Details of the Target

General Information of Target

Target ID LDTP06090
Target Name Elongin-A (ELOA)
Gene Name ELOA
Gene ID 6924
Synonyms
TCEB3; Elongin-A; EloA; Elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Transcription elongation factor B polypeptide 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEH
VGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATG
SRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSP
PSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVS
QNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKK
EKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPK
VKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKK
KKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEKPAGADLAKLRKVPDVL
PVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGS
KCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLI
EETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQ
AKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKIKIKPAPYPMGSSHASASSISFNPSPE
EPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR
Target Bioclass
Other
Subcellular location
Nucleus
Function
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).; As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.
Uniprot ID
Q14241
Ensemble ID
ENST00000613537.5
HGNC ID
HGNC:11620

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K83(0.23)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C339(2.06)  LDD0169  [3]
DBIA
 Probe Info  		C568(408.93); C610(7.93)  LDD0209  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C610(0.00); C581(0.00); C339(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C610(0.00); C581(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C610(0.00); C581(0.00)  LDD0037  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		C339(0.00); C568(0.00)  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C339(2.02)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(2.06)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C581(1.08); C610(0.81)  LDD0531  [11]
 LDCM0215  AC10 PaTu 8988t C610(0.89)  LDD1094  [11]
 LDCM0216  AC100 HCT 116 C581(0.72)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C581(0.75)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C581(0.93)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C581(0.66)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C581(0.73)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C581(0.74)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C581(0.61)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C581(0.62)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C581(0.54)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C581(0.68)  LDD0542  [11]
 LDCM0226  AC11 PaTu 8988t C610(0.98)  LDD1105  [11]
 LDCM0227  AC110 HCT 116 C581(0.54)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C581(0.53)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C581(0.54)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C581(1.27)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C581(0.97)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C581(0.96)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C581(0.91)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C581(0.99)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C581(0.95)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C581(0.75)  LDD0553  [11]
 LDCM0237  AC12 PaTu 8988t C610(0.76)  LDD1116  [11]
 LDCM0238  AC120 HCT 116 C581(0.75)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C581(1.01)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C581(0.80)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C581(0.80)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C581(0.93)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C581(0.91)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C581(0.92)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C581(0.83)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C581(0.37)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C581(0.52)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C581(0.40)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C581(0.60)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C581(0.40)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C581(0.52)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C581(0.35)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C581(0.47)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C581(0.37)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C581(0.50)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C581(0.29)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C581(0.29)  LDD0575  [11]
 LDCM0259  AC14 PaTu 8988t C610(1.11)  LDD1138  [11]
 LDCM0260  AC140 HCT 116 C581(0.26)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C581(0.25)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C581(0.40)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C581(0.72); C610(0.94)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C581(0.44); C610(0.70)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C610(0.77); C581(1.03)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C610(0.79); C581(2.52)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C610(0.72); C581(2.73)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C610(0.86); C581(0.95)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C610(0.84); C581(2.23)  LDD0586  [11]
 LDCM0270  AC15 PaTu 8988t C610(0.92)  LDD1149  [11]
 LDCM0271  AC150 HCT 116 C610(0.71); C581(8.23)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C610(0.87); C581(4.99)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C610(0.61); C581(3.49)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C610(0.92); C581(3.48)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C581(1.70); C610(0.72)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C581(11.10); C610(0.64)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C581(10.00); C610(1.02)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C581(2.57); C610(1.15)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C581(0.84)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C581(0.80)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C581(0.74)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C610(0.88); C581(1.04)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C581(0.75)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C581(0.79)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C581(0.89)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C581(0.73)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C581(0.87)  LDD0601  [11]
 LDCM0285  AC25 PaTu 8988t C581(0.82); C610(0.80)  LDD1164  [11]
 LDCM0286  AC26 PaTu 8988t C581(1.15); C610(2.03)  LDD1165  [11]
 LDCM0287  AC27 PaTu 8988t C581(0.86); C610(1.53)  LDD1166  [11]
 LDCM0288  AC28 PaTu 8988t C581(0.81); C610(0.66)  LDD1167  [11]
 LDCM0289  AC29 PaTu 8988t C581(1.24); C610(1.47)  LDD1168  [11]
 LDCM0290  AC3 HCT 116 C610(0.89); C581(1.14)  LDD0607  [11]
 LDCM0291  AC30 PaTu 8988t C581(0.77); C610(0.76)  LDD1170  [11]
 LDCM0292  AC31 PaTu 8988t C581(0.86); C610(1.05)  LDD1171  [11]
 LDCM0293  AC32 PaTu 8988t C581(0.99); C610(0.79)  LDD1172  [11]
 LDCM0294  AC33 PaTu 8988t C581(0.82); C610(0.62)  LDD1173  [11]
 LDCM0295  AC34 PaTu 8988t C581(0.80); C610(0.90)  LDD1174  [11]
 LDCM0296  AC35 HCT 116 C610(0.89); C581(1.07)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C581(0.94); C610(1.10)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C610(0.86); C581(0.89)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C581(0.92); C610(1.08)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C581(0.81); C610(1.18)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C610(0.77); C581(1.19)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C610(0.81); C581(0.87)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C610(0.94); C581(1.04)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C610(0.97); C581(1.02)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C581(1.03); C610(1.29)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C581(0.98); C610(1.07)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C610(0.89); C581(0.90)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C610(1.15); C581(1.26)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C610(1.09); C581(1.21)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C581(1.51); C610(2.13)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C610(0.95); C581(1.10)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C610(0.86); C581(1.11)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C581(1.04); C610(1.10)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C581(1.56); C610(1.91)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C610(1.14); C581(1.22)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C610(0.97); C581(1.07)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C610(0.73); C581(1.06)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C610(1.15); C581(1.20)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C610(1.25); C581(1.39)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C610(0.46)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C610(0.52)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C610(0.37)  LDD0639  [11]
 LDCM0323  AC6 PaTu 8988t C610(1.32)  LDD1202  [11]
 LDCM0324  AC60 HCT 116 C610(0.48)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C610(0.89)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C610(0.49)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C610(0.53)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C610(0.48)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C610(0.60)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C610(0.55)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C610(0.49)  LDD0648  [11]
 LDCM0332  AC68 PaTu 8988t C581(1.19); C610(1.46)  LDD1211  [11]
 LDCM0333  AC69 PaTu 8988t C581(1.10); C610(1.20)  LDD1212  [11]
 LDCM0334  AC7 PaTu 8988t C610(0.76)  LDD1213  [11]
 LDCM0335  AC70 PaTu 8988t C581(1.00); C610(1.25)  LDD1214  [11]
 LDCM0336  AC71 PaTu 8988t C581(1.18); C610(1.84)  LDD1215  [11]
 LDCM0337  AC72 PaTu 8988t C581(0.77); C610(1.10)  LDD1216  [11]
 LDCM0338  AC73 PaTu 8988t C581(0.85); C610(1.09)  LDD1217  [11]
 LDCM0339  AC74 PaTu 8988t C581(0.95); C610(1.26)  LDD1218  [11]
 LDCM0340  AC75 PaTu 8988t C581(0.87); C610(1.33)  LDD1219  [11]
 LDCM0341  AC76 PaTu 8988t C581(0.77); C610(1.05)  LDD1220  [11]
 LDCM0342  AC77 PaTu 8988t C581(1.24); C610(2.58)  LDD1221  [11]
 LDCM0343  AC78 PaTu 8988t C581(0.92); C610(1.02)  LDD1222  [11]
 LDCM0344  AC79 PaTu 8988t C581(1.21); C610(2.29)  LDD1223  [11]
 LDCM0345  AC8 PaTu 8988t C610(0.80)  LDD1224  [11]
 LDCM0346  AC80 PaTu 8988t C581(1.05); C610(1.42)  LDD1225  [11]
 LDCM0347  AC81 PaTu 8988t C581(0.82); C610(1.36)  LDD1226  [11]
 LDCM0348  AC82 PaTu 8988t C581(0.94); C610(1.32)  LDD1227  [11]
 LDCM0349  AC83 HCT 116 C581(1.15)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C581(1.34)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C581(1.08)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C581(1.39)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C581(1.44)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C581(1.22)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C581(1.42)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C581(1.25)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C581(1.25)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C581(1.26)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C581(1.08)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C581(1.08)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C581(1.17)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C581(0.90)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C581(1.88)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C581(0.67)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C581(0.69)  LDD0683  [11]
 LDCM0248  AKOS034007472 PaTu 8988t C610(1.54)  LDD1127  [11]
 LDCM0356  AKOS034007680 PaTu 8988t C610(0.98)  LDD1235  [11]
 LDCM0275  AKOS034007705 PaTu 8988t C610(0.70)  LDD1154  [11]
 LDCM0156  Aniline NCI-H1299 12.26  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C610(0.90); C339(0.98)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C610(0.81); C339(1.07); C581(0.89)  LDD1572  [12]
 LDCM0369  CL100 HCT 116 C610(0.62); C581(0.94)  LDD0686  [11]
 LDCM0370  CL101 PaTu 8988t C610(0.78)  LDD1249  [11]
 LDCM0371  CL102 PaTu 8988t C610(0.73)  LDD1250  [11]
 LDCM0372  CL103 PaTu 8988t C610(0.78)  LDD1251  [11]
 LDCM0373  CL104 PaTu 8988t C610(1.00)  LDD1252  [11]
 LDCM0374  CL105 HCT 116 C581(0.61)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C581(0.74)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C581(0.62)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C581(0.66)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C581(0.63)  LDD0695  [11]
 LDCM0379  CL11 HEK-293T C610(1.19); C339(1.05)  LDD1583  [12]
 LDCM0380  CL110 HCT 116 C581(0.61)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C581(0.70)  LDD0698  [11]
 LDCM0382  CL112 PaTu 8988t C581(0.71); C610(0.58)  LDD1261  [11]
 LDCM0383  CL113 PaTu 8988t C581(0.78); C610(0.65)  LDD1262  [11]
 LDCM0384  CL114 PaTu 8988t C581(0.81); C610(0.63)  LDD1263  [11]
 LDCM0385  CL115 PaTu 8988t C581(0.83); C610(0.55)  LDD1264  [11]
 LDCM0386  CL116 PaTu 8988t C581(1.36); C610(1.83)  LDD1265  [11]
 LDCM0387  CL117 HCT 116 C610(0.88); C581(1.04)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C581(0.88); C610(1.01)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C610(0.92); C581(0.94)  LDD0706  [11]
 LDCM0390  CL12 HEK-293T C610(1.17); C339(0.98); C581(1.01)  LDD1594  [12]
 LDCM0391  CL120 HCT 116 C581(0.91); C610(1.39)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C581(0.85); C610(0.92)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C610(1.20); C581(1.24)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C610(0.87); C581(1.04)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C610(0.93); C581(1.05)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C610(0.64)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C610(0.38)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C610(0.42)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C610(0.41)  LDD0716  [11]
 LDCM0400  CL13 HEK-293T C610(0.86); C339(0.96)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C610(1.17); C339(1.00)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C339(1.00); C581(0.93)  LDD1606  [12]
 LDCM0403  CL16 PaTu 8988t C610(0.77)  LDD1282  [11]
 LDCM0404  CL17 PaTu 8988t C610(0.91)  LDD1283  [11]
 LDCM0405  CL18 PaTu 8988t C610(0.69)  LDD1284  [11]
 LDCM0406  CL19 PaTu 8988t C610(0.72)  LDD1285  [11]
 LDCM0407  CL2 HEK-293T C610(1.06); C339(0.98)  LDD1611  [12]
 LDCM0408  CL20 PaTu 8988t C610(0.72)  LDD1287  [11]
 LDCM0409  CL21 PaTu 8988t C610(0.71)  LDD1288  [11]
 LDCM0410  CL22 PaTu 8988t C610(0.70)  LDD1289  [11]
 LDCM0411  CL23 PaTu 8988t C610(1.40)  LDD1290  [11]
 LDCM0412  CL24 PaTu 8988t C610(1.15)  LDD1291  [11]
 LDCM0413  CL25 PaTu 8988t C610(0.95)  LDD1292  [11]
 LDCM0414  CL26 PaTu 8988t C610(0.75)  LDD1293  [11]
 LDCM0415  CL27 PaTu 8988t C610(0.87)  LDD1294  [11]
 LDCM0416  CL28 PaTu 8988t C610(0.98)  LDD1295  [11]
 LDCM0417  CL29 PaTu 8988t C610(1.04)  LDD1296  [11]
 LDCM0418  CL3 HEK-293T C339(1.08); C581(0.90)  LDD1622  [12]
 LDCM0419  CL30 PaTu 8988t C610(0.97)  LDD1298  [11]
 LDCM0420  CL31 PaTu 8988t C610(0.52)  LDD1299  [11]
 LDCM0421  CL32 PaTu 8988t C610(0.69)  LDD1300  [11]
 LDCM0422  CL33 PaTu 8988t C610(0.48)  LDD1301  [11]
 LDCM0423  CL34 PaTu 8988t C610(0.57)  LDD1302  [11]
 LDCM0424  CL35 PaTu 8988t C610(0.47)  LDD1303  [11]
 LDCM0425  CL36 PaTu 8988t C610(0.75)  LDD1304  [11]
 LDCM0426  CL37 PaTu 8988t C610(0.60)  LDD1305  [11]
 LDCM0428  CL39 PaTu 8988t C610(0.72)  LDD1307  [11]
 LDCM0429  CL4 HEK-293T C339(0.89); C581(1.07)  LDD1633  [12]
 LDCM0430  CL40 PaTu 8988t C610(0.64)  LDD1309  [11]
 LDCM0431  CL41 PaTu 8988t C610(0.52)  LDD1310  [11]
 LDCM0432  CL42 PaTu 8988t C610(0.59)  LDD1311  [11]
 LDCM0433  CL43 PaTu 8988t C610(0.64)  LDD1312  [11]
 LDCM0434  CL44 PaTu 8988t C610(0.71)  LDD1313  [11]
 LDCM0435  CL45 PaTu 8988t C610(0.59)  LDD1314  [11]
 LDCM0436  CL46 PaTu 8988t C610(0.83)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C610(1.03)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C610(0.88)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C610(0.82)  LDD1318  [11]
 LDCM0440  CL5 HEK-293T C610(0.84); C339(0.87)  LDD1644  [12]
 LDCM0441  CL50 PaTu 8988t C610(0.66)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C610(0.89)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C610(0.83)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C610(1.01)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C610(1.13)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C610(0.69)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C610(0.65)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C610(0.86)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C610(0.85)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C610(1.00)  LDD1329  [11]
 LDCM0451  CL6 HEK-293T C339(0.91); C581(1.01)  LDD1654  [12]
 LDCM0452  CL60 PaTu 8988t C610(1.01)  LDD1331  [11]
 LDCM0453  CL61 HCT 116 C581(0.86)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C581(0.91)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C581(0.88)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C581(0.80)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C581(0.95)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C581(0.76)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C581(0.86)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C581(0.91)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C581(2.12)  LDD0778  [11]
 LDCM0462  CL7 HEK-293T C610(0.93); C339(0.91); C581(1.05)  LDD1665  [12]
 LDCM0463  CL70 HCT 116 C581(0.99)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C581(0.97)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C581(0.92)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C581(0.77)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C581(0.90)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C581(0.94)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C581(0.73)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C581(0.70)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C581(0.68)  LDD0789  [11]
 LDCM0473  CL8 HEK-293T C339(0.63); C581(0.97)  LDD1676  [12]
 LDCM0474  CL80 HCT 116 C581(1.12)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C581(0.68)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C581(0.70)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C581(0.69)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C581(0.83)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C581(0.77)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C581(0.75)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C581(0.75)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C581(0.63)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C581(0.88)  LDD0800  [11]
 LDCM0484  CL9 HEK-293T C610(1.13); C339(0.92); C581(0.90)  LDD1687  [12]
 LDCM0485  CL90 HCT 116 C581(1.01)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C581(0.92); C610(0.97)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C581(1.15); C610(0.81)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C581(1.16); C610(0.88)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C581(1.12); C610(0.74)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C581(0.74); C610(0.66)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C581(1.00); C610(0.82)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C581(1.05); C610(0.77)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C581(1.02); C610(0.62)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C581(1.02); C610(0.60)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C339(1.05); C581(0.95)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C568(2.49); C610(1.78)  LDD1702  [13]
 LDCM0572  Fragment10 Ramos C339(0.59)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C339(3.55)  LDD2190  [14]
 LDCM0588  Fragment30 Ramos C339(1.41)  LDD2199  [14]
 LDCM0590  Fragment32 Ramos C339(1.05)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C581(1.04)  LDD0785  [11]
 LDCM0566  Fragment4 Ramos C339(1.97)  LDD2184  [14]
 LDCM0427  Fragment51 PaTu 8988t C610(0.62)  LDD1306  [11]
 LDCM0614  Fragment56 Ramos C339(0.84)  LDD2205  [14]
 LDCM0022  KB02 HEK-293T C339(0.95)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C568(408.93); C610(7.93)  LDD0209  [4]
 LDCM0024  KB05 G361 C610(2.55); C581(2.01)  LDD3311  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
MyoD family inhibitor (MDFI) MDFI family Q99750
Kelch-like protein 2 (KLHL2) . O95198
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Cytospin-A (SPECC1L) Cytospin-A family Q69YQ0
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Liprin-alpha-1 (PPFIA1) Liprin family Q13136
Colorectal mutant cancer protein (MCC) MCC family P23508
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Axin-2 (AXIN2) . Q9Y2T1
Centrobin (CNTROB) . Q8N137
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Period circadian protein homolog 2 (PER2) . O15055
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840