Details of the Target

General Information of Target

Target ID LDTP05398
Target Name Peroxisome proliferator-activated receptor delta (PPARD)
Gene Name PPARD
Gene ID 5467
Synonyms
NR1C2; PPARB; Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
Target Type
Clinical trial
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR1 subfamily
Subcellular location
Nucleus
Function
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
TTD ID
T36557
Uniprot ID
Q03181
DrugMap ID
TT2JWF6
Ensemble ID
ENST00000311565.4
HGNC ID
HGNC:9235
ChEMBL ID
CHEMBL3979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.G302E .
MCC13 SNV: p.R144C .
MOLT4 SNV: p.V279I .
NCIH23 SNV: p.Q374R DBIA    Probe Info 
NCIH661 SNV: p.V367F .
SKMEL28 SNV: p.E6Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C111(0.74)  LDD2227  [1]
DBIA
 Probe Info  		C249(1.14); C251(1.14)  LDD0532  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C249(1.14); C251(1.14)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C249(1.29); C251(1.29)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C249(1.07); C251(1.07)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C249(1.13); C251(1.13)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C249(1.37); C251(1.37)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C249(1.10); C251(1.10)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C249(1.09); C251(1.09)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C249(1.19); C251(1.19)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C249(1.08); C251(1.08)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C249(1.42); C251(1.42)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C249(1.30); C251(1.30)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C249(1.50); C251(1.50)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C249(1.19); C251(1.19)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C249(1.16); C251(1.16)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C249(1.33); C251(1.33)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C249(0.98); C251(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C249(1.11); C251(0.98)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C249(1.12); C251(1.16)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C249(1.31); C251(1.24)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C249(1.21); C251(0.96)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C249(1.08); C251(1.04)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C249(1.20); C251(1.06)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C249(1.11); C251(1.11)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C249(0.99); C251(1.01)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C249(1.10); C251(0.81)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C249(1.11); C251(1.06)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C249(1.09); C251(0.85)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C249(1.09); C251(0.85)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C249(1.06); C251(0.97)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C249(1.27); C251(1.18)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C249(1.04); C251(0.97)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C249(0.91); C251(0.91)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C249(1.29); C251(1.29)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C249(1.36); C251(1.36)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C249(1.16); C251(1.16)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C249(1.55); C251(1.55)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C249(1.20); C251(1.20)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C249(1.54); C251(1.54)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C249(1.31); C251(1.31)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C249(1.54); C251(1.54)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C249(1.46); C251(1.46)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C249(1.88); C251(1.88)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C249(2.30); C251(2.30)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C249(1.01); C251(1.01)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C249(2.07); C251(2.07)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C249(2.16); C251(2.16)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C249(1.74); C251(1.74)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C249(1.28); C251(1.28)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C251(0.91); C249(0.95)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C249(0.97); C251(1.01)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C251(1.05); C249(1.09)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C249(0.93); C251(0.94)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C251(0.94); C249(0.95)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C249(1.17); C251(1.19)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C249(1.31); C251(1.31)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C249(0.97); C251(1.01)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C249(1.11); C251(1.29)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C249(0.94); C251(1.06)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C251(1.07); C249(1.09)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C249(0.96); C251(1.07)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C249(1.25); C251(1.20)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C249(1.17); C251(1.10)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C249(1.14); C251(1.15)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C249(1.11); C251(1.11)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C249(1.24); C251(1.24)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C249(1.15); C251(1.15)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C249(0.86); C251(0.86)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C249(1.08); C251(1.08)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C249(1.11); C251(1.11)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C249(0.99); C251(0.99)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C249(0.93); C251(0.93)  LDD0601  [2]
 LDCM0296  AC35 HCT 116 C249(0.79); C251(0.79)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C249(0.89); C251(0.89)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C249(0.86); C251(0.86)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C249(0.94); C251(0.94)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C249(1.00); C251(1.00)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C249(1.10); C251(1.10)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C249(0.96); C251(0.96)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C249(0.95); C251(0.95)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C249(1.09); C251(1.09)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C249(0.79); C251(0.79)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C249(0.80); C251(0.80)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C249(1.40); C251(1.40)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C249(1.15); C251(1.15)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C249(1.19); C251(1.19)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C249(1.17); C251(1.17)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C249(1.09); C251(1.09)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C249(0.88); C251(0.88)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C249(0.97); C251(0.97)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C249(1.16); C251(1.16)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C249(0.85); C251(0.85)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C249(1.20); C251(1.20)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C249(0.94); C251(0.94)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C249(1.06); C251(1.06)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C249(1.02); C251(1.02)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C249(1.17); C251(1.17)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C249(1.16); C251(1.16)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C249(1.16); C251(1.16)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C249(1.12); C251(1.12)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C249(1.06); C251(1.06)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C249(1.25); C251(1.25)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C249(1.05); C251(1.05)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C249(1.10); C251(1.10)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C249(1.18); C251(1.18)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C249(1.07); C251(1.07)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C249(0.99); C251(0.99)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C249(1.21); C251(1.21)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C249(1.19); C251(1.19)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C249(0.97); C251(0.97)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C249(0.93); C251(0.93)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C249(1.10); C251(1.10)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C249(0.81); C251(0.81)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C249(0.83); C251(0.83)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C249(0.73); C251(0.73)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C249(0.93); C251(0.93)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C249(1.03); C251(1.03)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C249(0.97); C251(0.97)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C249(0.98); C251(0.98)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C249(1.27); C251(1.27)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C249(0.81); C251(0.81)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C249(0.92); C251(0.92)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C249(1.16); C251(1.16)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C249(1.26); C251(1.26)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C249(1.11); C251(1.11)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C249(1.35); C251(1.35)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C249(2.00); C251(2.00)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C249(1.54); C251(1.54)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C249(1.84); C251(1.84)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C249(1.48); C251(1.48)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C249(1.59); C251(1.59)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C249(1.12); C251(1.12)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C249(1.40); C251(1.40)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C249(1.37); C251(1.37)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C249(1.02); C251(1.02)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C249(1.49); C251(1.49)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C249(1.05); C251(1.05)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C249(2.20); C251(2.20)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C249(1.54); C251(1.54)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C249(1.31); C251(1.31)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C249(1.34); C251(1.34)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C249(1.21); C251(1.21)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C249(1.14); C251(1.14)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C111(0.74)  LDD2227  [1]
 LDCM0370  CL101 HCT 116 C249(1.58); C251(1.58)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C249(2.36); C251(2.36)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C249(1.60); C251(1.60)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C249(2.49); C251(2.49)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C249(1.63); C251(1.63)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C249(1.86); C251(1.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C249(1.44); C251(1.44)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C249(1.37); C251(1.37)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C249(3.03); C251(3.03)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C249(2.35); C251(2.35)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C249(2.02); C251(2.02)  LDD0698  [2]
 LDCM0387  CL117 HCT 116 C249(0.93); C251(0.93)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C249(1.14); C251(1.14)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C249(1.23); C251(1.23)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C249(1.01); C251(1.01)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C249(1.97); C251(1.97)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C249(2.17); C251(2.17)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C249(1.54); C251(1.54)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C249(2.00); C251(2.00)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C249(2.47); C251(2.47)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C249(1.52); C251(1.52)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C249(1.23); C251(1.23)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C249(1.11); C251(1.11)  LDD0716  [2]
 LDCM0403  CL16 HCT 116 C249(1.29); C251(1.29)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C249(2.77); C251(2.77)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C249(1.21); C251(1.21)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C249(1.04); C251(1.04)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C249(1.11); C251(1.11)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C249(3.81); C251(3.81)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C249(1.04); C251(1.04)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C249(1.16); C251(1.16)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C249(1.37); C251(1.37)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C249(2.73); C251(2.73)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C249(1.45); C251(1.45)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C249(1.19); C251(1.19)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C249(2.13); C251(2.13)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C249(1.27); C251(1.27)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C249(1.15); C251(1.15)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C249(0.91); C251(0.91)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C249(1.39); C251(1.39)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C249(1.83); C251(1.83)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C249(2.01); C251(2.01)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C249(1.54); C251(1.54)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C249(1.27); C251(1.27)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C249(1.11); C251(1.11)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C249(1.33); C251(1.33)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C249(1.32); C251(1.32)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C249(2.22); C251(2.22)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C249(1.01); C251(1.01)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C249(1.10); C251(1.10)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C249(1.41); C251(1.41)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C249(1.49); C251(1.49)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C249(2.47); C251(2.47)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C249(1.24); C251(1.24)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C249(4.60); C251(4.60)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C249(1.41); C251(1.41)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C249(2.69); C251(2.69)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C249(5.01); C251(5.01)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C249(1.66); C251(1.66)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C249(3.65); C251(3.65)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C249(5.03); C251(5.03)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C249(1.05); C251(1.05)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C249(0.99); C251(0.99)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C249(2.18); C251(2.18)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C249(1.35); C251(1.35)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C249(1.37); C251(1.37)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C249(2.71); C251(2.71)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C249(1.51); C251(1.51)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C249(1.22); C251(1.22)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C249(1.71); C251(1.71)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C249(1.08); C251(1.08)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C249(3.60); C251(3.60)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C249(1.21); C251(1.21)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C249(0.96); C251(0.96)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C249(1.00); C251(1.00)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C249(2.26); C251(2.26)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C249(2.11); C251(2.11)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C249(1.57); C251(1.57)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C249(2.23); C251(2.23)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C249(1.77); C251(1.77)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C249(2.73); C251(2.73)  LDD0784  [2]
 LDCM0468  Fragment33 HCT 116 C249(1.39); C251(1.39)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C249(1.96); C251(1.96)  LDD0744  [2]
 LDCM0022  KB02 ECC2 C94(1.72)  LDD2320  [3]
 LDCM0023  KB03 ECC2 C94(2.20)  LDD2737  [3]
 LDCM0024  KB05 SH4 C94(2.31)  LDD3321  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prelamin-A/C (LMNA) Intermediate filament family P02545
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-linolenic Acid Small molecular drug DB00132
Bezafibrate Small molecular drug DB01393
Fenofibric Acid Small molecular drug DB13873
Icosapent Small molecular drug DB00159
Oleic Acid Small molecular drug DB04224
Rosiglitazone Small molecular drug DB00412
Sulindac Small molecular drug DB00605
Treprostinil Small molecular drug DB00374
Troglitazone Small molecular drug DB00197
Valproic Acid Small molecular drug DB00313
Fish Oil . DB13961
Glycerin . DB09462
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mbx-8025 Small molecular drug D03OSG
Gft-505 . D0LW1Y
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
T3d-959 . D0ZT8A
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cer-002 . D06KPR
Kd3010 . D01PVV
Sar351034 . D04NJS
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Kd-3020 . D06GFG
Investigative
Click To Hide/Show 21 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(11e)-octadec-11-enoic Acid Small molecular drug D0V6DE
Cardarine Small molecular drug DB05416
Cis-vaccenic Acid Small molecular drug DB04801
Gsk-0660 Small molecular drug D06VBQ
Gsk-3787 Small molecular drug D0NM0G
Gw0742x Small molecular drug D0K1TQ
Gw2433 Small molecular drug D0XR8Q
Heptyl Glucoside Small molecular drug DB03338
Heptyl-beta-d-glucopyranoside Small molecular drug D06IBV
L-165041 Small molecular drug D0YK9T
L-165461 Small molecular drug D0F0MP
L-783483 Small molecular drug D08QXD
L-796449 Small molecular drug D09JII
Phthalic Acid Small molecular drug DB02746
{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)Propoxy]Phenoxy}Acetic Acid Small molecular drug DB08078
(2s)-2-{3-[({[2-fluoro-4-(Trifluoromethyl)Phenyl]Carbonyl}Amino)Methyl]-4-methoxybenzyl}Butanoic Acid . DB07070
2-({[3-(34-dihydroisoquinolin-2(1h)-ylsulfonyl)Phenyl]Carbonyl}Amino)Benzoic Acid . DB07691
Clinofibrate . DB09006
Db-900 . D01ARG
Elafibranor . DB05187
Savx-1 . D07USR
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid25416646-compound-figure5-c Small molecular drug D0V0JN
Discontinued
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk-677954 Small molecular drug D0S6KX
Gw-501516 Small molecular drug D05HDX
Indeglitazar Small molecular drug D09OHP
Sodelglitazar Small molecular drug D01JGG
Cs-204 . D0V0TT

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840