Details of the Target

General Information of Target

Target ID LDTP05705
Target Name Ankyrin-3 (ANK3)
Gene Name ANK3
Gene ID 288
Synonyms
Ankyrin-3; ANK-3; Ankyrin-G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDY
IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA
EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA
LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH
IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD
GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV
DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL
KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE
VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA
REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT
PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV
TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG
AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN
VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETM
NEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE
GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSL
RHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRI
TCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL
RSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRI
KQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFS
PIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDI
TGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKM
NDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGG
QQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHK
KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFST
RPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSS
VKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTF
SSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVS
PVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATAT
LQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL
YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLT
TETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQ
TDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSD
KGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTND
IGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMAD
SFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPP
VITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQ
MKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAF
QSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA
EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE
ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGES
YRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYK
DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRT
VKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELL
ASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA
PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQ
VFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKA
MPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRE
NHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDH
PGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMS
KETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKES
PSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQ
ECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYE
FTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS
NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVI
RVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQKEL
ESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDL
QDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKP
PSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGL
DFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP
FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQP
QSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRT
PIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHD
FQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCV
RDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKA
LTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVT
TTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKK
MQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRR
TGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKK
WVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGW
QNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPE
AKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKP
CVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm, cytoskeleton
Function
Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions.; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
Uniprot ID
Q12955
Ensemble ID
ENST00000280772.7
HGNC ID
HGNC:494

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1409(0.96)  LDD0531  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		C738(0.00); C1369(0.00); C1430(0.00); C4233(0.00)  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		14.40  LDD0443  [6]
NAIA_5
 Probe Info  		C1430(0.00); C1409(0.00)  LDD2223  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1409(0.96)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C1409(1.11)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C4321(1.85)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C4321(1.68)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C4321(1.41)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C4321(1.77)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C4321(1.37)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C4321(1.82)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C4321(1.44)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C4321(1.40)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C4321(1.30)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C4321(0.88)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C1409(0.83)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C4321(1.16)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C4321(0.96)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C4321(1.02)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C1409(1.45); C4321(1.30)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C1409(1.29); C4321(0.83)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C1409(1.19); C4321(0.94)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C1409(1.44); C4321(0.88)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C1409(1.36); C4321(1.13)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C1409(1.33); C4321(1.11)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C1409(1.05); C4321(0.91)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C1409(0.58)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C1409(1.25); C4321(0.83)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C1409(1.08); C4321(1.31)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C1409(1.25); C4321(0.94)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C1409(0.89); C4321(1.47)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C1409(0.95); C4321(1.20)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C1409(1.19); C4321(0.82)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C1409(1.08); C4321(0.81)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C1409(0.92); C4321(1.15)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C1409(0.83)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C1409(0.82)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C1409(0.93)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C1409(0.95)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C1409(0.87)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C1409(1.17)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C1409(1.06)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C1409(1.04)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C1409(1.15)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C1409(0.87)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C1409(1.08)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C1409(1.24)  LDD0607  [1]
 LDCM0296  AC35 HCT 116 C1409(0.93)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1409(0.91)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1409(1.08)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1409(1.21)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1409(1.13)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C1409(1.05)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C1409(1.18)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1409(1.10)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1409(1.22)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1409(1.31)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1409(1.08)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1409(1.03)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C1409(1.06)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C1409(1.08)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C1409(0.93)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C1409(1.00)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C1409(1.28)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C1409(1.03)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C1409(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C1409(0.84)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C1409(0.98)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C1409(1.02)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C1409(0.90)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C1409(1.24)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C1409(0.90)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C1409(0.97)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C1409(0.71)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C1409(0.95)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C1409(0.65)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C1409(0.63)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C1409(0.64)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C1409(0.53)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C1409(0.54)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C1409(0.67)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C1409(0.53)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C1409(0.85)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C1409(0.81)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1409(0.90)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C1409(0.87)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C1409(1.06)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1409(0.91)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1409(1.07)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1409(1.20)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1409(0.99)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1409(0.98)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1409(0.86)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1409(0.98)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1409(0.93)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1409(1.07)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C1409(1.04)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C1409(0.94)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1409(0.84)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1409(0.99)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C1409(1.56); C4321(2.43)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1409(1.50); C4321(2.64)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1409(1.21); C4321(2.34)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1409(1.52); C4321(2.02)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1409(1.43); C4321(1.92)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1409(1.38); C4321(2.23)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1409(1.35); C4321(1.71)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1409(1.41); C4321(1.91)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1409(1.21); C4321(1.48)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1409(1.33); C4321(2.14)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1409(1.10); C4321(1.81)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1409(1.11); C4321(1.60)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1409(1.57); C4321(2.05)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1409(1.27); C4321(1.63)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1409(1.41); C4321(1.89)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C4321(2.42)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C4321(2.08)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C1409(0.78)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C1409(0.93)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C1409(0.86)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C4233(1.01)  LDD2171  [1]
 LDCM0632  CL-Sc Hep-G2 C4321(1.99); C4321(1.43)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C1409(0.82)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1409(1.01)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C1409(1.12)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C1409(0.79)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C1409(0.72)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C1409(0.86)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C1409(0.72)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C1409(0.83)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C1409(0.80)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C1409(0.89)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C1409(0.96)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C1409(0.95)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C1409(0.89)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C1409(0.95)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C1409(1.00)  LDD0698  [1]
 LDCM0387  CL117 HCT 116 C1409(0.84)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1409(0.83)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1409(1.13)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C1409(1.04)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C1409(0.89)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C1409(1.06)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C1409(1.06)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C1409(1.28)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C1409(1.33)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C1409(1.01)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C1409(1.10)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C1409(1.26)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C1409(0.94)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C1409(0.91)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1409(0.94)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1409(0.70)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C1409(0.95)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1409(0.63)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C1409(0.87)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C1409(0.70)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C1409(0.86)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C1409(0.81)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C1409(0.68)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C1409(0.85)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C1409(0.80)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C1409(1.02)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1409(0.75)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1409(0.94)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1409(0.72)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1409(0.79)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1409(0.73)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C1409(1.00)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C1409(0.60)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C1409(0.77)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C1409(0.78)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1409(1.09)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1409(1.05)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1409(1.05)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1409(0.91)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1409(1.04)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1409(0.79)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C1409(1.02)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C1409(0.83)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1409(0.91)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1409(1.04)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1409(0.99)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1409(1.00)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1409(0.99)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C1409(1.45)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1409(1.05)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1409(1.21)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1409(1.30)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C1409(0.96)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C1409(1.13)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1409(1.98)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1409(1.04)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1409(1.14)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1409(1.02)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1409(1.00)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1409(1.06)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1409(0.96)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1409(1.10)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1409(1.25)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C1409(0.87)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C1409(1.09)  LDD0769  [1]
 LDCM0462  CL7 HCT 116 C1409(1.02)  LDD0779  [1]
 LDCM0469  CL76 HCT 116 C1409(0.79); C4321(1.21)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1409(0.68); C4321(0.93)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1409(0.66); C4321(0.86)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1409(0.79); C4321(1.11)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C1409(0.81)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C1409(0.69); C4321(1.04)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1409(0.90); C4321(0.94)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1409(0.58); C4321(1.28)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1409(0.81); C4321(0.87)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1409(0.84); C4321(1.11)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1409(0.66); C4321(1.24)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1409(0.62); C4321(1.33)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1409(1.14); C4321(1.03)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1409(1.13); C4321(1.13)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1409(0.60); C4321(0.53)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C1409(0.82)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C1409(0.56); C4321(0.71)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C1409(1.12)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C1409(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C1409(1.02)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C1409(1.04)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C1409(0.90)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C1409(1.06)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C1409(1.13)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C1409(1.11)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C1409(1.11)  LDD0811  [1]
 LDCM0634  CY-0357 Hep-G2 C4233(1.07)  LDD2228  [7]
 LDCM0427  Fragment51 HCT 116 C1409(0.85)  LDD0744  [1]
 LDCM0022  KB02 22RV1 C998(3.30); C564(2.44)  LDD2243  [9]
 LDCM0023  KB03 22RV1 C998(4.09); C564(4.04)  LDD2660  [9]
 LDCM0024  KB05 G361 C998(4.48); C564(3.44); C945(0.98)  LDD3311  [9]
 LDCM0021  THZ1 HCT 116 C4233(1.01)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NGFI-A-binding protein 2 (NAB2) NAB family Q15742

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840