Details of the Target

General Information of Target

Target ID LDTP03589
Target Name cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B)
Gene Name PRKAR1B
Gene ID 5575
Synonyms
cAMP-dependent protein kinase type I-beta regulatory subunit
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKE
ENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPK
DYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG
EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTL
RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTA
SVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLG
PCSEILKRNIQRYNSFISLTV
Target Bioclass
Other
Family
CAMP-dependent kinase regulatory chain family
Subcellular location
Cell membrane
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Uniprot ID
P31321
Ensemble ID
ENST00000360274.8
HGNC ID
HGNC:9390
ChEMBL ID
CHEMBL2320

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C347(0.95)  LDD1700  [1]
DBIA
 Probe Info  		C18(1.04)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Acrolein
 Probe Info  		H53(0.00); C362(0.00)  LDD0217  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]
AOyne
 Probe Info  		13.60  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C347(0.84)  LDD2103  [1]
 LDCM0214  AC1 HEK-293T C18(0.88)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C18(0.83)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C18(1.09)  LDD0824  [2]
 LDCM0230  AC113 HCT 116 C18(1.38)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C18(1.30)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C18(1.95)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C18(1.43)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C18(1.25)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C18(1.23)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C18(1.15)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C18(0.99)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C18(1.46)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C18(1.30)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C18(1.51)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C18(0.98)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C18(1.25)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C18(1.31)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C18(1.48)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C18(1.40)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C18(1.12)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C18(0.72)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C18(1.11)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C18(0.76)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C18(0.68)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C18(1.01)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C18(1.08)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C18(0.97)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C18(0.90)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C18(0.77)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C18(0.98)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C18(0.95)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C18(0.86)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C18(0.92)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C18(1.17)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C18(0.64)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C18(1.22)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C18(1.55)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C18(1.33)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C18(1.58)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C18(1.64)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C18(2.36)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C18(1.67)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C18(0.89)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C18(1.37)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C18(1.21)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C18(1.63)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C18(2.73)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C18(1.52)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C18(1.40)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C18(1.27)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C18(1.08)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C18(1.36)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C18(1.56)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C18(1.27)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C18(0.93)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C18(1.36)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C18(1.47)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C18(1.14)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C18(1.74)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C18(0.97)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C18(0.78)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C18(0.75)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C18(0.72)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C18(0.65)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C18(0.68)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C18(1.00)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C18(0.70)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C18(0.80)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C18(0.74)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C18(0.75)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C18(0.75)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C362(1.04)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C362(1.07)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C362(1.17); C18(0.97)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C362(1.06); C18(1.08)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C362(0.95); C18(1.12)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C18(1.05)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C362(1.10)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C362(0.96); C18(1.11)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C362(0.97); C18(1.02)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C362(1.07)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C362(0.98)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C362(0.98); C18(0.96)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C362(1.02); C18(1.02)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C362(1.04); C18(1.03)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C362(0.99)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C362(0.98); C18(0.98)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C18(0.85)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C362(1.06); C18(1.02)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C362(1.07)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C362(1.10)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C362(1.00); C18(0.94)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C362(1.05); C18(1.07)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C362(1.02); C18(1.04)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C362(0.96)  LDD1558  [9]
 LDCM0320  AC57 HCT 116 C18(1.17)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C18(1.43)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C18(1.51)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C18(0.92)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C18(1.33)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C18(1.21)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C18(1.52)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C18(1.59)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C18(1.59)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C18(1.43)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C18(1.40)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C18(1.72)  LDD0648  [2]
 LDCM0334  AC7 HEK-293T C18(0.80)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C18(0.81)  LDD0943  [2]
 LDCM0545  Acetamide MDA-MB-231 C347(0.32)  LDD2138  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C347(0.63)  LDD2113  [1]
 LDCM0248  AKOS034007472 HEK-293T C18(0.82)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C18(0.83)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C18(0.76)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C18(1.04)  LDD0078  [2]
 LDCM0367  CL1 PaTu 8988t C18(1.15)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C18(1.95)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C18(0.86)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C18(0.75)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C18(0.76)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C18(0.81)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C18(0.77)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C18(2.16)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C18(3.03)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C18(1.88)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C18(2.64)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C18(2.49)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C18(1.06)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C18(2.21)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C18(2.37)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C18(0.71)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C18(0.74)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C18(0.65)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C18(0.65)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C18(0.69)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C362(1.08); C18(0.99)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C362(1.09)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C362(1.09); C18(1.10)  LDD1593  [9]
 LDCM0390  CL12 PaTu 8988t C18(1.40)  LDD1269  [2]
 LDCM0391  CL120 HEK-293T C362(1.00); C18(1.07)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C362(1.02); C18(0.97)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C362(1.05)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C362(1.06); C18(0.95)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C362(0.95); C18(1.13)  LDD1599  [9]
 LDCM0396  CL125 HCT 116 C18(1.12)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C18(1.13)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C18(1.13)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C18(1.47)  LDD0716  [2]
 LDCM0400  CL13 PaTu 8988t C18(1.84)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C18(2.37)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C18(1.83)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C18(1.03)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C18(0.96)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C18(0.92)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C18(1.00)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C18(1.26)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C18(0.91)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C18(1.09)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C18(0.84)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C18(1.01)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C18(0.91)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C18(0.89)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C18(1.02)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C18(1.05)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C18(1.02)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C18(0.99)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C18(1.19)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C18(0.84)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C18(0.72)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C18(0.85)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C18(0.79)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C18(0.88)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C18(0.82)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C18(0.83)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C18(0.73)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C18(0.84)  LDD1026  [2]
 LDCM0429  CL4 PaTu 8988t C18(1.40)  LDD1308  [2]
 LDCM0430  CL40 HEK-293T C18(0.68)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C18(0.80)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C18(0.83)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C18(0.79)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C18(0.89)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C18(0.83)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C18(0.82)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C18(0.80)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C18(0.82)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C18(0.98)  LDD1037  [2]
 LDCM0440  CL5 PaTu 8988t C18(1.52)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C18(0.99)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C18(1.04)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C18(1.25)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C18(1.09)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C18(0.99)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C18(0.83)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C18(0.80)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C18(0.99)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C18(0.96)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C18(0.88)  LDD1048  [2]
 LDCM0451  CL6 PaTu 8988t C18(1.85)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C18(0.94)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C18(0.93)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C18(1.00)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C18(1.01)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C18(0.93)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C18(0.90)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C18(1.19)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C18(1.10)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C18(1.08)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C18(1.06)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C18(1.85)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C18(1.26)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C18(1.19)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C18(1.00)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C18(1.07)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C18(1.00)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C18(0.86)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C18(0.80)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C18(0.68)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C18(0.76)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C18(1.39)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C18(0.91)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C18(0.76)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C18(0.93)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C18(1.09)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C18(0.73)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C18(0.72)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C18(0.64)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C18(0.83)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C18(0.87)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C18(0.83)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C18(1.59)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C18(0.96)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C18(0.90)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C18(0.90)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C18(0.85)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C18(0.74)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C18(0.77)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C18(0.87)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C18(0.89)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C18(0.90)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C18(0.92)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C362(1.01); C18(0.95)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C18(1.14)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C18(0.99)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C18(1.87)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C18(2.44)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C18(3.74)  LDD0082  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C347(1.11)  LDD2094  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C347(1.04)  LDD2098  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C347(1.29)  LDD2105  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C347(0.45)  LDD2106  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C347(0.92)  LDD2110  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C347(0.55)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C347(0.79)  LDD2116  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C347(0.70)  LDD2118  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C347(0.72)  LDD2126  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C347(0.54)  LDD2133  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C347(0.95)  LDD1700  [1]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C347(0.73)  LDD2151  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C347(1.84)  LDD2153  [1]
 LDCM0021  THZ1 HCT 116 C18(1.00)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) EEF2KMT family Q96G04
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) TRAFAC class YlqF/YawG GTPase family Q9NVN8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
SAP30-binding protein (SAP30BP) HCNGP family Q9UHR5
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Retinoic acid receptor gamma (RARG) Nuclear hormone receptor family P13631
Thyroid hormone receptor alpha (THRA) Nuclear hormone receptor family P10827
DNA polymerase epsilon subunit 4 (POLE4) . Q9NR33
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biorientation of chromosomes in cell division protein 1-like 2 (BOD1L2) BOD1 family Q8IYS8
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) CAMP-dependent kinase regulatory chain family P10644
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Proteasome assembly chaperone 1 (PSMG1) PSMG1 family O95456
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
A-kinase anchor protein 14 (AKAP14) . Q86UN6
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Chromobox protein homolog 8 (CBX8) . Q9HC52
Golgin subfamily A member 1 (GOLGA1) . Q92805
Guanylyl cyclase-activating protein 1 (GUCA1A) . P43080
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
SHC-transforming protein 3 (SHC3) . Q92529
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) . Q9BZF9
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402