Details of the Target

General Information of Target

Target ID LDTP01338
Target Name Serine hydrolase RBBP9 (RBBP9)
Gene Name RBBP9
Gene ID 10741
Synonyms
BOG; RBBP10; Serine hydrolase RBBP9; EC 3.-.-.-; B5T-overexpressed gene protein; Protein BOG; Retinoblastoma-binding protein 10; RBBP-10; Retinoblastoma-binding protein 9; RBBP-9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFME
TELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQW
EKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKS
LLKVPA
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
RBBP9 family
Function
Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.
TTD ID
T12084
Uniprot ID
O75884
DrugMap ID
TTUA38Z
Ensemble ID
ENST00000337227.9
HGNC ID
HGNC:9892
ChEMBL ID
CHEMBL1075121

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C39(0.72)  LDD2089  [1]
HHS-475
 Probe Info  		Y129(1.42)  LDD0264  [2]
IPM
 Probe Info  		C39(11.90)  LDD1701  [1]
DBIA
 Probe Info  		C39(0.59)  LDD0563  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C127(0.00); C65(0.00); C163(0.00); C39(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C65(0.00); C163(0.00); C39(0.00); C127(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		C163(0.00); C127(0.00)  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C127(0.00); C65(0.00); C163(0.00); C39(0.00)  LDD0037  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
NAIA_5
 Probe Info  		C127(0.00); C39(0.00); C65(0.00); C163(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C39(1.03)  LDD2117  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C39(0.50)  LDD2132  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C39(0.59)  LDD2131  [1]
 LDCM0214  AC1 HEK-293T C39(0.94); C163(1.03); C127(0.88); C65(0.87)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C163(0.81)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C163(0.87)  LDD1105  [3]
 LDCM0237  AC12 PaTu 8988t C163(0.93)  LDD1116  [3]
 LDCM0246  AC128 HCT 116 C39(0.59)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C39(1.20)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C39(0.74)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C39(1.15)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C39(1.04)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C39(0.84)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C39(0.77)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C39(0.77)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C39(0.93)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C39(1.03)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C39(0.97)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C39(0.95)  LDD0575  [3]
 LDCM0259  AC14 PaTu 8988t C163(0.90)  LDD1138  [3]
 LDCM0260  AC140 HCT 116 C39(0.84)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C39(0.90)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C39(1.19)  LDD0579  [3]
 LDCM0270  AC15 PaTu 8988t C163(0.83)  LDD1149  [3]
 LDCM0276  AC17 HCT 116 C163(0.90)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C163(0.83)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C163(0.95)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C39(0.95); C163(1.11); C127(1.09); C65(0.90)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C163(0.87)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C163(0.89)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C163(0.86)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C163(0.80)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C163(0.85)  LDD0601  [3]
 LDCM0285  AC25 PaTu 8988t C39(1.26)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C39(1.04)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C39(0.87)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C39(0.90)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C39(1.01)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C39(0.94); C163(1.10); C127(0.95)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C39(0.91)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C39(1.27)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C39(0.92)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C39(0.84)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C39(0.66)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C163(0.98)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C163(1.02)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C163(1.00)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C163(1.13)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C163(0.91)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C39(0.99); C163(1.06); C127(0.99); C65(1.02)  LDD1540  [10]
 LDCM0302  AC40 HCT 116 C163(0.89)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C163(1.05)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C163(1.00)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C163(0.96)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C163(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C163(1.04)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C163(0.98)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C163(0.99)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C163(0.96)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C163(0.76)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C39(0.99); C163(1.00); C127(1.03)  LDD1551  [10]
 LDCM0313  AC50 HCT 116 C163(0.81)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C163(0.90)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C163(1.02)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C163(1.00)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C163(0.86)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C163(0.75)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C163(0.66)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C39(0.92); C163(0.99); C127(0.94); C65(0.84)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C39(1.05); C163(1.03); C127(1.09); C65(0.86)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C39(0.97); C163(1.05); C127(1.04)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C163(0.96)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C39(1.02); C163(0.96); C127(0.93); C65(1.05)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C39(1.03); C163(0.99); C127(0.99)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C39(0.91); C127(0.89)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C39(1.03); C163(0.95)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C39(0.97); C163(1.01); C127(0.96)  LDD1567  [10]
 LDCM0334  AC7 PaTu 8988t C163(0.91)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C163(0.94)  LDD1224  [3]
 LDCM0349  AC83 PaTu 8988t C163(1.07); C39(1.31)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C163(1.14); C39(1.18)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C163(1.08); C39(1.43)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C163(1.07); C39(1.32)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C163(1.17); C39(1.48)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C163(1.10); C39(1.60)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C163(1.14); C39(1.45)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C163(0.87); C39(1.64)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C163(1.03); C39(1.55)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C163(1.11); C39(1.07)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C163(1.02); C39(1.85)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C163(1.09); C39(1.35)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C163(1.01); C39(1.21)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C163(0.86); C39(1.57)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C163(1.09); C39(1.63)  LDD1243  [3]
 LDCM0545  Acetamide MDA-MB-231 C39(0.35)  LDD2138  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C39(0.81)  LDD2113  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C163(0.81)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C163(0.95)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C163(0.92)  LDD1154  [3]
 LDCM0498  BS-3668 MDA-MB-231 C39(0.57)  LDD2091  [1]
 LDCM0632  CL-Sc Hep-G2 C163(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C39(1.22)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C39(0.62)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C39(0.92); C163(1.00); C127(1.07)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C163(0.96)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C163(1.04)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C163(0.62)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C163(0.85)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C163(0.90)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C163(0.92)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C163(0.97)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C163(0.91)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C163(0.93)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C39(0.50)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C163(0.85)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C163(0.89)  LDD0698  [3]
 LDCM0382  CL112 PaTu 8988t C39(1.21)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C39(1.07)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C39(0.98)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C39(1.16)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C39(1.23)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C163(0.69)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C163(1.03)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C163(0.87)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C39(0.53)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C163(0.98)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C163(0.78)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C163(0.90)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C163(0.92)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C163(0.83)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C39(1.01); C163(0.92)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C39(1.21); C163(0.94); C127(1.10)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C39(0.94); C163(0.99); C127(1.10); C65(1.02)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C39(0.98); C163(0.89); C127(1.07)  LDD1603  [10]
 LDCM0400  CL13 HCT 116 C39(0.65)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C39(1.10)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C39(0.61)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C39(0.65)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C39(0.64)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C39(0.58)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C39(0.46)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C39(1.35)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C39(0.30)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C39(0.30)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C39(0.37)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C39(0.32)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C39(0.66)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C39(0.79)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C39(0.38)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C39(0.61)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C39(0.30)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C39(0.33)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C39(1.09)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C39(0.55)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C163(1.11); C39(0.72)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C163(0.91); C39(0.67)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C163(0.67); C39(0.54)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C163(0.82); C39(0.44)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C163(0.87); C39(0.46)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C163(0.94); C39(0.55)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C163(0.96); C39(0.41)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C163(0.80); C39(0.48)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C39(0.86)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C163(0.65); C39(0.49)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C163(0.83); C39(0.60)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C163(0.56); C39(0.27)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C163(0.75); C39(0.37)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C163(0.81); C39(0.52)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C163(0.80); C39(0.40)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C39(0.98); C127(0.95)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C39(0.96); C163(1.10)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C39(1.07); C163(0.99); C127(0.79)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C39(1.01); C163(0.94)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C39(0.97)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C39(1.03); C163(0.99); C127(1.12)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C39(0.94); C163(1.04); C127(0.99)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C39(1.06); C163(1.01); C127(1.13); C65(0.94)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C39(1.36); C163(1.13); C127(1.17); C65(0.98)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C39(0.98); C163(1.10); C127(0.87)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C39(1.02); C163(1.00); C127(0.92); C65(1.04)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C39(1.20); C163(0.97); C127(1.10)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C39(1.00); C127(0.88)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C39(0.99); C163(1.05)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C39(0.80)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C39(1.07); C163(1.00); C127(0.78)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C163(1.17)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C163(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C163(1.03)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C163(1.01)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C163(1.06)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C163(1.08)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C163(0.98)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C163(1.12)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C163(1.19)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C39(0.69)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C163(1.05)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C163(0.93)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C163(1.17)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C163(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C163(1.00)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C39(0.78)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C39(0.83)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C39(0.82)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C39(0.65)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C39(0.54)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C39(0.86)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C39(0.81)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C39(0.44)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C39(0.55)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C39(0.31)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C39(0.79)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C39(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C39(0.81)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C39(0.52)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C39(0.31)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C39(0.89)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C39(1.29)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C39(1.02); C163(1.10); C127(0.83)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C39(1.17); C163(1.06); C127(0.89); C65(1.04)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C39(1.23); C163(0.97); C127(1.07)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C39(0.91); C127(0.81)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C39(1.69); C163(1.02)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C39(0.87); C163(0.94); C127(1.03)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C39(1.14); C163(1.07)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C39(1.09); C163(1.04); C127(1.07)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C39(0.95); C163(1.09); C127(1.05); C65(0.88)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C39(0.85); C163(0.99); C127(0.95); C65(0.88)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C39(6.43)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C163(1.17)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C163(0.68); C39(0.28)  LDD0744  [3]
 LDCM0116  HHS-0101 DM93 Y129(1.42)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y129(1.00)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y129(1.43)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y129(1.40)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y129(2.03)  LDD0268  [2]
 LDCM0022  KB02 HEK-293T C39(0.99); C163(1.04); C127(1.04)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C39(0.93); C163(1.03); C127(1.06)  LDD1497  [10]
 LDCM0024  KB05 G361 C127(2.16); C39(3.99)  LDD3311  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C39(1.13)  LDD2102  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C39(0.63)  LDD2121  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C39(0.72)  LDD2089  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C39(0.83)  LDD2099  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C39(1.26)  LDD2101  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C39(0.82)  LDD2108  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C39(0.73)  LDD2109  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C39(0.81)  LDD2111  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C39(0.71)  LDD2115  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C39(1.06)  LDD2119  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C39(0.94)  LDD2120  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C39(1.01)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C39(0.85)  LDD2125  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C39(0.96)  LDD2126  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C39(1.08)  LDD2127  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C39(0.85)  LDD2128  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C39(0.97)  LDD2129  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C39(0.54)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C39(1.03)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C39(0.83)  LDD2136  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C39(0.64)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C39(1.27)  LDD2141  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C39(0.85)  LDD2143  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C39(2.21)  LDD2144  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C39(0.63)  LDD2146  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C39(0.66)  LDD2148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RCC1 and BTB domain-containing protein 2 (RCBTB2) . O95199

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ala(1-naph)-pro-cn Small molecular drug D06WSN

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840