Details of the Target

General Information of Target

Target ID LDTP06039
Target Name Dystroglycan 1 (DAG1)
Gene Name DAG1
Gene ID 1605
Synonyms
Dystroglycan 1; Dystroglycan; Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan; Alpha-DG; Beta-dystroglycan; Beta-DG)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEA
VPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGL
PLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSS
ACAADEPVTVLTVILDADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSA
FMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIA
NKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRD
PVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPP
TTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSITRLETASPPTRI
RTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKL
REQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQ
GDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWT
NNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQFIP
VVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRK
GKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETT
PLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Secreted, extracellular space; Cell membrane
Function
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5.; [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses. Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2.
TTD ID
T63883
Uniprot ID
Q14118
DrugMap ID
TT4X7PG
Ensemble ID
ENST00000308775.7
HGNC ID
HGNC:2666
ChEMBL ID
CHEMBL3714399

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K611(5.00); K782(5.68); K793(1.25); K794(1.56)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K500(4.65)  LDD3494  [2]
DBIA
 Probe Info  		C713(0.40)  LDD0533  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		H624(0.00); H526(0.00)  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
HHS-465
 Probe Info  		K572(0.00); Y562(0.00)  LDD2240  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		12.55  LDD1850  [12]
C388
 Probe Info  		44.94  LDD2047  [12]
C390
 Probe Info  		21.71  LDD2049  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C713(0.99); C642(1.00); C264(1.02)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C713(0.96); C642(1.02); C264(0.78)  LDD1508  [13]
 LDCM0216  AC100 HCT 116 C713(0.40)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C713(0.48)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C713(0.29)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C713(0.47)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C713(0.36)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C713(0.31)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C713(0.73)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C713(0.56)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C713(0.40)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C713(0.30)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C713(1.05); C642(0.93); C264(1.12)  LDD1509  [13]
 LDCM0227  AC110 HCT 116 C713(0.45)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C713(0.33)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C713(0.38)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C713(0.72)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C713(0.93)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C713(0.78)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C713(0.95)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C713(1.18)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C713(0.67)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C713(1.06)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C713(1.10); C642(1.07); C264(0.97)  LDD1510  [13]
 LDCM0238  AC120 HCT 116 C713(1.12)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C713(0.81)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C713(1.16)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C713(1.57)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C713(1.78)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C713(0.80)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C713(0.95)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C713(1.05)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C713(0.90); C642(1.10); C264(1.00)  LDD1512  [13]
 LDCM0263  AC143 HCT 116 C713(0.96)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C713(1.29)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C713(1.06)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C713(0.96)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C713(0.94)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C713(0.91)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C713(1.20)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C713(0.93); C642(1.05); C264(1.06)  LDD1513  [13]
 LDCM0271  AC150 HCT 116 C713(1.05)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C713(1.18)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C713(0.93)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C713(1.27)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C713(0.99)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C713(2.25)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C713(1.68)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C713(1.86)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C713(0.97); C642(0.99); C264(1.00)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C713(1.06); C642(0.98); C264(0.91)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C713(1.58); C642(1.18); C264(1.13)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C713(0.95); C642(1.09); C264(0.98)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C713(1.09); C642(1.00); C264(0.91)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C713(1.03); C642(1.03); C264(0.97)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C713(0.98); C642(0.89); C264(1.04)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C713(0.94); C642(1.03); C264(1.15)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C713(0.94); C642(1.03); C264(0.97)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C713(1.05); C642(0.99); C264(0.96)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C713(1.06); C642(0.96); C264(0.95)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C713(1.08); C642(1.00); C264(1.08)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C713(1.00); C642(1.00); C264(1.05)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C713(0.92); C642(1.00); C264(0.92)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C713(1.04); C642(0.98); C264(1.05)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C713(1.00); C642(0.94); C264(0.88)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C713(1.02); C642(1.06); C264(1.05)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C713(1.01); C642(1.00); C264(0.98)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C713(1.08); C642(1.03); C264(1.07)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C713(0.95); C642(0.99); C264(0.90)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C713(1.00); C642(1.05); C264(1.09)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C713(1.09); C642(1.04); C264(0.96)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C713(0.86); C642(1.05); C264(0.97)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C713(0.92); C642(1.04); C264(1.00)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C713(0.97); C642(1.12); C264(1.04)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C713(1.08); C642(0.99); C264(0.98)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C713(0.97); C642(0.97); C264(1.04)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C713(1.11); C642(0.99); C264(1.07)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C713(1.17); C642(1.08); C264(0.95)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C713(1.04); C642(1.02); C264(1.17)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C713(1.04); C642(1.05); C264(0.98)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C713(1.09); C642(1.04); C264(1.00)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C713(1.05); C642(1.06); C264(0.98)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C713(0.90); C642(0.97); C264(1.11)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C713(0.93); C642(1.11); C264(1.17)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C713(1.01); C642(1.04); C264(1.00)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C713(0.94); C642(1.07); C264(0.96)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C713(1.01); C642(1.10); C264(0.88)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C713(0.99); C642(1.09); C264(1.01)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C713(1.03); C642(1.09); C264(1.05)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C713(0.98); C642(1.10); C264(1.01)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C713(0.99); C642(0.95); C264(0.89)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C713(0.91); C642(1.11); C264(1.01)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C713(0.91); C642(1.03); C264(0.97)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C713(1.04); C642(0.97); C264(0.99)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C713(1.05); C642(1.06); C264(0.89)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C713(1.02); C642(1.08); C264(1.11)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C713(0.96); C642(0.96); C264(1.15)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C713(1.06); C642(0.98); C264(1.05)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C713(1.01); C642(0.95); C264(0.92)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C713(1.00); C642(0.94); C264(0.92)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C713(0.97); C642(0.98); C264(1.01)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C713(1.00); C642(1.05); C264(1.05)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C713(0.83); C642(1.00); C264(1.01)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C713(0.96); C642(0.93); C264(0.99)  LDD1569  [13]
 LDCM0349  AC83 HCT 116 C713(0.80)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C713(2.13)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C713(1.11)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C713(1.41)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C713(1.09)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C713(1.11)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C713(1.02)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C713(0.70)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C713(0.90)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C713(1.17)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C713(0.97)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C713(0.84)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C713(1.95)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C713(1.23)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C713(1.31)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C713(0.32)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C713(0.38)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C713(1.01); C642(1.08); C264(0.97)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C713(0.95); C642(1.05); C264(0.97)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C713(0.92); C642(1.03); C264(0.95)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C713(0.98); C642(0.97); C264(1.10)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C713(1.05); C642(1.22); C264(1.03)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C713(1.00); C642(1.08); C264(0.98)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C713(1.02); C642(1.15); C264(1.09)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C713(0.97); C642(1.02); C264(0.97)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C713(1.02); C642(1.08); C264(0.94)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C713(1.02); C642(0.98); C264(0.92)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C713(1.09); C642(0.95); C264(1.25)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C713(0.97); C642(1.15); C264(0.98)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C713(0.95); C642(1.04); C264(1.05)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C713(1.11); C642(0.98); C264(0.85)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C713(1.02); C642(0.99); C264(1.08)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C713(1.02); C642(1.02); C264(0.97)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C713(1.14); C642(1.02); C264(1.14)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C713(1.01); C642(1.01); C264(1.06)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C713(1.12); C642(0.99); C264(1.06)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C713(1.04); C642(0.94); C264(1.05)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C713(1.02); C642(1.12); C264(1.25)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C713(1.03); C642(1.10); C264(0.98)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C713(1.05); C642(1.05); C264(0.99)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C713(1.04); C642(1.02); C264(1.07)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C713(1.02); C642(1.09); C264(0.98)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C713(0.98); C642(1.08); C264(1.05)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C713(1.11); C642(0.98); C264(1.02)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C713(1.04); C642(1.08); C264(0.98)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C713(1.07); C642(1.11); C264(1.11)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C713(0.99); C642(1.16); C264(1.01)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C713(0.96); C642(1.09); C264(1.05)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C713(1.00); C642(1.05); C264(1.03)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C713(0.98); C642(1.08); C264(0.92)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C713(1.01); C642(1.02); C264(0.99)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C713(1.02); C642(1.09); C264(0.99)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C713(1.09); C642(0.97); C264(1.10)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C713(1.19); C642(1.03); C264(1.23)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C713(1.01); C642(1.09); C264(0.90)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C713(1.11); C642(1.02); C264(1.03)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C713(1.07); C642(1.01); C264(0.99)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C713(1.20); C642(1.11); C264(1.00)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C713(0.97); C642(1.12); C264(0.90)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C713(0.99); C642(1.21); C264(1.04)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C713(0.98); C642(1.05); C264(0.88)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C713(1.16); C642(1.13); C264(1.02)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C713(1.15); C642(1.08); C264(1.01)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C713(1.06); C642(1.21); C264(0.92)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C713(1.00); C642(1.07); C264(1.06)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C713(1.05); C642(0.98); C264(0.89)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C713(1.00); C642(1.14); C264(0.84)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C713(0.98); C642(1.09); C264(1.00)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C713(1.00); C642(1.08); C264(0.99)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C713(1.03); C642(1.12); C264(0.93)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C713(1.03); C642(1.02); C264(1.02)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C713(1.02); C642(1.11); C264(0.96)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C713(0.93); C642(1.04); C264(0.84)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C713(1.01); C642(1.16); C264(1.14)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C713(1.05); C642(1.14); C264(1.01)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C713(1.30); C642(1.22); C264(1.05)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C713(1.04); C642(1.02); C264(0.97)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C713(1.10); C642(1.11); C264(1.02)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C713(0.97); C642(0.96); C264(0.94)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C713(0.92); C642(0.97); C264(1.13)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C713(1.12); C642(1.02); C264(0.90)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C713(1.09); C642(1.07); C264(0.93)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C713(1.02); C642(0.99); C264(0.91)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C713(0.99); C642(0.98); C264(1.13)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C713(1.10); C642(1.11); C264(0.88)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C713(1.02); C642(1.07); C264(0.83)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C713(1.12); C642(0.97); C264(0.95)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C713(1.16); C642(1.09); C264(1.00)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C713(1.17); C642(1.03); C264(0.99)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C713(1.10); C642(1.21); C264(1.00)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C713(1.08); C642(1.02); C264(0.84)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C713(0.89); C642(0.99); C264(0.89)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C713(1.09); C642(0.95); C264(1.03)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C713(1.00); C642(0.98); C264(1.12)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C713(1.05); C642(1.07); C264(0.98)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C713(1.12); C642(1.06); C264(1.12)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C713(1.12); C642(1.25); C264(0.95)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C713(1.10); C642(1.16); C264(1.03)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C713(1.21); C642(1.12); C264(0.94)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C713(1.19); C642(1.26); C264(1.07)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C713(1.05); C642(1.18); C264(0.86)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C713(0.91); C642(1.11); C264(1.11)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C713(1.18); C642(1.18); C264(0.95)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C713(1.06); C642(1.05); C264(0.99)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C713(0.90); C642(0.95); C264(0.95)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C713(0.95); C642(0.98); C264(1.15)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C713(1.00); C642(1.06); C264(0.94)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C713(1.09); C642(1.22); C264(1.01)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C713(1.05); C642(1.06); C264(1.05)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C713(1.06); C642(1.09); C264(0.79)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C713(1.08); C642(1.18); C264(1.09)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C713(1.07); C642(1.10); C264(0.94)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C713(1.09); C642(1.07); C264(0.90)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C713(0.94); C642(1.12); C264(0.98)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C713(0.99); C642(1.05); C264(0.98)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C713(1.13); C642(1.11); C264(0.90)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C713(1.09); C642(1.08); C264(0.97)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C713(1.02); C642(1.12); C264(1.00)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C713(0.95); C642(1.03); C264(0.94)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C713(1.04); C642(0.97); C264(0.84)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C713(1.08); C642(1.02); C264(1.02)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C713(0.99); C642(1.11); C264(1.00)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C713(0.95); C642(1.03); C264(0.94)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C713(1.43); C642(1.24); C264(1.04)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C713(1.05); C642(1.13); C264(0.95)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C713(1.07); C642(1.08); C264(0.94)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C713(1.06); C642(1.04); C264(0.89)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C713(1.04); C642(1.07); C264(0.99)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C713(0.96); C642(0.96); C264(1.21)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C713(0.91); C642(1.02); C264(0.97)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C713(1.05); C642(1.04); C264(0.88)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C713(1.10); C642(1.02); C264(0.93)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C713(0.98); C642(1.01); C264(0.96)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C713(0.99); C642(1.02); C264(0.99)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C713(1.05); C642(1.01); C264(0.87)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C713(1.20); C642(1.25); C264(1.17)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C713(1.06); C642(1.04); C264(1.08)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C713(1.07); C642(1.03); C264(0.95)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C713(1.05); C642(0.99); C264(0.93)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C713(1.08); C642(0.99); C264(0.94)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C713(1.30); C642(1.17); C264(1.24)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C713(1.04); C642(1.02); C264(1.13)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C713(1.03); C642(1.04); C264(1.08)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C713(1.07); C642(1.03); C264(0.99)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C713(1.02); C642(0.95); C264(0.91)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C713(1.05); C642(1.03); C264(1.00)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C713(1.03); C642(1.02); C264(0.93)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C713(0.95); C642(1.06); C264(0.96)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C713(0.85); C642(0.90); C264(1.35)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C713(1.11); C642(1.04); C264(1.54)  LDD1497  [13]
 LDCM0024  KB05 Hs 936.T C713(1.92)  LDD3313  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Utrophin (UTRN) . P46939
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840