Details of the Target

General Information of Target

Target ID LDTP04609
Target Name PMS1 protein homolog 1 (PMS1)
Gene Name PMS1
Gene ID 5378
Synonyms
PMSL1; PMS1 protein homolog 1; DNA mismatch repair protein PMS1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQLPAATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEG
IKAVDAPVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQ
YVLDGSGHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFG
ILKPDLRIVFVHNKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFL
PKCDADHSFTSLSTPERSFIFINSRPVHQKDILKLIRHHYNLKCLKESTRLYPVFFLKID
VPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTNSYENNKTDVSAADIVL
SKTAETDVLFNKVESSGKNYSNVDTSVIPFQNDMHNDESGKNTDDCLNHQISIGDFGYGH
CSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISSVKHTQSENGNKDHIDESGE
NEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILVPEKSLPCKVSNNNYPIPEQMN
LNEDSCNKKSNVIDNKSGKVTAYDLLSNRVIKKPMSASALFVQDHRPQFLIENPKTSLED
ATLQIEELWKTLSEEEKLKYEEKATKDLERYNSQMKRAIEQESQMSLKDGRKKIKPTSAW
NLAQKHKLKTSLSNQPKLDELLQSQIEKRRSQNIKMVQIPFSMKNLKINFKKQNKVDLEE
KDEPCLIHNLRFPDAWLMTSKTEVMLLNPYRVEEALLFKRLLENHKLPAEPLEKPIMLTE
SLFNGSHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMAN
CLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDI
IYRMKHQFGNEIKECVHGRPFFHHLTYLPETT
Target Type
Literature-reported
Target Bioclass
Other
Family
DNA mismatch repair MutL/HexB family
Subcellular location
Nucleus
Function Probably involved in the repair of mismatches in DNA.
TTD ID
T45779
Uniprot ID
P54277
DrugMap ID
TTX1ISF
Ensemble ID
ENST00000409593.5
HGNC ID
HGNC:9121

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA Deletion: p.N57GfsTer7 .
DU145 SNV: p.A304S .
EFO27 SNV: p.R500M .
KYSE150 SNV: p.Y563Ter DBIA    Probe Info 
MELHO SNV: p.S467L .
MOLT4 SNV: p.K821E .
SKMM2 SNV: p.K872R .
SW403 SNV: p.K677R .
SW837 Substitution: p.E59K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.89  LDD0402  [1]
Probe 1
 Probe Info  		Y563(7.58)  LDD3495  [2]
BTD
 Probe Info  		C868(2.30)  LDD2140  [3]
AHL-Pu-1
 Probe Info  		C725(7.58)  LDD0169  [4]
DBIA
 Probe Info  		C725(5.01)  LDD0209  [5]
IA-alkyne
 Probe Info  		C725(20.00)  LDD1704  [6]
Acrolein
 Probe Info  		C725(0.00); H728(0.00)  LDD0227  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C725(7.58)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C868(1.37)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C457(0.97)  LDD0532  [12]
 LDCM0216  AC100 PaTu 8988t C457(1.05)  LDD1095  [12]
 LDCM0217  AC101 PaTu 8988t C457(0.88)  LDD1096  [12]
 LDCM0218  AC102 PaTu 8988t C457(0.91)  LDD1097  [12]
 LDCM0219  AC103 PaTu 8988t C457(1.19)  LDD1098  [12]
 LDCM0220  AC104 PaTu 8988t C457(0.88)  LDD1099  [12]
 LDCM0221  AC105 PaTu 8988t C457(0.94)  LDD1100  [12]
 LDCM0222  AC106 PaTu 8988t C457(1.04)  LDD1101  [12]
 LDCM0223  AC107 PaTu 8988t C457(0.84)  LDD1102  [12]
 LDCM0224  AC108 PaTu 8988t C457(1.12)  LDD1103  [12]
 LDCM0225  AC109 PaTu 8988t C457(1.05)  LDD1104  [12]
 LDCM0226  AC11 HCT 116 C457(1.23)  LDD0543  [12]
 LDCM0227  AC110 PaTu 8988t C457(1.14)  LDD1106  [12]
 LDCM0228  AC111 PaTu 8988t C457(1.19)  LDD1107  [12]
 LDCM0229  AC112 PaTu 8988t C457(1.14)  LDD1108  [12]
 LDCM0230  AC113 HEK-293T C457(1.14)  LDD0828  [12]
 LDCM0231  AC114 HEK-293T C457(0.98)  LDD0829  [12]
 LDCM0232  AC115 HEK-293T C457(1.10)  LDD0830  [12]
 LDCM0233  AC116 HEK-293T C457(1.04)  LDD0831  [12]
 LDCM0234  AC117 HEK-293T C457(0.76)  LDD0832  [12]
 LDCM0235  AC118 HEK-293T C457(0.99)  LDD0833  [12]
 LDCM0236  AC119 HEK-293T C457(0.93)  LDD0834  [12]
 LDCM0237  AC12 HCT 116 C457(1.03)  LDD0554  [12]
 LDCM0238  AC120 HEK-293T C457(1.05)  LDD0836  [12]
 LDCM0239  AC121 HEK-293T C457(0.95)  LDD0837  [12]
 LDCM0240  AC122 HEK-293T C457(0.93)  LDD0838  [12]
 LDCM0241  AC123 HEK-293T C457(1.09)  LDD0839  [12]
 LDCM0242  AC124 HEK-293T C457(0.96)  LDD0840  [12]
 LDCM0243  AC125 HEK-293T C457(0.96)  LDD0841  [12]
 LDCM0244  AC126 HEK-293T C457(1.03)  LDD0842  [12]
 LDCM0245  AC127 HEK-293T C457(1.09)  LDD0843  [12]
 LDCM0246  AC128 PaTu 8988t C457(1.06)  LDD1125  [12]
 LDCM0247  AC129 PaTu 8988t C457(1.10)  LDD1126  [12]
 LDCM0249  AC130 PaTu 8988t C457(1.01)  LDD1128  [12]
 LDCM0250  AC131 PaTu 8988t C457(0.96)  LDD1129  [12]
 LDCM0251  AC132 PaTu 8988t C457(1.03)  LDD1130  [12]
 LDCM0252  AC133 PaTu 8988t C457(1.02)  LDD1131  [12]
 LDCM0253  AC134 PaTu 8988t C457(0.97)  LDD1132  [12]
 LDCM0254  AC135 PaTu 8988t C457(1.12)  LDD1133  [12]
 LDCM0255  AC136 PaTu 8988t C457(1.03)  LDD1134  [12]
 LDCM0256  AC137 PaTu 8988t C457(1.09)  LDD1135  [12]
 LDCM0257  AC138 PaTu 8988t C457(1.13)  LDD1136  [12]
 LDCM0258  AC139 PaTu 8988t C457(0.97)  LDD1137  [12]
 LDCM0259  AC14 HCT 116 C457(1.02)  LDD0576  [12]
 LDCM0260  AC140 PaTu 8988t C457(1.29)  LDD1139  [12]
 LDCM0261  AC141 PaTu 8988t C457(1.18)  LDD1140  [12]
 LDCM0262  AC142 PaTu 8988t C457(1.04)  LDD1141  [12]
 LDCM0263  AC143 HCT 116 C457(0.90)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C457(0.82)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C457(0.92)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C457(0.79)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C457(0.93)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C457(0.97)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C457(1.02)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C457(0.92)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C457(1.05)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C457(0.90)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C457(0.98)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C457(0.97)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C457(0.98)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C457(1.03)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C457(0.96)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C457(0.81)  LDD2161  [12]
 LDCM0276  AC17 PaTu 8988t C546(0.96); C457(1.08)  LDD1155  [12]
 LDCM0277  AC18 PaTu 8988t C546(1.27); C457(1.37)  LDD1156  [12]
 LDCM0278  AC19 PaTu 8988t C546(0.95); C457(1.18)  LDD1157  [12]
 LDCM0280  AC20 PaTu 8988t C546(1.19); C457(1.27)  LDD1159  [12]
 LDCM0281  AC21 PaTu 8988t C546(1.00); C457(1.33)  LDD1160  [12]
 LDCM0282  AC22 PaTu 8988t C546(1.11); C457(1.49)  LDD1161  [12]
 LDCM0283  AC23 PaTu 8988t C546(1.47); C457(1.38)  LDD1162  [12]
 LDCM0284  AC24 PaTu 8988t C546(1.35); C457(1.58)  LDD1163  [12]
 LDCM0285  AC25 PaTu 8988t C546(1.00); C725(1.17); C457(0.94)  LDD1164  [12]
 LDCM0286  AC26 PaTu 8988t C546(1.17); C725(1.40); C457(1.08)  LDD1165  [12]
 LDCM0287  AC27 PaTu 8988t C546(1.27); C725(1.76); C457(1.13)  LDD1166  [12]
 LDCM0288  AC28 PaTu 8988t C546(1.54); C725(1.55); C457(1.25)  LDD1167  [12]
 LDCM0289  AC29 PaTu 8988t C546(1.26); C725(1.11); C457(1.15)  LDD1168  [12]
 LDCM0291  AC30 PaTu 8988t C546(1.08); C725(1.01); C457(0.99)  LDD1170  [12]
 LDCM0292  AC31 PaTu 8988t C546(1.01); C725(1.06); C457(0.95)  LDD1171  [12]
 LDCM0293  AC32 PaTu 8988t C546(1.17); C725(1.16); C457(1.10)  LDD1172  [12]
 LDCM0294  AC33 PaTu 8988t C546(1.71); C725(1.55); C457(1.34)  LDD1173  [12]
 LDCM0295  AC34 PaTu 8988t C546(1.50); C725(1.17); C457(1.10)  LDD1174  [12]
 LDCM0296  AC35 HEK-293T C457(0.97)  LDD0894  [12]
 LDCM0297  AC36 HEK-293T C457(0.91)  LDD0895  [12]
 LDCM0298  AC37 HEK-293T C457(0.91)  LDD0896  [12]
 LDCM0299  AC38 HEK-293T C457(1.03)  LDD0897  [12]
 LDCM0300  AC39 HEK-293T C457(1.19)  LDD0898  [12]
 LDCM0301  AC4 HEK-293T C336(0.82); C457(1.02)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C457(0.89)  LDD0900  [12]
 LDCM0303  AC41 HEK-293T C457(0.93)  LDD0901  [12]
 LDCM0304  AC42 HEK-293T C457(0.93)  LDD0902  [12]
 LDCM0305  AC43 HEK-293T C457(0.93)  LDD0903  [12]
 LDCM0306  AC44 HEK-293T C457(0.95)  LDD0904  [12]
 LDCM0307  AC45 HEK-293T C457(1.04)  LDD0905  [12]
 LDCM0308  AC46 PaTu 8988t C725(1.00)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C725(1.11)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C725(1.52)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C725(1.25)  LDD1190  [12]
 LDCM0312  AC5 HEK-293T C457(0.98)  LDD1551  [11]
 LDCM0313  AC50 PaTu 8988t C725(1.39)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C725(1.07)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C725(1.20)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C725(2.23)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C725(1.72)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C725(1.23)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C725(1.25)  LDD1198  [12]
 LDCM0320  AC57 HCT 116 C457(1.10)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C457(0.97)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C457(1.27)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C457(1.13)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C457(1.10)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C457(1.09)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C457(1.16)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C457(1.14)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C457(1.14)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C457(1.04)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C457(0.91)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C457(1.03)  LDD0648  [12]
 LDCM0332  AC68 HEK-293T C457(1.03)  LDD0930  [12]
 LDCM0333  AC69 HEK-293T C457(0.98)  LDD0931  [12]
 LDCM0334  AC7 HCT 116 C457(0.95)  LDD0651  [12]
 LDCM0335  AC70 HEK-293T C457(0.89)  LDD0933  [12]
 LDCM0336  AC71 HEK-293T C457(0.93)  LDD0934  [12]
 LDCM0337  AC72 HEK-293T C457(1.11)  LDD0935  [12]
 LDCM0338  AC73 HEK-293T C457(0.97)  LDD0936  [12]
 LDCM0339  AC74 HEK-293T C457(0.91)  LDD0937  [12]
 LDCM0340  AC75 HEK-293T C457(1.02)  LDD0938  [12]
 LDCM0341  AC76 HEK-293T C457(0.86)  LDD0939  [12]
 LDCM0342  AC77 HEK-293T C457(0.88)  LDD0940  [12]
 LDCM0343  AC78 HEK-293T C457(0.89)  LDD0941  [12]
 LDCM0344  AC79 HEK-293T C457(0.87)  LDD0942  [12]
 LDCM0345  AC8 HCT 116 C457(1.06)  LDD0662  [12]
 LDCM0346  AC80 HEK-293T C457(0.89)  LDD0944  [12]
 LDCM0347  AC81 HEK-293T C457(0.86)  LDD0945  [12]
 LDCM0348  AC82 HEK-293T C457(0.97)  LDD0946  [12]
 LDCM0365  AC98 PaTu 8988t C457(0.95)  LDD1244  [12]
 LDCM0366  AC99 PaTu 8988t C457(0.86)  LDD1245  [12]
 LDCM0248  AKOS034007472 HCT 116 C457(1.03)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C457(1.16)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C457(0.95)  LDD0592  [12]
 LDCM0367  CL1 HCT 116 C457(0.96)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C457(1.08)  LDD0685  [12]
 LDCM0370  CL101 HCT 116 C457(0.92)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C457(1.06)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C457(0.92)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C457(1.02)  LDD0690  [12]
 LDCM0374  CL105 PaTu 8988t C546(1.15); C457(1.20)  LDD1253  [12]
 LDCM0375  CL106 PaTu 8988t C546(1.19); C457(1.22)  LDD1254  [12]
 LDCM0376  CL107 PaTu 8988t C546(0.92); C457(1.03)  LDD1255  [12]
 LDCM0377  CL108 PaTu 8988t C546(1.13); C457(1.39)  LDD1256  [12]
 LDCM0378  CL109 PaTu 8988t C546(1.36); C457(1.35)  LDD1257  [12]
 LDCM0379  CL11 HCT 116 C457(0.87)  LDD0696  [12]
 LDCM0380  CL110 PaTu 8988t C546(1.33); C457(1.40)  LDD1259  [12]
 LDCM0381  CL111 PaTu 8988t C546(1.50); C457(1.65)  LDD1260  [12]
 LDCM0382  CL112 PaTu 8988t C546(1.56); C725(1.16); C457(1.03)  LDD1261  [12]
 LDCM0383  CL113 PaTu 8988t C546(0.87); C725(1.20); C457(1.01)  LDD1262  [12]
 LDCM0384  CL114 PaTu 8988t C546(1.16); C725(1.87); C457(1.11)  LDD1263  [12]
 LDCM0385  CL115 PaTu 8988t C546(1.36); C725(1.08); C457(1.04)  LDD1264  [12]
 LDCM0386  CL116 PaTu 8988t C546(1.22); C725(1.44); C457(1.17)  LDD1265  [12]
 LDCM0387  CL117 HEK-293T C457(1.13)  LDD0985  [12]
 LDCM0388  CL118 HEK-293T C457(0.83)  LDD0986  [12]
 LDCM0389  CL119 HEK-293T C457(0.82)  LDD0987  [12]
 LDCM0390  CL12 HCT 116 C457(1.06)  LDD0707  [12]
 LDCM0391  CL120 HEK-293T C457(1.03)  LDD0989  [12]
 LDCM0392  CL121 PaTu 8988t C725(1.34)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C725(1.39)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C725(1.68)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C725(1.41)  LDD1274  [12]
 LDCM0396  CL125 HCT 116 C457(1.00)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C457(1.26)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C457(1.02)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C457(1.15)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C457(1.04)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C457(0.93)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C457(0.85)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C457(1.01)  LDD0720  [12]
 LDCM0404  CL17 PaTu 8988t C546(0.97); C725(1.62); C457(1.33)  LDD1283  [12]
 LDCM0405  CL18 PaTu 8988t C546(0.77); C725(1.38); C457(1.47)  LDD1284  [12]
 LDCM0406  CL19 PaTu 8988t C546(0.84); C725(1.45); C457(1.41)  LDD1285  [12]
 LDCM0407  CL2 HCT 116 C457(0.86)  LDD0724  [12]
 LDCM0408  CL20 PaTu 8988t C546(0.90); C725(1.78); C457(1.46)  LDD1287  [12]
 LDCM0409  CL21 PaTu 8988t C546(1.21); C725(2.44); C457(1.77)  LDD1288  [12]
 LDCM0410  CL22 PaTu 8988t C546(0.99); C725(2.09); C457(1.38)  LDD1289  [12]
 LDCM0411  CL23 PaTu 8988t C546(1.53); C725(1.92); C457(1.49)  LDD1290  [12]
 LDCM0412  CL24 PaTu 8988t C546(0.80); C725(1.48); C457(1.28)  LDD1291  [12]
 LDCM0413  CL25 PaTu 8988t C546(1.01); C725(1.38); C457(1.28)  LDD1292  [12]
 LDCM0414  CL26 PaTu 8988t C546(0.84); C725(1.54); C457(1.43)  LDD1293  [12]
 LDCM0415  CL27 PaTu 8988t C546(1.28); C725(1.47); C457(1.45)  LDD1294  [12]
 LDCM0416  CL28 PaTu 8988t C546(1.52); C725(2.60); C457(1.53)  LDD1295  [12]
 LDCM0417  CL29 PaTu 8988t C546(1.34); C725(1.99); C457(1.55)  LDD1296  [12]
 LDCM0418  CL3 HCT 116 C457(0.89)  LDD0735  [12]
 LDCM0419  CL30 PaTu 8988t C546(0.97); C725(1.35); C457(1.41)  LDD1298  [12]
 LDCM0420  CL31 PaTu 8988t C546(1.07); C725(1.20); C457(1.06)  LDD1299  [12]
 LDCM0421  CL32 HCT 116 C457(1.11)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C457(1.23)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C457(1.01)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C457(0.87)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C457(0.78)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C457(0.95)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C457(0.98)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C457(0.80)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C457(0.93)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C457(0.92)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C457(0.78)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C457(0.93)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C457(0.78)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C457(0.78)  LDD0752  [12]
 LDCM0436  CL46 PaTu 8988t C457(1.08)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C457(0.94)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C457(1.11)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C457(1.01)  LDD1318  [12]
 LDCM0440  CL5 HCT 116 C457(1.01)  LDD0757  [12]
 LDCM0441  CL50 PaTu 8988t C457(1.59)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C457(1.26)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C457(1.23)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C457(1.58)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C457(1.23)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C457(1.13)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C457(1.16)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C457(1.04)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C457(1.27)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C457(1.18)  LDD1329  [12]
 LDCM0451  CL6 HCT 116 C457(0.95)  LDD0768  [12]
 LDCM0452  CL60 PaTu 8988t C457(1.28)  LDD1331  [12]
 LDCM0453  CL61 HCT 116 C457(0.95)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C457(0.92)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C457(0.94)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C457(0.96)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C457(0.89)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C457(0.87)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C457(0.92)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C457(0.95)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C457(0.95)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C457(1.03)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C457(0.92)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C457(0.94)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C457(1.15)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C457(1.09)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C457(0.96)  LDD0784  [12]
 LDCM0470  CL77 HEK-293T C868(0.82)  LDD1673  [11]
 LDCM0473  CL8 HCT 116 C457(1.08)  LDD0790  [12]
 LDCM0474  CL80 HEK-293T C336(0.79); C457(1.11)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C457(1.12)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C336(1.29)  LDD1679  [11]
 LDCM0480  CL86 HEK-293T C457(0.91)  LDD1683  [11]
 LDCM0483  CL89 HEK-293T C868(0.95)  LDD1686  [11]
 LDCM0484  CL9 HCT 116 C457(0.92)  LDD0801  [12]
 LDCM0487  CL92 HEK-293T C336(1.21); C457(1.00)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C457(0.98)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C336(1.79)  LDD1692  [11]
 LDCM0493  CL98 HEK-293T C457(0.94)  LDD1696  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C725(1.89)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C457(0.98)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C457(0.82)  LDD0744  [12]
 LDCM0022  KB02 T cell-activated C725(20.00)  LDD1704  [6]
 LDCM0023  KB03 Jurkat C725(5.01)  LDD0209  [5]
 LDCM0024  KB05 HMCB C457(2.60)  LDD3312  [13]
 LDCM0109  NEM HeLa C725(0.00); H728(0.00)  LDD0227  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C868(2.30)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Dynein light chain Tctex-type 3 (DYNLT3) Dynein light chain Tctex-type family P51808

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840