Details of the Target

General Information of Target

Target ID LDTP05135
Target Name DENN domain-containing protein 2B (DENND2B)
Gene Name DENND2B
Gene ID 6764
Synonyms
HTS1; ST5; DENN domain-containing protein 2B; HeLa tumor suppression 1; Suppression of tumorigenicity 5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH
SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG
AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR
MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET
EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL
PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST
KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP
PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK
STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP
PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST
TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR
FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY
QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC
RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA
PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI
FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK
ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN
TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ
MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Target Bioclass
Other
Subcellular location
Cytoplasm, cell cortex
Function
[Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.; [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.; [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
Uniprot ID
P78524
Ensemble ID
ENST00000313726.11
HGNC ID
HGNC:11350

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.I940T .
J82 SNV: p.S680I .
LNCaP clone FGC Deletion: p.P73QfsTer53 .
MFE319 Deletion: p.K635SfsTer12 .
NALM6 SNV: p.E397K; p.V872M .
NUGC3 SNV: p.R226W .
RKO SNV: p.E194K .
TOV21G SNV: p.S32Y; p.G787W; p.V872M DBIA    Probe Info 
UMUC3 SNV: p.S559Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C235(2.74); C131(2.09)  LDD0171  [1]
DBIA
 Probe Info  		C804(23.91)  LDD0209  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C235(2.74); C131(2.09)  LDD0171  [1]
 LDCM0214  AC1 PaTu 8988t C804(0.72)  LDD1093  [5]
 LDCM0215  AC10 HEK-293T C746(0.97); C804(0.92)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C746(1.04); C804(0.93)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C746(0.96); C804(0.83)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C746(1.03); C804(0.72)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C746(1.27); C804(0.91)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C746(1.13); C804(0.92)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C746(1.20); C804(0.84)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C746(0.75); C804(0.76)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C746(1.19); C804(0.77)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C746(0.96); C804(0.80)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C746(0.82); C804(0.90)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C746(1.09); C804(0.90)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C746(1.47); C804(0.73)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C746(2.32); C804(0.84)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C746(1.78); C804(0.80)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C804(0.91)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C804(0.99)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C804(0.95)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C804(0.96)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C804(1.03)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C804(0.89)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C804(1.17)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C746(1.12); C804(1.09)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C804(1.03)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C804(1.36)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C804(1.03)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C804(0.85)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C804(1.20)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C804(1.06)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C804(1.01)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C804(0.97)  LDD0562  [5]
 LDCM0259  AC14 HEK-293T C746(0.96); C804(0.97)  LDD0857  [5]
 LDCM0263  AC143 PaTu 8988t C746(0.99); C804(0.76)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C746(0.97); C804(0.72)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C746(0.94); C804(0.88)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C746(0.83); C804(0.77)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C746(0.89); C804(0.80)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C746(0.94); C804(0.83)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C746(0.99); C804(0.74)  LDD1148  [5]
 LDCM0270  AC15 HEK-293T C746(1.24); C804(0.94)  LDD0868  [5]
 LDCM0271  AC150 PaTu 8988t C746(0.99); C804(0.95)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C746(0.91); C804(1.03)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C746(0.90); C804(0.74)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C746(0.95); C804(1.07)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C746(1.00); C804(0.93)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C746(1.01); C804(0.85)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C746(0.94); C804(0.75)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C746(0.86); C804(0.91)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C804(0.94)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C804(0.89)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C804(0.99)  LDD0595  [5]
 LDCM0279  AC2 PaTu 8988t C804(0.51)  LDD1158  [5]
 LDCM0280  AC20 HCT 116 C804(1.11)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C804(0.93)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C804(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C804(0.92)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C804(0.97)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C804(0.81)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C804(0.85)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C804(0.91)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C804(0.84)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C804(1.02)  LDD0606  [5]
 LDCM0290  AC3 PaTu 8988t C804(0.83)  LDD1169  [5]
 LDCM0291  AC30 HCT 116 C804(1.00)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C804(1.03)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C804(0.97)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C804(0.91)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C804(0.90)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C746(0.78)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C746(0.99)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C746(1.00)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C746(1.11)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C746(1.03)  LDD0898  [5]
 LDCM0301  AC4 PaTu 8988t C804(0.66)  LDD1180  [5]
 LDCM0302  AC40 HEK-293T C746(1.38)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C746(0.91)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C746(1.54)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C746(0.91)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C746(1.05)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C746(0.91)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C746(1.04); C804(0.94)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C746(0.99); C804(0.95)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C746(1.06); C804(0.99)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C746(1.00); C804(0.96); C876(0.83)  LDD1550  [6]
 LDCM0312  AC5 PaTu 8988t C804(0.74)  LDD1191  [5]
 LDCM0313  AC50 HEK-293T C746(1.11); C804(1.05)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C746(1.00); C804(0.93)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C746(0.95); C804(0.94)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C746(1.04); C804(1.02)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C746(0.97); C804(0.88)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C746(1.04); C804(0.96)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C746(1.03); C804(1.05)  LDD1558  [6]
 LDCM0320  AC57 PaTu 8988t C746(0.97); C804(0.87)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C746(0.89); C804(0.87)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C746(0.87); C804(0.93)  LDD1201  [5]
 LDCM0323  AC6 HEK-293T C746(1.13); C804(0.98)  LDD0921  [5]
 LDCM0324  AC60 PaTu 8988t C746(1.02); C804(0.74)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C746(0.99); C804(0.85)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C746(0.78); C804(0.94)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C746(0.85); C804(0.99)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C746(0.94); C804(0.76)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C746(0.88); C804(0.87)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C746(0.90); C804(0.97)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C746(0.90); C804(0.80)  LDD1210  [5]
 LDCM0332  AC68 HEK-293T C804(1.28)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C804(1.01)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C746(0.88); C804(1.05)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C804(1.27)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C804(1.26)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C804(1.07)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C804(1.26)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C804(1.38)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C804(1.14)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C804(1.46)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C804(1.25)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C804(1.14)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C804(1.44)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C746(1.65); C804(1.12)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C804(1.32)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C804(1.36)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C804(1.37)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C804(1.20)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C804(1.22)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C804(0.98)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C804(1.01)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C804(1.01)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C804(1.10)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C804(1.12)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C804(0.86)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C804(1.07)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C804(0.92)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C804(0.97)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C804(0.97)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C804(0.89)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C804(0.93)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C804(0.92)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C746(0.92); C804(0.91)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C746(1.09); C804(0.98)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C746(1.01); C804(1.07)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C746(1.20); C804(1.01)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C746(1.26); C804(0.92)  LDD0873  [5]
 LDCM0367  CL1 PaTu 8988t C746(0.99); C804(0.87)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C746(0.78); C804(0.96)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C804(0.72)  LDD1248  [5]
 LDCM0370  CL101 HEK-293T C746(1.70); C804(1.23)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C746(1.59); C804(1.13)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C746(1.47); C804(1.07)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C746(1.30); C804(1.12)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C804(0.98)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C804(1.00)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C804(1.01)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C804(1.01)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C804(0.98)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C746(0.93); C804(0.98)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C804(1.11)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C804(1.12)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C804(0.91)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C804(1.02)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C804(1.19)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C804(1.18)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C804(1.03)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C746(1.39)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C746(0.94)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C746(1.05)  LDD0987  [5]
 LDCM0390  CL12 PaTu 8988t C746(0.88); C804(1.09)  LDD1269  [5]
 LDCM0391  CL120 HEK-293T C746(0.95)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C746(1.06); C804(0.92); C876(0.95)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C746(1.15); C804(1.05)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C746(0.88); C804(1.23)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C746(1.00); C804(0.78)  LDD1599  [6]
 LDCM0396  CL125 PaTu 8988t C746(1.00); C804(0.90)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C746(0.84); C804(0.92)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C746(0.89); C804(0.93)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C746(0.94); C804(0.86)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C746(0.81); C804(1.19)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C746(0.82); C804(1.79)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C746(0.77); C804(1.10)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C804(0.82)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C804(0.91)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C804(0.78)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C804(0.77)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C746(0.88); C804(1.30)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C804(0.75)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C804(0.75)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C804(1.01)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C804(0.85)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C804(0.66)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C804(0.78)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C804(0.89)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C804(0.73)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C804(0.70)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C804(0.66)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C746(0.92); C804(0.81)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C804(0.65)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C746(2.45)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C746(1.20)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C746(1.28)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C746(1.35)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C746(1.17)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C746(1.46)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C746(1.97)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C746(1.49)  LDD1026  [5]
 LDCM0429  CL4 PaTu 8988t C746(0.91); C804(1.10)  LDD1308  [5]
 LDCM0430  CL40 HEK-293T C746(2.45)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C746(1.95)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C746(1.49)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C746(1.29)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C746(2.85)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C746(1.89)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C804(0.92)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C804(1.09)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C804(0.95)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C804(0.86)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C746(0.84); C804(1.08)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C804(0.84)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C804(0.85)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C804(0.94)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C804(1.56)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C804(1.12)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C804(0.94)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C804(1.07)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C804(1.08)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C804(1.02)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C804(1.03)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C746(0.77); C804(1.16)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C804(0.94)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C746(1.01)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C746(1.45)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C746(1.60)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C746(1.14)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C746(1.03)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C746(0.92)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C746(1.21)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C746(1.02)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C746(1.00)  LDD1059  [5]
 LDCM0462  CL7 PaTu 8988t C746(0.83); C804(1.12)  LDD1341  [5]
 LDCM0463  CL70 HEK-293T C746(0.80)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C746(1.19)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C746(1.28)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C746(1.09)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C746(1.68)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C804(1.10)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C804(1.16)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C804(0.90)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C804(1.08)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C746(0.80); C804(1.02)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C804(0.94)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C804(0.97)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C804(1.01)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C804(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C804(1.16)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C804(1.08)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C804(1.03)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C804(1.01)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C804(1.18)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C804(1.03)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C746(0.92); C804(1.36)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C804(1.12)  LDD0802  [5]
 LDCM0486  CL91 PaTu 8988t C804(0.66)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C804(0.65)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C804(0.69)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C804(0.73)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C804(0.61)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C804(0.74)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C804(0.69)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C804(0.74)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C804(0.65)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C746(1.00); C804(0.92)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C746(1.42)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C746(1.30)  LDD1025  [5]
 LDCM0022  KB02 HEK-293T C746(0.91); C804(0.98)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C804(23.91)  LDD0209  [2]
 LDCM0024  KB05 G361 C746(3.36)  LDD3311  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840