Details of the Target

General Information of Target

Target ID LDTP03452
Target Name Retinoblastoma-like protein 1 (RBL1)
Gene Name RBL1
Gene ID 5933
Synonyms
Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFEDKPHAEGAAVVAAAGEALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLA
CSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRE
RIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTL
FVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFT
ASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKGECLLDLSSFTDNSK
AVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFE
KKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQSIVAGLKNAPSDQLINIFESCV
RNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQET
RRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVV
IRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNNFETG
NGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTAGSAKRRL
FGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKVTI
PLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGIN
RPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHL
DQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNIND
DFEMIDCDLEDATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMDA
PPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNM
IRQGEQRTKKRVIAIDSDAESPAKRVCQENDDVLLKRLQDVVSERANH
Target Bioclass
Other
Family
Retinoblastoma protein (RB) family
Subcellular location
Nucleus
Function
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.
Uniprot ID
P28749
Ensemble ID
ENST00000344359.7
HGNC ID
HGNC:9893

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K1044E .
HEPG2 SNV: p.C807Y .
HT115 SNV: p.F826L .
MDAMB231 SNV: p.P246L .
MFE319 SNV: p.A952V .
MOLT4 Deletion: p.F102LfsTer4 IA-alkyne    Probe Info 
NCIH3122 SNV: p.L206F DBIA    Probe Info 
OAW42 SNV: p.R838S .
RL952 SNV: p.K717E .
SNU423 SNV: p.I1021V .
YSCCC SNV: p.K682Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K95(5.88)  LDD0277  [1]
IPM
 Probe Info  		C419(0.27)  LDD1701  [2]
DBIA
 Probe Info  		C1047(1.01)  LDD0078  [3]
IA-alkyne
 Probe Info  		C419(0.00); C288(0.00); C918(0.00)  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
NAIA_5
 Probe Info  		C1047(0.00); C505(0.00); C504(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C84(0.94)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C84(1.08)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C84(1.07)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C84(0.96)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C84(0.80)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C84(0.71)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C84(0.84)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C84(0.98)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C84(1.06)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C84(0.89)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C84(1.05)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C84(0.91)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C84(1.15)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C84(0.87)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C84(1.14)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C84(1.07)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C84(0.81)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C84(1.40)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C84(1.23)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C84(0.94)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C84(1.04)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C84(0.91)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C84(0.80)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C84(1.10)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C84(0.98)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C84(1.05)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C84(0.92)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C84(1.05)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C84(1.22)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C84(1.05)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C84(0.74)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C84(0.99)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C84(0.95)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C84(1.02)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C84(1.23)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C84(0.88)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C84(1.93)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C84(1.12)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C84(1.11)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C84(0.99)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C84(1.50)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C84(1.50)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C84(1.49)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C84(1.11)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C84(1.64)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C84(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C84(1.27)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C84(1.10)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C84(1.19)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C84(1.44)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C84(1.13)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C84(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C84(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C84(1.47)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C84(1.35)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C84(1.20)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C84(0.75)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C84(0.96)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C84(1.07)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C84(1.19)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C84(1.72)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C84(1.19)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C84(1.13)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C84(1.37)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C84(1.37)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C84(1.28)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C84(1.35)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C84(1.51)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C918(1.04); C84(1.00); C1047(1.02); C288(0.90)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C918(0.97); C84(0.98); C1047(0.99); C288(0.98)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C918(0.88); C84(1.01); C1047(0.95); C288(1.01)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C918(1.01); C84(0.88); C1047(0.97); C288(0.91)  LDD1550  [7]
 LDCM0312  AC5 HCT 116 C84(1.36)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C918(0.99); C84(1.01); C1047(1.06); C168(1.04)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C918(0.92); C84(0.93); C1047(0.90); C288(1.09)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C918(0.90); C84(0.92); C1047(0.94); C288(0.97)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C918(1.03); C84(1.04); C1047(0.92); C288(0.95)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C918(1.07); C84(1.00); C1047(0.95); C288(0.96)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C918(0.95); C84(0.99); C1047(1.04); C288(0.97)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C918(1.04); C84(1.00); C1047(0.90); C288(0.96)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C918(1.06); C84(0.98); C1047(0.98); C288(0.98)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C918(0.95); C84(0.98); C1047(0.91); C168(1.11)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C918(1.01); C84(0.92); C1047(0.93); C288(1.03)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C84(1.10)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C918(0.94); C84(1.01); C1047(0.99); C288(0.98)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C918(0.99); C84(1.02); C1047(1.04); C288(0.95)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C918(1.06); C84(0.94); C1047(0.98); C288(0.93)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C918(1.04); C84(0.98); C1047(1.20); C288(1.02)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C918(0.93); C84(0.94); C1047(0.92); C288(0.92)  LDD1567  [7]
 LDCM0334  AC7 HCT 116 C84(1.08)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C84(0.91)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C84(1.41)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C84(0.87)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C84(0.94)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C84(0.98)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C84(0.78)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C84(0.57)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C84(0.86)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C84(0.84)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C84(0.70)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C84(0.69)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C84(0.92)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C84(1.01)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C84(0.68)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C84(0.79)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C84(1.08)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C84(0.76)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C84(0.78)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C84(0.84)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C1047(1.01)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C84(0.87)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C84(1.78)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C84(1.07)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C84(1.28)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C84(0.97)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C84(0.77)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C84(0.72)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C84(1.58)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C84(1.58)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C84(1.52)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C84(1.87)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C84(1.64)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C84(1.26)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C84(1.16)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C84(1.58)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C84(1.05)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C84(1.26)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C84(0.98)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C84(1.08)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C84(1.39)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C84(1.83)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C84(1.79)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C84(1.16)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C84(0.88)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C84(1.60)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C918(0.91); C84(1.08); C1047(1.01); C288(0.95)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C918(1.01); C84(1.03); C1047(0.97); C288(1.17)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C918(0.87); C84(1.37); C1047(0.83); C288(1.31)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C918(0.86); C84(1.15); C1047(0.65); C288(1.15)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C918(0.89); C84(1.06); C1047(0.89); C288(0.95)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C918(0.97); C84(0.91); C1047(1.08); C288(0.99)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C918(0.97); C84(1.02); C1047(0.81); C288(1.01)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C918(1.00); C84(0.90); C1047(0.86); C288(1.04)  LDD1603  [7]
 LDCM0400  CL13 HCT 116 C84(1.08)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C84(0.77)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C84(1.03)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C84(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C84(0.92)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C84(0.99)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C84(1.06)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C84(0.79)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C84(1.15)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C84(1.13)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C84(1.07)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C84(0.98)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C84(1.06)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C84(0.81)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C84(1.16)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C84(1.00)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C84(1.07)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C84(1.27)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C84(0.90)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C84(1.06)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C84(1.02)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C84(0.90)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C84(0.90)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C84(1.02)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C84(1.02)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C84(1.15)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C84(0.97)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C84(0.91)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C84(1.05)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C84(0.88)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C84(0.89)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C84(0.94)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C84(0.99)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C84(0.88)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C84(0.97)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C918(0.98); C84(1.10); C1047(0.84); C288(0.94)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C918(1.03); C84(1.17); C1047(0.62); C288(1.16)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C918(1.00); C84(1.24); C1047(1.06); C288(0.98)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C918(0.83); C84(1.09); C1047(0.93); C288(1.07)  LDD1643  [7]
 LDCM0440  CL5 HCT 116 C84(1.06)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C918(0.91); C84(1.04); C1047(1.00); C288(1.18)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C918(0.84); C84(0.93); C1047(0.89); C288(1.18)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C918(1.02); C84(1.18); C1047(1.03); C288(1.25)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C918(1.04); C84(1.58); C1047(0.97); C168(1.45)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C918(0.99); C84(1.01); C1047(1.02); C288(1.21)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C918(0.93); C84(1.19); C1047(1.21); C288(1.10)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C918(1.21); C84(1.15); C1047(1.11); C288(1.20)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C918(1.02); C84(1.10); C1047(0.74); C288(1.12)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C918(0.97); C84(1.24); C1047(0.66); C288(1.18)  LDD1653  [7]
 LDCM0451  CL6 HCT 116 C84(1.26)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C918(1.01); C84(1.22); C1047(1.10); C288(0.97)  LDD1655  [7]
 LDCM0453  CL61 PaTu 8988t C918(0.71)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C918(0.54)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C918(0.73)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C918(0.94)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C918(0.66)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C918(0.85)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C918(0.81)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C918(1.21)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C918(0.77)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C84(1.18)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C918(1.23)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C918(0.68)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C918(0.71)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C918(1.16)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C918(1.08)  LDD1346  [3]
 LDCM0469  CL76 HEK-293T C918(0.96); C84(0.90); C1047(0.78); C288(0.95)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C918(1.10); C84(1.16); C1047(0.96); C288(1.13)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C918(0.98); C84(1.04); C1047(0.99); C168(1.08)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C918(1.06); C84(0.93); C1047(1.00); C288(0.95)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C84(1.08)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C918(0.97); C84(1.03); C1047(0.94); C288(1.04)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C918(0.99); C84(1.04); C1047(1.15); C288(1.01)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C918(1.00); C84(1.02); C1047(0.92); C288(1.07)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C918(0.98); C84(1.23); C1047(0.73); C288(1.17)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C918(1.01); C84(1.23); C1047(1.00); C288(1.18)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C918(0.81); C84(1.09); C1047(0.87); C288(0.93)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C918(1.05); C84(0.98); C1047(0.98); C288(1.05)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C918(0.83); C84(0.98); C1047(0.86); C288(0.94)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C918(0.85); C84(0.96); C1047(0.94); C288(1.03)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C918(0.97); C84(1.06); C1047(0.99); C288(1.15)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C84(1.31)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C918(1.12); C84(1.58); C1047(0.92); C168(1.82)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C84(1.09)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C84(0.72)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C84(0.73)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C84(0.72)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C84(1.06)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C84(1.08)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C84(0.97)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C84(1.38)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C84(1.68)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C918(0.82); C84(1.02); C1047(1.14); C288(0.93)  LDD1698  [7]
 LDCM0625  F8 Ramos C1047(1.05)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C1047(1.54)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C1047(12.05)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C1047(0.93)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C1047(0.87)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C1047(0.87)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C1047(1.02)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C1047(1.07)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C1047(1.27)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C1047(1.00)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C1047(0.85)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C1047(0.95)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C1047(0.80)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C1047(1.64)  LDD2201  [8]
 LDCM0468  Fragment33 PaTu 8988t C918(0.96)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C1047(0.88)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C1047(0.84)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C84(1.13)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C1047(0.98)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C1047(1.16)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C1047(1.15)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C1047(1.40)  LDD2188  [8]
 LDCM0022  KB02 HCT 116 C918(1.66)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C918(1.33)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C918(1.54)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) CMGC Ser/Thr protein kinase family Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) CMGC Ser/Thr protein kinase family Q9Y463
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Forkhead box protein O3 (FOXO3) . O43524
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578