Details of the Target

General Information of Target

Target ID LDTP01543
Target Name Histone acetyltransferase KAT7 (KAT7)
Gene Name KAT7
Gene ID 11143
Synonyms
HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; EC 2.3.1.48; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVR
NLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTAD
HDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYN
FNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQ
DDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLEN
LTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYA
RLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQN
LCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQ
YMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEIS
IKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDP
SCLKWTPPKGT
Target Bioclass
Enzyme
Family
MYST (SAS/MOZ) family
Subcellular location
Nucleus
Function
Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development . Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation. Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4. H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II. Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation. H3K14ac is also required for T-cell development. KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing. Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange. Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites. Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity.; Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells.
Uniprot ID
O95251
Ensemble ID
ENST00000259021.9
HGNC ID
HGNC:17016
ChEMBL ID
CHEMBL3774299

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.L434F .
CALU1 SNV: p.M157T .
HCT15 SNV: p.R361W .
NALM6 SNV: p.P125L DBIA    Probe Info 
SKMEL2 SNV: p.R361Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C418(0.00); C422(0.00); C602(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C368(0.87); C371(0.87)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C602(0.00); C474(0.00)  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C368(1.12); C371(1.08); C474(1.12)  LDD0812  [2]
 LDCM0230  AC113 HEK-293T C368(1.18); C474(1.18)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C368(0.94); C474(0.94)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C368(0.81); C474(0.81)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C368(0.85); C474(0.85)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C368(0.68); C474(0.68)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C368(0.82); C474(0.82)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C368(1.01); C474(1.01)  LDD0834  [2]
 LDCM0238  AC120 HEK-293T C368(0.95); C474(0.95)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C368(1.35); C474(1.35)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C368(1.04); C474(1.04)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C368(1.25); C474(1.25)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C368(1.08); C474(1.08)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C368(0.94); C474(0.94)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C368(1.59); C474(1.59)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C368(1.55); C474(1.55)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C368(0.99); C371(0.99); C602(1.00)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C368(1.03); C371(1.03); C602(1.18)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C368(0.86); C371(0.86); C602(1.04)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C368(1.11); C371(1.11); C602(1.05)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C368(0.95); C371(0.95); C602(1.02)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C368(1.00); C371(1.00); C602(1.03)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C368(0.91); C371(0.91); C602(0.98)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C368(0.86); C371(0.86); C602(0.96)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C368(0.90); C371(0.90); C602(1.03)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C368(1.13); C371(1.13); C602(1.03)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C368(0.96); C371(0.96); C602(0.94)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C368(0.75); C371(0.75); C602(1.01)  LDD0575  [2]
 LDCM0260  AC140 HCT 116 C368(0.81); C371(0.81); C602(0.98)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C368(0.89); C371(0.89); C602(1.05)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C368(1.17); C371(1.17); C602(1.23)  LDD0579  [2]
 LDCM0263  AC143 HEK-293T C371(0.87)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C371(0.90)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C371(1.00)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C371(0.99)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C371(1.07)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C371(1.19)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C371(1.06)  LDD0867  [2]
 LDCM0271  AC150 HEK-293T C371(1.05)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C371(1.12)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C371(0.99)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C371(1.19)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C371(0.91)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C371(1.00)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C371(1.00)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C371(1.47)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C602(0.99); C368(1.08); C371(1.08)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C602(0.91); C368(1.07); C371(1.07)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C602(0.78); C368(1.01); C371(1.01)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C368(0.74); C371(0.91); C474(0.74)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C602(0.90); C368(1.06); C371(1.06)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C602(0.85); C368(1.02); C371(1.02)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C368(0.94); C371(0.94); C602(1.05)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C602(0.79); C368(0.88); C371(0.88)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C602(0.96); C368(1.22); C371(1.22)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C602(0.84)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C602(0.68)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C602(0.69)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C602(0.66)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C602(0.73)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C368(0.86); C371(1.03); C474(0.86)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C602(0.63)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C602(0.74)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C602(0.62)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C602(0.57)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C602(0.60)  LDD0612  [2]
 LDCM0301  AC4 HEK-293T C368(0.77); C371(0.94); C474(0.77)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C474(1.03)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C474(1.06)  LDD1549  [4]
 LDCM0312  AC5 HEK-293T C368(0.73); C371(1.00); C474(0.73)  LDD0910  [2]
 LDCM0319  AC56 HEK-293T C474(1.13)  LDD1558  [4]
 LDCM0320  AC57 HCT 116 C368(0.93); C371(0.93)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C368(0.90); C371(0.90)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C368(0.79); C371(0.79)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C368(0.86); C371(0.86)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C368(0.81); C371(0.81)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C368(0.81); C371(0.81)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C368(0.72); C371(0.72)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C368(0.85); C371(0.85)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C368(0.91); C371(0.91)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C368(0.94); C371(0.94)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C368(0.73); C371(0.73)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C602(0.86)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C602(0.82)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C602(0.63)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C602(0.92)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C602(0.67)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C602(1.07)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C602(0.98)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C602(1.00)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C602(0.76)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C602(0.76)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C602(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C602(0.90)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C474(0.97)  LDD1569  [4]
 LDCM0346  AC80 HCT 116 C602(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C602(1.33)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C602(1.02)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C368(0.55); C371(0.55)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C368(0.65); C371(0.65)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C368(0.65); C371(0.65)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C368(0.75); C371(0.75)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C368(0.71); C371(0.71)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C368(0.56); C371(0.56)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C368(0.66); C371(0.66)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C368(0.57); C371(0.57)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C368(0.92); C371(0.92)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C368(0.73); C371(0.73)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C368(0.77); C371(0.77)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C368(1.24); C371(1.24)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C368(0.62); C371(0.62)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C368(1.50); C371(1.50)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C368(0.65); C371(0.65)  LDD0681  [2]
 LDCM0275  AKOS034007705 HEK-293T C474(1.21)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C368(0.87); C371(0.87)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C368(1.24); C371(0.80); C474(1.24)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C368(3.10); C371(0.63); C474(3.10)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C368(0.98); C371(1.00); C474(0.98)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C220(1.01)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C474(0.92)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C474(1.16)  LDD1577  [4]
 LDCM0374  CL105 HCT 116 C602(0.70); C368(0.98); C371(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C602(0.70); C368(1.03); C371(1.03)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C602(0.67); C368(0.85); C371(0.85)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C602(0.69); C368(0.94); C371(0.94)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C602(0.87); C368(0.96); C371(0.96)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C368(2.01); C371(0.86); C474(2.01)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C602(0.71); C368(0.87); C371(0.87)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C602(0.78); C368(0.87); C371(0.87)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C602(0.79)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C602(0.57)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C602(0.71)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C602(0.69)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C602(0.66)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C220(0.98)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C474(1.01)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C368(2.20); C371(0.83); C474(2.20)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C474(1.25)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C220(1.01)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C474(1.14)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C474(1.12)  LDD1599  [4]
 LDCM0396  CL125 HCT 116 C368(0.97); C371(0.97)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C368(1.02); C371(1.02)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C368(0.94); C371(0.94)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C368(0.80); C371(0.80)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C368(1.29); C371(1.12); C474(1.29)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C368(2.07); C371(0.87); C474(2.07)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C368(1.87); C371(0.82); C474(1.87)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C371(1.15)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C371(1.05)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C371(0.92)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C371(0.98)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C368(1.78); C371(1.09); C474(1.78)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C371(0.94)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C371(0.99)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C371(0.93)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C371(1.14)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C371(1.04)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C371(0.96)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C371(1.06)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C371(1.05)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C371(1.18)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C371(0.92)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C368(1.72); C371(0.62); C474(1.72)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C371(1.03)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C368(0.97); C371(0.97)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C368(1.31); C371(1.31)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C368(1.09); C371(1.09)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C368(0.79); C371(0.79)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C368(1.02); C371(1.02)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C368(1.02); C371(1.02)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C368(0.87); C371(0.87)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C368(0.77); C371(0.77)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C368(1.52); C371(0.77); C474(1.52)  LDD1027  [2]
 LDCM0430  CL40 HCT 116 C368(0.98); C371(0.98)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C368(1.00); C371(1.00)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C368(0.96); C371(0.96)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C368(0.95); C371(0.95)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C368(0.93); C371(0.93)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C368(0.66); C371(0.66)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C368(0.94); C371(0.94)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C368(0.98); C371(0.98)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C368(0.94); C371(0.94)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C368(0.87); C371(0.87)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C368(1.62); C371(0.84); C474(1.62)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C368(0.96); C371(0.96)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C368(0.85); C371(0.85)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C368(0.84); C371(0.84)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C368(0.92); C371(0.92)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C368(0.78); C371(0.78)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C368(0.86); C371(0.86)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C368(0.83); C371(0.83)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C368(1.04); C371(1.04)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C368(1.06); C371(1.06)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C368(0.89); C371(0.89)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C368(1.43); C371(0.83); C474(1.43)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C368(1.03); C371(1.03)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C368(0.84); C371(0.84)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C368(0.77); C371(0.77)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C368(0.68); C371(0.68)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C368(0.66); C371(0.66)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C368(0.87); C371(0.87)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C368(0.63); C371(0.63)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C368(0.87); C371(0.87)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C368(0.75); C371(0.75)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C368(1.08); C371(1.08)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C368(1.39); C371(0.63); C474(1.39)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C368(0.83); C371(0.83)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C368(0.75); C371(0.75)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C368(1.07); C371(1.07)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C368(0.71); C371(0.71)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C368(0.77); C371(0.77)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C368(0.95); C371(0.95)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C368(1.07); C371(1.07)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C368(0.85); C371(0.85)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C368(0.71); C371(0.71)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C368(1.39); C371(1.79); C474(1.14)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C368(1.90); C371(1.90)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C368(0.85); C371(0.85)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C368(0.67); C371(0.67)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C368(0.61); C371(0.61)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C368(0.72); C371(0.72)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C368(0.75); C371(0.75)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C368(0.96); C371(0.96)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C368(0.62); C371(0.62)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C368(0.52); C371(0.52)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C368(0.83); C371(0.83)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C368(1.21); C371(1.67); C474(1.22)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C368(0.99); C371(0.99)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C368(0.64); C371(1.17); C474(0.64)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C368(0.57); C371(1.36); C474(0.57)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C368(0.74); C371(0.86); C474(0.74)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C368(0.75); C371(0.76); C474(0.75)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C368(0.84); C371(0.77); C474(0.84)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C368(0.83); C371(1.01); C474(0.83)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C368(0.67); C371(1.30); C474(0.67)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C368(0.79); C371(1.04); C474(0.79)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C368(0.61); C371(1.14); C474(0.61)  LDD1092  [2]
 LDCM0468  Fragment33 HCT 116 C368(0.92); C371(0.92)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C368(0.78); C371(0.78)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C602(0.92); C220(0.90)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C602(0.97); C220(0.90)  LDD1497  [4]
 LDCM0024  KB05 NALM-6 C474(1.49)  LDD3339  [5]
 LDCM0021  THZ1 HCT 116 C368(1.23); C371(1.23)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Jade-1 (JADE1) JADE family Q6IE81
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
Centrosomal protein of 126 kDa (CEP126) . Q9P2H0
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840