Details of the Target

General Information of Target

Target ID LDTP05658
Target Name Tastin (TROAP)
Gene Name TROAP
Gene ID 10024
Synonyms
Tastin; Trophinin-assisting protein; Trophinin-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTRQATKDPLLRGVSPTPSKIPVRSQKRTPFPTVTSCAVDQENQDPRRWVQKPPLNIQR
PLVDSAGPRPKARHQAETSQRLVGISQPRNPLEELRPSPRGQNVGPGPPAQTEAPGTIEF
VADPAALATILSGEGVKSCHLGRQPSLAKRVLVRGSQGGTTQRVQGVRASAYLAPRTPTH
RLDPARASCFSRLEGPGPRGRTLCPQRLQALISPSGPSFHPSTRPSFQELRRETAGSSRT
SVSQASGLLLETPVQPAFSLPKGEREVVTHSDEGGVASLGLAQRVPLRENREMSHTRDSH
DSHLMPSPAPVAQPLPGHVVPCPSPFGRAQRVPSPGPPTLTSYSVLRRLTVQPKTRFTPM
PSTPRVQQAQWLRGVSPQSCSEDPALPWEQVAVRLFDQESCIRSLEGSGKPPVATPSGPH
SNRTPSLQEVKIQRIGILQQLLRQEVEGLVGGQCVPLNGGSSLDMVELQPLLTEISRTLN
ATEHNSGTSHLPGLLKHSGLPKPCLPEECGEPQPCPPAEPGPPEAFCRSEPEIPEPSLQE
QLEVPEPYPPAEPRPLESCCRSEPEIPESSRQEQLEVPEPCPPAEPRPLESYCRIEPEIP
ESSRQEQLEVPEPCPPAEPGPLQPSTQGQSGPPGPCPRVELGASEPCTLEHRSLESSLPP
CCSQWAPATTSLIFSSQHPLCASPPICSLQSLRPPAGQAGLSNLAPRTLALRERLKSCLT
AIHCFHEARLDDECAFYTSRAPPSGPTRVCTNPVATLLEWQDALCFIPVGSAAPQGSP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Uniprot ID
Q12815
Ensemble ID
ENST00000257909.8
HGNC ID
HGNC:12327

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V24A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C718(0.92); C724(0.92)  LDD0532  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
AOyne
 Probe Info  		14.40  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C718(0.92); C724(0.92)  LDD0532  [1]
 LDCM0216  AC100 PaTu 8988t C718(1.24); C724(1.24)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C718(0.98); C724(0.98)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C718(1.01); C724(1.01)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C718(1.21); C724(1.21)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C718(0.90); C724(0.90)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C718(0.87); C724(0.87)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C718(1.17); C724(1.17)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C718(0.92); C724(0.92)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C718(0.94); C724(0.94)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C718(1.41); C724(1.41)  LDD1104  [1]
 LDCM0226  AC11 HCT 116 C718(1.05); C724(1.05)  LDD0543  [1]
 LDCM0227  AC110 PaTu 8988t C718(1.38); C724(1.38)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C718(1.27); C724(1.27)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C718(1.41); C724(1.41)  LDD1108  [1]
 LDCM0230  AC113 HCT 116 C718(0.89); C724(0.89)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C718(1.09); C724(1.09)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C718(1.37); C724(1.37)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C718(1.08); C724(1.08)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C718(1.30); C724(1.30)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C718(0.98); C724(0.98)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C718(0.93); C724(0.93)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C718(1.06); C724(1.06)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C718(1.10); C724(1.10)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C718(0.86); C724(0.86)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C718(0.91); C724(0.91)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C718(0.83); C724(0.83)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C718(0.90); C724(0.90)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C718(1.04); C724(1.04)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C718(1.19); C724(1.19)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C718(1.03); C724(1.03)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C718(0.73); C724(0.73)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C718(1.02); C724(1.02)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C718(1.25); C724(1.25)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C718(1.09); C724(1.09)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C718(1.66); C724(1.66)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C718(1.14); C724(1.14)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C718(1.25); C724(1.25)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C718(1.04); C724(1.04)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C718(1.54); C724(1.54)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C718(1.06); C724(1.06)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C718(0.93); C724(0.93)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C718(1.37); C724(1.37)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C718(0.95); C724(0.95)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C718(1.90); C724(1.90)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C718(1.25); C724(1.25)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C718(1.43); C724(1.43)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C718(1.09); C724(1.09)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C718(1.92); C724(1.92)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C718(1.45); C724(1.45)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C718(1.97); C724(1.97)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C718(1.93); C724(1.93)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C718(2.79); C724(2.79)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C718(2.07); C724(2.07)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C718(1.00); C724(1.00)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C718(1.22); C724(1.22)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C718(1.15); C724(1.15)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C718(2.46); C724(2.46)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C718(3.03); C724(3.03)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C718(2.45); C724(2.45)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C718(2.27); C724(2.27)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C718(1.32); C724(1.32)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C718(1.81); C724(1.81)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C718(1.04); C724(1.04)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C718(1.13); C724(1.13)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C718(1.06); C724(1.06)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C647(1.14)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C718(1.06); C724(1.06)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C718(1.07); C724(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C718(1.05); C724(1.05)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C718(0.90); C724(0.90)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C718(0.98); C724(0.98)  LDD0601  [1]
 LDCM0286  AC26 HEK-293T C647(1.07)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C38(1.02)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C647(1.21); C38(0.87)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C380(1.00)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C38(1.25)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C647(0.96)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C647(0.89)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C647(0.97); C38(1.29)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C647(1.33)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C718(0.99); C724(0.99)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C718(1.01); C724(1.01)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C718(0.89); C724(0.89)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C718(1.11); C724(1.11)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C718(1.08); C724(1.08)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C647(1.10); C38(0.82)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C718(0.92); C724(0.92)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C718(0.96); C724(0.96)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C718(0.90); C724(0.90)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C718(0.83); C724(0.83)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C718(0.82); C724(0.82)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C718(1.04); C724(1.04)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C718(0.77); C724(0.77)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C718(0.72); C724(0.72)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C718(0.77); C724(0.77)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C718(0.92); C724(0.92)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C380(0.92)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C718(0.89); C724(0.89)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C718(0.93); C724(0.93)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C718(0.81); C724(0.81)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C718(0.86); C724(0.86)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C718(0.89); C724(0.89)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C718(0.91); C724(0.91)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C718(0.97); C724(0.97)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C718(0.89); C724(0.89)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C718(1.03); C724(1.03)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C718(0.94); C724(0.94)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C718(0.97); C724(0.97)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C718(1.27); C724(1.27)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C718(1.05); C724(1.05)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C718(1.03); C724(1.03)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C718(1.32); C724(1.32)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C718(1.06); C724(1.06)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C718(1.14); C724(1.14)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C718(1.11); C724(1.11)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C718(1.24); C724(1.24)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C718(0.79); C724(0.79)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C718(0.77); C724(0.77)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C718(1.20); C724(1.20)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C718(0.90); C724(0.90)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C718(0.68); C724(0.68)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C718(0.89); C724(0.89)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C718(1.23); C724(1.23)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C718(0.93); C724(0.93)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C718(0.93); C724(0.93)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C718(0.82); C724(0.82)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C718(0.92); C724(0.92)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C718(0.96); C724(0.96)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C718(0.87); C724(0.87)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C718(1.08); C724(1.08)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C718(0.87); C724(0.87)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C718(0.86); C724(0.86)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C718(0.65); C724(0.65)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C718(1.38); C724(1.38)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C718(1.39); C724(1.39)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C718(1.38); C724(1.38)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C718(1.22); C724(1.22)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C718(0.92); C724(0.92)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C718(0.97); C724(0.97)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C718(1.22); C724(1.22)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C718(1.05); C724(1.05)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C718(1.38); C724(1.38)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C718(1.42); C724(1.42)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C718(1.00); C724(1.00)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C718(1.88); C724(1.88)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C718(1.08); C724(1.08)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C718(1.28); C724(1.28)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C718(1.48); C724(1.48)  LDD0681  [1]
 LDCM0365  AC98 PaTu 8988t C718(0.96); C724(0.96)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C718(0.88); C724(0.88)  LDD1245  [1]
 LDCM0248  AKOS034007472 HCT 116 C718(1.17); C724(1.17)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C718(0.90); C724(0.90)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C718(1.00); C724(1.00)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C718(0.99); C724(0.99)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C718(1.41); C724(1.41)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C718(0.81); C724(0.81)  LDD0685  [1]
 LDCM0370  CL101 HCT 116 C718(0.90); C724(0.90)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C718(0.87); C724(0.87)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C718(0.95); C724(0.95)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C718(1.01); C724(1.01)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C718(1.00); C724(1.00)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C718(0.89); C724(0.89)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C718(0.94); C724(0.94)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C718(0.80); C724(0.80)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C718(1.14); C724(1.14)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C718(1.63); C724(1.63)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C718(0.83); C724(0.83)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C718(1.12); C724(1.12)  LDD0698  [1]
 LDCM0383  CL113 HEK-293T C647(1.03)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C647(1.07)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C647(0.95); C38(1.06)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C718(1.16); C724(1.16)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C718(0.81); C724(0.81)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C718(0.89); C724(0.89)  LDD0987  [1]
 LDCM0390  CL12 HCT 116 C718(0.90); C724(0.90)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C718(0.97); C724(0.97)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C718(0.80); C724(0.80)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C718(0.90); C724(0.90)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C718(1.29); C724(1.29)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C718(0.92); C724(0.92)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C718(1.10); C724(1.10)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C718(1.10); C724(1.10)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C718(1.18); C724(1.18)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C718(0.88); C724(0.88)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C718(0.84); C724(0.84)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C718(1.04); C724(1.04)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C718(1.27); C724(1.27)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C718(1.06); C724(1.06)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C718(1.18); C724(1.18)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C718(1.12); C724(1.12)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C718(1.11); C724(1.11)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C718(0.98); C724(0.98)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C718(1.24); C724(1.24)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C718(0.93); C724(0.93)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C718(0.90); C724(0.90)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C718(1.30); C724(1.30)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C718(0.92); C724(0.92)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C718(0.85); C724(0.85)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C718(1.01); C724(1.01)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C718(1.09); C724(1.09)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C718(1.05); C724(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C718(1.04); C724(1.04)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C718(1.03); C724(1.03)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C718(0.97); C724(0.97)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C718(1.05); C724(1.05)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C718(0.98); C724(0.98)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C718(1.49); C724(1.49)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C718(1.12); C724(1.12)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C718(1.36); C724(1.36)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C718(0.83); C724(0.83)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C718(1.31); C724(1.31)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C718(1.08); C724(1.08)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C718(0.89); C724(0.89)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C718(1.12); C724(1.12)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C718(0.93); C724(0.93)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C718(0.97); C724(0.97)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C718(0.97); C724(0.97)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C718(1.32); C724(1.32)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C718(1.03); C724(1.03)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C718(0.85); C724(0.85)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C718(1.13); C724(1.13)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C718(1.20); C724(1.20)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C718(1.01); C724(1.01)  LDD1037  [1]
 LDCM0440  CL5 HCT 116 C718(0.96); C724(0.96)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C718(1.00); C724(1.00)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C718(1.31); C724(1.31)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C718(0.96); C724(0.96)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C718(1.08); C724(1.08)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C718(1.30); C724(1.30)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C718(0.95); C724(0.95)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C718(0.94); C724(0.94)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C718(1.56); C724(1.56)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C718(1.12); C724(1.12)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C718(1.01); C724(1.01)  LDD1048  [1]
 LDCM0451  CL6 HCT 116 C718(1.12); C724(1.12)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C718(1.15); C724(1.15)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C647(0.94)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C647(1.08)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C647(0.87); C38(0.97)  LDD1658  [7]
 LDCM0458  CL66 HEK-293T C647(1.21)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C38(1.14)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C647(1.10); C38(1.15)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C380(0.91)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C718(0.77); C724(0.77)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C647(1.02)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C647(1.01)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C647(0.96); C38(1.61)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C647(1.06)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C647(1.25)  LDD1670  [7]
 LDCM0471  CL78 HEK-293T C647(1.17)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C38(1.16)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C718(2.67); C724(2.67)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C647(0.93); C38(0.90)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C380(0.90)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C647(0.97)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C647(0.95)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C647(0.92); C38(1.20)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C647(0.92)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C647(1.12)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C647(0.82); C38(0.91)  LDD1684  [7]
 LDCM0484  CL9 HCT 116 C718(0.88); C724(0.88)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C647(0.95)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C38(1.08)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C647(0.93); C38(1.01)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C380(1.50)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C647(1.16)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C647(0.96)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C647(0.84); C38(1.07)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C647(0.91)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C647(1.26)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C647(0.75); C38(0.92)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C647(0.86); C38(1.23)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C647(0.77); C38(1.12)  LDD1671  [7]
 LDCM0427  Fragment51 HCT 116 C718(0.82); C724(0.82)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C647(0.97)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C647(0.96)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1155 C380(2.72)  LDD3342  [8]
 LDCM0021  THZ1 HCT 116 C718(0.99); C724(0.99)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) CMGC Ser/Thr protein kinase family Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) CMGC Ser/Thr protein kinase family Q9Y463
Receptor tyrosine-protein kinase erbB-4 (ERBB4) Tyr protein kinase family Q15303
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Bystin (BYSL) Bystin family Q13895
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Protein Mis18-beta (OIP5) Mis18 family O43482
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840