Details of the Target

General Information of Target

Target ID LDTP04840
Target Name Zinc finger protein 445 (ZNF445)
Gene Name ZNF445
Gene ID 353274
Synonyms
ZFP445; ZKSCAN15; ZNF168; Zinc finger protein 445; ZFP445; Zinc finger protein 168; Zinc finger protein with KRAB and SCAN domains 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQ
LRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNP
ESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALG
DHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVE
VTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQ
PKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSR
QKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKH
FRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHT
VGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKP
YKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCS
QCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECRE
GFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAY
RSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIH
QRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRF
WCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQW
CGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACS
QSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSN
LARHMKNHIRD
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance.
Uniprot ID
P59923
Ensemble ID
ENST00000396077.8
HGNC ID
HGNC:21018

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C215(0.89)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C599(0.91); C602(0.91)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C820(1.05); C959(0.95); C215(0.93); C365(0.92)  LDD1508  [4]
 LDCM0230  AC113 HEK-293T C215(1.06); C845(1.18)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C215(0.95); C845(0.90)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C215(1.01); C845(1.03)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C215(0.89); C845(0.96)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C215(1.07); C845(1.09)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C215(1.17); C845(1.11)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C215(1.17); C845(1.08)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C820(0.96); C959(0.96)  LDD1510  [4]
 LDCM0238  AC120 HEK-293T C215(1.00); C845(1.04)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C215(1.07); C845(1.04)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C215(1.18); C845(1.11)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C215(1.23); C845(0.97)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C215(1.25); C845(1.36)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C215(1.22); C845(1.15)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C215(1.46); C845(1.25)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C215(1.78); C845(1.53)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C215(0.63); C845(0.55)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C215(0.58); C845(0.67)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C215(0.67); C845(0.62)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C215(0.55); C845(0.55)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C215(0.61); C845(0.64)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C215(0.96); C845(0.86)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C215(0.61); C845(0.58)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C215(0.78); C845(0.84)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C215(0.71); C845(0.61)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C215(0.90); C845(0.97)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C215(0.81); C845(0.55)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C215(1.21); C845(1.28)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C820(1.24); C959(0.97); C215(1.04)  LDD1512  [4]
 LDCM0260  AC140 HEK-293T C215(0.70); C845(0.63)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C215(0.76); C845(0.67)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C215(0.80); C845(0.74)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C599(1.08); C602(1.08)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C599(1.18); C602(1.18)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C599(1.24); C602(1.24)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C599(1.25); C602(1.25)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C599(1.18); C602(1.18)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C599(1.58); C602(1.58)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C599(1.31); C602(1.31)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C820(1.15); C959(0.89); C215(1.04)  LDD1513  [4]
 LDCM0271  AC150 HCT 116 C599(1.09); C602(1.09)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C599(1.06); C602(1.06)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C599(1.27); C602(1.27)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C599(1.42); C602(1.42)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C599(1.04); C602(1.04)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C599(1.35); C602(1.35)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C599(0.98); C602(0.98)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C599(0.99); C602(0.99)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C820(1.26)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C820(0.90); C959(0.89); C215(1.13); C365(0.85)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C599(1.02); C602(1.02)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C820(0.85); C959(1.07)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C820(0.99); C959(1.08); C955(1.11)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C820(1.00); C959(0.95); C215(1.02)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C820(0.97); C959(0.86); C215(1.18)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C820(1.10); C959(1.07); C215(1.14)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C215(1.31); C845(0.90)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C215(1.31); C845(1.12)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C215(1.35); C845(1.20)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C215(1.43); C845(1.48)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C215(1.31); C845(1.16)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C599(0.96); C602(0.96)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C215(1.29); C845(1.06)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C215(1.16); C845(0.97)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C215(1.54); C845(1.13)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C215(1.25); C845(1.04)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C215(1.33); C845(0.95)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C599(0.78); C602(0.78)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C599(0.84); C602(0.84)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C599(0.96); C602(0.96)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C599(0.97); C602(0.97)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C599(1.03); C602(1.03)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C599(0.95); C602(0.95)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C599(0.98); C602(0.98)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C599(0.92); C602(0.92)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C599(0.83); C602(0.83)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C599(0.92); C602(0.92)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C599(0.97); C602(0.97)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C599(1.07); C602(1.07)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C215(1.44); C599(0.92); C602(0.92)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C215(1.66); C599(0.88); C602(0.88)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C215(1.63); C599(0.99); C602(0.99)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C215(1.41); C599(0.87); C602(0.87)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C599(0.93); C602(0.93)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C215(2.16); C599(0.86); C602(0.86)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C215(1.51); C599(1.02); C602(1.02)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C215(1.33); C599(0.79); C602(0.79)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C215(1.48); C599(0.75); C602(0.75)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C215(1.81); C599(0.82); C602(0.82)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C215(1.78); C599(0.82); C602(0.82)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C215(1.85); C599(0.88); C602(0.88)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C820(0.94)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C820(0.85); C959(1.01); C215(0.90); C365(0.88)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C820(0.98); C959(0.93); C215(1.14)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C820(0.81); C959(1.11)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C820(1.11); C959(1.02); C955(1.06)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C820(0.90); C959(0.92); C215(0.92)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C820(0.94); C959(0.81); C215(1.25)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C820(1.06); C959(1.02); C215(1.00)  LDD1567  [4]
 LDCM0332  AC68 HEK-293T C215(1.24); C845(1.18)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C215(1.23); C845(1.36)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C820(0.95); C959(0.97); C215(1.10)  LDD1568  [4]
 LDCM0335  AC70 HEK-293T C215(1.49); C845(1.41)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C215(1.25); C845(1.33)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C215(1.25); C845(1.38)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C215(1.34); C845(1.40)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C215(2.11); C845(2.43)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C215(1.34); C845(1.28)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C215(1.33); C845(1.00)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C215(1.23); C845(1.08)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C215(1.37); C845(1.18)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C215(1.31); C845(1.51)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C820(1.24); C959(1.11); C215(1.18)  LDD1569  [4]
 LDCM0346  AC80 HEK-293T C215(1.27); C845(1.29)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C215(1.11); C845(1.06)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C215(1.48); C845(1.40)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C845(1.03)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C845(1.43)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C845(1.11)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C845(0.98)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C845(1.28)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C845(1.61)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C845(1.34)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C845(1.28)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C845(1.18)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C845(1.23)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C845(0.96)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C845(1.81)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C845(1.43)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C845(1.17)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C845(2.24)  LDD0962  [1]
 LDCM0248  AKOS034007472 HEK-293T C820(0.88); C959(1.07); C955(1.13)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C820(1.10)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C820(0.91); C959(0.98); C215(1.61)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C215(0.89)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C820(1.51); C959(1.05); C215(0.80)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C820(1.19); C959(1.11); C215(1.11)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C599(0.89); C602(0.89)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C820(1.18); C959(1.07); C215(0.93)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C959(1.05); C215(0.68)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C959(0.94); C955(1.17); C365(0.89)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C959(0.86); C955(1.01)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C820(1.17); C959(1.09); C215(0.97)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C959(0.85); C215(0.95)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C959(1.08); C955(0.96); C365(0.85)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C959(0.89); C955(0.92)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C820(0.87); C959(1.00); C215(1.17)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C820(0.82); C959(1.04); C215(1.28)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C959(1.02); C215(0.67)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C959(0.92); C955(1.20); C365(0.94)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C215(1.44); C845(1.24)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C215(1.28); C845(1.03)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C215(1.66); C845(1.54)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C215(1.25); C845(1.11)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C215(1.39); C845(1.13)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C599(0.84); C602(0.84)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C599(0.91); C602(0.91)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C599(0.95); C602(0.95)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C820(0.84); C959(1.01); C215(1.35)  LDD1594  [4]
 LDCM0391  CL120 HCT 116 C599(0.85); C602(0.85)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C215(1.49); C599(0.78); C602(0.78)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C215(1.73); C599(0.70); C602(0.70)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C215(1.65); C599(1.07); C602(1.07)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C215(1.26); C599(0.83); C602(0.83)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C820(0.86); C959(1.05); C215(1.11)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C959(1.05); C215(0.85)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C959(1.17); C955(0.88); C365(1.13)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C959(0.96); C955(0.90)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C820(1.32); C959(1.10); C215(1.25)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C959(1.03); C215(0.84)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C959(1.08); C955(1.14); C365(1.26)  LDD1606  [4]
 LDCM0403  CL16 HCT 116 C845(0.76)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C845(0.75)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C845(0.80)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C845(0.58)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C959(1.02); C215(0.88)  LDD1611  [4]
 LDCM0408  CL20 HCT 116 C845(0.44)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C845(0.40)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C845(0.47)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C845(0.67)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C845(0.41)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C845(0.47)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C845(0.59)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C845(0.75)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C845(0.53)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C845(0.52)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C959(1.18); C955(0.98); C365(0.94)  LDD1622  [4]
 LDCM0419  CL30 HCT 116 C845(0.96)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C845(0.30)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C845(0.40)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C845(0.34)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C845(0.24)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C845(0.22)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C845(0.27)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C845(0.23)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C845(0.20)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C959(1.24); C955(0.91)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C845(0.36)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C845(0.20)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C845(0.22)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C845(0.23)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C845(0.30)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C845(0.29)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C599(0.89); C602(0.89); C845(1.94)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C599(1.04); C602(1.04); C845(1.58)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C599(0.88); C602(0.88); C845(1.88)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C599(0.96); C602(0.96); C845(1.61)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C820(1.13)  LDD1644  [4]
 LDCM0441  CL50 HCT 116 C599(0.96); C602(0.96); C845(1.63)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C599(0.87); C602(0.87); C845(1.49)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C599(1.04); C602(1.04); C845(1.71)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C599(0.92); C602(0.92); C845(1.52)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C599(0.99); C602(0.99); C845(1.47)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C599(0.87); C602(0.87); C845(1.70)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C599(0.89); C602(0.89); C845(1.28)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C599(0.85); C602(0.85); C845(1.55)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C599(0.86); C602(0.86); C845(1.98)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C599(1.03); C602(1.03); C845(1.27)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C820(0.91); C959(0.88); C215(1.13); C365(1.12)  LDD1654  [4]
 LDCM0452  CL60 HCT 116 C599(1.01); C602(1.01); C845(1.11)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C845(0.89)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C845(0.78)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C845(0.78)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C845(0.60)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C845(0.72)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C845(0.45)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C845(0.47)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C845(0.52)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C845(1.03)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C845(0.58)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C845(0.57)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C845(1.08)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C845(0.88)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C845(0.50)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C599(0.74); C602(0.74)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C599(0.94); C602(0.94)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C599(1.00); C602(1.00)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C599(0.82); C602(0.82)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C820(0.82); C959(1.32)  LDD1676  [4]
 LDCM0474  CL80 HCT 116 C599(1.28); C602(1.28)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C599(0.97); C602(0.97)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C599(1.26); C602(1.26)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C599(0.90); C602(0.90)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C599(0.87); C602(0.87)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C599(0.89); C602(0.89)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C599(1.06); C602(1.06)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C599(1.09); C602(1.09)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C599(0.98); C602(0.98)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C599(0.93); C602(0.93)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C820(1.30); C959(1.19); C955(1.10)  LDD1687  [4]
 LDCM0485  CL90 HCT 116 C599(0.96); C602(0.96)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C599(0.85); C602(0.85)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C599(0.83); C602(0.83)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C599(0.95); C602(0.95)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C599(0.91); C602(0.91)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C599(1.25); C602(1.25)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C599(1.07); C602(1.07)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C599(0.98); C602(0.98)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C599(0.84); C602(0.84)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C599(0.95); C602(0.95)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C959(1.10); C955(0.91); C365(0.88)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C845(0.46)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C845(0.25)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C820(1.09); C215(0.77); C955(0.87); C959(0.95)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C820(1.04); C215(1.10); C955(0.95); C959(1.05)  LDD1497  [4]
 LDCM0024  KB05 COLO792 C959(2.04)  LDD3310  [5]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840