1.08); C1868(1.08); C1871(1.08)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1863(1.21); C1868(1.21); C1871(1.21)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1863(1.18); C1868(1.18); C1871(1.18)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1814(1.43)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1814(1.54)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1814(1.68)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C2225(1.24)  LDD1562  [14]
 LDCM0324  AC60 HCT 116 C1814(1.72)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1814(1.50)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1814(1.75)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1814(1.46)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1814(1.43)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1814(1.68)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1814(1.93)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1814(1.78)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1863(1.10); C1868(1.10); C1871(1.10)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1863(1.05); C1868(1.05); C1871(1.05)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C2225(1.10); C1814(1.03); C508(0.89); C1524(1.08)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C1863(1.11); C1868(1.11); C1871(1.11)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1863(0.89); C1868(0.89); C1871(0.89)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C1863(0.94); C1868(0.94); C1871(0.94)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1863(1.11); C1868(1.11); C1871(1.11)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1863(1.03); C1868(1.03); C1871(1.03)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1863(0.99); C1868(0.99); C1871(0.99)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1863(0.98); C1868(0.98); C1871(0.98)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1863(0.96); C1868(0.96); C1871(0.96)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1863(0.87); C1868(0.87); C1871(0.87)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C1863(1.01); C1868(1.01); C1871(1.01)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C2225(0.98); C1814(1.14); C2317(0.99)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C1863(0.95); C1868(0.95); C1871(0.95)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1863(0.73); C1868(0.73); C1871(0.73)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1863(0.82); C1868(0.82); C1871(0.82)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1868(1.30); C1871(1.30); C1814(1.46)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1814(1.01); C1868(1.28); C1871(1.28)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1868(1.18); C1871(1.18); C1814(1.29)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1868(0.85); C1871(0.85); C1814(0.96)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1868(1.05); C1871(1.05); C1814(1.19)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1868(0.89); C1871(0.89); C1814(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1814(1.03); C1868(1.41); C1871(1.41)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1814(0.77); C1868(0.95); C1871(0.95)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1868(1.49); C1871(1.49); C1814(1.55)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1868(1.09); C1871(1.09); C1814(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1868(1.07); C1871(1.07); C1814(1.30)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1814(0.99); C1868(0.99); C1871(0.99)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1814(1.26); C1868(1.31); C1871(1.31)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1814(0.98); C1868(1.18); C1871(1.18)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1868(1.12); C1871(1.12); C1814(1.19)  LDD0681  [5]
 LDCM0248  AKOS034007472 HEK-293T C2225(1.00); C1935(1.10)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C2225(1.04); C1814(1.09); C508(0.77); C1524(1.12)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C2225(0.86); C1814(1.02); C2317(1.00)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C2225(1.08)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C2225(1.24)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C2225(0.81); C508(0.93)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C2225(0.96)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C2225(0.88); C1814(1.15)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C2225(1.09)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C2225(1.07); C508(1.03)  LDD1577  [14]
 LDCM0374  CL105 HCT 116 C1814(1.00)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1814(0.97)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1814(1.02)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1814(1.03)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1814(0.92)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C2225(1.18); C1814(1.19); C508(0.92); C1524(0.94)  LDD1583  [14]
 LDCM0380  CL110 HCT 116 C1814(1.11)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1814(0.93)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1863(0.91); C1868(0.91); C1871(0.91); C1814(0.99)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1863(0.90); C1868(0.90); C1871(0.90); C1814(1.01)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1863(0.93); C1868(0.93); C1871(0.93); C1814(1.07)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1863(0.94); C1868(0.94); C1871(0.94); C1814(1.24)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1863(0.96); C1868(0.96); C1871(0.96); C1814(1.14)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C1863(0.89); C1868(0.89); C1871(0.89); C1814(0.94)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1863(0.93); C1868(0.93); C1871(0.93); C1814(1.23)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1863(0.93); C1868(0.93); C1871(0.93); C1814(1.34)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C2225(0.80); C1814(1.21); C2317(1.14)  LDD1594  [14]
 LDCM0391  CL120 HCT 116 C1863(0.82); C1868(0.82); C1871(0.82); C1814(1.29)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1863(3.27); C1868(3.27); C1871(3.27)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1863(1.07); C1868(1.07); C1871(1.07)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1863(0.99); C1868(0.99); C1871(0.99)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1863(1.08); C1868(1.08); C1871(1.08)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1814(1.17)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1814(1.40)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1814(1.16)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1814(1.47)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C2225(1.08)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C2225(0.83); C1814(1.38)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C2225(1.10)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C2225(1.11); C508(0.98)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C2225(1.02); C1814(1.02); C508(0.71); C1524(0.94)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C2225(0.99); C2317(1.06)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C2225(1.06); C508(1.03)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C2225(0.85); C1814(1.04)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C2225(1.36); C508(1.02); C1524(0.96)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C2225(1.23); C1935(0.84)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C2225(1.11)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C2225(1.18); C1814(1.36); C508(1.09); C1524(1.15)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C2225(0.94); C1814(1.18); C2317(1.08)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C2225(1.21)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C2225(1.01); C1814(1.26)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C2225(1.14)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C2225(1.18); C508(0.72)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C2225(1.02); C1814(1.03); C508(0.81); C1524(0.98)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C2225(1.18)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C2225(1.01); C2317(1.07)  LDD1623  [14]
 LDCM0420  CL31 HCT 116 C1814(0.83)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1814(0.69)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1814(0.81)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1814(0.84)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1814(0.86)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1814(0.75)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1814(0.93)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1814(0.64)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C2225(1.36); C508(0.91)  LDD1633  [14]
 LDCM0430  CL40 HCT 116 C1814(0.84)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1814(0.78)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1814(0.80)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1814(0.93)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1814(0.93)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1814(0.78)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1814(0.59)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1814(0.77)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1814(0.75)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1814(0.82)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C2225(1.25); C1814(1.05); C508(1.00); C1524(1.22)  LDD1644  [14]
 LDCM0441  CL50 HCT 116 C1814(0.65)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1814(0.68)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1814(0.64)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1814(0.69)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1814(0.91)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1814(0.77)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1814(0.66)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1814(0.77)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1814(0.75)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1814(0.91)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C2225(1.13); C2317(1.09)  LDD1654  [14]
 LDCM0452  CL60 HCT 116 C1814(0.84)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1814(1.12)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1814(1.16)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1814(1.12)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1814(1.33)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1814(1.13)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1814(1.46)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1814(1.30)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1814(1.27)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1814(1.05)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C2225(1.25); C508(1.11)  LDD1665  [14]
 LDCM0463  CL70 HCT 116 C1814(1.25)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1814(1.22)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1814(1.15)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1814(1.10)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1814(1.14)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C2225(1.07); C508(0.80)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C2225(0.89); C1814(1.07); C508(1.01); C1524(1.00)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C2225(1.19); C2317(0.97)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C2225(1.10); C508(0.95)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C2225(1.38); C508(0.99); C1524(0.71)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C2225(1.20); C508(1.09); C1524(0.98)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C2225(1.08); C1935(1.04)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C2225(1.10)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C2225(1.24); C1814(1.19); C508(0.98); C1524(0.92)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C2225(0.81); C1814(1.12); C2317(0.95)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C2225(0.90)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C2225(1.00); C1814(1.10)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C2225(1.04)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C2225(1.16); C508(0.86)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C2225(1.12); C1814(1.15); C508(0.83); C1524(1.05)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C2225(1.10); C1935(1.77)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C2225(1.07); C2317(0.88)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C2225(1.09); C508(1.03)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C2225(1.13); C508(1.10); C1524(0.88)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C2225(1.04); C1935(0.74)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C2225(1.37)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C2225(1.11); C1814(1.32); C508(0.94); C1524(1.09)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C2225(0.85); C1814(1.04); C2317(1.06)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C2225(0.86)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C2225(0.97); C1814(1.07)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C2225(1.08)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C2225(1.21)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C2317(1.14)  LDD1702  [15]
 LDCM0625  F8 Ramos C684(0.90); C1448(1.09); C508(1.27)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C1448(1.71); C508(1.42)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C684(3.96); C1448(20.00); C508(1.24)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C684(1.97); C1448(0.70); C508(1.98)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C684(1.81); C1448(0.75)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C684(1.16); C1448(0.79); C508(0.96)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C684(2.71); C1448(0.80); C508(1.21)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C684(1.00); C1448(0.77); C508(2.45)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C684(1.21); C1448(1.02); C508(1.62)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C684(0.94); C1448(0.77); C508(1.36)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C684(0.99); C1448(0.83); C508(0.63)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C684(2.62); C1448(1.04); C508(1.72)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C684(1.29); C1448(1.27); C508(1.14)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C1448(1.42); C508(2.38)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C1814(1.20)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C684(1.31); C1448(0.61); C508(0.89)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C1448(0.97); C508(0.97)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C1814(1.00)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C684(1.42); C1448(1.15); C508(3.59)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C684(1.46); C1448(1.76); C508(0.96)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C1448(0.83); C508(1.05)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C1448(1.09); C508(1.06)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C2317(1.00); C508(1.03); C2225(0.91)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C2317(1.12); C508(1.09); C2225(0.92)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C2317(2.98)  LDD3310  [17]
 LDCM0109  NEM HeLa N.A.  LDD0226  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840