Details of the Target

General Information of Target

Target ID LDTP01551
Target Name Poly [ADP-ribose] polymerase tankyrase-1 (TNKS)
Gene Name TNKS
Gene ID 8658
Synonyms
PARP5A; PARPL; TIN1; TINF1; TNKS1; Poly [ADP-ribose] polymerase tankyrase-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; Poly [ADP-ribose] polymerase 5A; Protein poly-ADP-ribosyltransferase tankyrase-1; EC 2.4.2.-; TNKS-1; TRF1-interacting ankyrin-related ADP-ribose polymerase; Tankyrase I; Tankyrase-1; TANK1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR
HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP
AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA
NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV
LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV
NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL
LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV
TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL
AGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA
GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP
LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN
RDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP
LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD
KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA
LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERK
EGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLI
KGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGG
IFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER
HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF
LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTA
TAAEQKT
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
ARTD/PARP family
Subcellular location
Cytoplasm
Function
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
TTD ID
T39231
Uniprot ID
O95271
DrugMap ID
TTVUSO7
Ensemble ID
ENST00000310430.11
HGNC ID
HGNC:11941
ChEMBL ID
CHEMBL6164

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.D804MfsTer49 .
DU145 SNV: p.G68V .
HCC44 SNV: p.P129S .
HCT116 SNV: p.E734K DBIA    Probe Info 
HT115 SNV: p.R383Q; p.R383Ter .
HUPT3 SNV: p.H12N .
IGROV1 SNV: p.R683Q .
KMCH1 SNV: p.S47F .
MFE319 SNV: p.C427F .
MOLT4 SNV: p.R1180C .
NB1 SNV: p.A599T .
NCIH1703 SNV: p.H859R .
NCIH2172 SNV: p.Q1325H .
OCILY3 SNV: p.N465I .
PEO1 SNV: p.R678G .
RKO SNV: p.I1068M .
SHP77 SNV: p.S1264G .
SNGM SNV: p.L976V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C670(0.58); C677(0.58)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
YN-1
 Probe Info  		N.A.  LDD0447  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C670(0.58); C677(0.58)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C670(0.46); C677(0.46)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C670(0.43); C677(0.43); C823(0.69); C830(0.69)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C670(0.50); C677(0.50); C823(0.46); C830(0.46)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C670(0.48); C677(0.48); C823(0.41); C830(0.41)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C670(0.36); C677(0.36); C823(0.56); C830(0.56)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C670(0.38); C677(0.38); C823(0.49); C830(0.49)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C670(0.52); C677(0.52); C823(0.45); C830(0.45)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C670(0.38); C677(0.38); C823(0.63); C830(0.63)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C670(0.54); C677(0.98); C823(0.47); C830(0.47)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C670(0.44); C677(0.30); C823(0.94); C830(0.94)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C670(0.47); C677(0.34); C823(0.50); C830(0.50)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C670(0.45); C677(0.45)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C670(0.45); C677(0.31); C823(0.69); C830(0.69)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C670(0.47); C677(0.38); C823(0.71); C830(0.71)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C670(0.50); C677(0.65); C823(0.52); C830(0.52)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C451(0.80); C466(0.80); C823(1.06); C830(1.06)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C451(0.84); C466(0.84); C823(1.01); C830(0.98)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C451(0.81); C466(0.81); C823(1.14); C830(1.10)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C451(0.77); C466(0.77); C823(1.31); C830(0.98)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C451(0.82); C466(0.82); C823(1.05); C830(1.29)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C451(0.70); C466(0.70); C823(1.16); C830(1.02)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C451(0.83); C466(0.83); C823(1.10); C830(1.02)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C670(0.90); C677(0.90)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C451(0.70); C466(0.70); C823(1.16); C830(1.06)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C451(0.79); C466(0.79); C823(1.03); C830(1.34)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C451(0.70); C466(0.70); C823(1.19); C830(1.02)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C451(0.76); C466(0.76); C823(1.40); C830(1.04)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C451(0.68); C466(0.68); C823(1.23); C830(1.30)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C451(0.89); C466(0.89); C823(1.17); C830(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C451(0.82); C466(0.82); C823(1.18); C830(1.02)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C451(0.69); C466(0.69); C823(1.26); C830(0.99)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C823(0.96); C830(0.96)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C823(1.08); C830(1.08)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C823(1.04); C830(1.04)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C823(1.01); C830(1.01)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C823(0.88); C830(0.88)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C823(1.08); C830(1.08)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C823(0.76); C830(0.76)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C823(0.82); C830(0.82)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C823(0.80); C830(0.80)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C823(0.79); C830(0.79)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C823(0.52); C830(0.52)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C823(0.66); C830(0.66)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C670(0.69); C677(0.69)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C823(0.51); C830(0.51)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C823(0.48); C830(0.48)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C823(0.84); C830(0.84)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C823(0.75); C830(0.75); C451(0.92); C466(0.92)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C670(0.51); C677(0.51); C451(0.89); C466(0.89)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C670(0.58); C677(0.58); C451(0.81); C466(0.81)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C670(0.70); C677(0.70); C451(1.00); C466(1.00)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C670(0.60); C677(0.60); C823(0.97); C830(0.97)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C823(0.74); C830(0.74); C670(0.78); C677(0.78)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C670(0.65); C677(0.65); C823(0.73); C830(0.73)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C670(0.60); C677(0.60)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C670(0.63); C677(0.63); C823(0.96); C830(0.96)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C670(0.75); C677(0.75); C451(0.87); C466(0.87)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C670(0.59); C677(0.59); C823(0.61); C830(0.61)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C670(0.80); C677(0.80); C823(0.88); C830(0.88)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C451(0.87); C466(0.87); C670(0.68); C677(0.68)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C451(1.02); C466(1.02); C670(0.64); C677(0.64)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C451(1.15); C466(1.15); C670(1.26); C677(1.26)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C451(1.00); C466(1.00); C670(0.84); C677(0.84)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C677(0.69); C670(0.81)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C677(0.73); C670(0.77)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C677(0.70); C670(0.72)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C670(0.67); C677(0.67)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C677(0.65); C670(0.83)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C677(0.78); C670(0.86)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C677(0.97); C670(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C677(0.72); C670(0.86)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C677(0.84); C670(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C451(0.73); C466(0.73); C670(0.83); C677(0.83)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C670(0.62); C677(0.62); C451(0.93); C466(0.93)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C670(0.65); C677(0.65); C451(0.90); C466(0.90)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C670(0.71); C677(0.71); C451(0.92); C466(0.92)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C670(0.68); C677(0.68); C451(0.94); C466(0.94)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C670(0.65); C677(0.65)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C670(0.67); C677(0.67); C451(1.00); C466(1.00)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C670(0.76); C677(0.76); C451(1.04); C466(1.04)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C670(0.64); C677(0.64); C451(1.15); C466(1.15)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C670(0.63); C677(0.63); C451(0.94); C466(0.94)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C670(0.53); C677(0.53); C451(0.97); C466(0.97)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C670(1.16); C677(1.16)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C670(1.16); C677(1.16)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C670(1.09); C677(1.09)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C670(1.08); C677(1.08)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C670(0.92); C677(0.92)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C670(0.50); C677(0.50)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C670(0.98); C677(0.98)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C670(1.02); C677(1.02)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C670(0.99); C677(0.99)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C670(1.06); C677(1.06)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C670(1.03); C677(1.03)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C670(1.09); C677(1.09)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C451(1.02); C466(1.02)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C451(0.88); C466(0.88)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C451(1.05); C466(1.05)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C451(1.05); C466(1.05)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C670(0.49); C677(0.49)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C451(1.05); C466(1.05)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C451(1.01); C466(1.01)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C451(0.99); C466(0.99)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C451(0.99); C466(0.99)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C451(0.98); C466(0.98)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C451(1.07); C466(1.07)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C451(1.38); C466(1.38)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C670(0.72); C677(0.72)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C670(0.62); C677(0.62)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C670(0.54); C677(0.54)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C670(0.48); C677(0.48)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C670(0.61); C677(0.61)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C670(0.84); C677(0.84)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C670(0.65); C677(0.65)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C670(0.62); C677(0.62)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C670(0.57); C677(0.57)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C670(0.65); C677(0.65)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C670(0.73); C677(0.73)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C670(0.64); C677(0.64)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C670(0.90); C677(0.90); C451(1.01); C466(1.01)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C670(0.83); C677(0.83); C823(0.89); C830(0.89)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C670(0.57); C677(0.57)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C670(0.84); C677(0.84); C823(0.86); C830(0.86)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C670(0.90); C677(0.90); C451(1.02); C466(1.02)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C670(0.79); C677(0.79); C823(0.89); C830(0.89)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C670(0.87); C677(0.87); C823(0.89); C830(0.89)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C451(0.85); C466(0.85); C823(0.89); C830(0.89)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C823(0.94); C830(0.94); C670(1.06); C677(1.06)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C670(0.81); C677(0.81); C823(0.82); C830(0.82)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C670(0.80); C677(0.80); C823(0.89); C830(0.89)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C670(1.06); C677(1.06); C451(1.08); C466(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C823(0.85); C830(0.85); C670(0.86); C677(0.86)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C670(0.45); C677(0.45)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C823(0.81); C830(0.81); C451(0.88); C466(0.88)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C451(0.81); C466(0.81); C823(1.08); C830(1.08)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C823(1.03); C830(1.03); C670(1.17); C677(1.17)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C670(0.59); C677(0.59); C823(1.02); C830(1.02)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C670(0.73); C677(0.73); C823(0.85); C830(0.85)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C670(0.76); C677(0.76); C823(1.04); C830(1.04)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C670(0.52); C677(0.52); C823(1.04); C830(1.04)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C670(0.91); C677(0.91); C823(0.95); C830(0.95)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C670(0.62); C677(0.62); C823(0.87); C830(0.87)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C670(0.63); C677(0.63); C823(1.12); C830(1.12)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C670(0.93); C677(0.93); C823(1.20); C830(1.20)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C670(0.58); C677(0.58); C823(1.01); C830(1.01)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C670(0.52); C677(0.52); C823(1.11); C830(1.11)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C670(0.70); C677(0.70); C823(0.91); C830(0.91)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C670(0.68); C677(0.68); C823(0.81); C830(0.81)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C823(1.04); C830(1.04); C670(1.21); C677(1.21)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C670(0.66); C677(0.66); C823(0.97); C830(0.97)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C670(0.60); C677(0.60); C823(1.05); C830(1.05)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C670(0.41); C677(0.41); C823(0.55); C830(0.55)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C823(0.48); C830(0.48); C670(0.53); C677(0.53)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C670(0.63); C677(0.63)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C670(0.54); C677(0.54)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C670(0.39); C677(0.39)  LDD0592  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0367  CL1 HCT 116 C670(1.33); C677(1.33)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C670(1.41); C677(1.41)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C670(0.48); C677(0.48)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C670(0.41); C677(0.41)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C670(0.50); C677(0.50)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C670(0.49); C677(0.49)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C670(0.51); C677(0.51)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C677(0.63); C670(0.80)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C677(0.58); C670(0.86)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C677(0.56); C670(0.74)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C677(0.50); C670(0.74)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C677(0.67); C670(0.74)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C670(1.10); C677(1.10)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C677(0.62); C670(0.83)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C677(0.65); C670(0.73)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C451(0.84); C466(0.84); C670(0.91); C677(0.91)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C670(0.60); C677(0.60); C451(0.83); C466(0.83)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C670(0.73); C677(0.73); C451(0.88); C466(0.88)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C670(0.64); C677(0.64); C451(0.91); C466(0.91)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C670(0.63); C677(0.63); C451(0.85); C466(0.85)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C670(1.05); C677(1.05)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C670(0.96); C677(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C670(0.94); C677(0.94)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C670(1.21); C677(1.21)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C670(1.06); C677(1.06)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C451(1.70); C466(1.70)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C451(1.05); C466(1.05)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C451(1.15); C466(1.15)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C451(1.17); C466(1.17)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C670(0.75); C677(0.75)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C670(0.57); C677(0.57)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C670(0.91); C677(0.91)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C670(0.70); C677(0.70)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C670(1.37); C677(1.37)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C670(1.26); C677(1.26)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C670(1.05); C677(1.05)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C823(0.72); C830(0.72)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C823(0.63); C830(0.63)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C823(1.07); C830(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C823(0.87); C830(0.87)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C670(1.47); C677(1.47)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C823(0.73); C830(0.73)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C823(0.63); C830(0.63)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C823(0.76); C830(0.76)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C823(0.71); C830(0.71)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C823(0.74); C830(0.74)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C823(0.61); C830(0.61)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C823(0.83); C830(0.83)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C823(0.93); C830(0.93)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C823(0.70); C830(0.70)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C823(0.68); C830(0.68)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C670(1.33); C677(1.33)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C823(0.81); C830(0.81)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C670(0.83); C677(0.83)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C670(0.60); C677(0.60)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C670(0.55); C677(0.55)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C670(0.59); C677(0.59)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C670(0.61); C677(0.61)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C670(0.85); C677(0.85)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C670(0.56); C677(0.56)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C670(0.60); C677(0.60)  LDD1307  [2]
 LDCM0429  CL4 HCT 116 C670(1.76); C677(1.76)  LDD0746  [2]
 LDCM0430  CL40 PaTu 8988t C670(0.68); C677(0.68)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C670(0.60); C677(0.60)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C670(0.55); C677(0.55)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C670(0.60); C677(0.60)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C670(0.56); C677(0.56)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C670(0.70); C677(0.70)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C670(0.76); C677(0.76)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C670(0.82); C677(0.82)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C670(0.70); C677(0.70)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C670(0.89); C677(0.89)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C670(1.07); C677(1.07)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C670(0.94); C677(0.94)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C670(0.78); C677(0.78)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C670(0.88); C677(0.88)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C670(0.68); C677(0.68)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C670(0.87); C677(0.87)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C670(0.91); C677(0.91)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C670(0.47); C677(0.47)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C670(0.77); C677(0.77)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C670(0.56); C677(0.56)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C670(0.69); C677(0.69)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C670(1.50); C677(1.50)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C670(0.75); C677(0.75)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C823(0.97); C830(0.97)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C823(0.77); C830(0.77)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C823(0.83); C830(0.83)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C823(0.61); C830(0.61)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C823(0.79); C830(0.79)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C823(0.74); C830(0.74)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C823(0.77); C830(0.77)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C823(0.72); C830(0.72)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C823(1.09); C830(1.09)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C670(0.93); C677(0.93)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C823(0.79); C830(0.79)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C823(0.80); C830(0.80)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C823(0.85); C830(0.85)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C823(0.64); C830(0.64)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C823(0.79); C830(0.79)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C670(1.09); C677(1.09)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C670(0.68); C677(0.68)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C670(0.65); C677(0.65)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C670(0.69); C677(0.69)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C670(1.07); C677(1.07)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C670(1.29); C677(1.29)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C670(0.79); C677(0.79)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C670(0.73); C677(0.73)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C670(0.69); C677(0.69)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C670(0.86); C677(0.86)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C670(0.77); C677(0.77)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C670(0.85); C677(0.85)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C670(0.84); C677(0.84)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C670(0.65); C677(0.65)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C670(0.94); C677(0.94)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C670(1.52); C677(1.52)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C670(1.14); C677(1.14)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C670(0.64); C677(0.64)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C670(0.66); C677(0.66)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C670(0.83); C677(0.83)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C670(0.55); C677(0.55)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C670(0.58); C677(0.58)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C670(0.77); C677(0.77)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C670(0.67); C677(0.67)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C670(0.69); C677(0.69)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C670(0.50); C677(0.50)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C427(1.19)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C823(0.86); C830(0.86)  LDD0785  [2]
 LDCM0427  Fragment51 PaTu 8988t C670(0.59); C677(0.59)  LDD1306  [2]
 LDCM0022  KB02 A101D C895(2.45)  LDD2250  [7]
 LDCM0023  KB03 A101D C895(2.16)  LDD2667  [7]
 LDCM0024  KB05 OVCAR-5 C607(2.57)  LDD3383  [7]
 LDCM0109  NEM HeLa N.A.  LDD0225  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylhydrolase ARH3 (ADPRS) ADP-ribosylglycohydrolase family Q9NX46
ADP-ribose glycohydrolase OARD1 (OARD1) . Q9Y530
E3 ubiquitin-protein ligase RNF146 (RNF146) . Q9NTX7
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) . Q9NWT6
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-sugar transporter protein SLC35A5 (SLC35A5) Nucleotide-sugar transporter family Q9BS91
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin-45 (BLZF1) . Q9H2G9
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Formin-binding protein 1 (FNBP1) FNBP1 family Q96RU3
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Centromere protein J (CENPJ) TCP10 family Q9HC77
182 kDa tankyrase-1-binding protein (TNKS1BP1) . Q9C0C2
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
Innate immunity activator protein (INAVA) . Q3KP66
Nuclear mitotic apparatus protein 1 (NUMA1) . Q14980
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27841036-compound-37 Small molecular drug D0F5TD
Stenoparib Small molecular drug DP48WE

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840